Bioactive peptides from meat muscle and by-products: Generation, functionality and application as functional ingredients

Meat Science

Volumn 98, Issue 2, 2014, Pages 227-239

  Lafarga, Tomas ^a   Hayes, Maria ^a  

^a TEAGASC   (Ireland)

Author keywords

ACE I; Bioactive peptides; Blood; Meat by products; Mental health; PEP

Indexed keywords

AMINO ACIDS; BLOOD; HEALTH; MEATS; MUSCLE;

ACE-I; BIOACTIVE PEPTIDES; MEAT BY-PRODUCTS; MENTAL HEALTH; PEP;

PEPTIDES;

ANTIHYPERTENSIVE AGENT; ANTIINFECTIVE AGENT; ANTIOXIDANT; FIBRINOLYTIC AGENT; MUSCLE PROTEIN; PEPTIDE;

ANALYSIS; ANIMAL; BOVINE; CHEMISTRY; CHICKEN; ISOLATION AND PURIFICATION; MEAT; METABOLIC SYNDROME X; PIG; SKELETAL MUSCLE;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTIHYPERTENSIVE AGENTS; ANTIOXIDANTS; CATTLE; CHICKENS; FIBRINOLYTIC AGENTS; MEAT; METABOLIC SYNDROME X; MUSCLE PROTEINS; MUSCLE, SKELETAL; PEPTIDES; SWINE;

EID: 84902970002     PISSN: 03091740     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.meatsci.2014.05.036     Document Type: Review

References (114)

