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Volumn 120, Issue 17, 2012, Pages 3510-3518

Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemia

Author keywords

[No Author keywords available]

Indexed keywords

JANUS KINASE 1; JANUS KINASE 2; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; RUXOLITINIB;

EID: 84868528389     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-03-415448     Document Type: Article
Times cited : (238)

References (54)
  • 1
    • 84863772728 scopus 로고    scopus 로고
    • Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: A report from the Children's Oncology Group
    • Hunger SP, Lu X, Devidas M, et al. Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the Children's Oncology Group. J Clin Oncol. 2012;30(14):1663-1669.
    • (2012) J Clin Oncol , vol.30 , Issue.14 , pp. 1663-1669
    • Hunger, S.P.1    Lu, X.2    Devidas, M.3
  • 2
    • 58749097408 scopus 로고    scopus 로고
    • Asubtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: A genomewide classification study
    • Den Boer ML, van Slegtenhorst M, De Menezes RX, et al.Asubtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genomewide classification study. Lancet Oncol. 2009;10(2): 125-134.
    • (2009) Lancet Oncol , vol.10 , Issue.2 , pp. 125-134
    • Den Boer, M.L.1    Van Slegtenhorst, M.2    De Menezes, R.X.3
  • 3
    • 80052922387 scopus 로고    scopus 로고
    • Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group
    • Zhang J, Mullighan CG, Harvey RC, et al. Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood. 2011; 118(11):3080-3087.
    • (2011) Blood , vol.118 , Issue.11 , pp. 3080-3087
    • Zhang, J.1    Mullighan, C.G.2    Harvey, R.C.3
  • 4
    • 58749109707 scopus 로고    scopus 로고
    • Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia
    • Mullighan CG, Su X, Zhang J, et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med. 2009;360(5):470-480.
    • (2009) N Engl J Med , vol.360 , Issue.5 , pp. 470-480
    • Mullighan, C.G.1    Su, X.2    Zhang, J.3
  • 6
    • 34249733805 scopus 로고    scopus 로고
    • High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression
    • DOI 10.1038/sj.leu.2404691, PII 2404691
    • Kuiper RP, Schoenmakers EF, van Reijmersdal SV, et al. High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression. Leukemia. 2007;21(6):1258-1266. (Pubitemid 46831815)
    • (2007) Leukemia , vol.21 , Issue.6 , pp. 1258-1266
    • Kuiper, R.P.1    Schoenmakers, E.F.P.M.2    Van Reijmersdal, S.V.3    Hehir-Kwa, J.Y.4    Van Kessel, A.G.5    Van Leeuwen, F.N.6    Hoogerbrugge, P.M.7
  • 7
    • 38349177862 scopus 로고    scopus 로고
    • Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray
    • Kawamata N, Ogawa S, Zimmermann M, et al. Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray. Blood. 2008;111(2):776-784.
    • (2008) Blood , vol.111 , Issue.2 , pp. 776-784
    • Kawamata, N.1    Ogawa, S.2    Zimmermann, M.3
  • 8
    • 78649742010 scopus 로고    scopus 로고
    • Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: Correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome
    • Harvey RC, Mullighan CG, Wang X, et al. Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome. Blood. 2010; 116(23):4874-4884.
    • (2010) Blood , vol.116 , Issue.23 , pp. 4874-4884
    • Harvey, R.C.1    Mullighan, C.G.2    Wang, X.3
  • 9
    • 84865118132 scopus 로고    scopus 로고
    • Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia
    • Roberts KG, Morin RD, Zhang J, et al. Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia. Cancer Cell. 2012;22(2):153-166.
    • (2012) Cancer Cell , vol.22 , Issue.2 , pp. 153-166
    • Roberts, K.G.1    Morin, R.D.2    Zhang, J.3
  • 10
    • 70350680415 scopus 로고    scopus 로고
    • Rearrangement of CRLF2 in B-progenitor- And Down syndrome-associated acute lymphoblastic leukemia
    • Mullighan CG, Collins-Underwood JR, Phillips LA, et al. Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia. Nat Genet. 2009;41(11):1243-1246.
    • (2009) Nat Genet , vol.41 , Issue.11 , pp. 1243-1246
    • Mullighan, C.G.1    Collins-Underwood, J.R.2    Phillips, L.A.3
  • 11
    • 70350519430 scopus 로고    scopus 로고
    • Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia
    • Russell LJ, Capasso M, Vater I, et al. Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. Blood. 2009;114(13):2688-2698.
