An evolutionarily conserved dileucine motif in Shal K+ channels mediates dendritic targeting

Nature Neuroscience

Volumn 6, Issue 3, 2003, Pages 243-250

  Rivera, Jacqueline F ^a   Ahmad, Shoeb ^a   Quick, Michael W ^a   Liman, Emily R ^a   Arnold, Don B ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CD8 ANTIGEN; LEUCINE; MEMBRANE PROTEIN; POTASSIUM CHANNEL; SHAL POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CONTROLLED STUDY; DENDRITE; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; NERVE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN TARGETING; RAT; SEQUENCE ANALYSIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD8; CELLS, CULTURED; CONSERVED SEQUENCE; DENDRITES; ENDOCYTOSIS; KV1.3 POTASSIUM CHANNEL; KV1.4 POTASSIUM CHANNEL; LEUCINE; MOLECULAR SEQUENCE DATA; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN TRANSPORT; PYRAMIDAL CELLS; RATS; RECOMBINANT FUSION PROTEINS; SHAL POTASSIUM CHANNELS;

EID: 0037374279     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1020     Document Type: Article

References (43)

1. + conduction and selectivity. Science 280, 69-77 (1998).
2. Veh, R.W. et al. Immunohistochemical localization of five members of the Kv1 channel subunits: contrasting subcellular locations and neuron-specific co-localizations in rat brain. Eur. J. Neurosci. 7, 2189-2205 (1995).
3. Smart, S.L. et al. Deletion of the K(V)1.1 potassium channel causes epilepsy in mice. Neuron 20, 809-819 (1998).
4. + channel proteins in rat central neurons. Neuron 9, 271-284 (1992).
5. Baro, D.J. et al. Molecular underpinnings of motor pattern generation: differential targeting of shal and shaker in the pyloric motor system. J. Neurosci. 20, 6619-6630 (2000).
6. Song, W.J. et al. Somatodendritic depolarization-activated potassium currents in rat neostriatal cholinergic interneurons are predominantly of the A type and attributable to coexpression of Kv4.2 and Kv4.1 subunits. J. Neurosci. 18, 3124-3137 (1998).
7. Cooper, E.C., Milroy, A., Jan, Y.N., Jan, L.Y. & Lowenstein, D.H. Presynaptic localization of Kv1.4-containing A-type potassium channels near excitatory synapses in the hippocampus. J. Neurosci. 18, 965-974 (1998).
8. Tsunoda, S., Sun, Y., Suzuki, E. & Zuker, C. Independent anchoring and assembly mechanisms of INAD signaling complexes in Drosophila photoreceptors. J. Neurosci. 21, 150-158 (2001).
9. Lim, S.T., Antonucci, D.E., Scannevin, R.H. & Trimmer, J.S. A novel targeting signal for proximal clustering of the Kv2.1 K+ channel in hippocampal neurons. Neuron 25, 385-397 (2000).
10. Garrido, J.J. et al. Identification of an axonal determinant in the C-terminus of the sodium channel Na(v)1.2. EMBO J. 20, 5950-5961 (2001).
11. Burack, M.A., Silverman, M.A. & Banker, G. The role of selective transport in neuronal protein sorting. Neuron 26, 465-472 (2000).
12. Hunziker, W., Harter, C., Matter, K. & Mellman, I. Basolateral sorting in MDCK cells requires a distinct cytoplasmic domain determinant. Cell 66, 907-920 (1991).
13. Matter, K. & Mellman, I. Mechanisms of cell polarity: sorting and transport in epithelial cells. Curr. Opin. Cell Biol. 6, 545-554 (1994).
14. Dotti, C.G. & Simons, K. Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture. Cell 62, 63-72 (1990).
15. Casanova, J.E., Apodaca, G. & Mostov, K.E. An autonomous signal for basolateral sorting in the cytoplasmic domain of the polymeric immunoglobulin receptor. Cell 66, 65-75 (1991).
16. Matter, K., Yamamoto, E.M. & Mellman, I. Structural requirements and sequence motifs for polarized sorting and endocytosis of LDL and Fc receptors in MDCK cells. J. Cell Biol. 126, 991-1004 (1994).
17. Odorizzi, G. & Trowbridge, I.S. Structural requirements for basolateral sorting of the human transferrin receptor in the biosynthetic and endocytic pathways of Madin-Darby canine kidney cells. J. Cell Biol. 137, 1255-1264 (1997).
