Application of proteomics to the areas of milk production, processing and quality control - A review

International Journal of Dairy Technology

Volumn 67, Issue 2, 2014, Pages 153-166

  Abd El Salam, Mohamed H ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Cheese ripening; Colostrum; Genetic variants; Lactosylation; Mastitis; Milk protein; Proteomics

Indexed keywords

EID: 84897961230     PISSN: 1364727X     EISSN: 14710307     Source Type: Journal    
DOI: 10.1111/1471-0307.12116     Document Type: Review

References (107)

1. Addis M F, Pisanu S, Ghisaura S et al. (2011) Proteomics and pathway analyses of the milk fat globule in sheep naturally infected by Mycoplasma agalactiae provide indications of the in vivo response of the mammary epithelium to bacterial infection. Infection and Immunity 79 3833-3845.
2. Alonso-Fauste I, Andrés M, Iturralde M, Lampreave F, Gallart J and Alava M A (2012) Proteomic characterization by 2-DE in bovine serum and whey from healthy and mastitis affected farm animals. Journal of Proteomics 75 3015-3030.
3. Angeletti R, Gioacchini A M, Seraglia R, Piro R and Traldi P (1998) The potential of matrix-assisted laser desorption/ionization mass spectrometry in the quality control of water buffalo mozzarella cheese. Journal of Mass Spectrometry 33 525-531.
4. Ansari P, Stoppacher N, Rudolf J, Schuhmacher R and Baumgartner S (2011) Selection of possible marker peptides for the detection of major ruminant milk proteins in food by liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry 399 1105-1115.
5. Arena S, Renzone G, Novi G, Paffetti A, Boranardini G, Santucci A and Scaloni A (2010) Modern proteomic methodologies for the characterization of lactolysation protein targets in milk. Proteomics 10 3414-3434.
6. Arena S, Renzone G, Novi G and Scaloni A (2011) Redox proteomics of fat globules unveils bound protein lactosylation and compositional changes in milk samples subjected to various technological procedures. Journal of Proteomics 74 2453-2475.
7. Baeker R, Haebel S, Schlatterer K and Schlatterer B (2002) Lipocalin-type prostaglandin D synthetase in milk. A new biomarker for bovine mastitis. Prostaglandins and Other Lipid Mediators 67 75-88.
8. Bendixen E, Danielsen M, Hollung K, Gianazza E and Miller I (2011) Farm animal proteomics. A review. Journal of Proteomics 74 282-293.
9. Bindexin E (2013) Understanding proteome. In Proteomics in Foods Principles and Applications, pp. 3-20. Toledrá F and Nollet L M L, eds. New York, NY: Springer.
10. Bissonnette N, Dudemaine P L, Thibault C and Robitaille G (2012) Proteomic analysis and immunodetection of the bovine milk osteopontin isoforms. Journal of Dairy Science 95 567-579.
11. Boehmer J L, Bannerman D D, Shefcheck K and Ward J L (2008) Proteomic analysis of differentially expressed proteins in bovine milk during experimentally induced Escherichia coli mastitis. Journal of Dairy Science 91 4206-4218.
12. Boehmer J L, DeGrasse J A, McFarland M A, Tall E A, Shefcheck K J, Ward J L and Bannerman D D (2010a) The proteomic advantage: label-free quantification of proteins expressed in bovine milk during experimentally induced coliform mastitis. Veterinary, Immunology and Immunopathology 138 252-266.
13. Boehmer J L, Ward J L, Peters R R, Shefcheck K J, McFarland M A and Bannerman D D (2010b) Proteomic analysis of the temporal expression of bovine milk proteins during coliform mastitis and label-free relative quantification. Journal of Dairy Science 93 593-603.
14. Bruckmaier R M (2005) Gene expression of factors related to the immune reaction in response to intramammary Escherichia coli lipopolysaccharide challenge. Journal of Dairy Research 72 120-124.
15. Calvano C D, DeCaglie C, Aresta A, Facchini L A and Zambonin C G (2013) MALDI-TOF mass spectrometric determination of intact phospholipids as marker of illegal bovine milk adultration of high quality milk. Analytical and Bioanalytical Chemistry 404 1641-1649.
16. Cattaneo S, Masotti F and Pellegrino L (2009) Liquid infant formulas: technological tools for limiting heat damage. Journal of Agricultural and Food Chemistry 57 10689-10694.
