The opioid haemorphin-7 in horses during low-speed and high-speed treadmill exercise to fatigue

Journal of Veterinary Medicine Series A: Physiology Pathology Clinical Medicine

Volumn 52, Issue 4, 2005, Pages 162-165

  Collinder, E ^a,d   Nyberg, F ^a,b   Sanderson Nydahl, K ^a,b   Gottlieb Vedi, M ^a,c   Lindholm, A ^a,d  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c Flyinge AB ^*  (Sweden)

^d Mälaren Equine Hospital   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

EQUIDAE; EQUUS CABALLUS;

HEMOGLOBIN; HEMORPHIN 7; LACTIC ACID; OPIATE PEPTIDE; PEPTIDE FRAGMENT;

ANIMAL; ANIMAL DISEASE; ANIMAL EXPERIMENT; ARTICLE; BLOOD; EXERCISE TEST; FEMALE; HEART RATE; HORSE; MALE; METABOLISM; PHYSIOLOGY; SKELETAL MUSCLE;

ANIMALS; EXERCISE TEST; FEMALE; HEART RATE; HEMOGLOBINS; HORSES; LACTIC ACID; MALE; MUSCLE, SKELETAL; OPIOID PEPTIDES; PEPTIDE FRAGMENTS; PHYSICAL CONDITIONING, ANIMAL;

EID: 23944524428     PISSN: 0931184X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1439-0442.2005.00712.x     Document Type: Article

References (33)

