Dendritic organelles for postsynaptic trafficking

Structural And Functional Organization Of The Synapse

Volumn , Issue , 2008, Pages 205-249

  Hanus, Cyril ^a   Ehlers, Michael D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84901071707     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-0-387-77232-5_8     Document Type: Chapter

References (309)

1. Adams I and Jones DG. Quantitative ultrastructural changes in rat cortical synapses during early-, mid-and late-adulthood. Brain Res 239: 349-363, 1982.
2. Adesnik H, Nicoll RA, and England PM. Photoinactivation of native AMPA receptors reveals their real-time trafficking. Neuron 48: 977-985, 2005.
3. Alberi S, Boda B, Steiner P, Nikonenko I, Hirling H, and Muller D. The endosomal protein NEEP21 regulates AMPA receptor-mediated synaptic transmission and plasticity in the hippocampus. Mol Cell Neurosci 29: 313-319, 2005.
4. Ali MY, Krementsova EB, Kennedy GG, Mahaffy R, Pollard TD, Trybus KM, and Warshaw DM. Myosin. Va maneuvers through actin intersections and diffuses along microtubules. Proc Natl Acad Sci USA 104: 4332-4336, 2007.
5. Allison DW, Chervin AS, Gelfand VI, and Craig AM. Postsynaptic scaffolds of excitatory and inhibitory synapses in hippocampal neurons: maintenance of core components independent of actin filaments and microtubules. J Neurosci 20: 4545-4554, 2000.
6. Altan-Bonnet N, Sougrat R, and Lippincott-Schwartz J. Molecular basis for Golgi maintenance and biogenesis. Curr Opin Cell Biol 16: 364-372, 2004.
7. Andrasfalvy BK and Magee JC. Distance-dependent increase in AMPA receptor number in the dendrites of adult hippocampal CA1 pyramidal neurons. J Neurosci 21: 9151-9159, 2001.
8. Antar LN, Afroz R, Dictenberg JB, Carroll RC, and Bassell GJ. Metabotropic glutamate receptor activation regulates fragile × mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses. J Neurosci 24: 2648-2655, 2004.
9. Aridor M, Guzik AK, Bielli A, and Fish KN. Endoplasmic reticulum export site formation and function in dendrites. J Neurosci 24: 3770-3776, 2004.
10. Ashby MC, De La Rue SA, Ralph GS, Uney J, Collingridge GL, and Henley JM. Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs. J Neurosci 24: 5172-5176, 2004.
11. Ashby MC, Maier SR, Nishimune A, and Henley JM. Lateral diffusion drives constitutive exchange of AMPA receptors at dendritic spines and is regulated by spine morphology. J Neurosci 26: 7046-7055, 2006.
12. Baas PW, Deitch JS, Black MM, and Banker GA. Polarity orientation of microtubules in hippocampal neurons: uniformity in the axon and nonuniformity in the dendrite. Proc Natl Acad Sci USA 85: 8335-8339, 1988.
13. Bagal AA, Kao JP, Tang CM, and Thompson SM. Long-term potentiation of exogenous glutamate responses at single dendritic spines. Proc Natl Acad Sci USA 102: 14434-14439, 2005.
14. Bard F and Malhotra V. The formation of TGN-to-plasma-membrane transport carriers. Annu Rev Cell Dev Biol 22: 439-455, 2006.
15. Bear MF, Huber KM, and Warren ST. The mGluR theory of fragile × mental retardation. Trends Neurosci 27: 370-377, 2004.
16. Bergmann JE. Using temperature-sensitive mutants of VSV to study membrane protein biogenesis. Methods Cell Biol 32: 85-110, 1989.
17. Blanpied TA, Scott DB, and Ehlers MD. Dynamics and regulation of clathrin coats at specialized endocytic zones of dendrites and spines. Neuron 36: 435-449, 2002.
18. Bloodgood BL and Sabatini BL. Neuronal activity regulates diffusion across the neck of dendritic spines. Science 310: 866-869, 2005.
19. Bonifacino JS and Rojas R. Retrograde transport from endosomes to the trans-Golgi network. Nat Rev Mol Cell Biol 7: 568-579, 2006.
20. Borgdorff AJ and Choquet D. Regulation of AMPA receptor lateral movements. Nature 417: 649-653, 2002.
21. Borgese N, Francolini M, and Snapp E. Endoplasmic reticulum architecture: structures in flux. Curr Opin Cell Biol 18: 358-364, 2006.
22. Boudreau AC and Wolf ME. Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens. J Neurosci 25: 9144-9151, 2005.
23. Brady ST. A novel brain ATPase with properties expected for the fast axonal transport motor. Nature 317: 73-75, 1985.
24. Bredt DS and Nicoll RA. AMPA receptor trafficking at excitatory synapses. Neuron 40: 361-379, 2003.
25. Bresler T, Shapira M, Boeckers T, Dresbach T, Futter M, Garner CC, Rosenblum K, Gundelfinger ED, and Ziv NE. Postsynaptic density assembly is fundamentally different from presynaptic active zone assembly. J Neurosci 24: 1507-1520, 2004.
26. Bridgman PC. Myosin-dependent transport in neurons. J Neurobiol 58: 164-174, 2004.
27. Broadwell RD and Cataldo AM. The neuronal endoplasmic reticulum: its cytochemistry and contribution to the endomembrane system. I. Cell bodies and dendrites. J Histochem Cytochem 31: 1077-1088, 1983.
28. Broutman G and Baudry M. Involvement of the secretory pathway for AMPA receptors in NMDA-induced potentiation in hippocampus. J Neurosci 21: 27-34, 2001.
29. Brown TC, Tran IC, Backos DS, and Esteban JA. NMDA receptor-dependent activation of the small GTPase Rab5 drives the removal of synaptic AMPA receptors during hippocampal LTD. Neuron 45: 81-94, 2005.
30. Burack MA, Silverman MA, and Banker G. The role of selective transport in neuronal protein sorting. Neuron 26: 465-472, 2000.
31. Cameron HA, Kaliszewski CK, and Greer CA. Organization of mitochondria in olfactory bulb granule cell dendritic spines. Synapse 8: 107-118, 1991.
32. Cameron PL, Sudhof TC, Jahn R, and De Camilli P. Colocalization of synaptophysin with transferrin receptors: implications for synaptic vesicle biogenesis. J Cell Biol 115: 151-164, 1991.
33. Camus G, Jasmin BJ, and Cartaud J. Polarized sorting of nicotinic acetylcholine receptors to the postsynaptic membrane in Torpedo electrocyte. Eur J Neurosci 10: 839-852, 1998.
34. Cataldo AM, Barnett JL, Pieroni C, and Nixon RA. Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis. J Neurosci 17: 6142-6151, 1997.
35. Cataldo AM, Hamilton DJ, Barnett JL, Paskevich PA, and Nixon RA. Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. J Neurosci 16: 186-199, 1996.
36. Cataldo AM, Petanceska S, Peterhoff CM, Terio NB, Epstein CJ, Villar A, Carlson EJ, Staufenbiel M, and Nixon RA. App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. J Neurosci 23: 6788-6792, 2003.
37. Charrier C, Ehrensperger MV, Dahan M, Levi S, and Triller A. Cytoskeleton regulation of glycine receptor number at synapses and diffusion in the plasma membrane. J Neurosci 26: 8502-8511, 2006.