17. Cavaletto M, Giuffrida M G and Conti A (2008) Milk fat globule membrane components: a proteomic approach. Advances in Experimental Medicine and Biology 606 129-141.
18. Cebo C, Caillat H, Bouvier F and Martin P (2010) Major proteins of the goat milk fat globule membrane. Journal of Dairy Science 93 868-876.
19. Cebo C, Lopez C, Henry C, Beauvallet C, Ménard O, Bevilacqua C, Bouvier F, Caillat H and Martin P (2012a) Goat αs1-casein genotype affects milk fat globule physicochemical properties and the composition of the milk fat globule membrane. Journal of Dairy Science 95 6215-6229.
20. Cebo C, Rebours E, Henry C, Makhzami S, Cosette P and Martin P (2012b) Identification of major milk fat globule membrane proteins from pony mare milk highlights the molecular diversity of lactadherin across species. Journal of Dairy Science 95 1085-1098.
21. Charlwood J, Hanrahan S, Tyldesley R, Langridge J, Dwek M and Camilleri P (2002) Use of proteomic methodology for the characterization of human milk fat globular membrane proteins. Analytical Biochemistry 301 314-324.
22. Chen R K, Chang L W, Chung Y Y, Lee M H and Ling Y C (2004) Quantification of cow milk adulteration in goat milk using high-performance liquid chromatography with electrospray ionization mass spectrometry. Rapid Communication of Mass Spectrometry 18 1167-1171.
23. Chiaradia E, Valiani A, Tartloglia M, Scappette F, Renzone G, Arena S, Avellini L, Benda S, Gaiti A and Scaloni A (2013) Ovine subclinical mastitis: proteomic analysis of whey and milk fat globule unveils putative diagnosis biomarkers in milk. Journal of Proteomics 88 141-159.
24. Cordewener J H, Luykx D M, Frankhuizen R, Bremer M G, Hooijerink H and America H (2009) Untargeted LC-Q-TOF mass spectrometry method for the detection of adulterations in skimmed-milk powder. Journal of Separation Science 32 1216-1223.
25. Cozzolino R, Passalacqua S, Salemi S, Malvagna P, Spina E and Garozzo D (2001) Identification of adulteration in milk by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Journal of Mass Spectrometry 36 1031-1037.
26. Cozzolino R, Passalacqua S, Salemi S and Garozzo D (2002) Identification of adulteration in water buffalo mozzarella and in ewe cheese by using whey proteins as biomarkers and matrix-assisted laser desorption/ionization mass spectrometry. Journal of Mass Spectrometry 37 985-991.
27. Cunsolo V, Muccilli V, Saletti R and Foti S (2011) Applications of mass spectrometry techniques in the investigation of milk proteome. European Journal of Mass Spectrometry 17 305-320.
28. D'Amato A, Bachi A, Fasoli E, Boschetti E, Peltre G, Sénéchal H and Righetti P G (2009) In-depth exploration of cow's whey proteome via combinatorial peptide ligand libraries. Journal of Proteome Research 8 3925-3936.
29. D'Ambrosio C, Arena S, Salzano A M, Renzone G, Ledda L and Scaloni A A (2008) Proteomic characterization of water buffalo milk fractions describing PTM of major species and the identification of minor components involved in nutrient delivery and defence against pathogens. Proteomics 8 3657-3666.
30. Di Luccia A, Faccia M, Incoronato C, Inglese F, Lamacchia C, Lamparalli S, Occidente M and Matassino D (2013) Processing. In Proteomics in Foods Principles and Applications, pp. 247-260. Toledrá F, Nollet L M L, eds. New York, NY: Springer.
31. Erbersdobler H F and Somoza V (2007) Forty years of furosine-forty years of using Maillard reaction products as indicators of the nutritional quality of foods. Molecular Nutrition and Food Research 51 423-430.
32. Faccia M, Gambacorta G, Liuzzi V A, Alviti G and Di Luccia A (2003) Influence of cheese weight and type of rennet on composition and proteolysis of "Canestrato Pugliese" cheese II.Chromatographic characterization of soluble nitrogen. Italian Journal of Food Science 15 75-84.
33. Faccia M, Picariello G, Trani A, Loizzo P, Gambacorta G, Lamacchia C and Di Luccia A (2012) Proteolysis of Cacioricotta cheese made from goat milk coagulated with capri fi g (Ficus carica sylvestris) or calf rennet. European Food Research and Technology 234 527-533.