    • (2009) Blood , vol.114 , Issue.13 , pp. 2688-2698
    • Russell, L.J.1    Capasso, M.2    Vater, I.3
  • 12
    • 79951845044 scopus 로고    scopus 로고
    • Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and CRLF2 deregulation: Results from the MRC ALL97 clinical trial
    • Ensor HM, Schwab C, Russell LJ, et al. Demographic, clinical, and outcome features of children with acute lymphoblastic leukemia and CRLF2 deregulation: results from the MRC ALL97 clinical trial. Blood. 2011;117(7):2129-2136.
    • (2011) Blood , vol.117 , Issue.7 , pp. 2129-2136
    • Ensor, H.M.1    Schwab, C.2    Russell, L.J.3
  • 13
    • 77954516863 scopus 로고    scopus 로고
    • Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia
    • Harvey RC, Mullighan CG, Chen IM, et al. Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia. Blood. 2010;115(26):5312-5321.
    • (2010) Blood , vol.115 , Issue.26 , pp. 5312-5321
    • Harvey, R.C.1    Mullighan, C.G.2    Chen, I.M.3
  • 14
    • 67249146555 scopus 로고    scopus 로고
    • JAK mutations in high-risk childhood acute lymphoblastic leukemia
    • Mullighan CG, Zhang J, Harvey RC, et al. JAK mutations in high-risk childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2009; 106(23):9414-9418.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.23 , pp. 9414-9418
    • Mullighan, C.G.1    Zhang, J.2    Harvey, R.C.3
  • 15
    • 76249096219 scopus 로고    scopus 로고
    • Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia
    • Yoda A, Yoda Y, Chiaretti S, et al. Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2010;107(1):252-257.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.1 , pp. 252-257
    • Yoda, A.1    Yoda, Y.2    Chiaretti, S.3
  • 16
    • 84859820034 scopus 로고    scopus 로고
    • Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: A Children's Oncology Group study
    • Chen IM, Harvey RC, Mullighan CG, et al. Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study. Blood. 2012;119(15):3512-3522.
    • (2012) Blood , vol.119 , Issue.15 , pp. 3512-3522
    • Chen, I.M.1    Harvey, R.C.2    Mullighan, C.G.3
  • 17
    • 77649214639 scopus 로고    scopus 로고
    • Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: A report from the International BFM Study Group
    • Hertzberg L, Vendramini E, Ganmore I, et al. Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group. Blood. 2010;115(5):1006-1017.
    • (2010) Blood , vol.115 , Issue.5 , pp. 1006-1017
    • Hertzberg, L.1    Vendramini, E.2    Ganmore, I.3
  • 18
    • 35448953345 scopus 로고    scopus 로고
    • Thymic stromal-derived lymphopoietin induces proliferation of pre-B leukemia and antagonizes mTOR inhibitors, suggesting a role for interleukin-7Ralpha signaling
    • DOI 10.1158/0008-5472.CAN-06-4704
    • Brown VI, Hulitt J, Fish J, et al. Thymic stromal-derived lymphopoietin induces proliferation of pre-B leukemia and antagonizes mTOR inhibitors, suggesting a role for interleukin-7Ralpha signaling. Cancer Res. 2007;67(20):9963-9970. (Pubitemid 47621246)
    • (2007) Cancer Research , vol.67 , Issue.20 , pp. 9963-9970
    • Brown, V.I.1    Hulitt, J.2    Fish, J.3    Sheen, C.4    Bruno, M.5    Xu, Q.6    Carroll, M.7    Fang, J.8    Teachey, D.9    Grupp, S.A.10
  • 19
    • 84864440264 scopus 로고    scopus 로고
    • Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia
    • Tasian SK, Doral MY, Borowitz MJ, et al. Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia. Blood. 2012; 120(4):833-842.
