Neuronal cotransport of glycine receptor and the scaffold protein gephyrin

Journal of Cell Biology

Volumn 172, Issue 3, 2006, Pages 441-451

  Maas, Christoph ^a   Tagnaouti, Nadia ^a   Loebrich, Sven ^a   Behrend, Bardo ^a   Lappe Siefke, Corinna ^a   Kneussel, Matthias ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DYNEIN ADENOSINE TRIPHOSPHATASE; GEPHYRIN; GLYCINE RECEPTOR; POSTSYNAPTIC RECEPTOR; SCAFFOLD PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL FRACTIONATION; CELL INTERACTION; CELL MOTILITY; COMPLEX FORMATION; CONTROLLED STUDY; DENDRITE; DEPOLYMERIZATION; EMBRYO; GENE CONTROL; GENE REARRANGEMENT; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IONIC STRENGTH; MICROTUBULE ASSEMBLY; MOLECULAR DYNAMICS; MOTONEURON; MOUSE; NEUROTRANSMISSION; NONHUMAN; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT; REFLEX RECRUITMENT; SEDIMENTATION; SYNAPSE VESICLE;

ANIMALIA;

EID: 31944448850     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200506066     Document Type: Article

References (52)

1. Ackermann, M., and A. Matus. 2003. Activity-induced targeting of profilin and stabilization of dendritic spine morphology. Nat. Neurosci. 6:1194-1200.
2. Ahmad, F.J., C.J. Echeverri, R.B. Vallee, and P.W. Baas. 1998. Cytoplasmic dynein and dynactin are required for the transport of microtubules into the axon. J. Cell Biol. 140:391-401.
3. Burkhardt, J.K., C.J. Echeverri, T. Nilsson, and R.B. Vallee. 1997. Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dyneindependent maintenance of membrane organelle distribution. J. Cell Biol. 139:469-484.
4. Choquet, D., and A. Triller. 2003. The role of receptor diffusion in the organization of the postsynaptic membrane. Nat. Rev. Neurosci. 4:251-265.
5. Danglot, L., P. Rostaing, A. Triller, and A. Bessis. 2004. Morphologically identified glycinergic synapses in the hippocampus. Mol. Cell. Neurosci. 27:394-403.
6. Dong, H., R.J. O'Brien, E.T. Fung, A.A. Lanahan, P.F. Worley, and R.L. Huganir. 1997. GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. Nature. 386:279-284.
7. Dujardin, D.L., and R.B. Vallee. 2002. Dynein at the cortex. Curr. Opin. Cell Biol. 14:44-49.
8. Dumoulin, A., P. Rostaing, C. Bedet, S. Levi, M.F. Isambert, J.P. Henry, A. Triller, and B. Gasnier. 1999. Presence of the vesicular inhibitory amino acid transporter in GABAergic and glycinergic synaptic terminal boutons. J. Cell Sci. 112:811-823.
9. Essrich, C., M. Lorez, J.A. Benson, J.M. Fritschy, and B. Luscher. 1998. Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrin. Nat. Neurosci. 1:563-571.
10. Feany, M.B., S. Lee, R.H. Edwards, and K.M. Buckley. 1992. The synaptic vesicle protein SV2 is a novel type of transmembrane transporter. Cell. 70:861-867.
11. Fischer, M., S. Kaech, U. Wagner, H. Brinkhaus, and A. Matus. 2000. Glutamate receptors regulate actin-based plasticity in dendritic spines. Nat. Neurosci. 3:887-894.
12. Fuhrmann, J.C., S. Kins, P. Rostaing, O. El Far, J. Kirsch, M. Sheng, A. Triller, H. Betz, and M. Kneussel. 2002. Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes. J. Neurosci. 22:5393-5402.