34. Fanton C, Delogu G, Maccioni E, Podda G, Seraglia R and Traldi P (1998) Matrix assisted laser desorption/ionization mass spectrometry in the dairy industry. 2. The protein fingerprint of ewe cheese and its application to detection of adulteration by bovine milk. Rapid Communication of Mass Spectrometry 12 1569-1573.
35. Fenaille F, Parised V, Tabet J C and Guy P A (2005) Carbonylation of milk powder proteins as consequences of processing conditions. Proteomics 5 3097-3104.
36. Froehlich J W, Chu C S, Tang N, Waddell K, Grimm R and Lebrilla C B (2011) Label-free liquid chromatography-tandem mass spectrometry analysis with automated phosphopeptide enrichment reveals dynamic human milk protein phosphorylation during lactation. Analytical Biochemistry 408 136-146.
37. Gagnaire V, Piot M, Camier B, Vissers J P C, Jan G and Le'onil J (2004) Survey of bacterial proteins released in cheese: a proteomic approach. International Journal of Food Microbiology 94 185-201.
38. Gagnaire V, Jardin J, Jan G and Lortal S (2009) Proteomics of milk and bacteria used in fermented dairy products. Journal of Dairy Science 92 811-825.
39. Gaiaschi A, Beretta B, Poiesi C, Conti A, Giuffrida M G, Galli C L and Restani P (2001) Proteolysis of β -casein as a marker of Grana Padano cheese ripening. Journal of Dairy Science 84 60-65.
40. Gao X, McMahon R J, Woo J G, Davidson B S, Morrow A L and Zhang Q (2012) Temporal changes in milk proteomes reveal developing milk functions. Journal of Proteome Research 11 3897-3907.
41. Guyomarc'h F, Watin F, Muir D D and Leavir J (2000) Lactolysation of milk proteins during the manufacture and storage of skimmilk powder. International Dairy Journal 10 863-872.
42. Han R X, Kim H R, Diao Y F, Lee M G and Jin D I (2012) Detection of early pregnancy-specific proteins in Holstein milk. Journal of Proteomics 75 3221-3229.
43. Hinz K, Larsen L B, Wellnitz O, Bruchmeier R M and Kelly A L (2012a) Proteolytic and proteomic changes in milk at quarter level following infusion with Escherichia coli lipopolysaccharides. Journal of Dairy Science 95 1655-1666.
44. Hinz K, O'Connor P M, O'Brien B, Huppertz T, Ross R P and Kelly A L (2012b) Proteomic study of proteolysis during ripening of cheddar cheese made from milk over a lactation cycle. Journal of Dairy Research 27 1-9.
45. Hisiesh J I and Pan P H (2012) Proteomic profiling of the coagulation of milk proteins induced by chymosin. Journal of Agricultural and Food Chemistry 60 2039-2045.
46. Hogarth C J, Fitzpatrick J L, Nolan A M, Young F J, Pitt A and Eckersall P D (2004) Differential protein composition of bovine whey: a comparison of whey from healthy animals and from those with clinical mastitis. Proteomics 4 2094-2100.
47. Holland J W, Deeth H C and Alewood P F (2004) Proteomic analysis of k-casein micro-heterogeneity. Proteomics 4 743-752.
48. Holland J W, Deeth H C and Alewood P F (2006) Resolution and characterisation of multiple isoforms of bovine k-casein by 2-DE following a reversible cysteine-tagging enrichment strategy. Proteomics 6 3087-3095.
49. Holland J W, Gupta R, Deeth H C and Alewood P F (2011) Proteomic analysis of temperature-dependent changes in stored UHT milk. Journal of Agricultural and Food Chemistry 59 1837-1846.
50. Hsieh J F and Pan P H (2012) Proteomic profiling of microbial transglutaminase- induced polymerization of milk proteins. Journal of Dairy Science 95 580-589.
51. Ibeagha-Awemu E I, Ibeagha A E, Messier S and Zhao X (2010) Proteomics, genomics, and pathway analyses of Escherichia coli and Staphylococcus aureus infected Milk whey reveal molecular pathways and networks involved in mastitis. Journal of Proteome Research 9 4604-4619.
52. Jardin J, Mollè D, Piot M, Lortal S and Gagnaire V (2012) Quantitative proteomic analysis of bacterial enzymes released in cheese during ripening. International Journal of Food Microbiology 155 19-28.