38. Chen L, Chetkovich DM, Petralia RS, Sweeney NT, Kawasaki Y, Wenthold RJ, Bredt DS, and Nicoll RA. Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature 408: 936-943, 2000.
39. Cheng D, Hoogenraad CC, Rush J, Ramm E, Schlager MA, Duong DM, Xu P, Wijayawardana SR, Hanfelt J, Nakagawa T, Sheng M, and Peng J. Relative and absolute quan tification of postsynaptic density proteome isolated from rat forebrain and cerebellum. Mol Cell Proteomics 5: 1158-1170, 2006.
40. Chowdhury S, Shepherd JD, Okuno H, Lyford G, Petralia RS, Plath N, Kuhl D, Huganir RL, and Worley PF. Arc/Arg3. 1 interacts with the endocytic machinery to regulate AMPA receptor trafficking. Neuron 52: 445-459, 2006.
41. Christopherson KS, Sweeney NT, Craven SE, Kang R, El-Husseini Ael D, and Bredt DS. Lipid-and protein-mediated multimerization of PSD-95: implications for receptor clustering and assembly of synaptic protein networks. J Cell Sci 116: 3213-3219, 2003.
42. Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, and Sudhof TC. Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J Biol Chem 280: 22365-22374, 2005.
43. Colicos MA, Collins BE, Sailor MJ, and Goda Y. Remodeling of synaptic actin induced by photoconductive stimulation. Cell 107: 605-616, 2001.
44. Colledge M, Snyder EM, Crozier RA, Soderling JA, Jin Y, Langeberg LK, Lu H, Bear MF, and Scott JD. Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Neuron 40: 595-607, 2003.
45. Collingridge GL, Isaac JT, and Wang YT. Receptor trafficking and synaptic plasticity. Nat Rev Neurosci 5: 952-962, 2004.
46. Comoletti D, De Jaco A, Jennings LL, Flynn RE, Gaietta G, Tsigelny I, Ellisman MH, and Taylor P. The Arg451Cys-neuroligin-3 mutation associated with autism reveals a defect in protein processing. J Neurosci 24: 4889-4893, 2004.
47. Cooney JR, Hurlburt JL, Selig DK, Harris KM, and Fiala JC. Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane. J Neurosci 22: 2215-2224, 2002.
48. Cottrell JR, Borok E, Horvath TL, and Nedivi E. CPG2: a brain-and synapse-specific protein that regulates the endocytosis of glutamate receptors. Neuron 44: 677-690, 2004.
49. Craven SE, El-Husseini AE, and Bredt DS. Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs. Neuron 22: 497-509, 1999.
50. Dahan M, Levi S, Luccardini C, Rostaing P, Riveau B, and Triller A. Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking. Science 302: 442-445, 2003.
51. de Anda FC, Pollarolo G, Da Silva JS, Camoletto PG, Feiguin F, and Dotti CG. Centrosome localization determines neuronal polarity. Nature 436: 704-708, 2005.
52. De Camilli P, Moretti M, Donini SD, Walter U, and Lohmann SM. Heterogeneous distribution of the cAMP receptor protein RII in the nervous system: evidence for its intracellular accumulation on microtubules, microtubule-organizing centers, and in the area of the Golgi complex. J Cell Biol 103: 189-203, 1986.
53. Debaigt C, Hirling H, Steiner P, Vincent JP, and Mazella J. Crucial role of neuronenriched endosomal protein of 21 kDa in sorting between degradation and recycling of internalized G-protein-coupled receptors. J Biol Chem 279: 35687-35691, 2004.
54. Delcroix JD, Valletta JS, Wu C, Hunt SJ, Kowal AS, and Mobley WC. NGF signaling in sensory neurons: evidence that early endosomes carry NGF retrograde signals. Neuron 39: 69-84, 2003.
55. Deller T, Korte M, Chabanis S, Drakew A, Schwegler H, Stefani GG, Zuniga A, Schwarz K, Bonhoeffer T, Zeller R, Frotscher M, and Mundel P. Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity. Proc Natl Acad Sci USA 100: 10494-10499, 2003.
56. DeSouza S, Fu J, States BA, and Ziff EB. Differential palmitoylation directs the AMPA receptor-binding protein ABP to spines or to intracellular clusters. J Neurosci 22: 3493-3503, 2002.
57. Di Paolo G and De Camilli P. Phosphoinositides in cell regulation and membrane dynamics. Nature 443: 651-657, 2006.
58. Dillon C and Goda Y. The actin cytoskeleton: integrating form and function at the synapse. Annu Rev Neurosci 28: 25-55, 2005.
59. Dong H, Zhang P, Liao D, and Huganir RL. Characterization, expression, and distribution of GRIP protein. Ann NY Acad Sci 868: 535-540, 1999.
60. Dotti CG, Parton RG, and Simons K. Polarized sorting of glypiated proteins in hippocampal neurons. Nature 349: 158-161, 1991.
61. Dotti CG and Simons K. Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture. Cell 62: 63-72, 1990.
62. Dotti CG, Sullivan CA, and Banker GA. The establishment of polarity by hippocampal neurons in culture. J Neurosci 8: 1454-1468, 1988.
63. Ehlers MD. Reinsertion or degradation of AMPA receptors determined by activitydependent endocytic sorting. Neuron 28: 511-525, 2000.
64. Ehlers MD, Heine M, Groc L, Lee MC, and Choquet D. Diffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity. Neuron 54: 447-460, 2007.
65. Ehrlich I and Malinow R. Postsynaptic density 95 controls AMPA receptor incorporation during long-term potentiation and experience-driven synaptic plasticity. J Neurosci 24: 916-927, 2004.
66. El-Husseini AE, Craven SE, Chetkovich DM, Firestein BL, Schnell E, Aoki C, and Bredt DS. Dual palmitoylation of PSD-95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering. J Cell Biol 148: 159-172, 2000.
67. El-Husseini Ael D, Schnell E, Dakoji S, Sweeney N, Zhou Q, Prange O, Gauthier-Campbell C, Aguilera-Moreno A, Nicoll RA, and Bredt DS. Synaptic strength regulated by palmitate cycling on PSD-95. Cell 108: 849-863, 2002.
68. Engqvist-Goldstein AE and Drubin DG. Actin assembly and endocytosis: from yeast to mammals. Annu Rev Cell Dev Biol 19: 287-332, 2003.
69. Etienne-Manneville S and Hall A. Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta. Cell 106: 489-498, 2001.
70. Etienne-Manneville S and Hall A. Rho GTPases in cell biology. Nature 420: 629-635, 2002.
71. Fang C, Deng L, Keller CA, Fukata M, Fukata Y, Chen G, and Luscher B. GODZmediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses. J Neurosci 26: 12758-12768, 2006.
72. Fishman PS, Farrand DA, and Kristt DA. Internalization of plasma proteins by cerebellar Purkinje cells. J Neurol Sci 100: 43-49, 1990.
73. Frick A, Magee J, Koester HJ, Migliore M, and Johnston D. Normalization of Ca2+ signals by small oblique dendrites of CA1 pyramidal neurons. J Neurosci 23: 3243-3250, 2003.
