메뉴 건너뛰기




Volumn 16, Issue SUPPL. 1, 2012, Pages

The paradigm of personalized therapy in oncology

Author keywords

Predictive biomarkers; Study design; Targeted anticancer agents

Indexed keywords

AFATINIB; CABOZANTINIB; CANERTINIB; CAPECITABINE; CARBOPLATIN; CRIZOTINIB; DOCETAXEL; ERLOTINIB; EVEROLIMUS; FORETINIB; GEFITINIB; GEMCITABINE; IMATINIB; LAPATINIB; LETROZOLE; MAYTANSINE; MK 2206; NERATINIB; NILOTINIB; PACLITAXEL; PELITINIB; PEMETREXED; PERTUZUMAB; PLATINUM; PROTEIN KINASE B INHIBITOR; RILOTUMUMAB; SELUMETINIB; SUNITINIB; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84857597802     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2011.637921     Document Type: Review
Times cited : (15)

References (66)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;44:646-74
    • (2011) Cell , vol.44 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0034256419 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors
    • Casper ES. Gastrointestinal stromal tumors. Curr Treat Options Oncol 2000;1:267-73
    • (2000) Curr Treat Options Oncol , vol.1 , pp. 267-273
    • Casper, E.S.1
  • 3
    • 0032857449 scopus 로고    scopus 로고
    • The biology of stem cell factor and its receptor C-kit
    • DOI 10.1016/S1357-2725(99)00076-X, PII S135727259900076X
    • Ashman LK. The biology of stem cell factor and its receptor c-kit. Int J Biochem Cell Biol 1999;31:1037-51 (Pubitemid 29454545)
    • (1999) International Journal of Biochemistry and Cell Biology , vol.31 , Issue.10 , pp. 1037-1051
    • Ashman, L.K.1
  • 7
    • 77950527979 scopus 로고    scopus 로고
    • Approval summary: Imatinib mesylate in the adjuvant treatment of malignant gastrointestinal stromal tumors
    • Cohen MH, Cortazar P, Justice R, Pazdur R. Approval summary: imatinib mesylate in the adjuvant treatment of malignant gastrointestinal stromal tumors. Oncologist 2010;15:300-7
    • (2010) Oncologist , vol.15 , pp. 300-307
    • Cohen, M.H.1    Cortazar, P.2    Justice, R.3    Pazdur, R.4
  • 8
    • 77949535841 scopus 로고    scopus 로고
    • Pharmacological management of gastrointestinal stromal tumours: An update on the role of sunitinib
    • Blay JY. Pharmacological management of gastrointestinal stromal tumours: an update on the role of sunitinib. Ann Oncol 2010;21:208-15
    • (2010) Ann Oncol , vol.21 , pp. 208-215
    • Blay, J.Y.1
  • 9
    • 56749156604 scopus 로고    scopus 로고
    • Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group
    • Heinrich MC, Owzar K, Corless CL, et al. Correlation of kinase genotype and clinical outcome in the North American Intergroup Phase III trial of imatinib mesylate for treatment of advanced gastrointestinal stromal tumor: CALGB 150105 Study by Cancer and Leukemia Group B and Southwest Oncology Group. J Clin Oncol 2008;26:5360-7
    • (2008) J Clin Oncol , vol.26 , pp. 5360-5367
    • Heinrich, M.C.1    Owzar, K.2    Corless, C.L.3
  • 10
    • 49749122255 scopus 로고    scopus 로고
    • Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumours
    • Lasota J, Miettinen M. Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumours. Histopathology 2008;53:245-66
    • (2008) Histopathology , vol.53 , pp. 245-266
    • Lasota, J.1    Miettinen, M.2
  • 11
    • 79953074766 scopus 로고    scopus 로고
    • Correlations between imatinib pharmacokinetics, pharmacodynamics, adherence, and clinical response in advanced metastatic gastrointestinal stromal tumor (GIST): An emerging role for drug blood level testing?