13. Giesemann, T., G. Schwarz, R. Nawrotzki, K. Berhorster, M. Rothkegel, K. Schluter, N. Schrader, H. Schindelin, R.R. Mendel, J. Kirsch, and B.M. Jockusch. 2003. Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system. J. Neurosci. 23:8330-8339.
14. Guillaud, L., M. Setou, and N. Hirokawa. 2003. KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons. J. Neurosci. 23:131-140.
15. Guzik, B.W., and L.S. Goldstein. 2004. Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction. Curr. Opin. Cell Biol. 16:443-450.
16. Harrison, A., and S.M. King. 2000. The molecular anatomy of dynein. Essays Biochem. 35:75-87.
17. Hirokawa, N., and R. Takemura. 2005. Molecular motors and mechanisms of directional transport in neurons. Nat. Rev. Neurosci. 6:201-214.
18. Holzbaur, E.L. 2004. Motor neurons rely on motor proteins. Trends Cell Biol. 14:233-240.
19. Karki, S., and E.L. Holzbaur. 1999. Cytoplasmic dynein and dynactin in cell division and intracellular transport. Curr. Opin. Cell Biol. 11:45-53.
20. Kennedy, M.B. 2000. Signal-processing machines at the postsynaptic density. Science. 290:750-754.
21. King, S.J., and T.A. Schroer. 2000. Dynactin increases the processivity of the cytoplasmic dynein motor. Nat. Cell Biol. 2:20-24.
22. King, S.M., E. Barbarese, J.F. Dillman III, R.S. Patel-King, J.H. Carson, and K.K. Pfister. 1996. Brain cytoplasmic and flagellar outer arm dyneins share a highly conserved Mr 8,000 light chain. J. Biol. Chem. 271:19358-19366.
23. Kirsch, J., and H. Betz. 1995. The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton. J. Neurosci. 15:4148-4156.
24. Kirsch, J., and H. Betz. 1998. Glycine-receptor activation is required for receptor clustering in spinal neurons. Nature. 392:717-720.
25. Kneussel, M. 2005. Postsynaptic scaffold proteins at non-synaptic sites. EMBO Rep. 6:22-27.
26. Kneussel, M., and H. Betz. 2000. Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation model. Trends Neurosci. 23:429-435.
27. Kneussel, M., J.H. Brandstatter, B. Laube, S. Stahl, U. Muller, and H. Betz. 1999. Loss of postsynaptic GABA(A) receptor clustering in gephyrindeficient mice. J. Neurosci. 19:9289-9297.
28. Langford, G.M. 1995. Actin- and microtubule-dependent organelle motors: interrelationships between the two motility systems. Curr. Opin. Cell Biol. 7:82-88.
29. Levi, S., C. Vannier, and A. Triller. 1998. Strychnine-sensitive stabilization of postsynaptic glycine receptor clusters. J. Cell Sci. 111:335-345.
30. Li, Z., and M. Sheng. 2003. Some assembly required: the development of neuronal synapses. Nat. Rev. Mol. Cell Biol. 4:833-841.
31. Lorenzo, L.E., A. Barbe, and H. Bras. 2004. Mapping and quantitative analysis of gephyrin cytoplasmic trafficking pathways in motoneurons, using an optimized transmission electron microscopy color imaging (TEMCI) procedure. J. Neurocytol. 33:241-249.
32. Marrs, G.S., S.H. Green, and M.E. Dailey. 2001. Rapid formation and remodeling of postsynaptic densities in developing dendrites. Nat. Neurosci. 4:1006-1013.
33. Moss, S.J., and T.G. Smart. 2001. Constructing inhibitory synapses. Nat. Rev. Neurosci. 2:240-250.
34. Naisbitt, S., J. Valtschanoff, D.W. Allison, C. Sala, E. Kim, A.M. Craig, R.J. Weinberg, and M. Sheng. 2000. Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein. J. Neurosci. 20:4524-4534.