1. Adje E., Balti R., kouach M., Guillochon D., Nedjar-Arroume N. α 67-106 of bovine hemoglobin: a new family of antimicrobial and angiotensin I-converting enzyme inhibitory peptides. European Food Research and Technology 2011, 232(4):637-646.
2. Agyei D., Danquah M.K. Industrial-scale manufacturing of pharmaceutical-grade bioactive peptides. Biotechnology Advances 2011, 29(3):272-277.
3. Aluko R.E. Food-protein-derived peptides as calmodulin inhibitors. Bioactive proteins and peptides as functional foods and nutraceuticals 2011, 55-66. Wiley-Blackwell, Ames, Iowa. Y. Mine, E. Li-Chan, B. Jiang (Eds.).
4. Alvarez C., Rendueles M., Diaz M. Production of porcine hemoglobin peptides at moderate temperature and medium pressure under a nitrogen stream. Functional and antioxidant properties. Journal of Agriculture and Food Chemistry 2012, 60(22):5636-5343.
5. Arihara K. Strategies for designing novel functional meat products. Meat Science 2006, 74(1):219-229.
6. Bah C.S.F., Bekhit A.E.-D.A., Carne A., McConnell M.A. Slaughterhouse blood: an emerging source of bioactive compounds. Comprehensive Reviews in Food Science and Food Safety 2013, 12(3):314-331.
7. Bailey A.J. Muscle proteins and muscle structure. Food proteins 1982, 245-260. Applied Science Publishers, Essex, England. P.F. Fox, J.J. Condon (Eds.).
8. Banerjee P., Shanthi C. Isolation of novel bioactive regions from bovine Achilles tendon collagen having angiotensin I-converting enzyme-inhibitory properties. Process Biochemistry 2012, 47(12):2335-2346.
9. Bauchart C., Remond D., Chambon C., Mirand P.P., Savary-Auzeloux I., Reynes C., Morzel M. Small peptides (<5kDa) found in ready-to-eat beef meat. Meat Science 2006, 74(4):658-666.
10. Bhakta G., Lim Z.X.H., Rai B., Lin T., Hui J.H., Prestwich G.D., van Wijnen A.J., Nurcombe V., Cool S.M. The influence of collagen and hyaluronan matrices on the delivery and bioactivity of bone morphogenetic protein-2 and ectopic bone formation. Acta Biomaterialia 2013, 9(11):9098-9106.
11. Bjelanovic M., Sørheim O., Slinde E., Puolanne E., Isaksson T., Egelandsdal B. Determination of the myoglobin states in ground beef using non-invasive reflectance spectrometry and multivariate regression analysis. Meat Science 2013, 95(3):451-457.
12. Brantl V., Gramsch C., Lottspeich F., Mertz R., Jaeger K.H., Herz A. Novel opioid peptides derived from haemoglobin: hemorphins. European Journal of Pharmacology 1986, 125(2):309-310.
13. Campbell D.J. The kallikrein-kinin system in humans. Clinical Experimental Pharmacoogy Physiology 2001, 28(12):1060-1065.
14. Chang C.-Y., Wu K.-C., Chiang S.-H. Antioxidant properties and protein compositions of porcine haemoglobin hydrolysates. Food Chemistry 2007, 100(4):1537-1543.
15. Chapleau N., Mangavel C., Compoint J.-P., de Lamballerie-Anton M. Effect of high-pressure processing on myofibrillar protein structure. Journal of the Science of Food and Agriculture 2004, 84(1):66-74.
16. Cheung I.W.Y., Nakayama S., Hsu M.N.K., Samaranayaka A.G.P., Li-Chan E.C.Y. Angiotensin-I converting enzyme inhibitory activity of hydrolysates from Oat (avena sativa) proteins by in silico and in vitro analyses. Journal of Agricultural and Food Chemistry 2009, 57(19):9234-9242.
17. Collinder E., Nyberg F., Sanderson-Nydahl K., Gottlieb-Vedi M., Lindholm A. The opioid haemorphin-7 in horses during Low-speed and high-speed treadmill exercise to fatigue. Journal of Veterinary Medicine Series A 2005, 52(4):162-165.
18. Crowe K.M., Francis C. Position of the academy of nutrition and dietetics: functional foods. Journal of the Academy of Nutrition and Dietetics 2013, 113(8):1096-1103.
19. Daoud R., Dubois V., Bors-Dodita L., Nedjar-Arroume N., Krier F., Chihib N.E., Mary P., Kouach M., Briand G., Guillochon D. New antibacterial peptide derived from bovine hemoglobin. Peptides 2005, 26(5):713-719.
