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Volumn 49, Issue 2, 2014, Pages 741-756

The emerging role of autoimmunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/cfs)

Author keywords

Autoimmune; Chronic fatigue syndrome; Cytokines; Inflammation; Myalgic encephalomyelitis; Oxidative and nitrosative stress

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIBODY; AUTOANTIBODY; CYTOKINE; DNA; EPITOPE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; LEPTIN; METHIONINE; NITRIC OXIDE; RITUXIMAB; TUMOR NECROSIS FACTOR ALPHA;

EID: 84896525898     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-013-8553-0     Document Type: Article
Times cited : (89)

References (232)
  • 1
    • 84875806770 scopus 로고    scopus 로고
    • A neuro-immune model of myalgic encephalomyelitis/chronic fatigue syndrome
    • 0885-7490
    • Morris G, Maes M (2012) A neuro-immune model of myalgic encephalomyelitis/chronic fatigue syndrome. Metab Brain Dis. 0885-7490
    • (2012) Metab Brain Dis
    • Morris, G.1    Maes, M.2
  • 5
    • 79953744583 scopus 로고    scopus 로고
    • Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
    • Maes M, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E (2011) Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS). Med Sci Monit 17:SC11-SC15
    • (2011) Med Sci Monit , vol.17
    • Maes, M.1    Kubera, M.2    Uytterhoeven, M.3    Vrydags, N.4    Bosmans, E.5
  • 6
    • 84867334006 scopus 로고    scopus 로고
    • Increased nuclear factor-κB and loss of p53 are key mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
    • Morris G, Maes M (2012) Increased nuclear factor-κB and loss of p53 are key mechanisms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Med Hypotheses 79:607-613
    • (2012) Med Hypotheses , vol.79 , pp. 607-613
    • Morris, G.1    Maes, M.2
  • 7
    • 43049146216 scopus 로고    scopus 로고
    • Chronic fatigue syndrome after human parvovirus B19 infection without persistent viremia
    • DOI 10.1159/000116723
    • Seishima M, Mizutani Y, Shibuya Y, Arakawa C (2008) Chronic fatigue syndrome after human parvovirus B19 infection without persistent viremia. Dermatology 216:341-346 (Pubitemid 351630101)
    • (2008) Dermatology , vol.216 , Issue.4 , pp. 341-346
    • Seishima, M.1    Mizutani, Y.2    Shibuya, Y.3    Arakawa, C.4
  • 8
    • 38449085803 scopus 로고    scopus 로고
    • Chronic fatigue syndrome is associated with chronic enterovirus infection of the stomach
    • DOI 10.1136/jcp.2007.050054
    • Chia JK, Chia AY (2008) Chronic fatigue syndrome is associated with chronic enterovirus infection of the stomach. J Clin Pathol 61:43-48 (Pubitemid 351158224)
    • (2008) Journal of Clinical Pathology , vol.61 , Issue.1 , pp. 43-48
    • Chia, J.K.S.1    Chia, A.Y.2
  • 9
    • 22844452824 scopus 로고    scopus 로고
    • Evidence for Brucella spp. and Mycoplasma spp. co-infections in blood of chronic fatigue syndrome patients
    • DOI 10.1300/J092v12n02-02
    • Nicolson GL, Nicolson NL, Haier J (2008) Chronic fatigue syndrome patients subsequently diagnosed with Lyme disease Borrelia burgdorferi: evidence for mycoplasma species co-infections. JCFS 14:5-17 (Pubitemid 41038899)
    • (2004) Journal of Chronic Fatigue Syndrome , vol.12 , Issue.2 , pp. 5-17
    • Nicolson, G.L.1    Gan, R.2    Haier, J.3
  • 10
    • 0042159921 scopus 로고    scopus 로고
    • Multiple co-infections (Mycoplasma, Chlamydia, human herpes virus-6) in blood of chronic fatigue syndrome patients: Association with signs and symptoms
    • DOI 10.1034/j.1600-0463.2003.1110504.x
    • Nicolson GL, Gan R, Haier J (2003) Multiple co-infections (Mycoplasma, Chlamydia, human herpesvirus-6) in blood of chronic fatigue syndrome patients: association with signs and symptoms. APMIS 111:557-566 (Pubitemid 36963175)
    • (2003) APMIS , vol.111 , Issue.5 , pp. 557-566
    • Nicolson, G.L.1    Gan, R.2    Haier, J.3
  • 16
    • 0031924322 scopus 로고    scopus 로고
    • A study of the immunology of the chronic fatigue syndrome: Correlation of immunologic parameters to health dysfunction
    • DOI 10.1006/clin.1997.4512
    • Hassan IS, Bannister BA, Akbar A, Weir W, Bofill M (1998) A study of the immunology of the chronic fatigue syndrome: correlation of immunologic markers to health dysfunction. Clin Immunol Immunopathol 87:60-67 (Pubitemid 28194163)
    • (1998) Clinical Immunology and Immunopathology , vol.87 , Issue.1 , pp. 60-67
    • Hassan, I.S.1    Bannister, B.A.2    Akbar, A.3    Weir, W.4    Bofill, M.5
  • 17
    • 33845967496 scopus 로고    scopus 로고
    • Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neopitopes formed by oxidative or nitrosative damage to lipids and proteins
