Neuronal polarity and trafficking

Neuron

Volumn 40, Issue 2, 2003, Pages 277-295

  Horton, April C ^a   Ehlers, Michael D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE PROTEIN; MEMBRANE PROTEIN; PROTEIN KINASE C; SNARE PROTEIN;

CELL FUNCTION; CELL MEMBRANE; CELL POLARITY; CYTOSKELETON; DENDRITE; DENDRITIC CELL; ENDOCYTOSIS; EXOCYTOSIS; MORPHOGENESIS; NERVE CELL; NERVE FIBER; NONHUMAN; PHYSIOLOGY; POLARIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TARGETING; REVIEW;

EID: 0141894133     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(03)00629-9     Document Type: Review

References (226)

1. Adams A.E., Johnson D.I., Longnecker R.M., Sloat B.F., Pringle J.R. CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae. J. Cell Biol. 111:1990;131-142.
2. Andrasfalvy B.K., Magee J.C. Distance-dependent increase in AMPA receptor number in the dendrites of adult hippocampal CA1 pyramidal neurons. J. Neurosci. 21:2001;9151-9159.
3. Augustine G.J., Santamaria F., Tanaka K. Local Calcium Signaling in Neurons. Neuron. 40:2003;331-346., this issue.
4. Augustine G.J., Burns M.E., DeBello W.M., Hilfiker S., Morgan J.R., Schweizer F.E., Tokumaru H., Umayahara K. Proteins involved in synaptic vesicle trafficking. J. Physiol. 520:1999;33-41.
5. Baas P.W. Microtubules and neuronal polarity. lessons from mitosis Neuron. 22:1999;23-31.
6. Baas P.W., Ahmad F.J. The transport properties of axonal microtubules establish their polarity orientation. J. Cell Biol. 120:1993;1427-1437.
7. Baas P.W., Deitch J.S., Black M.M., Banker G.A. Polarity orientation of microtubules in hippocampal neurons. uniformity in the axon and nonuniformity in the dendrite Proc. Natl. Acad. Sci. USA. 85:1988;8335-8339.
8. Baas P.W., Black M.M., Banker G.A. Changes in microtubule polarity orientation during the development of hippocampal neurons in culture. J. Cell Biol. 109:1989;3085-3094.
9. Bacallao R., Antony C., Dotti C., Karsenti E., Stelzer E.H., Simons K. The subcellular organization of Madin-Darby canine kidney cells during the formation of a polarized epithelium. J. Cell Biol. 109:1989;2817-2832.
10. Balda M.S., Whitney J.A., Flores C., Gonzalez S., Cereijido M., Matter K. Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J. Cell Biol. 134:1996;1031-1049.
11. Bastaki M., Braiterman L.T., Johns D.C., Chen Y.H., Hubbard A.L. Absence of direct delivery for single transmembrane apical proteins or their "Secretory" forms in polarized hepatic cells. Mol. Biol. Cell. 13:2002;225-237.
12. Berghs S., Aggujaro D., Dirkx R. Jr., Maksimova E., Stabach P., Hermel J.M., Zhang J.P., Philbrick W., Slepnev V., Ort T., Solimena M. betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system. J. Cell Biol. 151:2000;985-1002.
13. Bilder D. PDZ proteins and polarity. functions from the fly Trends Genet. 17:2001;511-519.
14. Bilder D., Perrimon N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature. 403:2000;676-680.
15. Bilder D., Li M., Perrimon N. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science. 289:2000;113-116.
16. Bilder D., Schober M., Perrimon N. Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat. Cell Biol. 5:2003;53-58.
17. Binder L.I., Frankfurter A., Rebhun L.I. The distribution of tau in the mammalian central nervous system. J. Cell Biol. 101:1985;1371-1378.
18. Blanpied T.A., Scott D.B., Ehlers M.D. Dynamics and regulation of clathrin coats at specialized endocytic zones of dendrites and spines. Neuron. 36:2002;435-449.
19. Boiko T., Rasband M.N., Levinson S.R., Caldwell J.H., Mandel G., Trimmer J.S., Matthews G. Compact myelin dictates the differential targeting of two sodium channel isoforms in the same axon. Neuron. 30:2001;91-104.
20. Boiko T., Van Wart A., Caldwell J.H., Levinson S.R., Trimmer J.S., Matthews G. Functional specialization of the axon initial segment by isoform-specific sodium channel targeting. J. Neurosci. 23:2003;2306-2313.
21. Bomsel M., Prydz K., Parton R.G., Gruenberg J., Simons K. Endocytosis in filter-grown Madin-Darby canine kidney cells. J. Cell Biol. 109:1989;3243-3258.
22. Bonifacino J.S., Traub L.M. Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu. Rev. Biochem. 72:2003;395-447.
23. Borgdorff A.J., Choquet D. Regulation of AMPA receptor lateral movements. Nature. 417:2002;649-653.
24. Bourrat F., Sotelo C. Migratory pathways and neuritic differentiation of inferior olivary neurons in the rat embryo. Axonal tracing study using the in vitro slab technique. Brain Res. 467:1988;19-37.
25. Bradke F., Dotti C.G. The role of local actin instability in axon formation. Science. 283:1999;1931-1934.
26. Braiman L., Alt A., Kuroki T., Ohba M., Bak A., Tennenbaum T., Sampson S.R. Activation of protein kinase C zeta induces serine phosphorylation of VAMP2 in the GLUT4 compartment and increases glucose transport in skeletal muscle. Mol. Cell. Biol. 21:2001;7852-7861.