20. Di Bernardini R., Harnedy P., Bolton D., Kerry J., O'Neill E., Mullen A.M., Hayes M. Antioxidant and antimicrobial peptidic hydrolysates from muscle protein sources and by-products. Food Chemistry 2011, 124(4):1296-1307.
21. Di Bernardini R., Mullen A.M., Bolton D., Kerry J., O'Neill E., Hayes M. Assessment of the angiotensin-I-converting enzyme (ACE-I) inhibitory and antioxidant activities of hydrolysates of bovine brisket sarcoplasmic proteins produced by papain and characterisation of associated bioactive peptidic fractions. Meat Science 2012, 90(1):226-235.
22. Escudero E., Mora L., Fraser P.D., Aristoy M.-C., Toldrá F. Identification of novel antioxidant peptides generated in Spanish dry-cured ham. Food Chemistry 2013, 138(2-3):1282-1288.
23. Escudero E., Sentandreu M.A., Arihara K., Toldra F. Angiotensin I-converting enzyme inhibitory peptides generated from in vitro gastrointestinal digestion of pork meat. Journal of Agriculture and Food Chemistry 2010, 58(5):2895-2901.
24. Escudero E., Toldrá F., Sentandreu M.A., Nishimura H., Arihara K. Antihypertensive activity of peptides identified in the in vitro gastrointestinal digest of pork meat. Meat Science 2012, 91(3):382-384.
25. Fitzgerald C., Gallagher E., Tasdemir E., Hayes M. Heart health peptides from macroalgae and their potential Use in functional foods. Journal of Agricultural and Food Chemistry 2013, 59:6829-6836.
26. Fogaça A.C., da Silva P.I., Miranda M.T.M., Bianchi A.G., Miranda A., Ribolla P.E.M., Daffre S. Antimicrobial activity of a bovine hemoglobin fragment in the tick Boophilus microplus. Journal of Biological Chemistry 1999, 274(36):25330-25334.
27. Franchini M., Mannucci P.M. A new era for anticoagulants. European Journal of Internal Medicine 2009, 20(6):562-568.
28. Froidevaux R., Krier F., Nedjar-Arroume N., Vercaigne-Marko D., Kosciarz E., Ruckebusch C., Dhulster P., Guillochon D. Antibacterial activity of a pepsin-derived bovine hemoglobin fragment. FEBS Letters 2001, 491(1-2):159-163.
29. Fulop T., Tessier D., Carpentier A. The metabolic syndrome. Pathologie Biologie 2006, 54(7):375-386.
30. Furie B., Furie B.C. In vivo thrombus formation. Journal of Thrombosis and Haemostasis 2007, 5(1):12-17.
31. Gómez-Guillén M.C., Giménez B., López-Caballero M.E., Montero M.P. Functional and bioactive properties of collagen and gelatin from alternative sources: A review. Food Hydrocolloids 2011, 25(8):1813-1827.
32. Hamden K., Mnafgui K., Amri Z., Aloulou A., Elfeki A. Inhibition of key digestive enzymes related to diabetes and hyperlipidemia and protection of liver-kidney functions by trigonelline in diabetic rats. Scientia Pharmaceutica 2012, 81(1):233-246.
33. Hermann M., Flammer A., Lüscher T.F. Nitric oxide in hypertension. The Journal of Clinical Hypertension 2006, 8(12):17-29.
34. Hill J.A., Olson E.N. An introduction to muscle. Muscle: fundamental biology and mechanisms of disease 2012, 3-10. Elsevier Science, San Diego, California. J. Hill, E. Olson (Eds.).
35. Hoffman L.C., Cawthorn D. Exotic protein sources to meet all needs. Meat Science 2013, 95(4):764-771.
36. Hu J., Xu M., Hang B., Wang L., Wang Q., Chen J., Song T., Fu D., Wang Z., Wang S., Liu X. Isolation and characterization of an antimicrobial peptide from bovine hemoglobin α-subunit. World Journal of Microbiology and Biotechnology 2011, 27(4):767-771.
37. Huff Lonergan E., Zhang W., Lonergan S.M. Biochemistry of postmortem muscle - Lessons on mechanisms of meat tenderization. Meat Science 2010, 86(1):184-195.
38. Huff-Lonergan E. Chemistry and biochemistry of meat. Handbook of meat processing 2010, 5-24. Wiley-Blackwell, Ames, Iowa. F. Toldrá (Ed.).