    • Maes M, Mihaylova I, Leunis JC (2006) Chronic fatigue syndrome is accompanied by an IgM-related immune response directed against neopitopes formed by oxidative or nitrosative damage to lipids and proteins. Neuro Endocrinol Lett 27:615-621 (Pubitemid 46050019)
    • (2006) Neuroendocrinology Letters , vol.27 , Issue.5 , pp. 615-621
    • Maes, M.1    Mihaylova, I.2    Leunis, J.-C.3
  • 18
    • 37849046499 scopus 로고    scopus 로고
    • Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: Evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression
    • Maes M, Mihaylova I, Leunis JC (2007) Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression. Neuro Endocrinol Lett 28:861-867
    • (2007) Neuro Endocrinol Lett , vol.28 , pp. 861-867
    • Maes, M.1    Mihaylova, I.2    Leunis, J.C.3
  • 19
    • 84865296409 scopus 로고    scopus 로고
    • Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology
    • Shungu DC, Weiduschat N, Murrough JW, Mao X, Pillemer S, Dyke JP, Medow MS, Natelson BH, Stewart JM, Mathew SJ (2012) Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. NMR Biomed 25(9):1073-1087
    • (2012) NMR Biomed , vol.25 , Issue.9 , pp. 1073-1087
    • Shungu, D.C.1    Weiduschat, N.2    Murrough, J.W.3    Mao, X.4    Pillemer, S.5    Dyke, J.P.6    Medow, M.S.7    Natelson, B.H.8    Stewart, J.M.9    Mathew, S.J.10
  • 20
    • 23444438707 scopus 로고    scopus 로고
    • Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms
    • DOI 10.1016/j.freeradbiomed.2005.04.020, PII S0891584905002121
    • Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJ (2005) Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Radic Biol Med 39:584-589 (Pubitemid 41112100)
    • (2005) Free Radical Biology and Medicine , vol.39 , Issue.5 , pp. 584-589
    • Kennedy, G.1    Spence, V.A.2    McLaren, M.3    Hill, A.4    Underwood, C.5    Belch, J.J.F.6
  • 21
    • 76049126501 scopus 로고    scopus 로고
    • Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder
    • Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E (2009) Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder. Neuro Endocrinol Lett 30:470-476
    • (2009) Neuro Endocrinol Lett , vol.30 , pp. 470-476
    • Maes, M.1    Mihaylova, I.2    Kubera, M.3    Uytterhoeven, M.4    Vrydags, N.5    Bosmans, E.6
  • 22
    • 77649244681 scopus 로고    scopus 로고
    • Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you: Disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME/CFS
    • Maes M, Twisk FN (2009) Why myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may kill you: disorders in the inflammatory and oxidative and nitrosative stress (IO&NS) pathways may explain cardiovascular disorders in ME/CFS. Neuro Endocrinol Lett 30:677-693
    • (2009) Neuro Endocrinol Lett , vol.30 , pp. 677-693
    • Maes, M.1    Twisk, F.N.2
  • 23
    • 84857359512 scopus 로고    scopus 로고
    • Evidence for inflammation and activation of cell-mediated immunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Increased interleukin-1, tumor necrosis factor-α, PMN-elastase, lysozyme and neopterin
    • Maes M, Twisk FNM, Kubera M, Ringel K (2011) Evidence for inflammation and activation of cell-mediated immunity in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): increased interleukin-1, tumor necrosis factor-α, PMN-elastase, lysozyme and neopterin. J Affect Disord 136:933-939
    • (2011) J Affect Disord , vol.136 , pp. 933-939
    • Maes, M.1    Twisk, F.N.M.2    Kubera, M.3    Ringel, K.4
  • 24
    • 35348868081 scopus 로고    scopus 로고
    • Not in the mind but in the cell: Increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome
    • Maes M, Mihaylova I, Kubera M, Bosmans E (2007) Not in the mind but in the cell: increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome. Neuro Endocrinol Lett 28:463-469 (Pubitemid 47577727)
    • (2007) Neuroendocrinology Letters , vol.28 , Issue.4 , pp. 463-469
    • Maes, M.1    Mihaylova, I.2    Kubera, M.3    Bosmans, E.4
  • 25
    • 35348845895 scopus 로고    scopus 로고
    • Not in the mind of neurasthenic lazybones but in the cell nucleus: Patients with chronic fatigue syndrome have increased production of nuclear factor kappa beta
    • Maes M, Mihaylova I, Bosmans E (2007) Not in the mind of neurasthenic lazybones but in the cell nucleus: patients with chronic fatigue syndrome have increased production of nuclear factor kappa beta. Neuro Endocrinol Lett 28:456-462 (Pubitemid 47577726)
    • (2007) Neuroendocrinology Letters , vol.28 , Issue.4 , pp. 456-462
    • Maes, M.1    Mihaylova, I.2    Bosmans, E.3
  • 26
    • 75149183179 scopus 로고    scopus 로고
    • Immunological similarities between cancer and chronic fatigue syndrome: The common link to fatigue?