27. Bredt D.S., Nicoll R.A. AMPA receptor trafficking at excitatory synapses. Neuron. 40:2003;361-379., this issue.
28. Brenman J.E., Gao F.B., Jan L.Y., Jan Y.N. Sequoia, a tramtrack-related zinc finger protein, functions as a pan-neural regulator for dendrite and axon morphogenesis in Drosophila. Dev. Cell. 1:2001;667-677.
29. Bretscher M.S. Getting membrane flow and the cytoskeleton to cooperate in moving cells. Cell. 87:1996;601-606.
30. Brown M.D., Banker G.A., Hussaini I.M., Gonias S.L., VandenBerg S.R. Low density lipoprotein receptor-related protein is expressed early and becomes restricted to a somatodendritic domain during neuronal differentiation in culture. Brain Res. 747:1997;313-317.
31. Burack M.A., Silverman M.A., Banker G. The role of selective transport in neuronal protein sorting. Neuron. 26:2000;465-472.
32. Cameron P.L., Sudhof T.C., Jahn R., De Camilli P. Colocalization of synaptophysin with transferrin receptors. implications for synaptic vesicle biogenesis J. Cell Biol. 115:1991;151-164.
33. Campbell D.S., Regan A.G., Lopez J.S., Tannahill D., Harris W.A., Holt C.E. Semaphorin 3A elicits stage-dependent collapse, turning, and branching in Xenopus retinal growth cones. J. Neurosci. 21:2001;8538-8547.
34. Carroll R.C., Zukin R.S. NMDA-receptor trafficking and targeting. implications for synaptic transmission and plasticity Trends Neurosci. 25:2002;571-577.
35. Catterall W.A. Localization of sodium channels in cultured neural cells. J. Neurosci. 1:1981;777-783.
36. Chant J. Cell polarity in yeast. Annu. Rev. Cell Dev. Biol. 15:1999;365-391.
37. Chant J., Herskowitz I. Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway. Cell. 65:1991;1203-1212.
38. Chen Y.A., Scheller R.H. SNARE-mediated membrane fusion. Nat. Rev. Mol. Cell Biol. 2:2001;98-106.
39. Colman D.R. Neuronal polarity and the epithelial metaphor. Neuron. 23:1999;649-651.
40. Craig A.M., Banker G. Neuronal polarity. Annu. Rev. Neurosci. 17:1994;267-310.
41. Craig A.M., Wyborski R.J., Banker G. Preferential addition of newly synthesized membrane protein at axonal growth cones. Nature. 375:1995;592-594.
42. da Silva J.S., Dotti C.G. Breaking the neuronal sphere. regulation of the actin cytoskeleton in neuritogenesis Nat. Rev. Neurosci. 3:2002;694-704.
43. De Almeida J.B., Stow J.L. Disruption of microtubules alters polarity of basement membrane proteoglycan secretion in epithelial cells. Am. J. Physiol. 261:1991;C691-C700.
44. de Hoop M., von Poser C., Lange C., Ikonen E., Hunziker W., Dotti C.G. Intracellular routing of wild-type and mutated polymeric immunoglobulin receptor in hippocampal neurons in culture. J. Cell Biol. 130:1995;1447-1459.
45. Deitch J.S., Banker G.A. An electron microscopic analysis of hippocampal neurons developing in culture. early stages in the emergence of polarity J. Neurosci. 13:1993;4301-4315.
46. den Hollander A.I., Ghiani M., de Kok Y.J., Wijnholds J., Ballabio A., Cremers F.P., Broccoli V. Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain. Mech. Dev. 110:2002;203-207.
47. Doray B., Ghosh P., Griffith J., Geuze H.J., Kornfeld S. Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network. Science. 297:2002;1700-1703.
48. Dotti C.G., Banker G.A. Experimentally induced alteration in the polarity of developing neurons. Nature. 330:1987;254-256.
49. Dotti C.G., Simons K. Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture. Cell. 62:1990;63-72.
50. Dotti C.G., Sullivan C.A., Banker G.A. The establishment of polarity by hippocampal neurons in culture. J. Neurosci. 8:1988;1454-1468.
51. Eaton S. Planar polarization of Drosophila and vertebrate epithelia. Curr. Opin. Cell Biol. 9:1997;860-866.
52. Ehlers M.D. Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting. Neuron. 28:2000;511-525.
53. Etemad-Moghadam B., Guo S., Kemphues K.J. Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos. Cell. 83:1995;743-752.
54. Etienne-Manneville S., Hall A. Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta. Cell. 106:2001;489-498.
55. Etienne-Manneville S., Hall A. Rho GTPases in cell biology. Nature. 420:2002;629-635.
56. Etienne-Manneville S., Hall A. Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Nature. 421:2003;753-756.
57. Fannon A.M., Colman D.R. A model for central synaptic junctional complex formation based on the differential adhesive specificities of the cadherins. Neuron. 17:1996;423-434.
58. Farquhar M.G., Palade G.E. Junctional complexes in various epithelia. J. Cell Biol. 17:1963;375-412.
59. Fili O., Michaelevski I., Bledi Y., Chikvashvili D., Singer-Lahat D., Boshwitz H., Linial M., Lotan I. Direct interaction of a brain voltage-gated K+ channel with syntaxin 1A. functional impact on channel gating J. Neurosci. 21:2001;1964-1974.