74. Fukata M, Fukata Y, Adesnik H, Nicoll RA, and Bredt DS. Identification of PSD-95 palmitoylating enzymes. Neuron 44: 987-996, 2004.
75. Gardiol A, Racca C, and Triller A. Dendritic and postsynaptic protein synthetic machinery. J Neurosci 19: 168-179, 1999.
76. Gerges NZ, Backos DS, and Esteban JA. Local control of AMPA receptor trafficking at the postsynaptic terminal by a small GTPase of the Rab family. J Biol Chem 279: 43870-43878, 2004.
77. Gerges NZ, Backos DS, Rupasinghe CN, Spaller MR, and Esteban JA. Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. EMBO J 25: 1623-1634, 2006.
78. Gerrow K, Romorini S, Nabi SM, Colicos MA, Sala C, and El-Husseini A. A preformed complex of postsynaptic proteins is involved in excitatory synapse development. Neuron 49: 547-562, 2006.
79. Geyer M and Wittinghofer A. GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins. Curr Opin Struct Biol 7: 786-792, 1997.
80. Gleason MR, Higashijima S, Dallman J, Liu K, Mandel G, and Fetcho JR. Translocation of CaM kinase II to synaptic sites in vivo. Nat Neurosci 6: 217-218, 2003.
81. Golgi C. On the structure of nerve cells. 1898. J Microsc 155: 3-7, 1989.
82. Gorczyca D, Ashley J, Speese S, Gherbesi N, Thomas U, Gundelfinger E, Gramates LS, and Budnik V. Postsynaptic membrane addition depends on the Discs-Large-interacting t-SNARE Gtaxin. J Neurosci 27: 1033-1044, 2007.
83. Graf ER, Zhang X, Jin SX, Linhoff MW, and Craig AM. Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell 119: 1013-1026, 2004.
84. Gray EG. Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study. J Anat 93: 420-433, 1959.
85. Gray EG. Electron microscopy of synaptic contacts on dendrite spines of the cerebral cortex. Nature 183: 1592-1593, 1959.
86. Gray EG and Guillery RW. A Note on the Dendritic Spine Apparatus. J Anat 97: 389-392, 1963.
87. Gray NW, Fourgeaud L, Huang B, Chen J, Cao H, Oswald BJ, Hemar A, and McNiven MA. Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer. Curr Biol 13: 510-515, 2003.
88. Gray NW, Kruchten AE, Chen J, and McNiven MA. A dynamin-3 spliced variant modulates the actin/cortactin-dependent morphogenesis of dendritic spines. J Cell Sci 118: 1279-1290, 2005.
89. Grbovic OM, Mathews PM, Jiang Y, Schmidt SD, Dinakar R, Summers-Terio NB, Ceresa BP, Nixon RA, and Cataldo AM. Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production. J Biol Chem 278: 31261-31268, 2003.
90. Grosshans BL, Ortiz D, and Novick P. Rabs and their effectors: achieving specificity in membrane traffic. Proc Natl Acad Sci USA 103: 11821-11827, 2006.
91. Gu C, Jan YN, and Jan LY. A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels. Science 301: 646-649, 2003.
92. Guillaud L, Setou M, and Hirokawa N. KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons. J Neurosci 23: 131-140, 2003.
93. Haass C and Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 8: 101-112, 2007.
94. Hanus C, Vannier C, and Triller A. Intracellular association of glycine receptor with gephyrin increases its plasma membrane accumulation rate. J Neurosci 24: 1119-1128, 2004.
95. Harms KJ, Tovar KR, and Craig AM. Synapse-specific regulation of AMPA receptor subunit composition by activity. J Neurosci 25: 6379-6388, 2005.
96. Harris KM. Structure, development, and plasticity of dendritic spines. Curr Opin Neurobiol 9: 343-348, 1999.
97. Hayashi T, Rumbaugh G, and Huganir RL. Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites. Neuron 47: 709-723, 2005.
98. Hazuka CD, Foletti DL, Hsu SC, Kee Y, Hopf FW, and Scheller RH. The sec6/8 complex is located at neurite outgrowth and axonal synapse-assembly domains. J Neurosci 19: 1324-1334, 1999.
99. Heerssen HM and Segal RA. Location, location, location: a spatial view of neurotrophin signal transduction. Trends Neurosci 25: 160-165, 2002.
100. Hering H and Sheng M. Dendritic spines: structure, dynamics and regulation. Nat Rev Neurosci 2: 880-888, 2001.
101. Heusser K and Schwappach B. Trafficking of potassium channels. Curr Opin Neurobiol 15: 364-369, 2005.
102. Hirokawa N and Takemura R. Molecular motors and mechanisms of directional transport in neurons. Nat Rev Neurosci 6: 201-214, 2005.
103. Holcman D and Triller A. Modeling synaptic dynamics driven by receptor lateral diffusion. Biophys J 91: 2405-2415, 2006.
104. Hoogenraad CC, Milstein AD, Ethell IM, Henkemeyer M, and Sheng M. GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking. Nat Neurosci 8: 906-915, 2005.
105. Horton AC and Ehlers MD. Dual modes of endoplasmic reticulum-to-Golgi transport in dendrites revealed by live-cell imaging. J Neurosci 23: 6188-6199, 2003.
106. Horton AC and Ehlers MD. Neuronal polarity and trafficking. Neuron 40: 277-295, 2003.
107. Horton AC and Ehlers MD. Secretory trafficking in neuronal dendrites. Nat Cell Biol 6: 585-591, 2004.
108. Horton AC, Racz B, Monson EE, Lin AL, Weinberg RJ, and Ehlers MD. Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis. Neuron 48: 757-771, 2005.
109. Hou L, Antion MD, Hu D, Spencer CM, Paylor R, and Klann E. Dynamic translational and proteasomal regulation of fragile × mental retardation protein controls mGluRdependent long-term depression. Neuron 51: 441-454, 2006.
110. Howe CL, Valletta JS, Rusnak AS, and Mobley WC. NGF signaling from clathrincoated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway. Neuron 32: 801-814, 2001.
111. Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, and Malinow R. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron 52: 831-843, 2006.
112. Hsu SC, Ting AE, Hazuka CD, Davanger S, Kenny JW, Kee Y, and Scheller RH. The mammalian brain rsec6/8 complex. Neuron 17: 1209-1219, 1996.
113. Huang K, Yanai A, Kang R, Arstikaitis P, Singaraja RR, Metzler M, Mullard A, Haigh B, Gauthier-Campbell C, Gutekunst CA, Hayden MR, and El-Husseini A. Huntingtininteracting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins. Neuron 44: 977-986, 2004.
114. Huber LA, Pimplikar S, Parton RG, Virta H, Zerial M, and Simons K. Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane. J Cell Biol 123: 35-45, 1993.
115. Ikonen E. Roles of lipid rafts in membrane transport. Curr Opin Cell Biol 13: 470-477, 2001.
116. Inoue A and Okabe S. The dynamic organization of postsynaptic proteins: translocating molecules regulate synaptic function. Curr Opin Neurobiol 13: 332-340, 2003.
117. Irie F and Yamaguchi Y. EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP. Nat Neurosci 5: 1117-1118, 2002.
118. Itoh T and De Camilli P. BAR, F-BAR (EFC) and ENTH/ANTH domains in the regulation of membrane-cytosol interfaces and membrane curvature. Biochim Biophys Acta 1761: 897-912, 2006.