39. Hui Y.H., Cross N., Kristinsson H.G., Lim M.H., Nip W.K., Siow L.F., Stanfield P.S. Biochemistry of seafood processing. Food biochemistry and food processing 2012, 344-364. Wiley-Blackwell, Ames, Iowa. B.K. Simpson, L.M.L. Nollet, F. Toldra, S. Benjakul, G. Paliyath, Y.H. Hui (Eds.).
40. Ianzer D., Konno K., Xavier C.H., Stöcklin R., Santos R.A.S., de Camargo A.C.M., Pimenta D.C. Hemorphin and hemorphin-like peptides isolated from dog pancreas and sheep brain are able to potentiate bradykinin activity in vivo. Peptides 2006, 27(11):2957-2966.
41. Inoue N., Hamasaki A., Hidaka S., Miura N., Fukahori M., Maruyama M., Kawahara S., Ohta K., Muguruma M. Analysis of the components of porcine liver hydrolysate and examination of the antioxidant activity and angiotensin converting enzyme (ACE)-inhibiting activity. Yakugaku Zasshi 2013, 133(1):107-115.
42. Jang A., Lee M. Purification and identification of angiotensin converting enzyme inhibitory peptides from beef hydrolysates. Meat Science 2005, 69(4):653-661.
43. Jang A., Jo C., Kang K.-S., Lee M. Antimicrobial and human cancer cell cytotoxic effect of synthetic angiotensin-converting enzyme (ACE) inhibitory peptides. Food Chemistry 2008, 107(1):327-336.
44. Jolles P. Structural aspects of milk-clotting process - comparative features with blood-clotting process. Molecular and Cellular Biochemistry 1975, 7(2):73-85.
45. Kalupahana N.S., Moustaid-Moussa N. The renin-angiotensin system: a link between obesity, inflammation and insulin resistance. Obesity Reviews 2012, 13(2):136-149.
46. Katayama K., Anggraeni H.E., Mori T., Ahhmed A.M., Kawahara S., Sugiyama M., Nakayama T., Maruyama M., Muguruma M. Porcine skeletal muscle troponin is a good source of peptides with angiotensin-I converting enzyme inhibitory activity and antihypertensive effects in spontaneously hypertensive rats. Journal of Agricultural and Food Chemistry 2008, 56(2):355-360.
47. Katayama K., Jamhari, Mori T., Kawahara S., Miake K., Kodama Y., Sugiyama M., Kawamura Y., Nakayama T., Maruyama M., Muguruma M. Angiotensin-I converting enzyme inhibitory peptide derived from porcine skeletal muscle myosin and its antihypertensive activity in spontaneously hypertensive rats. Journal of Food Science 2007, 72(9):S702-S706.
48. Katayama K., Tomatsu M., Fuchu H., Sugiyama M., Kawahara S., Yamauchi K., Kawamura Y., Muguruma M. Purification and characterization of an angiotensin I-converting enzyme inhibitory peptide derived from porcine troponin C. Animal Science Journal 2003, 74(1):53-58.
49. Khlebnikova N.N., Krupina N.A., Kushnareva E.Y., Zolotov N.N., Kryzhanovskii G.N. Effect of imipramine and prolyl endopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine on activity of proline-specific peptidases in the brain of rats with experimental anxious-depressive syndrome. Bulletin of Experimental Biology and Medicine 2012, 152(4):409-412.
50. Kim E.-K., Lee S.-J., Jeon B.-T., Moon S.-H., Kim B., Park T.-K., Han J.-S., Park P.-J. Purification and characterisation of antioxidative peptides from enzymatic hydrolysates of venison protein. Food Chemistry 2009, 114(4):1365-1370.
51. Korhonen H., Pihlanto A. Bioactive peptides: production and functionality. International Dairy Journal 2006, 16(9):945-960.
52. Korhonen H., Pihlanto-Leppäla A., Rantamäki P., Tupasela T. Impact of processing on bioactive proteins and peptides. Trends in Food Science & Technology 1998, 9(8-9):307-319.
53. Krishnan B., Smith T.L., Dubey P., Zapadka M.E., Torti F.M., Willingham M.C., Tallant E.A., Gallagher P.E. Angiotensin-(1-7) attenuates metastatic prostate cancer and reduces osteoclastogenesis. Prostate 2013, 73(1):71-82.
54. Lee S.-H., Kim S.-J., Lee Y.-S., Song M.-D., Kim I.-H., Won H.-S. De novo generation of short antimicrobial peptides with simple amino acid composition. Regulatory Peptides 2011, 166(1-3):36-41.