    • (2012) Blood , vol.120 , Issue.4 , pp. 833-842
    • Tasian, S.K.1    Doral, M.Y.2    Borowitz, M.J.3
  • 20
    • 0034657999 scopus 로고    scopus 로고
    • JAK-STAT signaling activated by Abl oncogenes
    • Danial NN, Rothman P. JAK-STAT signaling activated by Abl oncogenes. Oncogene. 2000; 19(21):2523-2531. (Pubitemid 30339208)
    • (2000) Oncogene , vol.19 , Issue.21 , pp. 2523-2531
    • Danial, N.N.1    Rothman, P.2
  • 22
    • 79961191931 scopus 로고    scopus 로고
    • Augmented therapy improves outcome for pediatric high risk acute lymphocytic leukemia: Results of Children's Oncology Group trial P9906
    • Bowman WP, Larsen EL, Devidas M, et al. Augmented therapy improves outcome for pediatric high risk acute lymphocytic leukemia: results of Children's Oncology Group trial P9906. Pediatr Blood Cancer. 2011;57(4):569-577.
    • (2011) Pediatr Blood Cancer , vol.57 , Issue.4 , pp. 569-577
    • Bowman, W.P.1    Larsen, E.L.2    Devidas, M.3
  • 24
    • 52649149525 scopus 로고    scopus 로고
    • mTOR inhibitors are synergistic with methotrexate: An effective combination to treat acute lymphoblastic leukemia
    • Teachey DT, Sheen C, Hall J, et al. mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia. Blood. 2008;112(5):2020-2023.
    • (2008) Blood , vol.112 , Issue.5 , pp. 2020-2023
    • Teachey, D.T.1    Sheen, C.2    Hall, J.3
  • 25
    • 77955889294 scopus 로고    scopus 로고
    • Selective JAK inhibition is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support
    • [abstract]. Abstract 0956
    • Fridman JS, Li J, Caulder E, et al. Selective JAK inhibition is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support [abstract]. Haematologica. 2008;93(Suppl 1):381: Abstract 0956.
    • (2008) Haematologica , vol.93 , Issue.SUPPL. 1 , pp. 381
    • Fridman, J.S.1    Li, J.2    Caulder, E.3
  • 28
    • 52949129499 scopus 로고    scopus 로고
    • Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates
    • Kotecha N, Flores NJ, Irish JM, et al. Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Cancer Cell. 2008;14(4):335-343.
    • (2008) Cancer Cell , vol.14 , Issue.4 , pp. 335-343
    • Kotecha, N.1    Flores, N.J.2    Irish, J.M.3
  • 29
    • 77954197414 scopus 로고    scopus 로고
    • Web-based analysis and publication of flow cytometry experiments
    • Chapter 10:Unit 10.17
    • Kotecha N, Krutzik PO, Irish JM. Web-based analysis and publication of flow cytometry experiments. Curr Protoc Cytom. 2010;Chapter 10:Unit 10.17.
    • (2010) Curr Protoc Cytom
    • Kotecha, N.1    Krutzik, P.O.2    Irish, J.M.3
  • 30
    • 51649109186 scopus 로고    scopus 로고
    • Human acute leukemia cells injected in NOD/ LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains
    • Agliano A, Martin-Padura I, Mancuso P, et al. Human acute leukemia cells injected in NOD/ LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains. Int J Cancer. 2008;123(9):2222-2227.
    • (2008) Int J Cancer , vol.123 , Issue.9 , pp. 2222-2227
    • Agliano, A.1    Martin-Padura, I.2    Mancuso, P.3
  • 31
    • 77956696835 scopus 로고    scopus 로고
    • Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis
    • Verstovsek S, Kantarjian H, Mesa RA, et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N Engl J Med. 2010;363(12):1117-1127.
    • (2010) N Engl J Med , vol.363 , Issue.12 , pp. 1117-1127
    • Verstovsek, S.1    Kantarjian, H.2    Mesa, R.A.3
  • 32
    • 0141508021 scopus 로고    scopus 로고
    • Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin
    • Ly C, Arechiga AF, Melo JV, Walsh CM, Ong ST. Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin. Cancer Res. 2003;63(18): 5716-5722. (Pubitemid 37187466)
    • (2003) Cancer Research , vol.63 , Issue.18 , pp. 5716-5722
    • Ly, C.1    Arechiga, A.F.2    Melo, J.V.3    Walsh, C.M.4    Ong, S.T.5
  • 33
    • 70350726344 scopus 로고    scopus 로고
    • A phase i study of the mammalian target of rapamycin inhibitor sirolimus and MEC chemotherapy in relapsed and refractory acute myelogenous leukemia
    • Perl AE, Kasner MT, Tsai DE, et al. A phase I study of the mammalian target of rapamycin inhibitor sirolimus and MEC chemotherapy in relapsed and refractory acute myelogenous leukemia. Clin Cancer Res. 2009;15(21):6732-6739.