119. Jacobson C, Schnapp B, and Banker GA. A change in the selective translocation of the Kinesin-1 motor domain marks the initial specification of the axon. Neuron 49: 797-804, 2006.
120. Jahn R, Lang T, and Sudhof TC. Membrane fusion. Cell 112: 519-533, 2003.
121. Jamain S, Quach H, Betancur C, Rastam M, Colineaux C, Gillberg IC, Soderstrom H, Giros B, Leboyer M, Gillberg C, and Bourgeron T. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nat Genet 34: 27-29, 2003.
122. Jan YN and Jan LY. The control of dendrite development. Neuron 40: 229-242, 2003.
123. Jareb M and Banker G. The polarized sorting of membrane proteins expressed in cultured hippocampal neurons using viral vectors. Neuron 20: 855-867, 1998.
124. Jasmin BJ, Antony C, Changeux JP, and Cartaud J. Nerve-dependent plasticity of the Golgi complex in skeletal muscle fibres: compartmentalization within the subneural sarcoplasm. Eur J Neurosci 7: 470-479, 1995.
125. Jasmin BJ, Cartaud J, Bornens M, and Changeux JP. Golgi apparatus in chick skeletal muscle: changes in its distribution during end plate development and after denervation. Proc Natl Acad Sci USA 86: 7218-7222, 1989.
126. Jasmin BJ, Changeux JP, and Cartaud J. Compartmentalization of cold-stable and acetylated microtubules in the subsynaptic domain of chick skeletal muscle fibre. Nature 344: 673-675, 1990.
127. Ju W, Morishita W, Tsui J, Gaietta G, Deerinck TJ, Adams SR, Garner CC, Tsien RY, Ellisman MH, and Malenka RC. Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors. Nat Neurosci 7: 244-253, 2004.
128. Kacharmina JE, Job C, Crino P, and Eberwine J. Stimulation of glutamate receptor protein synthesis and membrane insertion within isolated neuronal dendrites. Proc Natl Acad Sci USA 97: 11545-11550, 2000.
129. Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, and Malinow R. APP processing and synaptic function. Neuron 37: 925-937, 2003.
130. Kastning K, Kukhtina V, Kittler JT, Chen G, Pechstein A, Enders S, Lee SH, Sheng M, Yan Z, and Haucke V. Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2. Proc Natl Acad Sci USA 104: 2991-2996, 2007.
131. Kawakami R, Shinohara Y, Kato Y, Sugiyama H, Shigemoto R, and Ito I. Asymmetrical allocation of NMDA receptor epsilon2 subunits in hippocampal circuitry. Science 300: 990-994, 2003.
132. Keenan RJ, Freymann DM, Stroud RM, and Walter P. The signal recognition particle. Annu Rev Biochem 70: 755-775, 2001.
133. Keller CA, Yuan X, Panzanelli P, Martin ML, Alldred M, Sassoe-Pognetto M, and Luscher B. The gamma2 subunit of GABA (A) receptors is a substrate for palmitoylation by GODZ. J Neurosci 24: 5881-5891, 2004.
134. Keller P and Simons K. Post-Golgi biosynthetic trafficking. J Cell Sci 110 (Pt 24): 3001-3009, 1997.
135. Kennedy MJ and Ehlers MD. Organelles and trafficking machinery for postsynaptic plasticity. Annu Rev Neurosci 29: 325-362, 2006.
136. Kessels MM and Qualmann B. The syndapin protein family: linking membrane trafficking with the cytoskeleton. J Cell Sci 117: 3077-3086, 2004.
137. Kiebler MA and Bassell GJ. Neuronal RNA granules: movers and makers. Neuron 51: 685-690, 2006.
138. Kim E and Sheng M. PDZ domain proteins of synapses. Nat Rev Neurosci 5: 771-781, 2004.
139. Kirchhausen T. Clathrin. Annu Rev Biochem 69: 699-727, 2000.
140. Kittler JT, Arancibia-Carcamo IL, and Moss SJ. Association of GRIP1 with a GABA(A) receptor associated protein suggests a role for GRIP1 at inhibitory synapses. Biochem Pharmacol 68: 1649-1654, 2004.
141. Kittler JT, Delmas P, Jovanovic JN, Brown DA, Smart TG, and Moss SJ. Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J Neurosci 20: 7972-7977, 2000.
142. Kittler JT and Moss SJ. Modulation of GABAA receptor activity by phosphorylation and receptor trafficking: implications for the efficacy of synaptic inhibition. Curr Opin Neurobiol 13: 341-347, 2003.
143. Kittler JT, Thomas P, Tretter V, Bogdanov YD, Haucke V, Smart TG, and Moss SJ. Huntingtin-associated protein 1 regulates inhibitory synaptic transmission by modulating gamma-aminobutyric acid type A receptor membrane trafficking. Proc Natl Acad Sci USA 101: 12736-12741, 2004.
144. Kleizen B and Braakman I. Protein folding and quality control in the endoplasmic reticulum. Curr Opin Cell Biol 16: 343-349, 2004.
145. Kobayashi T, Storrie B, Simons K, and Dotti CG. A functional barrier to movement of lipids in polarized neurons. Nature 359: 647-650, 1992.
146. Koekkoek SK, Yamaguchi K, Milojkovic BA, Dortland BR, Ruigrok TJ, Maex R, De Graaf W, Smit AE, VanderWerf F, Bakker CE, Willemsen R, Ikeda T, Kakizawa S, Onodera K, Nelson DL, Mientjes E, Joosten M, De Schutter E, Oostra BA, Ito M, and De Zeeuw CI. Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile × syndrome. Neuron 47: 339-352, 2005.
147. Kopec CD, Li B, Wei W, Boehm J, and Malinow R. Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation. J Neurosci 26: 2000-2009, 2006.
148. Kupfer A, Dennert G, and Singer SJ. Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets. Proc Natl Acad Sci USA 80: 7224-7228, 1983.
149. Kuriu T, Inoue A, Bito H, Sobue K, and Okabe S. Differential control of postsynaptic density scaffolds via actin-dependent and -independent mechanisms. J Neurosci 26: 7693-7706, 2006.
150. Kusumi A, Nakada C, Ritchie K, Murase K, Suzuki K, Murakoshi H, Kasai RS, Kondo J, and Fujiwara T. Paradigm shift of the plasma membrane concept from the twodimensional continuum fluid to the partitioned fluid: high-speed single-molecule tracking of membrane molecules. Annu Rev Biophys Biomol Struct 34: 351-378, 2005.
151. Lang C, Barco A, Zablow L, Kandel ER, Siegelbaum SA, and Zakharenko SS. Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiation. Proc Natl Acad Sci USA 101: 16665-16670, 2004.
152. Langford GM. Myosin-V, a versatile motor for short-range vesicle transport. Traffic 3: 859-865, 2002.
153. Lau CG and Zukin RS. NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. Nat Rev Neurosci 8: 413-426, 2007.
154. Lavezzari G, McCallum J, Dewey CM, and Roche KW. Subunit-specific regulation of NMDA receptor endocytosis. J Neurosci 24: 6383-6391, 2004.