    • Meeus M, Mistiaen W, Lambrecht L, Nijs J (2011) Immunological similarities between cancer and chronic fatigue syndrome: the common link to fatigue? Anticancer Res 29:4717-4726
    • (2011) Anticancer Res , vol.29 , pp. 4717-4726
    • Meeus, M.1    Mistiaen, W.2    Lambrecht, L.3    Nijs, J.4
  • 27
    • 84871461680 scopus 로고    scopus 로고
    • IgM-mediated autoimmune responses directed against anchorage epitopes are greater in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) than in major depression
    • Maes M, Mihaylova I, Kubera M, Leunis JC, Twisk FN, Geffard M (2012) IgM-mediated autoimmune responses directed against anchorage epitopes are greater in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) than in major depression. Metab Brain Dis 27(4):415-423
    • (2012) Metab Brain Dis , vol.27 , Issue.4 , pp. 415-423
    • Maes, M.1    Mihaylova, I.2    Kubera, M.3    Leunis, J.C.4    Twisk, F.N.5    Geffard, M.6
  • 28
    • 84872370652 scopus 로고    scopus 로고
    • Myalgic encephalomyelitis (ME), chronic fatigue syndrome (CFS), and chronic fatigue (CF) are distinguished accurately: Results of supervised learning techniques applied on clinical and inflammatory data
    • Maes M, Twisk FN, Johnson C (2012) Myalgic encephalomyelitis (ME), chronic fatigue syndrome (CFS), and chronic fatigue (CF) are distinguished accurately: results of supervised learning techniques applied on clinical and inflammatory data. Psychiatry Res 200:754-760
    • (2012) Psychiatry Res , vol.200 , pp. 754-760
    • Maes, M.1    Twisk, F.N.2    Johnson, C.3
  • 29
    • 79956357538 scopus 로고    scopus 로고
    • Xenotropic murine leukemia virus-related virus-associated chronic fatigue syndrome reveals a distinct inflammatory signature
    • Lombardi V, Hagen KS, Hunter KW, Diamond JW, Smith-Gagen J, Yang W, Mikovits JA (2011) Xenotropic murine leukemia virus-related virus-associated chronic fatigue syndrome reveals a distinct inflammatory signature. In Vivo 25:307-314
    • (2011) In Vivo , vol.25 , pp. 307-314
    • Lombardi, V.1    Hagen, K.S.2    Hunter, K.W.3    Diamond, J.W.4    Smith-Gagen, J.5    Yang, W.6    Mikovits, J.A.7
  • 30
    • 84857369969 scopus 로고    scopus 로고
    • Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome
    • Maes M, Twisk FN, Kubera M, Ringel K, Leunis JC, Geffard M (2012) Increased IgA responses to the LPS of commensal bacteria is associated with inflammation and activation of cell-mediated immunity in chronic fatigue syndrome. J Affect Disord 136:909-917
    • (2012) J Affect Disord , vol.136 , pp. 909-917
    • Maes, M.1    Twisk, F.N.2    Kubera, M.3    Ringel, K.4    Leunis, J.C.5    Geffard, M.6
  • 31
    • 33645000725 scopus 로고    scopus 로고
    • In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation
    • Maes M, Mihaylova I, Leunis JC (2005) In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation. Neuro Endocrinol Lett 26:745-751
    • (2005) Neuro Endocrinol Lett , vol.26 , pp. 745-751
    • Maes, M.1    Mihaylova, I.2    Leunis, J.C.3
  • 32
    • 77957679024 scopus 로고    scopus 로고
    • Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity
    • Vermuelen RCW, Kurt RM, Visser FC, Sluiter W, Scholte HR (2010) Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity. J Transl Med 8:93
    • (2010) J Transl Med , vol.8 , pp. 93
    • Vermuelen, R.C.W.1    Kurt, R.M.2    Visser, F.C.3    Sluiter, W.4    Scholte, H.R.5
  • 34
    • 84864294525 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and the pathophysiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
    • Booth NE, Myhill S, McLaren-Howard J (2012) Mitochondrial dysfunction and the pathophysiology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Int J Clin Exp Med 5:208-220
    • (2012) Int J Clin Exp Med , vol.5 , pp. 208-220
    • Booth, N.E.1    Myhill, S.2    McLaren-Howard, J.3
  • 36
    • 0028803859 scopus 로고
    • Electron-microscopic Investigation of muscle mitochondria in chronic fatigue syndrome
    • Plioplys AV, Plioplys S (1995) Electron-microscopic Investigation of muscle mitochondria in chronic fatigue syndrome. Neuropsychobiol 32:175-181
    • (1995) Neuropsychobiol , vol.32 , pp. 175-181
    • Plioplys, A.V.1    Plioplys, S.2
  • 38
    • 0035726374 scopus 로고    scopus 로고
    • Plasma leptin in chronic fatigue syndrome and a placebo-controlled study of the effects of low-dose hydrocortisone on leptin secretion
    • DOI 10.1046/j.1365-2265.2001.01341.x
    • Cleare AJ, O'Keane V, Miell J (2001) Plasma leptin in chronic fatigue syndrome and a placebo-controlled study of the effects of low-dose hydrocortisone on leptin secretion. Clin Endocrinol (Oxf) 55:113-119 (Pubitemid 34204307)
    • (2001) Clinical Endocrinology , vol.55 , Issue.1 , pp. 113-119
    • Cleare, A.J.1    O'Keane, V.2    Miell, J.3
  • 39
    • 36549045494 scopus 로고    scopus 로고
    • The leptin hypothesis of depression: A potential link betweenmood disorders and obesity?