    • von Mehren M, Widmer N. Correlations between imatinib pharmacokinetics, pharmacodynamics, adherence, and clinical response in advanced metastatic gastrointestinal stromal tumor (GIST): an emerging role for drug blood level testing? Cancer Treat Rev 2011;37:291-9
    • (2011) Cancer Treat Rev , vol.37 , pp. 291-299
    • Von Mehren, M.1    Widmer, N.2
  • 14
    • 79251490374 scopus 로고    scopus 로고
    • New driver mutations in non-small-cell lung cancer
    • Pao W, Girard N. New driver mutations in non-small-cell lung cancer. Lancet Oncol 2011;12:175-80
    • (2011) Lancet Oncol , vol.12 , pp. 175-180
    • Pao, W.1    Girard, N.2
  • 15
    • 69949162760 scopus 로고    scopus 로고
    • Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
    • Mok TS, Wu YL, Thogprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361:947-57
    • (2009) N Engl J Med , vol.361 , pp. 947-957
    • Mok, T.S.1    Wu, Y.L.2    Thogprasert, S.3
  • 16
    • 75249087060 scopus 로고    scopus 로고
    • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomized phase III trial
    • Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomized phase III trial. Lancet Oncol 2010;11:121-8
    • (2010) Lancet Oncol , vol.11 , pp. 121-128
    • Mitsudomi, T.1    Morita, S.2    Yatabe, Y.3
  • 17
    • 77953930730 scopus 로고    scopus 로고
    • Gefitinib or chemotherapy for Non-Small-Cell Lung Cancer with mutated EGFR
    • Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for Non-Small-Cell Lung Cancer with mutated EGFR. N Engl J Med 2010;362:2380-8
    • (2010) N Engl J Med , vol.362 , pp. 2380-2388
    • Maemondo, M.1    Inoue, A.2    Kobayashi, K.3
  • 18
    • 79960889662 scopus 로고    scopus 로고
    • Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase III study
    • Zhou C, Wu YL, Chen G, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase III study. Lancet Oncol 2011;12:735-42
    • (2011) Lancet Oncol , vol.12 , pp. 735-742
    • Zhou, C.1    Wu, Y.L.2    Chen, G.3
  • 20
    • 70349342712 scopus 로고    scopus 로고
    • EML4-AKT:honing in on a new target in non-small-cell lung cancer
    • Horn L, Pao W. EML4-AKT:honing in on a new target in non-small-cell lung cancer. J Clin Oncol 2009;27:4247-53
    • (2009) J Clin Oncol , vol.27 , pp. 4247-4253
    • Horn, L.1    Pao, W.2
  • 21
    • 4944232647 scopus 로고    scopus 로고
    • Lung cancer: Intragenic ERBB2 kinase mutations in tumours
    • Stephens P, Hunter C, Bignell G, et al. Lung cancer: intragenic ERBB2 kinase mutations in tumours. Nature 2004;431:525-6
    • (2004) Nature , vol.431 , pp. 525-526
    • Stephens, P.1    Hunter, C.2    Bignell, G.3
  • 24
    • 0035949699 scopus 로고    scopus 로고
    • AKT plays a centralrole in tumorigenesis
    • Testa JR, Bellacosa A. AKT plays a centralrole in tumorigenesis. Proc Natl Acad Sci USA 2001;98:10983-5
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10983-10985
    • Testa, J.R.1    Bellacosa, A.2
  • 26
    • 79952753171 scopus 로고    scopus 로고
    • Clinical experience to date with nilotinib in gastrointestinal stromal tumors
    • Reichardt P, Montemurro M. Clinical experience to date with nilotinib in gastrointestinal stromal tumors. Semin Oncol 2011;38(Suppl 1):S20-7
    • (2011) Semin Oncol , vol.38 , Issue.SUPPL. 1
    • Reichardt, P.1    Montemurro, M.2
  • 27
    • 48649107410 scopus 로고    scopus 로고
    • Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signalling pathway genes in lung adenocarcinoma
    • Marks JL, Gong Y, Chitale D, et al. Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signalling pathway genes in lung adenocarcinoma. Cancer Res 2008;68:5524-8
    • (2008) Cancer Res , vol.68 , pp. 5524-5528
    • Marks, J.L.1    Gong, Y.2    Chitale, D.3
  • 29
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987;235:177-82 (Pubitemid 17231334)
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 33
    • 78649701154 scopus 로고    scopus 로고