53. Jensen H B, Holland J W, Poulsen N A and Larsen L B (2012a) Milk protein genetic variants and isoforms identified in bovine milk representing extremes in coagulation properties. Journal of Dairy Science 95 2891-2903.
54. Jensen H B, Poulsen N A, Møller1 H S, Stensballe A and Larsen L B (2012b) Comparative proteomic analysis of casein and whey as prepared by chymosin-induced separation, isoelectric precipitation or ultracentrifugation. Journal of Dairy Research 79 1-8.
55. Johnson P, Philo M, Watson A and Clare-Mills E N (2011) Rapid fingerprinting of milk thermal processing history by intact protein mass spectrometry with nondenaturing chromatography. Journal of Agricultural and Food Chemistry 59 12420-12427.
56. Larsen L B, Wedholm-Pallas A, Lindmark-Månsson H and Andrén A (2010) Different proteomic profiles of sweet whey and rennet casein obtained after preparation from raw versus heat-treated skimmed milk. Dairy Science & Technology 90 641-656.
57. Le A, Barton L D, Sanders J T and Zhang Q (2011) Exploration of bovine milk proteome in colostral and mature whey using an ion-exchange approach. Journal of Proteome Research 10 692-904.
58. Le T T, Deeth H C, Bhandri B, Alewood R F and Holland J W (2012) A proteomic approach to detect lactosylation and other chemical changes in stored milk protein concentrate. Food Chemistry 132 655-662.
59. Le T T, Debyser G, Gilbert W, Struijs K, Van Camp J, Van de Wiele T, Devreese B and Dewettink K (2013a) Distribution and isolation of milk fat globule membrane proteins during dairy processing as revealed by proteomic analysis. International Dairy Journal 32 110-120.
60. Le T D H, Bhandari B, Paul F, Alewood P F, and Holland J W (2013b) Quantification of lactosylation of whey proteins in stored milk powder using multiple reaction monitoring. Food Chemistry 141 1203-1210.
61. Liao Y, Alvarado R, Phinney B and Lönnerdal B (2011a) Proteomic characterization of human milk whey proteins during a twelve-month lactation period. Journal of Proteome Research 10 1746-1754.
62. Liao Y, Alvarado R, Phinney B and Lönnerdal B (2011b) Proteomic characterization of specific minor proteins in the human milk casein fraction. Journal of Proteome Research 10 5409-5415.
63. Losito I, Carbonara T, Monaci L and Palmisano F (2007) Evaluation of the thermal history of bovine milk from the lactosylation of whey proteins: an investigation by liquid chromatography-electrospray ionization mass spectrometry. Analytical and Bioanalytical Chemistry 389 2065-2074.
64. Luykx D M, Cordewener J H, Ferranti P, Frankhuizen R, Bremer M G, Hooijerink H and America H (2007) Identification of plant proteins in adulterated skimmed milk powder by high-performance liquid chromatography-mass spectrometry. Journal of Chromatography A 1164 189-197.
65. Manso M A, Léonil J, Jan G and Gagnaire V (2005) Application of proteomics to the characterization of milk and dairy products. International Dairy Journal 15 845-855.
66. Marvin L F, Parisod V, Fay L B and Guy P A (2002) Characterization of lactosylated protein of infant formula powders using two-dimensional gel electrophoresis and nano-electrospry mass spectrometry. Electrophoresis 23 2505-2512.
67. Matassino D, Gigante G, Inglese F, Serluca G and Di Luccia A (2007) Proteomic approach to the study of proteolysis in Podolian caciocavallo cheese. Italian Journal of Animal Science 6(suppl. 1) 450-452.
68. Matassino D, Gigante G, Inglese F, Romagnuolo F and Di Luccia A (2008) Safeguard of dairy products for a multifunctional rural development of Apennine bioterritories. Proteomics of 'Pecorino di Laticauda'. Preliminary results. In 3rd Symposium of the Mediterranean Livestock Industry Network "Strategies of the Dairy Sector in the Mediterranean Basin", pp. 86-93. Bari, 16-17 September 2008. URL www.aia.it/indexasp?section=uff_estari.
69. Mayer B, Al-Diab D, Vollmer G and Pischetsrieder M (2011) Mapping the glycoxidation product Nεcarboxy methyl lysine in milk proteome. Proteomics 11 420-428.
70. Meltretter J, Shmidt A, Humeny A, Becker C M and Pischetsreder M (2008) Analysis of the peptide profile of milk and its changes during thermal treatment and storage. Journal of Agricultural and Food Chemistry 56 2899-2906.