35. Neuhoff, H., M. Sassoe-Pognetto, P. Panzanelli, C. Maas, W. Witke, and M. Kneussel. 2005. The actin-binding protein profilin I is localized at synaptic sites in an activity-regulated manner. Eur. J. Neurosci. 21:15-25.
36. Oakley, B.R., and Y.N. Akkari. 1999. Gamma-tubulin at ten: progress and prospects. Cell Struct. Funct. 24:365-372.
37. Passafaro, M., C. Sala, M. Niethammer, and M. Sheng. 1999. Microtubule binding by CRIPT and its potential role in the synaptic clustering of PSD-95. Nat. Neurosci. 2:1063-1069.
38. Pepperkok, R., C. Schneider, L. Philipson, and W. Ansorge. 1988. Single cell assay with an automated capillary microinjection system. Exp. Cell Res. 178:369-376.
39. Quinlan, E.M., and S. Halpain. 1996. Emergence of activity-dependent, bidirectional control of microtubule-associated protein MAP2 phosphorylation during postnatal development. J. Neurosci. 16:7627-7637.
40. Rasmussen, H., T. Rasmussen, A. Triller, and C. Vannier. 2002. Strychnine-blocked glycine receptor is removed from synapses by a shift in insertion/degradation equilibrium. Mol. Cell. Neurosci. 19:201-215.
41. Saito, N., Y. Okada, Y. Noda, Y. Kinoshita, S. Kondo, and N. Hirokawa. 1997. KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles. Neuron. 18:425-438.
42. Samson, F., J.A. Donoso, I. Heller-Bettinger, D. Watson, and R.H. Himes. 1979. Nocodazole action on tubulin assembly, axonal ultrastructure and fast axoplasmic transport. J. Pharmacol. Exp. Ther. 208:411-417.
43. Sanes, J.R., and J.W. Lichtman. 2001. Induction, assembly, maturation and maintenance of a postsynaptic apparatus. Nat. Rev. Neurosci. 2:791-805.
44. Schmitt, B., P. Knaus, C.M. Becker, and H. Betz. 1987. The Mr 93,000 polypeptide of the postsynaptic glycine receptor complex is a peripheral membrane protein. Biochemistry. 26:805-811.
45. Setou, M., T. Nakagawa, D.H. Seog, and N. Hirokawa. 2000. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science. 288:1796-1802.
46. Setou, M., D.H. Seog, Y. Tanaka, Y. Kanai, Y. Takei, M. Kawagishi, and N. Hirokawa. 2002. Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites. Nature. 417:83-87.
47. Sola, M., M. Kneussel, I.S. Heck, H. Betz, and W. Weissenhorn. 2001. X-ray crystal structure of the trimeric N-terminal domain of gephyrin. J. Biol. Chem. 276:25294-25301.
48. Sola, M., V.N. Bavro, J. Timmins, T. Franz, S. Ricard-Blum, G. Schoehn, R.W. Ruigrok, I. Paarmann, T. Saiyed, G.A. O'Sullivan, et al. 2004. Structural basis of dynamic glycine receptor clustering by gephyrin. EMBO J. 23:2510-2519.
49. Star, E.N., D.J. Kwiatkowski, and V.N. Murthy. 2002. Rapid turnover of actin in dendritic spines and its regulation by activity. Nat. Neurosci. 5:239-246.
50. Washbourne, P., J.E. Bennett, and A.K. McAllister. 2002. Rapid recruitment of NMDA receptor transport packets to nascent synapses. Nat. Neurosci. 5:751-759.
51. Wu, H., J.E. Nash, P. Zamorano, and C.C. Garner. 2002. Interaction of SAP97 with minus-end-directed actin motor myosin VI. Implications for AMPA receptor trafficking. J. Biol. Chem. 277:30928-30934.
52. Wyszynski, M., E. Kim, F.C. Yang, and M. Sheng. 1998. Biochemical and immunocytochemical characterization of GRIP, a putative AMPA receptor anchoring protein, in rat brain. Neuropharmacology. 37:1335-1344.