A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels

Science

Volumn 301, Issue 5633, 2003, Pages 646-649

  Gu, Chen ^a   Jan, Yuh Nung ^a   Jan, Lily Yeh ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOELECTRIC POTENTIALS; BIOMEDICAL ENGINEERING; POTASSIUM; SURFACE CHEMISTRY; TRANSMITTERS; VOLTAGE CONTROL;

AXONAL TARGETINGS;

BIOCHEMICAL ENGINEERING;

CD4 ANTIGEN; HYBRID PROTEIN; TRANSFERRIN RECEPTOR; VOLTAGE GATED POTASSIUM CHANNEL;

BIOLOGY; PROTEIN;

ARTICLE; DENDRITIC CELL; GENE MUTATION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; NERVE CELL MEMBRANE POTENTIAL; NERVE FIBER; NEUROTRANSMITTER RELEASE; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN POLYMERIZATION; PROTEIN TARGETING;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENS, CD4; AXONS; BIOPOLYMERS; CELL LINE; CELL MEMBRANE; CELL POLARITY; CELLS, CULTURED; COS CELLS; DENDRITES; ENDOCYTOSIS; HIPPOCAMPUS; HUMANS; KV1.2 POTASSIUM CHANNEL; MODELS, MOLECULAR; MUTAGENESIS; NEURONS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, TRANSFERRIN; RECOMBINANT FUSION PROTEINS; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; SHAL POTASSIUM CHANNELS; TRANSFECTION;

EID: 0042266913     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1086998     Document Type: Article

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25. We thank J. Trimmer and Y. Hong for antibodies, G. Banker for the TfR-GFP construct, and members of the Jan lab for comments on the manuscript. This study is supported by an NIMH center grant to L.Y.J. Y.N.J. and L.Y.J. are Howard Hughes Medical Institute investigators.