Perifosine-induced inhibition of Akt attenuates brain-derived neurotrophic factor/TrkB-induced chemoresistance in neuroblastoma in vivo

Cancer

Volumn 117, Issue 23, 2011, Pages 5412-5422

  Li, Zhijie ^a   Oh, Doo Yi ^a   Nakamura, Katsuya ^a   Thiele, Carol J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Akt; brain derived neurotrophic factor; etoposide; neuroblastoma; perifosine; TrkB

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; ETOPOSIDE; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; PERIFOSINE; PLACEBO; PROTEIN KINASE B; RECOMBINANT BRAIN DERIVED NEUROTROPHIC FACTOR; TETRACYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME ASSAY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR GROWTH; TUMOR VOLUME; WESTERN BLOTTING;

BRAIN NEOPLASMS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; HUMANS; NEUROBLASTOMA; PHOSPHORYLATION; PHOSPHORYLCHOLINE; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, TRKB; TETRACYCLINE;

EID: 80054752480     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.26133     Document Type: Article

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