    • Evolving strategies for overcoming resistance to HER2-directed therapy: Targeting the PI3K/Akt/mTOR pathway
    • Nahta R, O'Regan RM. Evolving strategies for overcoming resistance to HER2-directed therapy: targeting the PI3K/Akt/mTOR pathway. Clin Breast Cancer 2010;10(Suppl 3):S72-8
    • (2010) Clin Breast Cancer , vol.10 , Issue.SUPPL. 3
    • Nahta, R.1    O'Regan, R.M.2
  • 34
    • 80051751593 scopus 로고    scopus 로고
    • Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy
    • Morrow PK, Wulf GM, Ensor J, et al. Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy. J Clin Oncol 2011;29:3126-32
    • (2011) J Clin Oncol , vol.29 , pp. 3126-3132
    • Morrow, P.K.1    Wulf, G.M.2    Ensor, J.3
  • 35
    • 70350623516 scopus 로고    scopus 로고
    • A phase II study of trastuzumab-DM1 (T-DM1), a HER2, in patients (pts) with HER2+ metastatic breast cancer (MBC): Final results. In: 2009 ASCO Annual Meeting
    • Vogel CL, Burris HA, Limentani S, et al. A phase II study of trastuzumab-DM1 (T-DM1), a HER2, in patients (pts) with HER2+ metastatic breast cancer (MBC): final results. In: 2009 ASCO Annual Meeting. J Clin Oncol 2009;27(Suppl 15):abstract 1017
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. 15 , pp. 1017
    • Vogel, C.L.1    Burris, H.A.2    Limentani, S.3
  • 39
    • 73149115341 scopus 로고    scopus 로고
    • Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
    • Johnston S, Pippen JE, Pivot X Jr, et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol 2009;27:5538-46
    • (2009) J Clin Oncol , vol.27 , pp. 5538-5546
    • Johnston, S.1    Pippen, J.E.2    Pivot Jr., X.3
  • 40
    • 40449112910 scopus 로고    scopus 로고
    • Letrozole versus letrozole plus lapatinib (GW572016) in hormone-sensitive, HER2-negative operable breast cancer: A double-blind, randomized, phase II study with biomarker evaluation (EGF109077-LAP107692/ LETLOB)
    • DOI 10.3816/CBC.2008.n.010
    • Frassoldati A, Guarneri V, Piacentini F, et al. Letrozole versus letrozole plus lapatinib (GW572016) in hormone-sensitive, HER2-negative operable breast cancer: a double-blind, randomized, Phase II study with biomarker evaluation (EGF109077-LAP107692/LETLOB). Clin Breast Cancer 2008;8:97-100 (Pubitemid 351346237)
    • (2008) Clinical Breast Cancer , vol.8 , Issue.1 , pp. 97-100
    • Frassoldati, A.1    Guarneri, V.2    Piacentini, F.3    Jovic, G.4    Giovannelli, S.5    Oliva, C.6    Conte, P.F.7
  • 41
    • 43249090582 scopus 로고    scopus 로고
    • Preoperative chemotherapy plus lapatinib or trastuzumab or both in HER2-positive operable breast cancer (CHERLOB trial)
    • DOI 10.3816/CBC.2008.n.022
    • Guarneri V, Frassoldati A, Piacentini F, et al. Preoperative chemotherapy plus lapatinib or trastuzumab or both in HER2-positive operable breast cancer (CHERLOB Trial). Clin Breast Cancer 2008;8:192-4 (Pubitemid 351655936)
    • (2008) Clinical Breast Cancer , vol.8 , Issue.2 , pp. 192-194
    • Guarneri, V.1    Frassoldati, A.2    Piacentini, F.3    Jovic, G.4    Giovannelli, S.5    Oliva, C.6    Conte, P.7
  • 42
    • 73849142191 scopus 로고    scopus 로고
    • Neratinib in combination with trastuzumab for the treatment of advanced breast cancer: A phase I/II study 2009 ASCO Annual Meeting
    • Swaby R, Blackwell K, Jiang Z, et al. Neratinib in combination with trastuzumab for the treatment of advanced breast cancer: a phase I/II study. In: 2009 ASCO Annual Meeting. J Clin Oncol 2009;27(Suppl 15):abstract 1004
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. 15 , pp. 1004
    • Swaby, R.1    Blackwell, K.2    Jiang, Z.3
  • 45
    • 1842605531 scopus 로고    scopus 로고
    • Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
    • DOI 10.1016/S1535-6108(04)00083-2, PII S1535610804000832
    • Franklin MC, Carey KD, Vajdos FF, et al. Insights into ErbBsignaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell 2004;5:317-28 (Pubitemid 38482068)