55. Lew R.A. HPLC in the analysis of peptide metabolism 2004, 275-291. Humana Press, Totowa, New Jersey. M.I. Aguilar (Ed.).
56. Leygonie C., Britz T.J., Hoffman L.C. Impact of freezing and thawing on the quality of meat: Review. Meat Science 2012, 91(2):93-98.
57. Li B., Chen F., Wang X., Ji B., Wu Y. Isolation and identification of antioxidative peptides from porcine collagen hydrolysate by consecutive chromatography and electrospray ionization-mass spectrometry. Food Chemistry 2007, 102(4):1135-1143.
58. Liu R., Wang M., Duan J.-a., Guo J.-m., Tang Y.-p. Purification and identification of three novel antioxidant peptides from Cornu Bubali (water buffalo horn). Peptides 2010, 31(5):786-793.
59. Lopez-Alarcon C., Denicola A. Evaluating the antioxidant capacity of natural products: A review on chemical and cellular-based assays. Analytica Chimica Acta 2013, 763:1-10.
60. López-Barrios L., Gutiérrez-Uribe J.A., Serna-Saldívar S.O. Bioactive peptides and hydrolysates from pulses and their potential Use as functional ingredients. Journal of Food Science 2014, 79(3):R273-R283.
61. Madjid M., Willerson J.T. Inflammatory markers in coronary heart disease. British Medical Bulletin 2011, 100(1):23-38.
62. Mars M., Stafleu A., de Graaf C. Use of satiety peptides in assessing the satiating capacity of foods. Physiology & Behavior 2012, 105(2):483-488.
63. Martinez-Alvarez O. Hormone-like peptides obtained by marine-protein hydrolysis and their bioactivities. Marine Proteins and Peptides 2013, 351-368. Wiley-Blackwell, Ames, Iowa. K. Se-Know (Ed.).
64. Matsui T., Tanaka M. Antihypertensive peptides and their underlying mechanisms. Bioactive proteins and peptides as functional foods and nutraceuticals 2011, 43-54. Wiley-Blackwell, Ames, Iowa. Y. Mine, E. Li-Chan, B. Jiang (Eds.).
65. Meakin P.J., Harper A.J., Hamilton D.L., Gallagher J., McNeilly A.D., Burgess L.A., Vaanholt L.M., Bannon K.A., Latcham J., Hussain I., Speakman J.R., Howlett D.R., Ashford M.L. Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice. Biochemical Journal 2012, 441(1):285-296.
66. Minkiewicz P., Dziuba J., Michalska J. Bovine meat proteins as potential precursors of biologically active peptides - A computational study based on the BIOPEP database. Food Science and Technology International 2011, 17(1):39-45.
67. Momeni N., Nordström B., Horstmann V., Avarseji H., Sivberg B. Alterations of prolyl endopeptidase activity in the plasma of children with autistic spectrum disorders. BMC Psychiatry 2005, 5(1):1-6.
68. Monzo A., Sperling E., Guttman A. Proteolytic enzyme-immobilization techniques for MS-based protein analysis. TrAC Trends in Analytical Chemistry 2009, 28(7):854-864.
69. Mooney C., Haslam N.J., Holton T.A., Pollastri G., Shields D.C. PeptideLocator: prediction of bioactive peptides in protein sequences. Bioinformatics 2013, 29(9):1120-1126.
70. Mora L., Sentandreu M.A., Koistinen K.M., Fraser P.D., Toldra F., Bramley P.M. Naturally generated small peptides derived from myofibrillar proteins in Serrano Dry-cured Ham. Journal of Agricultural and Food Chemistry 2009, 57(8):3228-3234.
71. Morain P., Lestage P., De Nanteuil G., Jochemsen R., Robin J.L., Guez D., Boyer P.A. S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment: Preclinical and clinical studies. CNS Drug Reviews 2002, 8(1):31-52.
72. Morimatsu F., Ito M., Budijanto S., Watanabe I., Furukawa Y., Kimura S. Plasma cholesterol-suppressing effect of papain-hydrolyzed pork meat in rats fed hypercholesterolemic diet. Journal of Nutrition Science and Vitaminology 1996, 42(2):145-153.
73. Muguruma M., Ahhmed A.M., Katayama K., Kawahara S., Maruyama M., Nakamura T. Identification of pro-drug type ACE inhibitory peptide sourced from porcine myosin B: Evaluation of its antihypertensive effects in vivo. Food Chemistry 2009, 114(2):516-522.
