Antihypertensive activity of peptides identified in the in vitro gastrointestinal digest of pork meat

Meat Science

Volumn 91, Issue 3, 2012, Pages 382-384

  Escudero, Elizabeth ^a,b   Toldrá, Fidel ^a   Sentandreu, Miguel Angel ^a   Nishimura, Hitoshi ^b   Arihara, Keizo ^b  

^a INSTITUTO DE AGROQUÍMICA Y TECNOLOGÍA DE ALIMENTOS CSIC   (Spain)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

Angiotensin I converting enzyme; Antihypertensive activity; Peptide; Pork meat; Spontaneously hypertensive rat

Indexed keywords

ANGIOTENSIN I-CONVERTING ENZYME; ANTI-HYPERTENSIVE ACTIVITIES; ANTIHYPERTENSIVE ACTION; ANTIHYPERTENSIVE ACTIVITY; FUNCTIONAL FOODS; IN-VITRO; IN-VIVO; INHIBITORY ACTIVITY; NUTRACEUTICALS; ORAL ADMINISTRATION; PORK MEAT; SPONTANEOUSLY HYPERTENSIVE RATS;

ENZYME ACTIVITY; OILS AND FATS; PEPTIDES;

MEATS;

RATTUS;

ANTIHYPERTENSIVE AGENT; CONNECTIN; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; MUSCLE PROTEIN; NEBULIN; PEPTIDE; PROTEIN KINASE;

ANIMAL; ARTICLE; DIGESTION; HYPERTENSION; MALE; MEAT; METABOLISM; PROTEIN INTAKE; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SWINE;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIHYPERTENSIVE AGENTS; DIETARY PROTEINS; DIGESTION; HYPERTENSION; MALE; MEAT; MUSCLE PROTEINS; PEPTIDES; PEPTIDYL-DIPEPTIDASE A; PROTEIN KINASES; RATS; RATS, INBRED SHR; SUS SCROFA;

EID: 84859591853     PISSN: 03091740     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.meatsci.2012.02.007     Document Type: Article

References (15)

1. Antonios T.F.T., Macgreger G.A. Angiotensin-converting enzyme-inhibitor in hypertension-potential problems. Journal of Hypertension 1995, 13:511-516.
2. Daniel W.W. Biostatistics: A foundation for analysis in the health sciences 1987, 135-140. John Wiley & Sons, New York.
3. Escudero E., Sentandreu M.A., Arihara K., Toldrá F. Angiotensin I-converting enzyme inhibitory peptides generated from in vitro gastrointestinal digestion of pork meat. Journal of Agricultural and Food Chemistry 2010, 58:2895-2901.
4. Hartmann R., Meisel H. Food-derived peptides with biological activity: From research to food applications. Current Opinion in Biotechnology 2007, 18:163-169.
5. Hollenberg N.K. The renin-angiotensin system and cardiovascular disease. Blood Pressure Supplement 2000, 1:5-8.
6. Houston M.C. The role of vascular biology, nutrition and nutraceuticals in the prevention and treatment of hypertension. Journal of the American Nutraceutical Association 2002, suppl. No.I:1-71.
7. Houston M.C. Nutraceuticals, vitamins, antioxidants and minerals in the prevention and treatment of hypertension. Progress Cardiovascular Disease 2005, 43:396-449.
8. Itou K., Nagahashi R., Saitou M., Akahane Y. Antihypertensive effect of narezushi, a fermented mackerel product, on spontaneously hypertensive rats. Fisheries Science 2007, 73:1344-1352.
9. Jiang Z., Tian B., Brodkorb A., Huo G. Production, analysis and in vivo evaluation of novel angiotensin-I-converting enzyme inhibitory peptides from bovine casein. Food chemistry 2010, 123:779-786.
10. Lopez-Fandino R., Otte J., Van Camp J. Physiological, chemical and technological aspects of milk-protein-derived peptides with antihypertensive and ACE-inhibitory activity. International Dairy Journal 2006, 16:1277-1293.
11. Nakashima Y., Arihara K., Sasaki A., Mio H., Ishikawa S., Itoh M. Antihypertensive activities of peptides derived from porcine skeletal muscle myosin in spontaneously hypertensive rats. Journal of Food Science 2002, 67:434-437.
12. Quian Z.J., Je J., Kim S.K. Antihypertensive effect of angiotensin I converting enzyme-inhibitory peptide from hydrolysates of bigeye tuna dark muscle, Thunnus obesus. Journal of Agricultural and Food Chemistry 2007, 55:8398-8403.
13. Ryan J.T., Ross R.P., Bolton D., Fitzgerald G.F., Staton C. Bioactive peptides from muscle sources: Meat and fish. Nutrients 2011, 3:765-791.
14. Unger T. The role of the renin-angiotensin system in the development of cardiovascular disease. American Journal of Cardiology 2002, 89:3A-9A.
15. Yoshii H., Tachi N., Ohba R., Sakamura O., Takeyama H., Itani T. Antihypertensive effect of ACE inhibitory oligopeptides from chicken egg yolk. Comparative Biochemistry and Physiology Part C 2001, 128:27-33.