    • (2004) Cancer Cell , vol.5 , Issue.4 , pp. 317-328
    • Franklin, M.C.1    Carey, K.D.2    Vajdos, F.F.3    Leahy, D.J.4    De Vos, A.M.5    Sliwkowski, M.X.6
  • 46
    • 1942474587 scopus 로고    scopus 로고
    • The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells
    • DOI 10.1158/0008-5472.CAN-03-3856
    • Nahta R, Hung MC, Esteva FJ. The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Res 2004;64:2343-6 (Pubitemid 38523885)
    • (2004) Cancer Research , vol.64 , Issue.7 , pp. 2343-2346
    • Nahta, R.1    Hung, M.-C.2    Esteva, F.J.3
  • 47
    • 52949085848 scopus 로고    scopus 로고
    • Ertumaxomab: A trifunctional antibody for breast cancer treatment
    • Kiewe P, Thiel E. Ertumaxomab: a trifunctional antibody for breast cancer treatment. Expert Opin Investig Drugs 2008;17:1553-8
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 1553-1558
    • Kiewe, P.1    Thiel, E.2
  • 48
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
    • Fong PC, Boss DS, Yap TA, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009;361:123-34
    • (2009) N Engl J Med , vol.361 , pp. 123-134
    • Fong, P.C.1    Boss, D.S.2    Yap, T.A.3
  • 49
    • 78649744892 scopus 로고    scopus 로고
    • Prognostic vs predictive molecular biomarkers in colorectal cancer: Is KRAS and BRAF wild type status required for anti-EGFR therapy?
    • Rizzo S, Bronte G, Fanale D, et al. Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy? Cancer Treat Rev 2010;36(Suppl 3):S56-61
    • (2010) Cancer Treat Rev , vol.36 , Issue.SUPPL. 3
    • Rizzo, S.1    Bronte, G.2    Fanale, D.3
  • 50
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008;359:1757-65
    • (2008) N Engl J Med , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 51
    • 79959337678 scopus 로고    scopus 로고
    • Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: Results of the randomized phase III MRC COIN trial
    • Maughan TS, Adams RA, Smith CG, et al. Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomized phase III MRC COIN trial. Lancet 2011;377:2103-14
    • (2011) Lancet , vol.377 , pp. 2103-2114
    • Maughan, T.S.1    Adams, R.A.2    Smith, C.G.3
  • 52
    • 77954215850 scopus 로고    scopus 로고
    • Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab
    • Tol J, Dijkstra JR, Klomp M, et al. Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab. Eur J Cancer 2010;46:1997-2009
    • (2010) Eur J Cancer , vol.46 , pp. 1997-2009
    • Tol, J.1    Dijkstra, J.R.2    Klomp, M.3
  • 53
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
    • De Roock W, Claes B, Bernasconi D, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 2010;11:753-62
    • (2010) Lancet Oncol , vol.11 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3
  • 54
    • 79960974482 scopus 로고    scopus 로고
    • New strategies in metastatic melanoma: Oncogene-defined taxonomy leads to therapeutic advances
    • Flaherty KT, Fisher DE. New strategies in metastatic melanoma: oncogene-defined taxonomy leads to therapeutic advances. Clin Cancer Res 2011;17:4922-8
    • (2011) Clin Cancer Res , vol.17 , pp. 4922-4928
    • Flaherty, K.T.1    Fisher, D.E.2
  • 55
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with Vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A, Robert C, et al. Improved survival with Vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011;364:2507-16
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 56
    • 78651418282 scopus 로고    scopus 로고
    • Mutant BRAF melanomas-dependence and resistance
    • Poulikakos PI, Rosen N. Mutant BRAF melanomas-dependence and resistance. Cancer Cell 2011;19:11-15
    • (2011) Cancer Cell , vol.19 , pp. 11-15
    • Poulikakos, P.I.1    Rosen, N.2
  • 57
    • 79953271634 scopus 로고    scopus 로고
    • The evolving war on cancer
    • Haber DA, Gray NS, Baselga J. The evolving war on cancer. Cell 2011;145:19-24