    • (2009) Clin Cancer Res , vol.15 , Issue.21 , pp. 6732-6739
    • Perl, A.E.1    Kasner, M.T.2    Tsai, D.E.3
  • 34
    • 51449096670 scopus 로고    scopus 로고
    • A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies
    • Rizzieri DA, Feldman E, Dipersio JF, et al. A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res. 2008;14(9):2756-2762.
    • (2008) Clin Cancer Res , vol.14 , Issue.9 , pp. 2756-2762
    • Rizzieri, D.A.1    Feldman, E.2    Dipersio, J.F.3
  • 35
    • 70449711127 scopus 로고    scopus 로고
    • Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: A Children's Oncology Group study
    • Schultz KR, Bowman WP, Aledo A, et al. Improved early event-free survival with imatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia: a Children's Oncology Group study. J Clin Oncol. 2009;27(31):5175-5181.
    • (2009) J Clin Oncol , vol.27 , Issue.31 , pp. 5175-5181
    • Schultz, K.R.1    Bowman, W.P.2    Aledo, A.3
  • 36
    • 84857837774 scopus 로고    scopus 로고
    • JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
    • Harrison C, Kiladjian JJ, Al-Ali HK, et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med. 2012; 366(9):787-798.
    • (2012) N Engl J Med , vol.366 , Issue.9 , pp. 787-798
    • Harrison, C.1    Kiladjian, J.J.2    Al-Ali, H.K.3
  • 37
    • 84863393110 scopus 로고    scopus 로고
    • A doubleblind, placebo-controlled trial of ruxolitinib for myelofibrosis
    • Verstovsek S, Mesa RA, Gotlib J, et al. A doubleblind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med. 2012;366(9):799-807.
    • (2012) N Engl J Med , vol.366 , Issue.9 , pp. 799-807
    • Verstovsek, S.1    Mesa, R.A.2    Gotlib, J.3
  • 39
    • 66149164593 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies
    • Teachey DT, Grupp SA, Brown VI. Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies. Br J Haematol. 2009; 145(5):569-580.
    • (2009) Br J Haematol , vol.145 , Issue.5 , pp. 569-580
    • Teachey, D.T.1    Grupp, S.A.2    Brown, V.I.3
  • 40
    • 76349104427 scopus 로고    scopus 로고
    • Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor
    • Janes MR, Limon JJ, So L, et al. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat Med. 2010;16(2): 205-213.
    • (2010) Nat Med , vol.16 , Issue.2 , pp. 205-213
    • Janes, M.R.1    Limon, J.J.2    So, L.3
  • 41
    • 84855919956 scopus 로고    scopus 로고
    • Synergistic activity of rapamycin and dexamethasone in vitro and in vivo in acute lymphoblastic leukemia via cell-cycle arrest and apoptosis
    • Zhang C, Ryu Y-K, Chen TZ, Hall CP, Webster DR, Kang MH. Synergistic activity of rapamycin and dexamethasone in vitro and in vivo in acute lymphoblastic leukemia via cell-cycle arrest and apoptosis. Leuk Res. 2012;36(3):342-349.
    • (2012) Leuk Res , vol.36 , Issue.3 , pp. 342-349
    • Zhang, C.1    Ryu, Y.-K.2    Chen, T.Z.3    Hall, C.P.4    Webster, D.R.5    Kang, M.H.6
  • 42
    • 79952708745 scopus 로고    scopus 로고
    • Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors
    • Batista A, Barata JT, Raderschall E, et al. Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors. Exp Hematol. 2011;39(4): 457.e3-472.e3.
    • (2011) Exp Hematol , vol.39 , Issue.4
    • Batista, A.1    Barata, J.T.2    Raderschall, E.3
  • 43
    • 73949122305 scopus 로고    scopus 로고
    • Stage 2 combination testing of rapamycin with cytotoxic agents by the Pediatric Preclinical Testing Program
    • Houghton PJ, Morton CL, Gorlick R, et al. Stage 2 combination testing of rapamycin with cytotoxic agents by the Pediatric Preclinical Testing Program. Mol Cancer Ther. 2010;9(1):101-112.