    • Lu XY (2007) The leptin hypothesis of depression: a potential link betweenmood disorders and obesity? Curr Opin Pharmacol 7:648-652
    • (2007) Curr Opin Pharmacol , vol.7 , pp. 648-652
    • Lu, X.Y.1
  • 43
    • 0027994742 scopus 로고
    • Immunological abnormalities in patients with chronic fatigue syndrome
    • DOI 10.1111/j.1365-3083.1994.tb03511.x
    • Tirelli U, Marotta G, Improta S, Pinto A (1994) Immunological abnormalities in patients with chronic fatigue syndrome. Scand J Immunol 40:601-608 (Pubitemid 24370687)
    • (1994) Scandinavian Journal of Immunology , vol.40 , Issue.6 , pp. 601-608
    • Tirelli, U.1    Marotta, G.2    Improta, S.3    Pinto, A.4
  • 46
    • 0025925136 scopus 로고
    • Antineuronal antibody levels in chronic fatigue syndrome patients with neurologic abnormalities
    • Buchwald MD, Wener MH, Komaroff AL (1991) Antineuronal antibody levels in chronic fatigue syndrome patients with neurologic abnormalities. Arthritis Rheum 34:1485-1486
    • (1991) Arthritis Rheum , vol.34 , pp. 1485-1486
    • Buchwald, M.D.1    Wener, M.H.2    Komaroff, A.L.3
  • 47
    • 0030794641 scopus 로고    scopus 로고
    • Antimuscle and anti-CNS circulating antibodies in chronic fatigue syndrome
    • Plioplys AV (1997) Antimuscle and anti-CNS circulating antibodies in chronic fatigue syndrome. Neurology 48:1717-1719
    • (1997) Neurology , vol.48 , pp. 1717-1719
    • Plioplys, A.V.1
  • 49
    • 34447535178 scopus 로고    scopus 로고
    • Antinuclear antibodies in patients with chronic fatigue syndrome
    • Nishikai M (2007) Antinuclear antibodies in patients with chronic fatigue syndrome. Nippon Rinsho 65:1067-1070
    • (2007) Nippon Rinsho , vol.65 , pp. 1067-1070
    • Nishikai, M.1
  • 50
    • 79954604116 scopus 로고    scopus 로고
    • An intriguing and hitherto unexplained cooccurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways
    • Maes M (2010) An intriguing and hitherto unexplained cooccurrence: depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways. Prog Neuropsychopharmacol. Biol Psychiatry 35:784-794
    • (2010) Prog Neuropsychopharmacol. Biol Psychiatry , vol.35 , pp. 784-794
    • Maes, M.1
  • 51
    • 0029646487 scopus 로고
    • High incidence of antibodies to 5-hydroxytryptamine, gangliosides and phospholipids in patients with chronic fatigue and fibromyalgia syndrome and their relatives: Evidence for a clinical entity of both disorders
    • Klein R, Berg PA (1995) High incidence of antibodies to 5-hydroxytryptamine, gangliosides and phospholipids in patients with chronic fatigue and fibromyalgia syndrome and their relatives: evidence for a clinical entity of both disorders. Eur J Med Res 1:21-26
    • (1995) Eur J Med Res , vol.1 , pp. 21-26
    • Klein, R.1    Berg, P.A.2
  • 52
    • 0025300414 scopus 로고
    • In search of the 'missing self': MHC molecules and NK cell recognition
    • Ljunggren HG, Karre K (1990) In search of the 'missing self': MHC molecules and NK cell recognition. Immunol Today 11:237-244
    • (1990) Immunol Today , vol.11 , pp. 237-244
    • Ljunggren, H.G.1    Karre, K.2
  • 53
    • 1842670944 scopus 로고    scopus 로고
    • The dynamic life of natural killer cells
    • DOI 10.1146/annurev.immunol.22.012703.104711
    • Yokoyama WM, Kim S, French AR (2004) The dynamic life of natural killer cells. Annu Rev Immunol 22:405-429 (Pubitemid 38680428)
    • (2004) Annual Review of Immunology , vol.22 , pp. 405-429
    • Yokoyama, W.M.1    Kim, S.2    French, A.R.3
  • 54
    • 70149100868 scopus 로고    scopus 로고
    • Regulatory NK-cell functions in inflammation and autoimmunity
    • Lunemann A, Lunemann JD, Munz C (2009) Regulatory NK-cell functions in inflammation and autoimmunity. Mol Med 15:352-358
    • (2009) Mol Med , vol.15 , pp. 352-358
    • Lunemann, A.1    Lunemann, J.D.2    Munz, C.3
  • 55
    • 46849090674 scopus 로고    scopus 로고
    • Noncytotoxic functions of NK cells: Direct pathogen restriction and assistance to adaptive immunity
    • Strowig T, Brilot F, Munz C (2008) Noncytotoxic functions of NK cells: direct pathogen restriction and assistance to adaptive immunity. J Immunol 180:7785-7791
    • (2008) J Immunol , vol.180 , pp. 7785-7791
    • Strowig, T.1    Brilot, F.2    Munz, C.3
  • 57
    • 0034919647 scopus 로고    scopus 로고
    • Innate immunity and autoimmunity: From self-protection to self-destruction
    • DOI 10.1016/S1471-4906(00)01821-4, PII S1471490600018214
    • Shi F, Ljunggren HG, Sarvetnick N (2001) Innate immunity and autoimmunity: from self-protection to self-destruction. Trends Immunol 22:97-101 (Pubitemid 32667529)
    • (2001) Trends in Immunology , vol.22 , Issue.2 , pp. 97-101
    • Shi, F.-D.1    Ljunggren, H.-G.2    Sarvetnick, N.3
  • 58
    • 0033178617 scopus 로고    scopus 로고
    • Inhibition of autoimmune T cell responses in the DA rat by bone marrow- derived NK cells in vitro: Implications for autoimmunity