74. Nedjar-Arroume N., Dubois-Delval V., Adje E.Y., Traisnel J., Krier F., Mary P., Kouach M., Briand G., Guillochon D. Bovine hemoglobin: An attractive source of antibacterial peptides. Peptides 2008, 29(6):969-977.
75. Nedjar-Arroume N., Dubois-Delval V., Miloudi K., Daoud R., Krier F., Kouach M., Briand G., Guillochon D. Isolation and characterization of four antibacterial peptides from bovine hemoglobin. Peptides 2006, 27(9):2082-2089.
76. Neville F., Cahuzac M., Konovalov O., Ishitsuka Y., Lee K.Y.C., Kuzmenko I., Kale G.M., Gidalevitz D. Lipid headgroup discrimination by antimicrobial peptide LL-37: Insight into mechanism of action. Biophysical Journal 2006, 90(4):1275-1287.
77. Norris R., Fitzgerald R.J. Antihypertensive peptides from food proteins. Bioactive food peptides in health and disease 2013, InTech., Rijeka, Croatia. B. Hernandez-Ledesma, C.C. Hsieh (Eds.).
78. Nyberg F., Carlsson A., Hallberg M. Casomorphins/hemorphins. Handbook of biologically active peptides 2013, 1550-1555. Elsevier, San Diego, California. A.J. Kastin (Ed.).
79. Ohmori T., Nakagami T., Tanaka H., Maruyama S. Isolation of prolylendopeptidase-inhibiting peptides from bovine brain. Biochemical and Biophysical Research Communications 1994, 202(2):809-815.
80. Paraskevas K.I., Nicolaides A.N., Mikhailidis D.P. Statins and venous thromboembolism: the jury is still out. Angiology 2013, 64(7):489-491.
81. Pereira P., Vicente A. Meat nutritional composition and nutritive role in the human diet. Meat Science 2013, 93(3):586-592.
82. Pham-Huy L.A., He H., Pham-Huy C. Free radicals, antioxidants in disease and health. International journal of biomedical science 2008, 4(2):89-96.
83. Piot J.M., Zhao Q., Guillochon D., Ricart G., Thomas D. Isolation and characterization of 2 opioid-peptides from a bovine hemoglobin peptic hydrolysate. Biochemical and Biophysical Research Communications 1992, 189(1):101-110.
84. Regulation (EC) No 1069/2009 of the European Parliament and of the Council of 21 October 2009 Laying down health rules as regards animal by-products and derived products not intended for human consumption and repealing Regulation (EC) No 1774/2002 (Animal by-product Regulation) [2009] OJEU L300/1.
85. Regulation (EC) No 835/2004 of the European Parliament and of the Council of 29 April 2004 Laying down specific hygiene rules for on the hygiene of foodstuffs [2004] OJEU L139/55.
86. Ribeiro-Oliveira A., Nogueira A.I., Pereira R.M., Boas W.W., Dos Santos R.A., Simoes Silva A.C. The renin-angiotensin system and diabetes: an update. Vascular Health Risk Management 2008, 4(4):787-803.
87. Rojas-Ronquillo R., Cruz-Guerrero A., Flores-Nájera A., Rodríguez-Serrano G., Gómez-Ruiz L., Reyes-Grajeda J.P., Jiménez-Guzmán J., García-Garibay M. Antithrombotic and angiotensin-converting enzyme inhibitory properties of peptides released from bovine casein by Lactobacillus casei Shirota. International Dairy Journal 2012, 26(2):147-154.
88. Rondeau P., Bourdon E. The glycation of albumin: structural and functional impacts. Biochimie 2011, 93(4):645-658.
89. Ruan G.H., Chen Z.Y., Wei M.P., Liu Y.H., Li H.Y., Du F.Y. The study on microwave assisted enzymatic digestion of ginkgo protein. Journal of Molecular Catalysis B-Enzymatic 2013, 94:23-28.
90. Saiga A., Tanabe S., Nishimura T. Antioxidant activity of peptides obtained from porcine myofibrillar proteins by protease treatment. Journal of Agriculture and Food Chemistry 2003, 51(12):3661-3667.
91. Sentandreu M.A., Coulis G., Ouali A. Role of muscle endopeptidases and their inhibitors in meat tenderness. Trends in Food Science & Technology 2002, 13(12):400-421.
92. Sentandreu M.A., Toldrá F. Evaluation of ACE inhibitory activity of dipeptides generated by the action of porcine muscle dipeptidyl peptidases. Food Chemistry 2006, 102(2):511-515.