60. Finger F.P., Hughes T.E., Novick P. Sec3p is a spatial landmark for polarized secretion in budding yeast. Cell. 92:1998;559-571.
61. Foletti D.L., Prekeris R., Scheller R.H. Generation and maintenance of neuronal polarity. mechanisms of transport and targeting Neuron. 23:1999;641-644.
62. Folsch H., Ohno H., Bonifacino J.S., Mellman I. A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells. Cell. 99:1999;189-198.
63. Francesconi A., Duvoisin R.M. Alternative splicing unmasks dendritic and axonal targeting signals in metabotropic glutamate receptor 1. J. Neurosci. 22:2002;2196-2205.
64. Fujiwara T., Ritchie K., Murakoshi H., Jacobson K., Kusumi A. Phospholipids undergo hop diffusion in compartmentalized cell membrane. J. Cell Biol. 157:2002;1071-1081.
65. Fukata Y., Itoh T.J., Kimura T., Menager C., Nishimura T., Shiromizu T., Watanabe H., Inagaki N., Iwamatsu A., Hotani H., Kaibuchi K. CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. Nat. Cell Biol. 4:2002;583-591. a.
66. Fukata Y., Kimura T., Kaibuchi K. Axon specification in hippocampal neurons. Neurosci. Res. 43:2002;305-315. b.
67. Fuller S.D., Simons K. Transferrin receptor polarity and recycling accuracy in "tight" and "leaky" strains of Madin-Darby canine kidney cells. J. Cell Biol. 103:1986;1767-1779.
68. Galli T., Zahraoui A., Vaidyanathan V.V., Raposo G., Tian J.M., Karin M., Niemann H., Louvard D. A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. Mol. Biol. Cell. 9:1998;1437-1448.
69. Gao F.B., Kohwi M., Brenman J.E., Jan L.Y., Jan Y.N. Control of dendritic field formation in Drosophila. the roles of flamingo and competition between homologous neurons Neuron. 28:2000;91-101.
70. Gardiol A., Racca C., Triller A. Dendritic and postsynaptic protein synthetic machinery. J. Neurosci. 19:1999;168-179.
71. Garrido J.J., Fernandes F., Giraud P., Mouret I., Pasqualini E., Fache M.P., Jullien F., Dargent B. Identification of an axonal determinant in the C-terminus of the sodium channel Na(v)1.2. EMBO J. 20:2001;5950-5961.
72. Gilbert T., Le Bivic A., Quaroni A., Rodriguez-Boulan E. Microtubular organization and its involvement in the biogenetic pathways of plasma membrane proteins in Caco-2 intestinal epithelial cells. J. Cell Biol. 113:1991;275-288.
73. Girod A., Storrie B., Simpson J.C., Johannes L., Goud B., Roberts L.M., Lord J.M., Nilsson T., Pepperkok R. Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum. Nat. Cell Biol. 1:1999;423-430.
74. Goda Y., Davis G.W. Mechanisms of synapse assembly and disassembly. Neuron. 40:2003;243-264., this issue.
75. Goldstein L.S.B. Do disorders of movement cause movement disorders and dementia? Neuron. 40:2003;415-425., this issue.
76. Goslin K., Banker G. Experimental observations on the development of polarity by hippocampal neurons in culture. J. Cell Biol. 108:1989;1507-1516.
77. Goslin K., Schreyer D.J., Skene J.H., Banker G. Development of neuronal polarity. GAP-43 distinguishes axonal from dendritic growth cones Nature. 336:1988;672-674.
78. Gotta M., Abraham M.C., Ahringer J. CDC-42 controls early cell polarity and spindle orientation in C. elegans. Curr. Biol. 11:2001;482-488.
79. Grindstaff K.K., Yeaman C., Anandasabapathy N., Hsu S.C., Rodriguez-Boulan E., Scheller R.H., Nelson W.J. Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. Cell. 93:1998;731-740.
80. Grosse G., Grosse J., Tapp R., Kuchinke J., Gorsleben M., Fetter I., Hohne-Zell B., Gratzl M., Bergmann M. SNAP-25 requirement for dendritic growth of hippocampal neurons. J. Neurosci. Res. 56:1999;539-546.
81. Grote E., Kelly R.B. Endocytosis of VAMP is facilitated by a synaptic vesicle targeting signal. J. Cell Biol. 132:1996;537-547.
82. Gu C., Jan Y.N., Jan L.Y. A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels. Science. 301:2003;646-649.
83. Guo W., Roth D., Walch-Solimena C., Novick P. The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis. EMBO J. 18:1999;1071-1080.
84. Habas R., Dawid I.B., He X. Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. Genes Dev. 17:2003;295-309.
85. Harris B.Z., Lim W.A. Mechanism and role of PDZ domains in signaling complex assembly. J. Cell Sci. 114:2001;3219-3231.
86. Hartmann M., Heumann R., Lessmann V. Synaptic secretion of BDNF after high-frequency stimulation of glutamatergic synapses. EMBO J. 20:2001;5887-5897.
87. Hazuka C.D., Foletti D.L., Hsu S.C., Kee Y., Hopf F.W., Scheller R.H. The sec6/8 complex is located at neurite outgrowth and axonal synapse-assembly domains. J. Neurosci. 19:1999;1324-1334.