71. Meltretter J, Birlouez-Aragon I, Becker C M and Pischetsrieder M (2009) Assessment of heat treatment of dairy products by MALDI-TOF-MS. Molecular Nutrition and Food Research 53 1487-1495.
72. Miranda G, Mahe M F, Leroux C and Martin P (2004) Proteomic tools to characterize the protein fraction of Equidae milk. Proteomics 4 2496-2509.
73. Molina E, Ramos M and Amigo L (2002) Characterisation of the casein fraction of Ibérico cheese by electrophoretic techniques. Journal of Science Food and Agriculture 82 1240-1245.
74. Monaci L and van Hengel A J (2007) Effect of heat treatment on the detection of intact bovine beta lactoglobulins by LC mass spectrometry. Journal of Agricultural and Food Chemistry 55 2985-2992.
75. Monaci L and van Hengel A J (2008) Development of a method for the quantification of whey allergen traces in mixed-fruit juices based on liquid chromatography with mass spectrometric detection. Journal of Chromatography A 92 113-120.
76. Muller L, Bartak P, Bednar P, Frysova I, Sevcik J and Lemr K (2008) Capillary electrophoresis-mass spectrometry - a fast and reliable tool for the monitoring of milk adulteration. Electrophoresis 29 2088-2093.
77. Napoli N, Aiello D, Di Donna L, Prendushi H and Sindona G (2007) Exploitation of endogenous protease activities in raw mastitic milk by MALDI-TOF/TOF. Analytical Chemistry 79 5941-5948.
78. Natale M, Bisson C, Monti G, Peltran A, Garoffo L P, Valentini S, Fabris C, Bertino E, Coscia A and Conti A (2004) Cow's milk allergens identification by two dimensional immunoblotting and mass spectrometry. Molecular Nutrition and Food Research 48 363-369.
79. Nicolaou N, Xu Y and Goodacre R (2011) MALDI-MS and multivariate analysis for the detection and quantification of different milk species. Analytical and Bioanalytical Chemistry 399 3491-3502.
80. Nissen A, Bendixen E, Ingvartsen K L and Røntved C M (2012) In-depth analysis of low abundant proteins in bovine colostrum using different fractionation techniques. Proteomics 12 2866-2878.
81. O'Donnell R, Holland J W, Deeth H C and Alewood P (2004) Milk proteomics. International Dairy Journal 14 1013-1023.
82. Olumee-Shabon Z, Swain T, Smith T E A, Tall E and Boehmer J L (2013) Proteomic analysis of differentially expressed proteins in caprine milk during experimentally induced endotoxin mastitis. Journal of Dairy Science 96 2903-2912.
83. Palmer D J, Kelly V C, Smit A M, Key S, Knight G G and Cooper G J (2006) Human colostrum: identification of minor proteins in aqueous phase by proteomics. Proteomics 6 2208-2216.
84. Pappa E C, Robertson J A, Rigby N M, Mellon F, Kandarakis I and Mills E N C (2008) Application of proteomic techniques to protein and peptide profiling of Teleme cheese made from different types of milk. International Dairy Journal 18 605-614.
85. Pinto C, Caira S, Cuollo M, Fierro O, Niicdadi M A, Chianase L and Addeo F (2012) Lactosylated casein phosphopeptides as a specific heated milks. Analytical and Bioanalytical Chemistry 402 1961-1972.
86. Pisanu S, Ghisaura S, Pagnozzi D, Biosa G, Tanca A, Roggio T, Uzzau S and Addis M F (2011) The sheep milk fat globule membrane proteome. Journal of Proteomics 74 350-358.
87. Pisanu S, Ghisaura S, Pagnozzi D, Falchi G, Biosa G, Tanca A, Roggio T, Uzzau S and Addis M F (2012) Characterization of sheep milk fat globule proteins by two-dimensional polyacrylamide gel electrophoresis/mass spectrometry and generation of a reference map. International Dairy Journal 24 78-86.
88. Reinhardt T A and Lippolis J D (2006) Bovine milk fat globule membrane proteome. Journal of Dairy Research 73 406-416.
89. Reinhardt T A and Lippolis J D (2008) Developmental changes in the milk fat globule membrane proteome during the transition from colostrum to milk. Journal of Dairy Science 91 2307-2318.