93. Shearer F., Lang C.C., Struthers A.D. Renin-Angiotensin-aldosterone system inhibitors in heart failure. Clinical Pharmacology and Therapeutics 2013, 94(4):459-467.
94. Shimizu M., Sawashita N., Morimatsu F., Ichikawa J., Taguchi Y., Ijiri Y., Yamamoto J. Antithrombotic papain-hydrolyzed peptides isolated from pork meat. Thrombosis Research 2009, 123(5):753-757.
95. Surks H.K. CGMP-dependent protein kinase I and smooth muscle relaxation: a tale of Two isoforms. Circulation Research 2007, 101(11):1078-1080.
96. Tierney M.S., Croft A.K., Hayes M. A review of antihypertensive and antioxidant activities in macroalgae. Botanica Marina 2010, 53(5):387-408.
97. Toldrá F., Aristoy M.C., Mora L., Reig M. Innovations in value-addition of edible meat by-products. Meat Science 2012, 92(3):290-296.
98. Trabulo S., Cardoso A.L., Mano M., De Lima M.C.P. Cell-penetrating peptides - mechanisms of cellular uptake and generation of delivery systems. Pharmaceuticals 2010, 3(4):961-993.
99. Ukeda H., Matsuda H., Osajima K., Matsufuji H., Matsui T., Osajima Y. Peptides from peptidic hydrolysate of heated sardine meat that inhibit angiotensin I converting enzyme. Nippon Nogei Kaishi 1992, 66:25-29.
100. Wang J.-Z., Zhang H.A.O., Zhang M., Yao W.-T., Mao X.-Y., Ren F.-Z. Antioxidant activity of hydrolysates and peptide fractions of porcine plasma albumin and globulin. Journal of Food Biochemistry 2008, 32(6):693-707.
101. Wilensky R.L., Shi Y., Mohler E., Hamamdzic D., Burgent M.E., Li J., Postle A., Fenning R.S., Bollinger J.G., Hoffman B., Pelchovitz D.J., Yang J., Mirabile R.C., Webb C.L., Zhang L., Zhang P., Gelb M.H., Walker M.C., Zalewski A., Macphee C.H. Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development. Nature Medicine 2008, 14(10):1059-1066.
102. Wilson J., Hayes M., Carney B. Angiotensin-I-converting enzyme and prolyl endopeptidase inhibitory peptides from natural sources with a focus on marine processing by-products. Food Chemistry 2011, 129(2):235-244.
103. World Health Organization (WHO) Prevention of recurrent heart attacks and strokes in low- and middle-income populations. Evidence-based recommendations for policy-makers and health professionals 2003, (Geneva).
104. World Health Organization (WHO) Promoting mental health: concepts, emerging evidence, practice 2005, (Geneva).
105. World Health Organization (WHO) Prevention of cardiovascular disease. Guidelines for assessment and management of cardiovascular risk 2007, (Geneva).
106. World Health Organization (WHO) Global status report on noncommunicable diseases 2010 2011, (Geneva).
107. World Health Organization (WHO) Mental Health: Action Plan 2013-2020 2013, (Geneva).
108. Xiong Y.L. Antioxidant peptides. Bioactive proteins and peptides as functional foods and nutraceuticals 2010, 29-42. Wiley-Blackwell, Ames, Iowa. Y. Mine, E. Li-Chan, B. Jiang (Eds.).
109. Xu X., Cao R., He L., Yang N. Antioxidant activity of hydrolysates derived from porcine plasma. Journal of the Science of Food and Agriculture 2009, 89(11):1897-1903.
110. Yu Y., Hu J.N., Miyaguchi Y.J., Bai X.F., Du Y.G., Lin B.C. Isolation and characterization of angiotensin I-converting enzyme inhibitory peptides derived from porcine hemoglobin. Peptides 2006, 27(11):2950-2956.
111. Yugandhar V.G., Clark M.A. Angiotensin III: A physiological relevant peptide of the renin angiotensin system. Peptides 2013, 46:26-32.
112. Zambrowicz A., Timmer M., Polanowski A., Lubec G., Trziszka T. Manufacturing of peptides exhibiting biological activity. Amino Acids 2013, 44(2):315-320.
113. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 2002, 415(6870):389-395.
114. Zhao Q., Garreau I., Sannier F., Piot J.M. Opioid peptides derived from hemoglobin: Hemorphins. Peptide Science 1997, 43(2):75-98.