    • (2010) Mol Cancer Ther , vol.9 , Issue.1 , pp. 101-112
    • Houghton, P.J.1    Morton, C.L.2    Gorlick, R.3
  • 45
    • 79956108320 scopus 로고    scopus 로고
    • Gain-offunction mutations in interleukin-7 receptor-alpha (IL7R) in childhood acute lymphoblastic leukemias
    • Shochat C, Tal N, Bandapalli OR, et al. Gain-offunction mutations in interleukin-7 receptor-alpha (IL7R) in childhood acute lymphoblastic leukemias. J Exp Med. 2011;208(5):901-908.
    • (2011) J Exp Med , vol.208 , Issue.5 , pp. 901-908
    • Shochat, C.1    Tal, N.2    Bandapalli, O.R.3
  • 46
    • 80053385665 scopus 로고    scopus 로고
    • Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
    • Zenatti PP, Ribeiro D, Li W, et al. Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nat Genet. 2011; 43(10):932-939.
    • (2011) Nat Genet , vol.43 , Issue.10 , pp. 932-939
    • Zenatti, P.P.1    Ribeiro, D.2    Li, W.3
  • 47
    • 84862907593 scopus 로고    scopus 로고
    • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
    • Zhang J, Ding L, Holmfeldt L, et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature. 2012;481(7380):157-163.
    • (2012) Nature , vol.481 , Issue.7380 , pp. 157-163
    • Zhang, J.1    Ding, L.2    Holmfeldt, L.3
  • 48
    • 84856932936 scopus 로고    scopus 로고
    • Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition
    • Weigert O, Lane AA, Bird L, et al. Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. J Exp Med. 2012;209(2): 259-273.
    • (2012) J Exp Med , vol.209 , Issue.2 , pp. 259-273
    • Weigert, O.1    Lane, A.A.2    Bird, L.3
  • 49
    • 77953193307 scopus 로고    scopus 로고
    • Lnk constrains myeloproliferative diseases in mice
    • Bersenev A, Wu C, Balcerek J, et al. Lnk constrains myeloproliferative diseases in mice. J Clin Invest. 2010;120(6):2058-2069.
    • (2010) J Clin Invest , vol.120 , Issue.6 , pp. 2058-2069
    • Bersenev, A.1    Wu, C.2    Balcerek, J.3
  • 50
    • 67149083222 scopus 로고    scopus 로고
    • Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F
    • Gery S, Cao Q, Gueller S, Xing H, Tefferi A, Koeffler HP. Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F. J Leukocyte Biol. 2009;85(6):957-965.
    • (2009) J Leukocyte Biol , vol.85 , Issue.6 , pp. 957-965
    • Gery, S.1    Cao, Q.2    Gueller, S.3    Xing, H.4    Tefferi, A.5    Koeffler, H.P.6
  • 51
    • 77953485892 scopus 로고    scopus 로고
    • Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms
    • Oh ST, Simonds EF, Jones C, et al. Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms. Blood. 2010;116(6):988-992.
    • (2010) Blood , vol.116 , Issue.6 , pp. 988-992
    • Oh, S.T.1    Simonds, E.F.2    Jones, C.3
  • 52
    • 0029983731 scopus 로고    scopus 로고
    • The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis
    • Corcoran AE, Smart FM, Cowling RJ, Crompton T, Owen MJ, Venkitaraman AR. The interleukin-7 receptor alpha chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis. EMBO J. 1996;15(8): 1924-1932. (Pubitemid 26119695)
    • (1996) EMBO Journal , vol.15 , Issue.8 , pp. 1924-1932
    • Corcoran, A.E.1    Smart, F.M.2    Cowling, R.J.3    Crompton, T.4    Owen, M.J.5    Venkitaraman, A.R.6
  • 54
    • 0028025041 scopus 로고
    • Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor
    • Venkitaraman AR, Cowling RJ. Interleukin-7 induces the association of phosphatidylinositol 3-kinase with the alpha chain of the interleukin-7 receptor. Eur J Immunol. 1994;24(9):2168-2174. (Pubitemid 24276551)
    • (1994) European Journal of Immunology , vol.24 , Issue.9 , pp. 2168-2174
    • Venkitaraman, A.R.1    Cowling, R.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.