    • (2011) Cell , vol.145 , pp. 19-24
    • Haber, D.A.1    Gray, N.S.2    Baselga, J.3
  • 58
    • 77953236472 scopus 로고    scopus 로고
    • Morphology, Attenuation, Size, and Structure (MASS) Criteria: Assessing response and predicting clinical outcome in metastatic renal cell carcinoma on antiangiogenic targeted therapy
    • Smith AD, Shah SN, Rini BI, et al. Morphology, Attenuation, Size, and Structure (MASS) Criteria: assessing response and predicting clinical outcome in metastatic renal cell carcinoma on antiangiogenic targeted therapy. Am J Radiol 2010;194:1470-8
    • (2010) Am J Radiol , vol.194 , pp. 1470-1478
    • Smith, A.D.1    Shah, S.N.2    Rini, B.I.3
  • 59
    • 79958038176 scopus 로고    scopus 로고
    • Parametric images via dynamic 18F-fluorodeoxyglucose positron emission tomographic data acquisition in predicting midterm outcome of liver metastases secondary to gastrointestinal stromal tumours
    • Apostolopoulos DJ, Dimitrakopoulou-Strauss A, Hohenberger P, et al. Parametric images via dynamic 18F-fluorodeoxyglucose positron emission tomographic data acquisition in predicting midterm outcome of liver metastases secondary to gastrointestinal stromal tumours. Eur J Nucl Med Mol Imaging 2011;38:1212-23
    • (2011) Eur J Nucl Med Mol Imaging , vol.38 , pp. 1212-1223
    • Apostolopoulos, D.J.1    Dimitrakopoulou-Strauss, A.2    Hohenberger, P.3
  • 60
    • 77956268839 scopus 로고    scopus 로고
    • Understanding resistance to EGFR inhibitors-impact on future treatment strategies
    • Wheeler DL, Dunn EF, Harari PM. Understanding resistance to EGFR inhibitors-impact on future treatment strategies. Nat Rev Clin Oncol 2010;7:493-507
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 493-507
    • Wheeler, D.L.1    Dunn, E.F.2    Harari, P.M.3
  • 61
    • 79952392467 scopus 로고    scopus 로고
    • Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
    • Bissell MJ, Hines WC. Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nature Med 2011;17:320-9
    • (2011) Nature Med , vol.17 , pp. 320-329
    • Bissell, M.J.1    Hines, W.C.2
  • 62
    • 77956673574 scopus 로고    scopus 로고
    • Epigenetic modifications in double-strand break DNA damage signalling and repair
    • Rossetto D, Truman AW, Kron SJ, Cote J. Epigenetic modifications in double-strand break DNA damage signalling and repair. Clin Cancer Res 2010;16:4543-52
    • (2010) Clin Cancer Res , vol.16 , pp. 4543-4552
    • Rossetto, D.1    Truman, A.W.2    Kron, S.J.3    Cote, J.4
  • 63
    • 79961170994 scopus 로고    scopus 로고
    • A ceRNA hypothesis: The Rosetta stone of a hidden RNA language?
    • Solmena L, Poliseno L, Tay Y, et al. A ceRNA hypothesis: the Rosetta stone of a hidden RNA language? Cell 2011;146:353-8
    • (2011) Cell , vol.146 , pp. 353-358
    • Solmena, L.1    Poliseno, L.2    Tay, Y.3
  • 64
    • 80052594392 scopus 로고    scopus 로고
    • BiKDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment
    • Lang J-Yu, Hsu JL, Meric-Bernstam F, et al. BiKDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer Cell 2011;20:341-56
    • (2011) Cancer Cell , vol.20 , pp. 341-356
    • Lang, J.-Y.U.1    Hsu, J.L.2    Meric-Bernstam, F.3
  • 65
    • 79953114311 scopus 로고    scopus 로고
    • A national cancer clinical trials system for targeted therapies
    • Mendelsohn J. A national cancer clinical trials system for targeted therapies. Sci Transl Med 2011;3:72-6
    • (2011) Sci Transl Med , vol.3 , pp. 72-76
    • Mendelsohn, J.1
  • 66
    • 79952415527 scopus 로고    scopus 로고
    • Taming the dragon: Genomic biomarkers to individualize the treatment of cancer
    • Majewski IJ, Bernards R. Taming the dragon: genomic biomarkers to individualize the treatment of cancer. Nat Med 2011;17:304-12
    • (2011) Nat Med , vol.17 , pp. 304-312
    • Majewski, I.J.1    Bernards, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.