90. Reinhardt T A, Sacco R E, Nonnate I J and Lippolis J D (2013) Bovine milk proteome: quantitative changes in normal milk exomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis. Journal of Proteomics 82 143-154.
91. Roncada P, Gaviraghi A, Liberatori S, Canas B, Bini L and Greppi G F (2002) Identification of caseins in goat milk. Proteomics 2 723-726.
92. Roncada P, Piras C, Soggiu A, Turk R, Urbani A and Bonizzi L (2012) Farm animal milk proteomics. Journal of Proteomics 75 4259-4274.
93. Saadaoui B, Henry C, Khorchani T, Mars M, Martin P and Cebo C (2013) Proteomics of the milk fat globule membrane from Camelus dromedarius. Proteomics 13 1180-1184.
94. Scaloni A, Perillo V, Franco P, Fedele E, Froio R, Ferrara L and Bergamo P (2002) Characterization of heat-induced lactosylation products in caseins by immunoenzymatic and mass spectrometric methodologies. Biochimica et Biophysica Acta 1598 30-39.
95. Smolenski G, Haines S, Kwan F Y-S, Bond J, Farr V, Davis S R, Stelwagen K and Wheeler T T (2007) Characterization of host defence proteins in milk using a proteomic approach. Journal of Proteome Research 6 207-215.
96. Somma A, Ferranti P, Addeo F, Mauriello R and Chianese L (2008) Peptidomic approach based on combined capillary isoelectric focusing and mass spectrometry for the characterization of the plasmin primary products from bovine and water buffalo beta-casein. Journal of Chromatography A 1192 294-300.
97. Sospedra I, Soler C, Mañes J and Soriano J M (2011) Analysis of staphylococcal enterotoxin A in milk by matrix-assisted laser desorption/ionization-time of flight mass spectrometry. Analytical and Bioanalytical Chemistry 400 1525-1531.
98. Strandberg Lutzow Y C, Donaldson L, Gray C P, Vuocolo T, Pearson R D, Reverter A, Byrne K A, Sheehy P A, Windon R and Tellam R L (2008) Identification of immune genes and proteins involved in the response of bovine mammary tissue to Staphylococcus aureus infection. BMC Veterinary Research 4 18-31.
99. Takimori S, Shimaoka H, Furukawa J et al. (2011) Alteration of the N-glycome of bovine milk glycoproteins during early lactation. FEBS Journal 278 3769-3781.
100. Trieu-Cuot P and Gripon J-C (1982) A study of proteolysis during Camembert cheese ripening using isoelectric focusing and two-dimensional electrophoresis. Journal of Dairy Research 49 501-510.
101. Vanderghem C, Blecker C, Danthine S, Deroanne C, Haubruge E, Guillonneau F, De Pauw E and Francis H (2008) Proteome analysis of the bovine milk fat globule: enhancement of membrane purification. International Dairy Journal 18 885-893.
102. Vincenzetti S, Amici A, Pucciarelli S, Vita A, Micozzi D, Carpi F M, Polzonetti V, Natalini P and Polidori P (2012) A proteomic study on donkey milk. Biochemistry and Analytical Biochemistry 1 109-118.
103. Wana J, Cui X-W, Zhang J, Fu Z-V, Guo X-R, Sun L-Z and Ji C-B (2013) Peptidome analysis of human skim milk in term and preterm milk. Biochemica Biophysica Research Communication 438 236-241.
104. Wedholm A, Møller H S, Stensballe A, Lindmark-Månsson H, Karlsson A H, Andersson R, Andrén A and Larsen L B (2008) Effect of minor milk proteins in chymosin separated whey and casein fractions on cheese yield as determined by proteomics and multivariate data analysis. Journal of Dairy Science 91 3787-3797.
105. Yamada M, Murakami K, Willingford J C and Yuki Y (2002) Identification of low abundance proteins of bovine colostral and mature milk using two dimensional electrophoresis followed by microsequencing and mass spectrometry. Electrophoresis 23 1153-1160.
106. Yang Y X, Wang J Q, Yuan T J, Bu D P, Yang J H, Sun P and Zhou L Y (2013) Effects of duodenal infusion of free α-linolenic acid on the plasma and milk proteome of lactating dairy cows. Animal 7 293-299.
107. Zhang Q and Carpenter C J (2013) Proteomics in milk and milk processing. In Proteomics in Foods: Principles and Applications, pp. 223-246. Toldrá F and Nollet L M L, eds. New York, NY: Springer.