88. Hirose T., Izumi Y., Nagashima Y., Tamai-Nagai Y., Kurihara H., Sakai T., Suzuki Y., Yamanaka T., Suzuki A., Mizuno K., Ohno S. Involvement of ASIP/ PAR-3 in the promotion of epithelial tight junction formation. J. Cell Sci. 115:2002;2485-2495.
89. Homma N., Takei Y., Tanaka Y., Nakata T., Terada S., Kikkawa M., Noda Y., Hirokawa N. Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension. Cell. 114:2003;229-239.
90. Horton A.C., Ehlers M.D. Dual modes of endoplasmic reticulum-to-Golgi transport in dendrites revealed by live-cell imaging. J. Neurosci. 23:2003;6188-6199.
91. Hsu S.C., Ting A.E., Hazuka C.D., Davanger S., Kenny J.W., Kee Y., Scheller R.H. The mammalian brain rsec6/8 complex. Neuron. 17:1996;1209-1219.
92. Hu C., Ahmed M., Melia T.J., Sollner T.H., Mayer T., Rothman J.E. Fusion of cells by flipped SNAREs. Science. 300:2003;1745-1749.
93. Huang E.J., Reichardt L.F. TRK receptors. Roles in neuronal signal transduction Annu. Rev. Biochem. 72:2003;609-642.
94. Huber A.B., Kolodkin A.L., Ginty D.D., Cloutier J.F. Signaling at the growth cone. Ligand-receptor complexes and the control of axon growth and guidance Annu. Rev. Neurosci. 26:2003;509-563.
95. Hung T.J., Kemphues K.J. PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos. Development. 126:1999;127-135.
96. Hunziker W., Harter C., Matter K., Mellman I. Basolateral sorting in MDCK cells requires a distinct cytoplasmic domain determinant. Cell. 66:1991;907-920.
97. Igarashi M., Kozaki S., Terakawa S., Kawano S., Ide C., Komiya Y. Growth cone collapse and inhibition of neurite growth by Botulinum neurotoxin C1. a t-SNARE is involved in axonal growth J. Cell Biol. 134:1996;205-215.
98. Ikonen E., Simons K. Protein and lipid sorting from the trans-Golgi network to the plasma membrane in polarized cells. Semin. Cell Dev. Biol. 9:1998;503-509.
99. Inagaki N., Chihara K., Arimura N., Menager C., Kawano Y., Matsuo N., Nishimura T., Amano M., Kaibuchi K. CRMP-2 induces axons in cultured hippocampal neurons. Nat. Neurosci. 4:2001;781-782.
100. Itoh M., Sasaki H., Furuse M., Ozaki H., Kita T., Tsukita S. Junctional adhesion molecule (JAM) binds to PAR-3. a possible mechanism for the recruitment of PAR-3 to tight junctions J. Cell Biol. 154:2001;491-497.
101. Jacob R., Naim H.Y. Apical membrane proteins are transported in distinct vesicular carriers. Curr. Biol. 11:2001;1444-1450.
102. Jahn R., Lang T., Sudhof T.C. Membrane fusion. Cell. 112:2003;519-533.
103. Jan Y.-N., Jan L.Y. The control of dendrite development. Neuron. 40:2003;229-242., this issue.
104. Jareb M., Banker G. The polarized sorting of membrane proteins expressed in cultured hippocampal neurons using viral vectors. Neuron. 20:1998;855-867.
105. Jenkins S.M., Bennett V. Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. J. Cell Biol. 155:2001;739-746.
106. Joberty G., Petersen C., Gao L., Macara I.G. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat. Cell Biol. 2:2000;531-539.
107. Johansson A., Driessens M., Aspenstrom P. The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. J. Cell Sci. 113:2000;3267-3275.
108. Kaether C., Skehel P., Dotti C.G. Axonal membrane proteins are transported in distinct carriers. a two-color video microscopy study in cultured hippocampal neurons Mol. Biol. Cell. 11:2000;1213-1224.
109. Kalil K., Szebenyi G., Dent E.W. Common mechanisms underlying growth cone guidance and axon branching. J. Neurobiol. 44:2000;145-158.
110. Kamiguchi H., Lemmon V. A neuronal form of the cell adhesion molecule L1 contains a tyrosine-based signal required for sorting to the axonal growth cone. J. Neurosci. 18:1998;3749-3756.
111. Kaplan M.R., Cho M.H., Ullian E.M., Isom L.L., Levinson S.R., Barres B.A. Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1. 6 at developing CNS nodes of Ranvier. Neuron. 30:2001;105-119.
112. Keller P., Toomre D., Diaz E., White J., Simons K. Multicolour imaging of post-Golgi sorting and trafficking in live cells. Nat. Cell Biol. 3:2001;140-149.
113. Knust E., Bossinger O. Composition and formation of intercellular junctions in epithelial cells. Science. 298:2002;1955-1959.
114. Knust E., Tepass U., Wodarz A. crumbs and stardust, two genes of Drosophila required for the development of epithelial cell polarity. Dev. Suppl. 261-268:1993.
115. Kobayashi T., Storrie B., Simons K., Dotti C.G. A functional barrier to movement of lipids in polarized neurons. Nature. 359:1992;647-650.
116. Kreitzer G., Marmorstein A., Okamoto P., Vallee R., Rodriguez-Boulan E. Kinesin and dynamin are required for post-Golgi transport of a plasma-membrane protein. Nat. Cell Biol. 2:2000;125-127.