18. Kundu, A. & Nayak, D.P. Analysis of the signals for polarized transport of influenza virus (A/WSN/33) neuraminidase and human transferrin receptor, type II transmembrane proteins. J. Virol. 68, 1812-1818 (1994).
19. Jareb, M. & Banker, G. The polarized sorting of membrane proteins expressed in cultured hippocampal neurons using viral vectors. Neuron 20, 855-867 (1998).
20. Stowell, J.N. & Craig, A.M. Axon/dendrite targeting of metabotropic glutamate receptors by their cytoplasmic carboxy-terminal domains [see comments]. Neuron 22, 525-536 (1999).
21. Francesconi, A. & Duvoisin, R.M. Alternative splicing unmasks dendritic and axonal targeting signals in metabotropic glutamate receptor I. J. Neurosci. 22, 2196-2205 (2002).
22. Ruberti, F. & Dotti, C.G. Involvement of the proximal C terminus of the AMPA receptor subunit GluR1 in dendritic sorting. J. Neurosci. 20, RC78 (2000).
23. Arnold, D., Feng, L., Kim, J. & Heintz, N. A strategy for the analysis of gene expression during neural development. Proc. Natl. Acad. Sci. USA 91, 9970-9974 (1994).
24. Moriyoshi, K., Richards, L.J., Akazawa, C., O'Leary, D.D. & Nakanishi, S. Labeling neural cells using adenoviral gene transfer of membrane-targeted GFP. Neuron 16, 255-260 (1996).
25. Yellen, G. The voltage-gated potassium channels and their relatives. Nature 419, 35-42 (2002).
26. Letourneur, F. & Klausner, R.D. A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. Cell 69, 1143-1157 (1992).
27. Matter, K., Hunziker, W. & Mellman, I. Basolateral sorting of LDL receptor in MDCK cells: the cytoplasmic domain contains two tyrosine-dependent targeting determinants. Cell 71, 741-753 (1992).
28. Craig, A.M., Wyborski, R.J. & Banker, G. Preferential addition of newly synthesized membrane protein at axonal growth cones. Nature 375, 592-594 (1995).
29. + channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature 387, 869-875 (1997).
30. + channels in dendrites of hippocampal CA1 pyramidal neurons by activation of PKA and PKC. J. Neurosci. 18, 3521-3528 (1998).
31. Ohno, H. et al. Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science 269, 1872-1875 (1995).
32. Rapoport, I., Chen, Y.C., Cupers, P., Shoelson, S.E. & Kirchhausen, T. Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif binding site. EMBO J. 17, 2148-2155 (1998).
33. Dwyer, N.D., Adler, C.E., Crump, J.G., L'Etoile, N.D. & Bargmann, C.I. Polarized dendritic transport and the AP-1 mu1 clathrin adaptor UNC-101 localize odorant receptors to olfactory cilia. Neuron 31, 277-287 (2001).
34. Nakagawa, T. et al. A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex. Cell 103, 569-581 (2000).
35. Hanlon, D.W., Yang, Z. & Goldstein, L.S. Characterization of KIFC2, a neuronal kinesin superfamily member in mouse. Neuron 18, 439-451 (1997).
36. Saito, N. et al. KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles. Neuron 18, 425-438 (1997).
37. Setou, M., Nakagawa, T., Seog, D.H. & Hirokawa, N. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science 288, 1796-1802 (2000).
38. Marszalek, J.R., Weiner, J.A., Farlow, S.J., Chun, J. & Goldstein, L.S. Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21 B. J. Cell Biol. 145, 469-479 (1999).
39. Setou, M. et al. Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites. Nature 417, 83-87 (2002).
40. + channel. Neuron 23, 149-157 (1999).
41. + (A-type) currents in rat brain. J. Neurophysiol. 79, 1081-1091 (1998).
42. Whitworth, T.L. & Quick, M.W. Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylation. J. Biol. Chem. 276, 42932-42937 (2001).
43. Koren, G., Liman, E.R., Logothetis, D.E., Nadal-Ginard, B. & Hess, P. Gating mechanism of a cloned potassium channel expressed in frog oocytes and mammalian cells. Neuron 4, 39-51 (1990).