    • Smeltz RB, Wolf NA, Swanborg RH (1999) Inhibition of autoimmune T cell responses in the DA rat by bone marrow-derived NK cells in vitro: implications for autoimmunity. J Immunol 163:1390-1397 (Pubitemid 29352759)
    • (1999) Journal of Immunology , vol.163 , Issue.3 , pp. 1390-1397
    • Smeltz, R.B.1    Wolf, N.A.2    Swanborg, R.H.3
  • 59
    • 0031897910 scopus 로고    scopus 로고
    • Role of natural killer cells and TCRγδ T cells in acute autoimmune encephalomyelitis
    • DOI 10.1002/(SICI)1521-4141(199805)28:05<1681::AID
    • Matsumoto Y, Kohyama K, Aikawa Y, Shin T, Kawazoe Y, Suzuki Y, Tanuma N (1998) Role of natural killer cells and TCRγδ T cells in acute autoimmune encephalomyelitis. Eur J Immunol 28:1681-1688 (Pubitemid 28221173)
    • (1998) European Journal of Immunology , vol.28 , Issue.5 , pp. 1681-1688
    • Matsumoto, Y.1    Kohyama, K.2    Aikawa, Y.3    Shin, T.4    Kawazoe, Y.5    Suzuki, Y.6    Tanuma, N.7
  • 60
    • 0034665289 scopus 로고    scopus 로고
    • IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-γ by NK cells
    • Shi FD, Takeda K, Akira S, Sarvetnick N, Ljunggren HG (2000) IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-γ by NK cells. J Immunol 165:3099-3104
    • (2000) J Immunol , vol.165 , pp. 3099-3104
    • Shi, F.D.1    Takeda, K.2    Akira, S.3    Sarvetnick, N.4    Ljunggren, H.G.5
  • 62
    • 0024792513 scopus 로고
    • Biology of natural killer cells
    • Trinchieri G (1989) Biology of natural killer cells. Adv Immunol 47:187-376
    • (1989) Adv Immunol , vol.47 , pp. 187-376
    • Trinchieri, G.1
  • 65
    • 14044262247 scopus 로고    scopus 로고
    • Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen
    • Vollmer TL, Liu R, Price M, Rhodes S, La Cava A, Shi FD (2005) Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen. J Immunol 174:2696-2701 (Pubitemid 40279684)
    • (2005) Journal of Immunology , vol.174 , Issue.5 , pp. 2696-2701
    • Vollmer, T.L.1    Liu, R.2    Price, M.3    Rhodes, S.4    La, C.A.5    Shi, F.-D.6
  • 66
    • 0037606040 scopus 로고    scopus 로고
    • bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: A potential new link between adaptive and innate immunity
    • bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity. Blood 101:3052-3057
    • (2003) Blood , vol.101 , pp. 3052-3057
    • Fehniger, T.A.1    Cooper, M.A.2    Nuovo, G.J.3    Cella, M.4    Facchetti, F.5    Colonna, M.6    Caligiuri, M.A.7
  • 69
    • 0024832397 scopus 로고
    • Natural killer cell number and activity in multiple sclerosis
    • DOI 10.1016/0022-510X(89)90222-0
    • Vranes Z, Poljakovic Z, Marusic M (1989) Natural killer cell number and activity in multiple sclerosis. J Neurol Sci 94:115-123 (Pubitemid 20019449)
    • (1989) Journal of the Neurological Sciences , vol.94 , Issue.1-3 , pp. 115-123
    • Vranes, Z.1    Poljakovic, Z.2    Marusic, M.3
  • 71
    • 56149086005 scopus 로고    scopus 로고
    • Spotlight on anti-CD25: Daclizumab in MS
    • Schippling DS, Martin R (2008) Spotlight on anti-CD25: daclizumab in MS. Int MS J 15:94-98
    • (2008) Int MS J , vol.15 , pp. 94-98
    • Schippling, D.S.1    Martin, R.2
  • 73
    • 0033009888 scopus 로고    scopus 로고
    • Natural killer cells in antiviral defense: Function and regulation by innate cytokines
    • DOI 10.1146/annurev.immunol.17.1.189
    • Biron CA, Nguyen KB, Pien GC, Cousens LP, Salazar-Mather TP (1999) Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol 17:189-220 (Pubitemid 29241123)
    • (1999) Annual Review of Immunology , vol.17 , pp. 189-220
    • Biron, C.A.1    Nguyen, K.B.2    Pien, G.C.3    Cousens, L.P.4    Salazar-Mather, T.P.5
  • 75
  • 76
    • 0034121856 scopus 로고    scopus 로고
    • High prevalence of enteroviral genomic sequences in myocardium from cases of endemic cardiomyopathy (Keshan disease) in China
    • Li Y, Peng T, Yang Y, Niu C, Archard LC, Zhang H (2000) High prevalence of enteroviral genomic sequences in myocardium from cases of endemic cardiomyopathy (Keshan disease) in China. Heart 83:696-701 (Pubitemid 30345976)
    • (2000) Heart , vol.83 , Issue.6 , pp. 696-701
    • Li, Y.1    Peng, T.2    Yang, Y.3    Niu, C.4    Archard, L.C.5    Zhang, H.6
  • 77
    • 31544479100 scopus 로고    scopus 로고
    • Molecular mimicry, bystander activation, or viral persistence: Infections and autoimmune disease
    • DOI 10.1128/CMR.19.1.80-94.2006
    • Fujinami RS, von Herrath MG, Christen U, Whitton JL (2006) Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease. Clin Microbiol Rev 19:80-94 (Pubitemid 43157648)
    • (2006) Clinical Microbiology Reviews , vol.19 , Issue.1 , pp. 80-94
    • Fujinami, R.S.1    Von Herrath, M.G.2    Christen, U.3    Whitton, J.L.4
  • 78
    • 0027313558 scopus 로고
    • Viral infections trigger multiple sclerosis relapses: A prospective seroepidemiological study
    • Andersen O, Lygner PE, Bergstrom T, Andersson M, Vahlne A (1993) Viral infections trigger multiple sclerosis relapses: a prospective seroepidemiological study. J Neurol 240:417-422 (Pubitemid 23277408)