117. Kreitzer G., Schmoranzer J., Low S.H., Li X., Gan Y., Weimbs T., Simon S.M., Rodriguez-Boulan E. Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells. Nat. Cell Biol. 5:2003;126-136.
118. Lamoureux P., Ruthel G., Buxbaum R.E., Heidemann S.R. Mechanical tension can specify axonal fate in hippocampal neurons. J. Cell Biol. 159:2002;499-508.
119. Lang T., Bruns D., Wenzel D., Riedel D., Holroyd P., Thiele C., Jahn R. SNAREs are concentrated in cholesterol-dependent clusters that define docking and fusion sites for exocytosis. EMBO J. 20:2001;2202-2213.
120. Lee S., Fan S., Makarova O., Straight S., Margolis B. A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia. Mol. Cell. Biol. 22:2002;1778-1791.
121. Lein P., Johnson M., Guo X., Rueger D., Higgins D. Osteogenic protein-1 induces dendritic growth in rat sympathetic neurons. Neuron. 15:1995;597-605.
122. Lemmers C., Medina E., Delgrossi M.H., Michel D., Arsanto J.P., Le Bivic A. hINADl/PATJ, a homolog of discs lost, interacts with crumbs and localizes to tight junctions in human epithelial cells. J. Biol. Chem. 277:2002;25408-25415.
123. Li L., Chin L.S. The molecular machinery of synaptic vesicle exocytosis. Cell. Mol. Life Sci. 60:2003;942-960.
124. Liljedahl M., Maeda Y., Colanzi A., Ayala I., Van Lint J., Malhotra V. Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi network. Cell. 104:2001;409-420.
125. Lim S.T., Antonucci D.E., Scannevin R.H., Trimmer J.S. A novel targeting signal for proximal clustering of the Kv2.1 K+ channel in hippocampal neurons. Neuron. 25:2000;385-397.
126. Lipschutz J.H., Guo W., O'Brien L.E., Nguyen Y.H., Novick P., Mostov K.E. Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins. Mol. Biol. Cell. 11:2000;4259-4275.
127. Low S.H., Chapin S.J., Weimbs T., Komuves L.G., Bennett M.K., Mostov K.E. Differential localization of syntaxin isoforms in polarized Madin-Darby canine kidney cells. Mol. Biol. Cell. 7:1996;2007-2018.
128. Low S.H., Chapin S.J., Wimmer C., Whiteheart S.W., Komuves L.G., Mostov K.E., Weimbs T. The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells. J. Cell Biol. 141:1998;1503-1513.
129. Luo L. Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity. Annu. Rev. Cell Dev. Biol. 18:2002;601-635.
130. Luo L., Liao Y.J., Jan L.Y., Jan Y.N. Distinct morphogenetic functions of similar small GTPases. Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion Genes Dev. 8:1994;1787-1802.
131. Luo L., Hensch T.K., Ackerman L., Barbel S., Jan L.Y., Jan Y.N. Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines. Nature. 379:1996;837-840.
132. Magee J.C., Cook E.P. Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons. Nat. Neurosci. 3:2000;895-903.
133. Maletic-Savatic M., Malinow R. Calcium-evoked dendritic exocytosis in cultured hippocampal neurons. Part I. trans-Golgi network-derived organelles undergo regulated exocytosis J. Neurosci. 18:1998;6803-6813.
134. Malinow R., Malenka R.C. AMPA receptor trafficking and synaptic plasticity. Annu. Rev. Neurosci. 25:2002;103-126.
135. Martinez-Arca S., Coco S., Mainguy G., Schenk U., Alberts P., Bouille P., Mezzina M., Prochiantz A., Matteoli M., Louvard D., Galli T. A common exocytotic mechanism mediates axonal and dendritic outgrowth. J. Neurosci. 21:2001;3830-3838.
136. Matus A., Bernhardt R., Hugh-Jones T. High molecular weight microtubule-associated proteins are preferentially associated with dendritic microtubules in brain. Proc. Natl. Acad. Sci. USA. 78:1981;3010-3014.
137. McAllister A.K., Katz L.C., Lo D.C. Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth. Neuron. 18:1997;767-778.
138. McNew J.A., Parlati F., Fukuda R., Johnston R.J., Paz K., Paumet F., Sollner T.H., Rothman J.E. Compartmental specificity of cellular membrane fusion encoded in SNARE proteins. Nature. 407:2000;153-159.
139. Medina E., Lemmers C., Lane-Guermonprez L., Le Bivic A. Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cells. Biol. Cell. 94:2002;305-313.
140. Minelli A., Brecha N.C., Karschin C., DeBiasi S., Conti F. GAT-1, a high-affinity GABA plasma membrane transporter, is localized to neurons and astroglia in the cerebral cortex. J. Neurosci. 15:1995;7734-7746.
141. Mlodzik M. Planar polarity in the Drosophila eye. a multifaceted view of signaling specificity and cross-talk EMBO J. 18:1999;6873-6879.
142. Mlodzik M. Planar cell polarization. do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet. 18:2002;564-571.
143. Monaghan M.M., Trimmer J.S., Rhodes K.J. Experimental localization of Kv1 family voltage-gated K+ channel alpha and beta subunits in rat hippocampal formation. J. Neurosci. 21:2001;5973-5983.