155. Lavezzari G, McCallum J, Lee R, and Roche KW. Differential binding of the AP-2 adaptor complex and PSD-95 to the C-terminus of the NMDA receptor subunit NR2B regulates surface expression. Neuropharmacology 45: 729-737, 2003.
156. Le Clainche C, Pauly BS, Zhang CX, Engqvist-Goldstein AE, Cunningham K, and Drubin DG. A Hip1R-cortactin complex negatively regulates actin assembly associated with endocytosis. EMBO J, 26: 1199-1210, 2007.
157. Lee MC, Miller EA, Goldberg J, Orci L, and Schekman R. Bi-directional protein transport between the ER and Golgi. Annu Rev Cell Dev Biol 20: 87-123, 2004.
158. Lee SH, Liu L, Wang YT, and Sheng M. Clathrin adaptor AP2 and NSF interact with overlapping sites of GluR2 and play distinct roles in AMPA receptor trafficking and hippocampal LTD. Neuron 36: 661-674, 2002.
159. Lee SH, Simonetta A, and Sheng M. Subunit rules governing the sorting of internalized AMPA receptors in hippocampal neurons. Neuron 43: 221-236, 2004.
160. Levine CG, Mitra D, Sharma A, Smith CL, and Hegde RS. The efficiency of protein compartmentalization into the secretory pathway. Mol Biol Cell 16: 279-291, 2005.
161. Li Z, Okamoto K, Hayashi Y, and Sheng M. The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell 119: 873-887, 2004.
162. Lin JW, Ju W, Foster K, Lee SH, Ahmadian G, Wyszynski M, Wang YT, and Sheng M. Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. Nat Neurosci 3: 1282-1290, 2000.
163. Lippincott-Schwartz J, Roberts TH, and Hirschberg K. Secretory protein trafficking and organelle dynamics in living cells. Annu Rev Cell Dev Biol 16: 557-589, 2000.
164. Lipschutz JH and Mostov KE. Exocytosis: the many masters of the exocyst. Curr Biol 12: R212-214, 2002.
165. Lise MF, Wong TP, Trinh A, Hines RM, Liu L, Kang R, Hines DJ, Lu J, Goldenring JR, Wang YT, and El-Husseini A. Involvement of myosin Vb in glutamate receptor trafficking. J Biol Chem 281: 3669-3678, 2006.
166. Lledo PM, Zhang X, Sudhof TC, Malenka RC, and Nicoll RA. Postsynaptic membrane fusion and long-term potentiation. Science 279: 399-403, 1998.
167. Lorincz A, Notomi T, Tamas G, Shigemoto R, and Nusser Z. Polarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites. Nat Neurosci 5: 1185-1193, 2002.
168. Lowenstein PR, Morrison EE, Bain D, Shering AF, Banting G, Douglas P, and Castro MG. Polarized distribution of the trans-Golgi network marker TGN38 during the in vitro development of neocortical neurons: effects of nocodazole and brefeldin A. Eur J Neurosci 6: 1453-1465, 1994.
169. Luscher C, Nicoll RA, Malenka RC, and Muller D. Synaptic plasticity and dynamic modulation of the postsynaptic membrane. Nat Neurosci 3: 545-550, 2000.
170. Lyford GL, Yamagata K, Kaufmann WE, Barnes CA, Sanders LK, Copeland NG, Gilbert DJ, Jenkins NA, Lanahan AA, and Worley PF. Arc, a growth factor and activityregulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron 14: 433-445, 1995.
171. Ma D and Jan LY. ER transport signals and trafficking of potassium channels and receptors. Curr Opin Neurobiol 12: 287-292, 2002.
172. Maas C, Tagnaouti N, Loebrich S, Behrend B, Lappe-Siefke C, and Kneussel M. Neuronal cotransport of glycine receptor and the scaffold protein gephyrin. J Cell Biol 172: 441-451, 2006.
173. Maletic-Savatic M, Koothan T, and Malinow R. Calcium-evoked dendritic exocytosis in cultured hippocampal neurons. Part II: mediation by calcium/calmodulin-dependent protein kinase II. J Neurosci 18: 6814-6821, 1998.
174. Maletic-Savatic M and Malinow R. Calcium-evoked dendritic exocytosis in cultured hippocampal neurons. Part I: trans-Golgi network-derived organelles undergo regulated exocytosis. J Neurosci 18: 6803-6813, 1998.
175. Marchand S, Bignami F, Stetzkowski-Marden F, and Cartaud J. The myristoylated protein rapsyn is cotargeted with the nicotinic acetylcholine receptor to the postsynaptic membrane via the exocytic pathway. J Neurosci 20: 521-528, 2000.
176. Marchand S, Stetzkowski-Marden F, and Cartaud J. Differential targeting of components of the dystrophin complex to the postsynaptic membrane. Eur J Neurosci 13: 221-229, 2001.
177. Marrs GS, Green SH, and Dailey ME. Rapid formation and remodeling of postsynaptic densities in developing dendrites. Nat Neurosci 4: 1006-1013, 2001.
178. Martin S and Henley JM. Activity-dependent endocytic sorting of kainate receptors to recycling or degradation pathways. EMBO J 23: 4749-4759, 2004.
179. Mathew D, Ataman B, Chen J, Zhang Y, Cumberledge S, and Budnik V. Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2. Science 310: 1344-1347, 2005.
180. Mathew D, Popescu A, and Budnik V. Drosophila amphiphysin functions during synaptic Fasciclin II membrane cycling. J Neurosci 23: 10710-10716, 2003.
181. Matlin KS and Simons K. Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation. Cell 34: 233-243, 1983.
182. Matsuzaki M, Ellis-Davies GC, Nemoto T, Miyashita Y, Iino M, and Kasai H. Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons. Nat Neurosci 4: 1086-1092, 2001.
183. Matsuzaki M, Honkura N, Ellis-Davies GC, and Kasai H. Structural basis of long-term potentiation in single dendritic spines. Nature 429: 761-766, 2004.
184. Matus A. Growth of dendritic spines: a continuing story. Curr Opin Neurobiol 15: 67-72, 2005.
185. Maxfield FR and McGraw TE. Endocytic recycling. Nat Rev Mol Cell Biol 5: 121-132, 2004.
186. Mehta SQ, Hiesinger PR, Beronja S, Zhai RG, Schulze KL, Verstreken P, Cao Y, Zhou Y, Tepass U, Crair MC, and Bellen HJ. Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components. Neuron 46: 219-232, 2005.
187. Miaczynska M, Pelkmans L, and Zerial M. Not just a sink: endosomes in control of signal transduction. Curr Opin Cell Biol 16: 400-406, 2004.
188. Miyata M, Finch EA, Khiroug L, Hashimoto K, Hayasaka S, Oda SI, Inouye M, Takagishi Y, Augustine GJ, and Kano M. Local calcium release in dendritic spines required for long-term synaptic depression. Neuron 28: 233-244, 2000.
189. Momiyama A, Silver RA, Hausser M, Notomi T, Wu Y, Shigemoto R, and Cull-Candy SG. The density of AMPA receptors activated by a transmitter quantum at the climbing fibre-Purkinje cell synapse in immature rats. J Physiol 549: 75-92, 2003.