    • (1993) Journal of Neurology , vol.240 , Issue.7 , pp. 417-422
    • Andersen, O.1    Lygner, P.-E.2    Bergstrom, T.3    Andersson, M.4    Vahlne, A.5
  • 79
    • 0031776202 scopus 로고    scopus 로고
    • Clinical relapses and disease activity on magnetic resonance imaging associated with viral upper respiratory tract infections in multiple sclerosis
    • Edwards S, Zvartau M, Clarke H, Irving W, Blumhardt LD (1998) Clinical relapses and disease activity on magnetic resonance imaging associated with viral upper respiratory tract infections in multiple sclerosis. J Neurol Neurosurg Psychiatry 64:736-741 (Pubitemid 28274406)
    • (1998) Journal of Neurology Neurosurgery and Psychiatry , vol.64 , Issue.6 , pp. 736-741
    • Edwards, S.1    Zvartau, M.2    Clarke, H.3    Irving, W.4    Blumhardt, L.D.5
  • 80
    • 0004820549 scopus 로고    scopus 로고
    • Chronic inflammatory and demyelinating diseases
    • 2nd Ed. Lippincott-Raven, Philadelphia
    • Johnson RT (1998) Chronic inflammatory and demyelinating diseases. In:Viral infections of the nervous system. 2nd Ed. Lippincott-Raven, Philadelphia, pp. 227-263
    • (1998) Viral Infections of the Nervous System , pp. 227-263
    • Johnson, R.T.1
  • 82
    • 33745070952 scopus 로고    scopus 로고
    • Multiple sclerosis and virus induced immune responses: Autoimmunity can be primed by molecular mimicry and augmented by bystander activation
    • DOI 10.1080/08916930500484799, PII P00435347267815
    • McCoy L, Tsunoda I, Fujinami RS (2006) Multiple sclerosis and virus induced immune responses: autoimmunity can be primed by molecular mimicry and augmented by bystander activation. Autoimmunity 39:9-19 (Pubitemid 43878516)
    • (2006) Autoimmunity , vol.39 , Issue.1 , pp. 9-19
    • McCoy, L.1    Tsunoda, I.2    Fujinami, R.S.3
  • 83
    • 33749320950 scopus 로고    scopus 로고
    • Bystander T cell activation - implications for HIV infection and other diseases
    • DOI 10.1016/j.it.2006.09.006, PII S1471490606002705
    • Bangs SC, McMichael AJ, Xu XN (2006) Bystander T cell activation - implications for HIV infection and other diseases. Trends Immunol 27:518-524 (Pubitemid 44499161)
    • (2006) Trends in Immunology , vol.27 , Issue.11 , pp. 518-524
    • Bangs, S.C.1    McMichael, A.J.2    Xu, X.-N.3
  • 84
    • 0027648238 scopus 로고
    • T cell adhesion, avidity regulation and signaling: A molecular analysis of CD2
    • Bierer BE, Hahn WC (1993) T cell adhesion, avidity regulation and signaling: a molecular analysis of CD2. Semin Immunol 5:249-261
    • (1993) Semin Immunol , vol.5 , pp. 249-261
    • Bierer, B.E.1    Hahn, W.C.2
  • 85
    • 0027935476 scopus 로고
    • Antigen-independent activation of naive and memory resting T cells by a cytokine combination
    • DOI 10.1084/jem.180.3.1159
    • Unutmaz D, Pilri P, Abrignani S (1994) Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J Exp Med 180:1159-1164 (Pubitemid 24256630)
    • (1994) Journal of Experimental Medicine , vol.180 , Issue.3 , pp. 1159-1164
    • Unutmaz, D.1    Pileri, P.2    Abrignani, S.3
  • 89
    • 0041888480 scopus 로고    scopus 로고
    • T cell dynamics in HIV-1 infection
    • DOI 10.1146/annurev.immunol.21.120601.141053
    • Douek DC, Picker LJ, Koup RA (2003) T cell dynamics in HIV-1 infection. Annu Rev Immunol 21:265-304 (Pubitemid 37174533)
    • (2003) Annual Review of Immunology , vol.21 , pp. 265-304
    • Douek, D.C.1    Picker, L.J.2    Koup, R.A.3
  • 90
    • 85047690906 scopus 로고    scopus 로고
    • Turnover of lymphocytes and conceptual paradigms in HIV infection
    • DOI 10.1172/JCI200319799
    • Silvestri G, Feinberg MB (2003) Turnover of lymphocytes and conceptual paradigms in HIV infection. J Clin Invest 112:821-824 (Pubitemid 38063737)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.6 , pp. 821-824
    • Silvestri, G.1    Feinberg, M.B.2
  • 91
    • 0032563934 scopus 로고    scopus 로고
    • Apoptosis: Getting rid of the bodies
    • Fadok VA, Henson PM (1998) Apoptosis: getting rid of the bodies. Curr Biol 8:R693-R695 (Pubitemid 28451026)
    • (1998) Current Biology , vol.8 , Issue.19
    • Fadok, V.A.1    Henson, P.M.2
  • 92
    • 37049031230 scopus 로고    scopus 로고
    • Interleukin-10 Expression in Macrophages during Phagocytosis of Apoptotic Cells Is Mediated by Homeodomain Proteins Pbx1 and Prep-1
    • DOI 10.1016/j.immuni.2007.11.014, PII S1074761307005493
    • Chung EY, Liu J, Homma Y, Zhang Y, Brendolan A, Saggese M, Han J, Silverstein R, Selleri L, Ma X (2007) Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1. Immunity 27:952-964 (Pubitemid 350251222)
    • (2007) Immunity , vol.27 , Issue.6 , pp. 952-964
    • Chung, E.Y.1    Liu, J.2    Homma, Y.3    Zhang, Y.4    Brendolan, A.5    Saggese, M.6    Han, J.7    Silverstein, R.8    Selleri, L.9    Ma, X.10
  • 93
    • 1642536490 scopus 로고    scopus 로고
    • Innate Immune Discrimination of Apoptotic Cells: Repression of Proinflammatory Macrophage Transcription is Coupled Directly to Specific Recognition