144. Montcouquiol M., Rachel R.A., Lanford P.J., Copeland N.G., Jenkins N.A., Kelley M.W. Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature. 423:2003;173-177.
145. Mostov K., Su T., ter Beest M. Polarized epithelial membrane traffic. conservation and plasticity Nat. Cell Biol. 5:2003;287-293.
146. Muller H.A., Wieschaus E. armadillo, bazooka, and stardust are critical for early stages in formation of the zonula adherens and maintenance of the polarized blastoderm epithelium in Drosophila. J. Cell Biol. 134:1996;149-163.
147. Mullins C., Bonifacino J.S. Structural requirements for function of yeast GGAs in vacuolar protein sorting, alpha-factor maturation, and interactions with clathrin. Mol. Cell. Biol. 21:2001;7981-7994.
148. Murthy M., Garza D., Scheller R.H., Schwarz T.L. Mutations in the exocyst component sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists. Neuron. 37:2003;433-447.
149. Nakada C., Ritchie K., Oba Y., Nakamura M., Hotta Y., Iino R., Kasai R.S., Yamaguchi K., Fujiwara T., Kusumi A. Accumulation of anchored proteins forms membrane diffusion barriers during neuronal polarization. Nat. Cell Biol. 5:2003;626-632.
150. Nakagawa T., Setou M., Seog D., Ogasawara K., Dohmae N., Takio K., Hirokawa N. A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex. Cell. 103:2000;569-581.
151. Nelson W.J. Adaptation of core mechanisms to generate cell polarity. Nature. 422:2003;766-774.
152. Nelson W.J., Yeaman C. Protein trafficking in the exocytic pathway of polarized epithelial cells. Trends Cell Biol. 11:2001;483-486.
153. Newman L.S., McKeever M.O., Okano H.J., Darnell R.B. Beta-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein. Cell. 82:1995;773-783.
154. Nirenberg M.J., Chan J., Vaughan R.A., Uhl G.R., Kuhar M.J., Pickel V.M. Immunogold localization of the dopamine transporter. an ultrastructural study of the rat ventral tegmental area J. Neurosci. 17:1997;5255-5262.
155. Nobes C.D., Hall A. Rho GTPases control polarity, protrusion, and adhesion during cell movement. J. Cell Biol. 144:1999;1235-1244.
156. O'Connell K.F., Maxwell K.N., White J.G. The spd-2 gene is required for polarization of the anteroposterior axis and formation of the sperm asters in the Caenorhabditis elegans zygote. Dev. Biol. 222:2000;55-70.
157. Ohno H., Stewart J., Fournier M.C., Bosshart H., Rhee I., Miyatake S., Saito T., Gallusser A., Kirchhausen T., Bonifacino J.S. Interaction of tyrosine-based sorting signals with clathrin-associated proteins. Science. 269:1995;1872-1875.
158. Osen-Sand A., Catsicas M., Staple J.K., Jones K.A., Ayala G., Knowles J., Grenningloh G., Catsicas S. Inhibition of axonal growth by SNAP-25 antisense oligonucleotides in vitro and in vivo. Nature. 364:1993;445-448.
159. Osen-Sand A., Staple J.K., Naldi E., Schiavo G., Rossetto O., Petitpierre S., Malgaroli A., Montecucco C., Catsicas S. Common and distinct fusion proteins in axonal growth and transmitter release. J. Comp. Neurol. 367:1996;222-234.
160. Owen D.J., Evans P.R. A structural explanation for the recognition of tyrosine-based endocytotic signals. Science. 282:1998;1327-1332.
161. Parlati F., Varlamov O., Paz K., McNew J.A., Hurtado D., Sollner T.H., Rothman J.E. Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity. Proc. Natl. Acad. Sci. USA. 99:2002;5424-5429.
162. Pevsner J., Volknandt W., Wong B.R., Scheller R.H. Two rat homologs of clathrin-associated adaptor proteins. Gene. 146:1994;279-283.
163. Piehl M., Cassimeris L. Organization and dynamics of growing microtubule plus ends during early mitosis. Mol. Biol. Cell. 14:2003;916-925.
164. Polleux F., Morrow T., Ghosh A. Semaphorin 3A is a chemoattractant for cortical apical dendrites. Nature. 404:2000;567-573.
165. Poyatos I., Ruberti F., Martinez-Maza R., Gimenez C., Dotti C.G., Zafra F. Polarized distribution of glycine transporter isoforms in epithelial and neuronal cells. Mol. Cell. Neurosci. 15:2000;99-111.
166. Prekeris R., Foletti D.L., Scheller R.H. Dynamics of tubulovesicular recycling endosomes in hippocampal neurons. J. Neurosci. 19:1999;10324-10337.
167. Pruyne D., Bretscher A. Polarization of cell growth in yeast. I. Establishment and maintenance of polarity states. J. Cell Sci. 113:2000;365-375.
168. Puertollano R., Aguilar R.C., Gorshkova I., Crouch R.J., Bonifacino J.S. Sorting of mannose 6-phosphate receptors mediated by the GGAs. Science. 292:2001;1712-1716.
169. Qiu R.G., Abo A., Steven Martin G. A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation. Curr. Biol. 10:2000;697-707.
170. Quilliam L.A., Khosravi-Far R., Huff S.Y., Der C.J. Guanine nucleotide exchange factors. activators of the Ras superfamily of proteins Bioessays. 17:1995;395-404.