190. Moss SJ and Smart TG. Constructing inhibitory synapses. Nat Rev Neurosci 2: 240-250, 2001.
191. Mundigl O, Matteoli M, Daniell L, Thomas-Reetz A, Metcalf A, Jahn R, and De Camilli P. Synaptic vesicle proteins and early endosomes in cultured hippocampal neurons: differential effects of Brefeldin A in axon and dendrites. J Cell Biol 122: 1207-1221, 1993.
192. Murthy M, Garza D, Scheller RH, and Schwarz TL. Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists. Neuron 37: 433-447, 2003.
193. Murthy M, Ranjan R, Denef N, Higashi ME, Schupbach T, and Schwarz TL. Sec6 mutations and the Drosophila exocyst complex. J Cell Sci 118: 1139-1150, 2005.
194. Nagerl UV, Eberhorn N, Cambridge SB, and Bonhoeffer T. Bidirectional activitydependent morphological plasticity in hippocampal neurons. Neuron 44: 759-767, 2004.
195. Naisbitt S, Kim E, Tu JC, Xiao B, Sala C, Valtschanoff J, Weinberg RJ, Worley PF, and Sheng M. Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Neuron 23: 569-582, 1999.
196. Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, Weinberg RJ, and Sheng M. Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein. J Neurosci 20: 4524-4534, 2000.
197. Nakada C, Ritchie K, Oba Y, Nakamura M, Hotta Y, Iino R, Kasai RS, Yamaguchi K, Fujiwara T, and Kusumi A. Accumulation of anchored proteins forms membrane diffusion barriers during neuronal polarization. Nat Cell Biol 5: 626-632, 2003.
198. Nimchinsky EA, Sabatini BL, and Svoboda K. Structure and function of dendritic spines. Annu Rev Physiol 64: 313-353, 2002.
199. Nixon RA. Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases. Neurobiol Aging 26: 373-382, 2005.
200. Nusser Z, Lujan R, Laube G, Roberts JD, Molnar E, and Somogyi P. Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus. Neuron 21: 545-559, 1998.
201. O'Brien RJ, Kamboj S, Ehlers MD, Rosen KR, Fischbach GD, and Huganir RL. Activity-dependent modulation of synaptic AMPA receptor accumulation. Neuron 21: 1067-1078, 1998.
202. Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, and LaFerla FM. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39: 409-421, 2003.
203. Oh MC, Derkach VA, Guire ES, and Soderling TR. Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation. J Biol Chem 281: 752-758, 2006.
204. Okabe S, Kim HD, Miwa A, Kuriu T, and Okado H. Continual remodeling of postsynaptic density and its regulation by synaptic activity. Nat Neurosci 2: 804-811, 1999.
205. Okamoto K, Nagai T, Miyawaki A, and Hayashi Y. Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity. Nat Neurosci 7: 1104-1112, 2004.
206. Osterweil E, Wells DG, and Mooseker MS. A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis. J Cell Biol 168: 329-338, 2005.
207. Ostroff LE, Fiala JC, Allwardt B, and Harris KM. Polyribosomes redistribute from dendritic shafts into spines with enlarged synapses during LTP in developing rat hippocampal slices. Neuron 35: 535-545, 2002.
208. Paglini G, Peris L, Diez-Guerra J, Quiroga S, and Caceres A. The Cdk5-p35 kinase associates with the Golgi apparatus and regulates membrane traffic. EMBO Rep 2: 1139-1144, 2001.
209. Pal A, Severin F, Lommer B, Shevchenko A, and Zerial M. Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease. J Cell Biol 172: 605-618, 2006.
210. Palade G. Intracellular aspects of the process of protein synthesis. Science 189: 347-358, 1975.
211. Palmer CL, Lim W, Hastie PG, Toward M, Korolchuk VI, Burbidge SA, Banting G, Collingridge GL, Isaac JT, and Henley JM. Hippocalcin functions as a calcium sensor in hippocampal LTD. Neuron 47: 487-494, 2005.
212. Park M, Penick EC, Edwards JG, Kauer JA, and Ehlers MD. Recycling endosomes supply AMPA receptors for LTP. Science 305: 1972-1975, 2004.
213. Park M, Salgado JM, Ostroff L, Helton TD, Robinson CG, Harris KM, and Ehlers MD. Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes. Neuron 52: 817-830, 2006.
214. Passafaro M, Piech V, and Sheng M. Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons. Nat Neurosci 4: 917-926, 2001.
215. Pearse BM, Smith CJ, and Owen DJ. Clathrin coat construction in endocytosis. Curr Opin Struct Biol 10: 220-228, 2000.
216. Perez-Otano I, Lujan R, Tavalin SJ, Plomann M, Modregger J, Liu XB, Jones EG, Heinemann SF, Lo DC, and Ehlers MD. Endocytosis and synaptic removal of NR3Acontaining NMDA receptors by PACSIN1/syndapin1. Nat Neurosci 9: 611-621, 2006.
217. Peters A, Palay SL, Webster HF. The fine structure of the nervous system. Oxford: Oxford University Press, 1991.
218. Petralia RS, Wang YX, Sans N, Worley PF, Hammer JA, 3rd, and Wenthold RJ. Glutamate receptor targeting in the postsynaptic spine involves mechanisms that are independent of myosin Va. Eur J Neurosci 13: 1722-1732, 2001.
219. Petralia RS, Wang YX, and Wenthold RJ. Internalization at glutamatergic synapses during development. Eur J Neurosci 18: 3207-3217, 2003.
220. Pierce JP, Mayer T, and McCarthy JB. Evidence for a satellite secretory pathway in neuronal dendritic spines. Curr Biol 11: 351-355, 2001.
221. Pierce JP, van Leyen K, and McCarthy JB. Translocation machinery for synthesis of integral membrane and secretory proteins in dendritic spines. Nat Neurosci 3: 311-313, 2000.
222. Popov V, Medvedev NI, Davies HA, and Stewart MG. Mitochondria form a filamentous reticular network in hippocampal dendrites but are present as discrete bodies in axons: a three-dimensional ultrastructural study. J Comp Neurol 492: 50-65, 2005.
223. Praefcke GJ and McMahon HT. The dynamin superfamily: universal membrane tubulation and fission molecules? Nat Rev Mol Cell Biol 5: 133-147, 2004.
224. Prange O, Wong TP, Gerrow K, Wang YT, and El-Husseini A. A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin. Proc Natl Acad Sci USA 101: 13915-13920, 2004.
225. Prekeris R, Foletti DL, and Scheller RH. Dynamics of tubulovesicular recycling endosomes in hippocampal neurons. J Neurosci 19: 10324-10337, 1999.
226. Prekeris R, Klumperman J, Chen YA, and Scheller RH. Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. J Cell Biol 143: 957-971, 1998.
227. Racca C, Stephenson FA, Streit P, Roberts JD, and Somogyi P. NMDA receptor content of synapses in stratum radiatum of the hippocampal CA1 area. J Neurosci 20: 2512-2522, 2000.
228. Racz B, Blanpied TA, Ehlers MD, and Weinberg RJ. Lateral organization of endocytic machinery in dendritic spines. Nat Neurosci 7: 917-918, 2004.
229. Ralston E, Lu Z, and Ploug T. The organization of the Golgi complex and microtubules in skeletal muscle is fiber type-dependent. J Neurosci 19: 10694-10705, 1999.
230. Rathenberg J, Kittler JT, and Moss SJ. Palmitoylation regulates the clustering and cell surface stability of GABAA receptors. Mol Cell Neurosci 26: 251-257, 2004.