    • Cvetanovic M, Ucker DS (2004) Innate immune discrimination of apoptotic cells: repression of proinflammatory macrophage transcription is coupled directly to specific recognition. J Immunol 172:880-889 (Pubitemid 38113745)
    • (2004) Journal of Immunology , vol.172 , Issue.2 , pp. 880-889
    • Cvetanovic, M.1    Ucker, D.S.2
  • 94
    • 2442665179 scopus 로고    scopus 로고
    • Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice
    • DOI 10.1126/science.1094359
    • Hanayama R, Tanaka M, Miyasaka K, Aozasa K, Koike M, Uchiyama Y, Nagata S (2004) Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice. Science 304:1147-1150 (Pubitemid 38661849)
    • (2004) Science , vol.304 , Issue.5674 , pp. 1147-1150
    • Hanayama, R.1    Tanaka, M.2    Miyasaka, K.3    Aozasa, K.4    Koike, M.5    Uchiyama, Y.6    Nagata, S.7
  • 95
    • 34547656330 scopus 로고    scopus 로고
    • Immunological consequences of apoptotic cell phagocytosis
    • Erwig LP, Henson PM (2007) Immunological consequences of apoptotic cell phagocytosis. Am J Pathol 171:2-8
    • (2007) Am J Pathol , vol.171 , pp. 2-8
    • Erwig, L.P.1    Henson, P.M.2
  • 96
    • 77649152255 scopus 로고    scopus 로고
    • Autoimmunity and the clearance of dead cells
    • Nagata S, Hanayama R, Kawane K (2010) Autoimmunity and the clearance of dead cells. Cell 140:619-630
    • (2010) Cell , vol.140 , pp. 619-630
    • Nagata, S.1    Hanayama, R.2    Kawane, K.3
  • 98
    • 0025932984 scopus 로고
    • Apoptosis: Mechanisms and roles in pathology
    • Arends MJ, Wyllie AH (1991) Apoptosis: mechanisms and roles in pathology. Int. Rev. Exp Pathol 32:223-254
    • (1991) Int. Rev. Exp Pathol , vol.32 , pp. 223-254
    • Arends, M.J.1    Wyllie, A.H.2
  • 100
    • 0030925774 scopus 로고    scopus 로고
    • FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
    • DOI 10.1093/emboj/16.10.2794
    • Medema JP, Scaffidi C, Kischkel FC, Shevchenko A, Mann M, Krammer PH, Peter ME (1997) FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J 16:2794-2804 (Pubitemid 27226216)
    • (1997) EMBO Journal , vol.16 , Issue.10 , pp. 2794-2804
    • Medema, J.P.1    Scaffidi, C.2    Kischkel, F.C.3    Shevchenko, A.4    Mann, M.5    Krammer, P.H.6    Peter, M.E.7
  • 101
    • 0030702084 scopus 로고    scopus 로고
    • Caspases: Intracellular signaling by proteolysis
    • Salvesen GS, Dixit VM (1997) Caspases: intracellular signaling by proteolysis. Cell 91:443-446 (Pubitemid 27508233)
    • (1997) Cell , vol.91 , Issue.4 , pp. 443-446
    • Salvesen, G.S.1    Dixit, V.M.2
  • 102
    • 84896527544 scopus 로고    scopus 로고
    • Could proteomic research deliver the next generation of treatments for pneumococcal meningitis?
    • Goonetilleke UR, Ward SA, Gordon SB (2009) Could proteomic research deliver the next generation of treatments for pneumococcal meningitis? Interdiscip Perspect Infect Dis 2009:214-216
    • (2009) Interdiscip Perspect Infect Dis , vol.2009 , pp. 214-216
    • Goonetilleke, U.R.1    Ward, S.A.2    Gordon, S.B.3
  • 103
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • Thornberry NA, Lazebnik Y (1998) Caspases: enemies within. Science 281:1312-1316 (Pubitemid 28406817)
    • (1998) Science , vol.281 , Issue.5381 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 104
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479-489 (Pubitemid 27508237)
    • (1997) Cell , vol.91 , Issue.4 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 105
    • 0030915587 scopus 로고    scopus 로고
    • Intracellular ATP levels determine cell death fate by apoptosis or necrosis
    • Eguchi Y, Shimizu S, Tsujimoto Y (1997) Intracellular ATP levels determine cell death fate by apoptosis or necrosis. Cancer Res 57:1835-1840 (Pubitemid 27209706)
    • (1997) Cancer Research , vol.57 , Issue.10 , pp. 1835-1840
    • Eguchi, Y.1    Shimizu, S.2    Tsujimoto, Y.3
  • 106
    • 0029042717 scopus 로고
    • Mechanisms of nuclear protein import
    • Melchior F, Gerace L (1995) Mechanisms of nuclear protein import. Curr Opin Cell Biol 7:310-318
    • (1995) Curr Opin Cell Biol , vol.7 , pp. 310-318
    • Melchior, F.1    Gerace, L.2
  • 108
    • 29944438881 scopus 로고    scopus 로고
    • Necrotic death as a cell fate
    • Zong WX, Thompson CB (2006) Necrotic death as a cell fate. Genes Dev 20:1-15
    • (2006) Genes Dev , vol.20 , pp. 1-15
    • Zong, W.X.1    Thompson, C.B.2
  • 110
    • 33646827842 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation
    • DOI 10.1074/jbc.M508135200
    • Xu Y, Huang S, Liu ZG, Han J (2006) Poly(ADP-ribose) polymerase-1 signalling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. J Biol Chem 281:8788-8795 (Pubitemid 43847985)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.13 , pp. 8788-8795
    • Xu, Y.1    Huang, S.2    Liu, Z.-G.3    Han, J.4
  • 111
    • 84891737756 scopus 로고    scopus 로고
    • Necrosis: An energy-dependent programmed cell death?
