The influence of collagen and hyaluronan matrices on the delivery and bioactivity of bone morphogenetic protein-2 and ectopic bone formation

Acta Biomaterialia

Volumn 9, Issue 11, 2013, Pages 9098-9106

  Bhakta, Gajadhar ^a   Lim, Zophia X H ^a   Rai, Bina ^a   Lin, Tingxuan ^a   Hui, James H ^b   Prestwich, Glenn D ^c   Van Wijnen, Andre J ^d   Nurcombe, Victor ^a   Cool, Simon M ^a,b  

^a INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c UNIVERSITY OF UTAH   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Collagen sponge; Glycosaminoglycan; Hydrogel; Osteogenesis; Release kinetics

Indexed keywords

BIOACTIVITY; BONE; COLLAGEN; COMPUTERIZED TOMOGRAPHY; DEFECTS; FRACTURE; HYALURONIC ACID;

BONE FORMATION; BONE MORPHOGENETIC PROTEIN-2; COLLAGEN SPONGE; ECTOPIC BONE FORMATIONS; GLYCOSAMINOGLYCANS; HYALURONAN; MATRIX; OSTEOGENESIS; RELEASE KINETICS; SUSTAINED RELEASE;

HYDROGELS;

BONE MORPHOGENETIC PROTEIN 2; COLLAGEN; COLLAGEN SPONGE; GLYCOSIL; HYALURONIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; BONE DEVELOPMENT; BONE MALFORMATION; ECTOPIC BONE FORMATION; FRACTURE HEALING; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE;

BOVINAE;

COLLAGEN SPONGE; GLYCOSAMINOGLYCAN; HYDROGEL; OSTEOGENESIS; RELEASE KINETICS;

ANIMALS; BIOCOMPATIBLE MATERIALS; BONE AND BONES; BONE MORPHOGENETIC PROTEIN 2; CATTLE; CELL LINE; COLLAGEN; DRUG DELIVERY SYSTEMS; FEMALE; HYALURONIC ACID; HYDROGELS; MICE; OSSIFICATION, HETEROTOPIC; PROSTHESIS IMPLANTATION; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; TRANSFORMING GROWTH FACTOR BETA; X-RAY MICROTOMOGRAPHY;

EID: 84885059536     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.07.008     Document Type: Article

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