231. Resh MD. Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. Biochim Biophys Acta 1451: 1-16, 1999.
232. Richards DA, De Paola V, Caroni P, Gahwiler BH, and McKinney RA. AMPA-receptor activation regulates the diffusion of a membrane marker in parallel with dendritic spine motility in the mouse hippocampus. J Physiol 558: 503-512, 2004.
233. Rivera JF, Ahmad S, Quick MW, Liman ER, and Arnold DB. An evolutionarily conserved dileucine motif in Shal K+ channels mediates dendritic targeting. Nat Neurosci 6: 243-250, 2003.
234. Roche KW, Standley S, McCallum J, Dune Ly C, Ehlers MD, and Wenthold RJ. Molecular determinants of NMDA receptor internalization. Nat Neurosci 4: 794-802, 2001.
235. Rodriguez-Boulan E, Kreitzer G, and Musch A. Organization of vesicular trafficking in epithelia. Nat Rev Mol Cell Biol 6: 233-247, 2005.
236. Rose CR and Konnerth A. Stores not just for storage. intracellular calcium release and synaptic plasticity. Neuron 31: 519-522, 2001.
237. Rosenberg M, Meier J, Triller A, and Vannier C. Dynamics of glycine receptor insertion in the neuronal plasma membrane. J Neurosci 21: 5036-5044, 2001.
238. Rosso S, Bollati F, Bisbal M, Peretti D, Sumi T, Nakamura T, Quiroga S, Ferreira A, and Caceres A. LIMK1 regulates Golgi dynamics, traffic of Golgi-derived vesicles, and process extension in primary cultured neurons. Mol Biol Cell 15: 3433-3449, 2004.
239. Ruberti F and Dotti CG. Involvement of the proximal C terminus of the AMPA receptor subunit GluR1 in dendritic sorting. J Neurosci 20: RC78, 2000.
240. Sabatini BL, Maravall M, and Svoboda K. Ca(2+) signaling in dendritic spines. Curr Opin Neurobiol 11: 349-356, 2001.
241. Saito N, Okada Y, Noda Y, Kinoshita Y, Kondo S, and Hirokawa N. KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles. Neuron 18: 425-438, 1997.
242. Sala C, Piech V, Wilson NR, Passafaro M, Liu G, and Sheng M. Regulation of dendritic spine morphology and synaptic function by Shank and Homer. Neuron 31: 115-130, 2001.
243. Sampo B, Kaech S, Kunz S, and Banker G. Two distinct mechanisms target membrane proteins to the axonal surface. Neuron 37: 611-624, 2003.
244. Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, and Wenthold RJ. NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Nat Cell Biol 5: 520-530, 2003.
245. Sans N, Racca C, Petralia RS, Wang YX, McCallum J, and Wenthold RJ. Synapseassociated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway. J Neurosci 21: 7506-7516, 2001.
246. Schatz G and Dobberstein B. Common principles of protein translocation across membranes. Science 271: 1519-1526, 1996.
247. Scheiffele P, Fan J, Choih J, Fetter R, and Serafini T. Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell 101: 657-669, 2000.
248. Schnell E and Nicoll RA. Hippocampal synaptic transmission and plasticity are preserved in myosin Va mutant mice. J Neurophysiol 85: 1498-1501, 2001.
249. Scott DB, Michailidis I, Mu Y, Logothetis D, and Ehlers MD. Endocytosis and degradative sorting of NMDA receptors by conserved membrane-proximal signals. J Neurosci 24: 7096-7109, 2004.
250. Seabra MC and Wasmeier C. Controlling the location and activation of Rab GTPases. Curr Opin Cell Biol 16: 451-457, 2004.
251. Setou M, Nakagawa T, Seog DH, and Hirokawa N. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science 288: 1796-1802, 2000.
252. Setou M, Seog DH, Tanaka Y, Kanai Y, Takei Y, Kawagishi M, and Hirokawa N. Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites. Nature 417: 83-87, 2002.
253. Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, and Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci 27: 2866-2875, 2007.
254. Sharma K, Fong DK, and Craig AM. Postsynaptic protein mobility in dendritic spines: long-term regulation by synaptic NMDA receptor activation. Mol Cell Neurosci 31: 702-712, 2006.
255. Shaw RM, Fay AJ, Puthenveedu MA, von Zastrow M, Jan YN, and Jan LY. Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions. Cell 128: 547-560, 2007.
256. Sheng M, Tsaur ML, Jan YN, and Jan LY. Subcellular segregation of two A-type K+ channel proteins in rat central neurons. Neuron 9: 271-284, 1992.
257. Shi S, Hayashi Y, Esteban JA, and Malinow R. Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons. Cell 105: 331-343, 2001.
258. Shi SH, Hayashi Y, Petralia RS, Zaman SH, Wenthold RJ, Svoboda K, and Malinow R. Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science 284: 1811-1816, 1999.
259. Shirane M and Nakayama KI. Protrudin induces neurite formation by directional membrane trafficking. Science 314: 818-821, 2006.
260. Silverman MA, Peck R, Glover G, He C, Carlin C, and Banker G. Motifs that mediate dendritic targeting in hippocampal neurons: a comparison with basolateral targeting signals. Mol Cell Neurosci 29: 173-180, 2005.
261. Singaraja RR, Hadano S, Metzler M, Givan S, Wellington CL, Warby S, Yanai A, Gutekunst CA, Leavitt BR, Yi H, Fichter K, Gan L, McCutcheon K, Chopra V, Michel J, Hersch SM, Ikeda JE, and Hayden MR. HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. Hum Mol Genet 11: 2815-2828, 2002.
262. Smith MA, Ellis-Davies GC, and Magee JC. Mechanism of the distance-dependent scaling of Schaffer collateral synapses in rat CA1 pyramidal neurons. J Physiol 548: 245-258, 2003.
263. Smotrys JE and Linder ME. Palmitoylation of intracellular signaling proteins: regulation and function. Annu Rev Biochem 73: 559-587, 2004.
264. Snyder EM, Nong Y, Almeida CG, Paul S, Moran T, Choi EY, Nairn AC, Salter MW, Lombroso PJ, Gouras GK, and Greengard P. Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci 8: 1051-1058, 2005.
265. Snyder EM, Philpot BD, Huber KM, Dong X, Fallon JR, and Bear MF. Internalization of ionotropic glutamate receptors in response to mGluR activation. Nat Neurosci 4: 1079-1085, 2001.
266. Sone M, Suzuki E, Hoshino M, Hou D, Kuromi H, Fukata M, Kuroda S, Kaibuchi K, Nabeshima Y, and Hama C. Synaptic development is controlled in the periactive zones of Drosophila synapses. Development 127: 4157-4168, 2000.
267. Sorkin A and Von Zastrow M. Signal transduction and endocytosis: close encounters of many kinds. Nat Rev Mol Cell Biol 3: 600-614, 2002.
268. Spacek J and Harris KM. Three-dimensional organization of smooth endoplasmic reticulum in hippocampal CA1 dendrites and dendritic spines of the immature and mature rat. J Neurosci 17: 190-203, 1997.
269. Star EN, Kwiatkowski DJ, and Murthy VN. Rapid turnover of actin in dendritic spines and its regulation by activity. Nat Neurosci 5: 239-246, 2002.
