The Exocyst complex associates with microtubules to mediate vesicle targeting and neurite outgrowth

Journal of Neuroscience

Volumn 21, Issue 11, 2001, Pages 3839-3848

  Vega, Irving E ^a   Hsu, Shu Chan ^a,b,c  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

Differentiation; Exocyst complex; Exocytosis; MAP kinase pathway; Microtubules; Neurite outgrowth; Vesicle targeting

Indexed keywords

CELL PROTEIN; EXOCYST; MITOGEN ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; GROWTH CONE; HIPPOCAMPUS; IMMUNOCYTOCHEMISTRY; MACROMOLECULE; MICROTUBULE; MOUSE; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SYNAPSE VESICLE;

EID: 0035370951     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-11-03839.2001     Document Type: Article

References (14)

1. Adam JC, Pringle JR, Peifer M (2000) Evidence for functional differentiation among Drosophila septins in cytokinesis and cellularization. Mol Biol Cell 11:3123-3135.
2. Bennett MK, Calakos N, Scheller RH (1992) Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones. Science 257:255-259.
3. Bock JB, Klumperman J, Davanger S, Scheller RH (1997) Syntaxin 6 functions in trans-Golgi network vesicle trafficking. Mol Biol Cell 8:1261-1271.
4. Bowser R, Muller H, Govindan B, Novick P (1992) Sec8p and Sec15p are components of a plasma membrane-associated 19.5S particle that may function downstream of Sec4p to control exocytosis. J Cell Biol 118:1041-1056.
5. Brinkeley BR (1985) Microtubule organizing centers. Annu Rev Cell Biol 1:145-172.
6. Dai J, Sheetz MP (1995) Axon membrane flows from the growth cone to the cell body, Cell 83:693-701.
7. Dent EW, Callaway JL, Szebenyl G, Baas PW, Kalil K (1999) Reorganization and movement of microtubules in axonal growth cones and developing interstitial branches. J Neurosci 19:8894-8908.
8. Finger FP, Hughes TE, Novick P (1998) Sec3p is a spatial landmark for polarized secretion in budding yeast. Cell 92:559-571.
9. Friedrich GA, Hildebrand JD, Soriano P (1997) The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse. Dev Biol 192:364-374.
10. Futerman AH, Banker GA (1996) The economics of neurite outgrowth - the addition of new membrane to growing axons. Trends Neurosci 19:144-149.
11. Greene LA, Tischler A (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73:2424-2428.
12. Grindstaff KK, Yeaman C, Anandasabapathy N, Hsu SC, Rodriguez-Boulan E, Scheller RH, Nelson WJ (1998) Sec6/8 complex is recruited to cell-cell contact and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. Cell 93:731-740.
13. Guo W, Sacher M, Barrowman J, Ferro-Novick S, Novick P (2000) Protein complexes in transport vesicle targeting. Trends Cell Biol 10:251-255.
14. Zhen M, Huang X, Bamber B, Jin Y (2000) Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a Ring-H2 domain. Neuron 26:331-343.