1. Aloni, B., A. Eitan, and A. Livne, 1977: The erythrocyte membrane site for the effect of temperature on osmotic fragility. Biochim. Biophys. Acta 465, 46-53.
2. Brantl, V., C. Gramsch, F. Lottspeich, R. Mertz, K. H. Jaeger, and A. Hertz, 1986: Novel opioid peptides derived from hemoglobin: hemorphins. Eur. J. Pharmacol. 125, 309-310.
3. Gladden, L. B., 2004: Lactate metabolism: a new paradigm for the third millennium. J. Physiol. 558, 5-30.
4. Glämsta, E. L., L. Mørklid, I. Lanz, and F. Nyberg, 1993: Concomitant increase in blood plasma levels of immunoreactive hemorphin-7 and β-endorphin following long distance running. Regul. Pept. 49, 9-18.
5. Gollnick, P. D., 1988: Energy metabolism and prolonged exercise. In: Lamb, M. R. (ed.), Prolonged Exercise, pp. 1-42. Benchmark Press, Indianapolis, IN.
6. Gottlieb, M., 1989: Muscle glycogen depletion patterns during draught work in standardbred horses. Equine Vet. J. 21, 110-115.
7. Hanzawa, K., M. Kai, A. Hiraga, and S. Watanabe, 1999a: Fragility of red cells during exercise is affected by blood pH and temperature. Equine Vet. J. 30 (Suppl.), 610-611.
8. Hanzawa, K., K. Kubo, M. Kai, A. Hiraga, and S. Watanabe, 1999b: Effects of exercise on density and osmotic fragility of circulating red cells in normal and splenectomized thoroughbred horses. J. Equine Sci. 10, 61-65.
9. Jain, N. C., 1993: Essentials of Veterinary Haematology. Lea & Febiger, Philadelphia, PA, pp. 145.
10. Jones, J. H., C. R. Taylor, A. Lindholm, R. Straub, K. E. Longworth, and R. M. Karas, 1989: Blood gas measurements during exercise: errors due to temperature correction. J. Appl. Physiol. 67, 879-884.
11. Kubo, K., S. Takagi, M. Murakami, and M. Kai, 1984: Heart rate and blood lactate concentrations of horses during maximal work. Bull. Equine Res. Inst. 21, 39-45.
12. Lantz, I., E. L. Glämsta, L. Talbäck, and F. Nyberg, 1991: Hemorphins derived from hemoglobin have an inhibitory action on angiotensin converting enzyme activity. FEBS Lett. 287, 39-41.
13. Lattanzio, S. B., and R. Eikelboom, 2003: Wheel access duration in rats: I. Effects on feeding and running. Behav. Neurosci. 117, 496-804.
14. Lee, J., A. L. Albiston, A. M. Allen, F. A. Mendelsohn, S. E. Ping, G. L. Barrett, M. Murphy, M. J. Morris, S. G. McDowall, and S. Y. Chai, 2004: Effect of I.C.V. injection of AT4 receptor ligands, NLE1-angiotensin IV and LVV-hemorphin-7, on spatial learning in rats. Neuroscience 124, 341-349.
15. Lindholm, A., and K. Piehl, 1974: Fibre composition, enzyme activities and concentrations of metabolites and electrolytes in muscle of Standardbred horses. Acta Vet. Scand. 15, 310-324.
16. Lindholm, A., and K. Saltin, 1974: The physiological and biochemical response of standardbred horses to exercise of varying speed and duration. Acta Vet. Scand. 15, 289-309.
17. Manohar, M., 1986: Blood flow to respiratory and limb muscles and to abdominal organs during maximal exertion in ponies. J. Physiol. 377, 25-35.
18. Manohar, M., T. E. Goetz, and A. S. Hassan, 2003: Preexercise hypervolemia does not affect arterial hypoxemia in thoroughbreds performing short-term high-intensity exercise. J. Appl. Physiol. 94, 2135-2144.
19. Matsuki, N., S. Tamura, K. Ono, T. Watari, R. Goitsuka, A. Yamanobe, A. Hiraga, K. Kubo, S. Takagi, A. Hasegawa, and N. Suzuki, 1991: Exercise-induced phosholipid degradation in the equine skeletal muscle and erythrocytes. J. Vet. Med. Sci. 53, 1001-1007.
20. McCutcheon, L. J., R. J. Geor, and K. W. Hinchcliff, 1999: Effects of prior exercise on muscle metabolism during sprint exercise in horses. J. Appl. Physiol. 87, 1914-1922.
21. Myers, J., and E. Ashley, 1997: Dangerous curves. A perspective on exercise, lactate, and the aerobic threshold. Chest 111, 789.
22. Nyberg, F., K. Sanderson, and E. L. Glämsta, 1997: The hemorphins: a new class of opioid peptides derived from the blood protein hemoglobin. Biopolymers 43, 147-156.
23. Pedersen, T. H., O. B. Nielsen, G. D. Lamb, and D. G. Sephenson, 2004: Intracellular acidosis enhances the excitability of working muscle. Science 305, 1144-1147.
24. Robergs, R. A., F. Ghiasvand, and D. Parker, 2004: Biochemistry of exercise-induced metabolic acidosis. Am. J. Physiol. Regul. Integr. Comp. Physiol 287, R502-R516.
25. Ronéus, N., B. Essén-Gustafsson, A. Lindholm, and Y. Ericksson, 1994: Plasma lactate response to submaximal and maximal exercise tests with training, and its relationship to performance and muscle characteristics in Standardbred trotters. Equine Vet. J. 26, 117-121.
26. Sanderson, K., P. E. Andrén, R. M. Caprioli, and F. Nyberg, 1996: In vitro metabolism of LVV-hemorphin-7 in human plasma studied by reversed-phase high-performance liquid chromatography and micro-electrospray mass spectrometry. J. Chromatogr. A743, 207-212.
27. Sanderson, K., F. Nyberg, and Z. Khalil, 1998: Modulation of peripheral inflammation by locally administered hemorphin-7. Inflamm. Res. 47, 49-55.
28. Scheffler, H., G. Koch, V. Brantl, and H. Teschemacher, 1990: Hemorphin-4 stimulates the release of a dynorphin immunoreactive material from rat pituitary tissue. In: Van Ree, J. M., A. H. Mulder, V. M. Wiegant, and T. B. Van Wimersma Greidanus (eds), New Leads in Opioid Research, pp. 379-380. Elsevier, Amsterdam.
29. Smith, M. A., and D. L. Yancey, 2003: Sensitivity to the effects of opioids in rats with free access to exercise wheels: mu-opioid tolerance and physical dependence. Psychopharmacology (Berlin) 168, 426-434.
30. Stragier, B., S. Sarre, P. Vanderheyden, G. Vauquelin, M. C. Fournie-Zaluski, G. Ebinger, and Y. Michotte, 2004: Metabolism of angiotensin II is required for its in vivo effect on dopamine release in the stratium of the rat. J. Neurochem. 90, 1251-1257.
31. Vargas-Perez, H., E. Borrelli, and J. L. Diaz, 2004: Wheel running use in dopamine D2L receptor knockout mice. Neurosci. Lett. 366, 172-175.
32. Wintrobe, 1993: Wintrobe's Clinical Hematology, 9th edn. Lea and Febiger, Philadelphia, PA, pp. 195-222.
33. Zhao, Q, I. Garreau, F. Sannier, and J. M. Piot, 1997. Opioid peptides derived from hemoglobin: hemorphins. Biopolymers 43, 75-98.