270. Steiner P, Alberi S, Kulangara K, Yersin A, Sarria JC, Regulier E, Kasas S, Dietler G, Muller D, Catsicas S, and Hirling H. Interactions between NEEP21, GRIP1 and GluR2 regulate sorting and recycling of the glutamate receptor subunit GluR2. EMBO J 24: 2873-2884, 2005.
271. Steiner P, Sarria JC, Glauser L, Magnin S, Catsicas S, and Hirling H. Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD. J Cell Biol 157: 1197-1209, 2002.
272. Steward O and Schuman EM. Compartmentalized synthesis and degradation of proteins in neurons. Neuron 40: 347-359, 2003.
273. Sudhof TC. The synaptic vesicle cycle. Annu Rev Neurosci 27: 509-547, 2004.
274. Sutton MA and Schuman EM. Dendritic protein synthesis, synaptic plasticity, and memory. Cell 127: 49-58, 2006.
275. Sytnyk V, Leshchyns'ka I, Delling M, Dityateva G, Dityatev A, and Schachner M. Neural cell adhesion molecule promotes accumulation of TGN organelles at sites of neuronto-neuron contacts. J Cell Biol 159: 649-661, 2002.
276. Takagishi Y, Oda S, Hayasaka S, Dekker-Ohno K, Shikata T, Inouye M, and Yamamura H. The dilute-lethal (dl) gene attacks a Ca2+ store in the dendritic spine of Purkinje cells in mice. Neurosci Lett 215: 169-172, 1996.
277. Tanaka J, Matsuzaki M, Tarusawa E, Momiyama A, Molnar E, Kasai H, and Shigemoto R. Number and density of AMPA receptors in single synapses in immature cerebellum. J Neurosci 25: 799-807, 2005.
278. Tardin C, Cognet L, Bats C, Lounis B, and Choquet D. Direct imaging of lateral movements of AMPA receptors inside synapses. EMBO J 22: 4656-4665, 2003.
279. Taylor KA. Regulation and recycling of myosin V. Curr Opin Cell Biol 19: 67-74, 2007.
280. Thery M and Bornens M. Cell shape and cell division. Curr Opin Cell Biol 18: 648-657, 2006.
281. Thomas P, Mortensen M, Hosie AM, and Smart TG. Dynamic mobility of functional GABAA receptors at inhibitory synapses. Nat Neurosci 8: 889-897, 2005.
282. Toni N, Buchs PA, Nikonenko I, Bron CR, and Muller D. LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite. Nature 402: 421-425, 1999.
283. Toni N, Buchs PA, Nikonenko I, Povilaitite P, Parisi L, and Muller D. Remodeling of synaptic membranes after induction of long-term potentiation. J Neurosci 21: 6245-6251, 2001.
284. Torre ER and Steward O. Demonstration of local protein synthesis within dendrites using a new cell culture system that permits the isolation of living axons and dendrites from their cell bodies. J Neurosci 12: 762-772, 1992.
285. Torre ER and Steward O. Protein synthesis within dendrites: glycosylation of newly synthesized proteins in dendrites of hippocampal neurons in culture. J Neurosci 16: 5967-5978, 1996.
286. Tovar KR and Westbrook GL. Mobile NMDA receptors at hippocampal synapses. Neuron 34: 255-264, 2002.
287. Triller A and Choquet D. Surface trafficking of receptors between synaptic and extrasynaptic membranes: and yet they do move! Trends Neurosci 28: 133-139, 2005.
288. Tu JC, Xiao B, Naisbitt S, Yuan JP, Petralia RS, Brakeman P, Doan A, Aakalu VK, Lanahan AA, Sheng M, and Worley PF. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23: 583-592, 1999.
289. Tuma PL and Hubbard AL. Transcytosis: crossing cellular barriers. Physiol Rev 83: 871-932, 2003.
290. Turrigiano GG and Nelson SB. Homeostatic plasticity in the developing nervous system. Nat Rev Neurosci 5: 97-107, 2004.
291. Ullrich O, Reinsch S, Urbe S, Zerial M, and Parton RG. Rab11 regulates recycling through the pericentriolar recycling endosome. J Cell Biol 135: 913-924, 1996.
292. Urrutia R, Henley JR, Cook T, and McNiven MA. The dynamins: redundant or distinct functions for an expanding family of related GTPases? Proc Natl Acad Sci USA 94: 377-384, 1997.
293. Vale RD. The molecular motor toolbox for intracellular transport. Cell 112: 467-480, 2003.
294. Vale RD, Reese TS, and Sheetz MP. Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility. Cell 42: 39-50, 1985.
295. van Rijnsoever C, Sidler C, and Fritschy JM. Internalized GABA-receptor subunits are transferred to an intracellular pool associated with the postsynaptic density. Eur J Neurosci 21: 327-338, 2005.
296. Vega IE and Hsu SC. The exocyst complex associates with microtubules to mediate vesicle targeting and neurite outgrowth. J Neurosci 21: 3839-3848, 2001.
297. Walikonis RS, Jensen ON, Mann M, Provance DW, Jr., Mercer JA, and Kennedy MB. Identification of proteins in the postsynaptic density fraction by mass spectrometry. J Neurosci 20: 4069-4080, 2000.
298. Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, and Selkoe DJ. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416: 535-539, 2002.
299. Washbourne P, Liu XB, Jones EG, and McAllister AK. Cycling of NMDA receptors during trafficking in neurons before synapse formation. J Neurosci 24: 8253-8264, 2004.
300. West AE, Neve RL, and Buckley KM. Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor. J Neurosci 17: 6038-6047, 1997.
301. Winckler B, Forscher P, and Mellman I. A diffusion barrier maintains distribution of membrane proteins in polarized neurons. Nature 397: 698-701, 1999.
302. Winckler B and Mellman I. Neuronal polarity: controlling the sorting and diffusion of membrane components. Neuron 23: 637-640, 1999.
303. Wisco D, Anderson ED, Chang MC, Norden C, Boiko T, Folsch H, and Winckler B. Uncovering multiple axonal targeting pathways in hippocampal neurons. J Cell Biol 162: 1317-1328, 2003.
304. Wolf ME, Sun X, Mangiavacchi S, and Chao SZ. Psychomotor stimulants and neuronal plasticity. Neuropharmacology 47(Suppl 1): 61-79, 2004.
305. Ye H, Kuruvilla R, Zweifel LS, and Ginty DD. Evidence in support of signaling endosome-based retrograde survival of sympathetic neurons. Neuron 39: 57-68, 2003.
306. Yoshihara M, Adolfsen B, Galle KT, and Littleton JT. Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth. Science 310: 858-863, 2005.
307. Yoshii A and Constantine-Paton M. BDNF induces transport of PSD-95 to dendrites through PI3K-AKT signaling after NMDA receptor activation. Nat Neurosci 10: 702-711, 2007.
308. Zhou Q, Homma KJ, and Poo MM. Shrinkage of dendritic spines associated with longterm depression of hippocampal synapses. Neuron 44: 749-757, 2004.
309. Zhou Q, Xiao M, and Nicoll RA. Contribution of cytoskeleton to the internalization of AMPA receptors. Proc Natl Acad Sci USA 98: 1261-1266, 2001.