171. Rios J.C., Rubin M., St Martin M., Downey R.T., Einheber S., Rosenbluth J., Levinson S.R., Bhat M., Salzer J.L. Paranodal interactions regulate expression of sodium channel subtypes and provide a diffusion barrier for the node of Ranvier. J. Neurosci. 23:2003;7001-7011.
172. Rivera J.F., Ahmad S., Quick M.W., Liman E.R., Arnold D.B. An evolutionarily conserved dileucine motif in Shal K+ channels mediates dendritic targeting. Nat. Neurosci. 6:2003;243-250.
173. Rojas R., Apodaca G. Immunoglobulin transport across polarized epithelial cells. Nat. Rev. Mol. Cell Biol. 3:2002;944-955.
174. Rosin-Arbesfeld R., Ihrke G., Bienz M. Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells. EMBO J. 20:2001;5929-5939.
175. Ruberti F., Dotti C.G. Involvement of the proximal C terminus of the AMPA receptor subunit GluR1 in dendritic sorting. J. Neurosci. 20:2000;RC78.
176. Salzer J.L. Nodes of Ranvier come of age. Trends Neurosci. 25:2002;2-5.
177. Salzer J.L. Polarized domains of myelinated axons. Neuron. 40:2003;297-318., this issue.
178. Sampo B., Kaech S., Kunz S., Banker G. Two distinct mechanisms target membrane proteins to the axonal surface. Neuron. 37:2003;611-624.
179. Sans N., Prybylowski K., Petralia R.S., Chang K., Wang Y.X., Racca C., Vicini S., Wenthold R.J. NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Nat. Cell Biol. 5:2003;520-530.
180. Schaefer A.W., Kamei Y., Kamiguchi H., Wong E.V., Rapoport I., Kirchhausen T., Beach C.M., Landreth G., Lemmon S.K., Lemmon V. L1 endocytosis is controlled by a phosphorylation-dephosphorylation cycle stimulated by outside-in signaling by L1. J. Cell Biol. 157:2002;1223-1232.
181. Schluesener H.J., Meyermann R., Jung S. Immunolocalization of vgr (BMP-6, DVR-6), a TGF-beta related cytokine, to Schwann cells of the rat peripheral nervous system. expression patterns are not modulated by autoimmune disease Glia. 13:1995;75-78.
182. Schmoranzer J., Simon S.M. Role of microtubules in fusion of post-Golgi vesicles to the plasma membrane. Mol. Biol. Cell. 14:2003;1558-1569.
183. Serge A., Fourgeaud L., Hemar A., Choquet D. Receptor activation and homer differentially control the lateral mobility of metabotropic glutamate receptor 5 in the neuronal membrane. J. Neurosci. 22:2002;3910-3920.
184. Setou M., Nakagawa T., Seog D.H., Hirokawa N. Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science. 288:2000;1796-1802.
185. Shapiro L., Colman D.R. The diversity of cadherins and implications for a synaptic adhesive code in the CNS. Neuron. 23:1999;427-430.
186. Sharp D.J., Yu W., Baas P.W. Transport of dendritic microtubules establishes their nonuniform polarity orientation. J. Cell Biol. 130:1995;93-103.
187. Sheng M., Kim M.J. Postsynaptic signaling and plasticity mechanisms. Science. 298:2002;776-780.
188. Sheng M., Tsaur M.L., Jan Y.N., Jan L.Y. Subcellular segregation of two A-type K+ channel proteins in rat central neurons. Neuron. 9:1992;271-284.
189. Shi S.H., Jan L.Y., Jan Y.N. Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity. Cell. 112:2003;63-75.
190. Shiba T., Takatsu H., Nogi T., Matsugaki N., Kawasaki M., Igarashi N., Suzuki M., Kato R., Earnest T., Nakayama K., Wakatsuki S. Structural basis for recognition of acidic-cluster dileucine sequence by GGA1. Nature. 415:2002;937-941.
191. Shorter J., Warren G. Golgi architecture and inheritance. Annu. Rev. Cell Dev. Biol. 18:2002;379-420.
192. Silletti S., Mei F., Sheppard D., Montgomery A.M. Plasmin-sensitive dibasic sequences in the third fibronectin-like domain of L1-cell adhesion molecule (CAM) facilitate homomultimerization and concomitant integrin recruitment. J. Cell Biol. 149:2000;1485-1502.
193. Simpson F., Bright N.A., West M.A., Newman L.S., Darnell R.B., Robinson M.S. A novel adaptor-related protein complex. J. Cell Biol. 133:1996;749-760.
194. Smith S.J. Neuronal cytomechanics. the actin-based motility of growth cones Science. 242:1988;708-715.
195. Stowell J.N., Craig A.M. Axon/dendrite targeting of metabotropic glutamate receptors by their cytoplasmic carboxy-terminal domains. Neuron. 22:1999;525-536.
196. Stricker C., Field A.C., Redman S.J. Statistical analysis of amplitude fluctuations in EPSCs evoked in rat CA1 pyramidal neurones in vitro. J. Physiol. 490:1996;419-441.
197. Sugihara K., Asano S., Tanaka K., Iwamatsu A., Okawa K., Ohta Y. The exocyst complex binds the small GTPase RalA to mediate filopodia formation. Nat. Cell Biol. 4:2002;73-78.
198. Sur C., Betz H., Schloss P. Localization of the serotonin transporter in rat spinal cord. Eur. J. Neurosci. 8:1996;2753-2757.
199. Takekuni K., Ikeda W., Fujito T., Morimoto K., Takeuchi M., Monden M., Takai Y. Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse. J. Biol. Chem. 278:2003;5497-5500.
200. Tepass U., Tanentzapf G., Ward R., Fehon R. Epithelial cell polarity and cell junctions in Drosophila. Annu. Rev. Genet. 35:2001;747-784.
201. TerBush D.R., Novick P. Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. J. Cell Biol. 130:1995;299-312.
202. TerBush D.R., Maurice T., Roth D., Novick P. The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J. 15:1996;6483-6494.
203. Tovar K.R., Westbrook G.L. Mobile NMDA receptors at hippocampal synapses. Neuron. 34:2002;255-264.
204. Tuma P.L., Hubbard A.L. Transcytosis. crossing cellular barriers Physiol. Rev. 83:2003;871-932.
205. van Meer G., Gumbiner B., Simons K. The tight junction does not allow lipid molecules to diffuse from one epithelial cell to the next. Nature. 322:1986;639-641.
206. Vega I.E., Hsu S.C. The exocyst complex associates with microtubules to mediate vesicle targeting and neurite outgrowth. J. Neurosci. 21:2001;3839-3848.
207. Veh R.W., Lichtinghagen R., Sewing S., Wunder F., Grumbach I.M., Pongs O. Immunohistochemical localization of five members of the Kv1 channel subunits. contrasting subcellular locations and neuron-specific co-localizations in rat brain Eur. J. Neurosci. 7:1995;2189-2205.
208. Wang H., Tang X., Liu J., Trautmann S., Balasundaram D., McCollum D., Balasubramanian M.K. The multiprotein exocyst complex is essential for cell separation in Schizosaccharomyces pombe. Mol. Biol. Cell. 13:2002;515-529.
209. Watts J.L., Etemad-Moghadam B., Guo S., Boyd L., Draper B.W., Mello C.C., Priess J.R., Kemphues K.J. par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3. Development. 122:1996;3133-3140.
210. Wedlich-Soldner R., Altschuler S., Wu L., Li R. Spontaneous cell polarization through actomyosin-based delivery of the Cdc42 GTPase. Science. 299:2003;1231-1235.
211. West A.E., Neve R.L., Buckley K.M. Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor. J. Neurosci. 17:1997;6038-6047.
212. White J., Johannes L., Mallard F., Girod A., Grill S., Reinsch S., Keller P., Tzschaschel B., Echard A., Goud B., Stelzer E.H. Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells. J. Cell Biol. 147:1999;743-760.
213. Wilson J.M., de Hoop M., Zorzi N., Toh B.H., Dotti C.G., Parton R.G. EEA1, a tethering protein of the early sorting endosome, shows a polarized distribution in hippocampal neurons, epithelial cells, and fibroblasts. Mol. Biol. Cell. 11:2000;2657-2671.
214. Winckler B., Mellman I. Neuronal polarity. controlling the sorting and diffusion of membrane components Neuron. 23:1999;637-640.
215. Winckler B., Forscher P., Mellman I. A diffusion barrier maintains distribution of membrane proteins in polarized neurons. Nature. 397:1999;698-701.
216. Wisco, D., Chang, M.C., Norden, C., and Folsch, H., Anderson, E.D., A., and Winckler, B. (2003). Two biosynthetic pathways to the axon: Pathway selection by axonal targeting signals in NgCAM is context-dependent. J. Cell Biol., in press.
217. Wittmann T., Bokoch G.M., Waterman-Storer C.M. Regulation of leading edge microtubule and actin dynamics downstream of Rac1. J. Cell Biol. 161:2003;845-851.
218. Wodarz A. Establishing cell polarity in development. Nat. Cell Biol. 4:2002;E39-E44.
219. Wodarz A., Hinz U., Engelbert M., Knust E. Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila. Cell. 82:1995;67-76.
220. Woods D.F., Bryant P.J. The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell. 66:1991;451-464.
221. Yamanaka T., Horikoshi Y., Suzuki A., Sugiyama Y., Kitamura K., Maniwa R., Nagai Y., Yamashita A., Hirose T., Ishikawa H., Ohno S. PAR-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex. Genes Cells. 6:2001;721-731.
222. Yeaman C., Grindstaff K.K., Nelson W.J. New perspectives on mechanisms involved in generating epithelial cell polarity. Physiol. Rev. 79:1999;73-98.
223. Zhang X., Bi E., Novick P., Du L., Kozminski K.G., Lipschutz J.H., Guo W. Cdc42 interacts with the exocyst and regulates polarized secretion. J. Biol. Chem. 276:2001;46745-46750.
224. Zhao Y., Sheng H.Z., Amini R., Grinberg A., Lee E., Huang S., Taira M., Westphal H. Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5. Science. 284:1999;1155-1158.
225. Zhou D., Lambert S., Malen P.L., Carpenter S., Boland L.M., Bennett V. AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. J. Cell Biol. 143:1998;1295-1304.
226. Zurzolo C., Le Bivic A., Quaroni A., Nitsch L., Rodriguez-Boulan E. Modulation of transcytotic and direct targeting pathways in a polarized thyroid cell line. EMBO J. 11:1992;2337-2344.