    • Chen Y (2009) Necrosis: an energy-dependent programmed cell death? UTMJ 86:110-112
    • (2009) UTMJ , vol.86 , pp. 110-112
    • Chen, Y.1
  • 113
    • 0034450123 scopus 로고    scopus 로고
    • Molecular mechanisms of NF-kappaB activation induced by bacterial lipopolysaccharide through Toll-like receptors
    • DOI 10.1179/096805100101532414
    • Zhang G, Ghosh S (2000) Molecular mechanisms of NF-kappaB activation induced by bacterial lipopolysaccharide through Toll-like receptors. J Endotoxin Res 6:453-457 (Pubitemid 32409432)
    • (2000) Journal of Endotoxin Research , vol.6 , Issue.6 , pp. 453-457
    • Zhang, G.1    Ghosh, S.2
  • 114
  • 115
    • 33750523632 scopus 로고    scopus 로고
    • NF-kappaB activation by reactive oxygen species: Fifteen years later
    • DOI 10.1016/j.bcp.2006.04.011, PII S0006295206002255, Cell Signalling, Transcription and Translation as Therapeutic Tergets
    • Gloire G, Legrand-Poels S, Piette J (2006) NF-kappaB activation by reactive oxygen species: fifteen years later. Biochem Pharmacol 72:1493-1505 (Pubitemid 44666727)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.11 , pp. 1493-1505
    • Gloire, G.1    Legrand-Poels, S.2    Piette, J.3
  • 116
    • 38349110194 scopus 로고    scopus 로고
    • Modulation of LPS stimulated NF-kappaB mediated nitric oxide production by PKCepsilon and JAK2 in RAW macrophages
    • Lond
    • Jones E, Adcock IM, Ahmed BY, Punchard NA (2007) Modulation of LPS stimulated NF-kappaB mediated nitric oxide production by PKCepsilon and JAK2 in RAW macrophages. J Inflamm (Lond) 4:23
    • (2007) J Inflamm , vol.4 , pp. 23
    • Jones, E.1    Adcock, I.M.2    Ahmed, B.Y.3    Punchard, N.A.4
  • 117
    • 33748441252 scopus 로고    scopus 로고
    • Alternative and Classical NF-kappaB Signaling Retain Autoreactive B Cells in the Splenic Marginal Zone and Result in Lupus-like Disease
    • DOI 10.1016/j.immuni.2006.07.010, PII S1074761306003864
    • Enzler T, Bonizzi G, Silverman GJ, Otero DC, Widhopf GF, Anzelon-Mills A, Rickert RC, Karin M (2006) Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenicmarginal zone and result in lupus-like disease. Immunity 25:403-415 (Pubitemid 44354213)
    • (2006) Immunity , vol.25 , Issue.3 , pp. 403-415
    • Enzler, T.1    Bonizzi, G.2    Silverman, G.J.3    Otero, D.C.4    Widhopf, G.F.5    Anzelon-Mills, A.6    Rickert, R.C.7    Karin, M.8
  • 119
    • 0142188050 scopus 로고    scopus 로고
    • Normal Induction but Attenuated Progression of Germinal Center Responses in BAFF and BAFF-R Signaling-Deficient Mice
    • DOI 10.1084/jem.20030495
    • Rahman ZS, Rao SP, Kalled SL, Manser T (2003) Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice. J Exp Med 198:1157-1169 (Pubitemid 37323381)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.8 , pp. 1157-1169
    • Rahman, Z.S.M.1    Rao, S.P.2    Kalled, S.L.3    Manser, T.4
  • 120
    • 79960918034 scopus 로고    scopus 로고
    • BAFF and selection of autoreactive B cells
    • Liu Z, Davidson A (2011) BAFF and selection of autoreactive B cells. Trends Immunol 32:388-394
    • (2011) Trends Immunol , vol.32 , pp. 388-394
    • Liu, Z.1    Davidson, A.2
  • 122
    • 0033532386 scopus 로고    scopus 로고
    • The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis
    • DOI 10.1084/jem.189.11.1839
    • Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M (1999) The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 189:1839-1845 (Pubitemid 29272700)
    • (1999) Journal of Experimental Medicine , vol.189 , Issue.11 , pp. 1839-1845
    • Li, Z.-W.1    Chu, W.2    Hu, Y.3    Delhase, M.4    Deerinck, T.5    Ellisman, M.6    Johnson, R.7    Karin, M.8
  • 123
    • 0036009115 scopus 로고    scopus 로고
    • NF-kappaB at the crossroads of life and death
    • Karin M, Lin A (2002) NF-kappaB at the crossroads of life and death. Nat Immunol 3:221-227
    • (2002) Nat Immunol , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 124
    • 0033996762 scopus 로고    scopus 로고
    • The IkappaB kinase (IKK) and NF-kappaB: Key elements of proinflammatory signalling
    • DOI 10.1006/smim.2000.0210
    • Karin M, Delhase M (2000) The I kappa B kinase (IKK) and NFkappa B: key elements of proinflammatory signalling. Semin Immunol 12:85-98 (Pubitemid 30114019)
    • (2000) Seminars in Immunology , vol.12 , Issue.1 , pp. 85-98
    • Karin, M.1    Delhase, M.2
  • 126
    • 2342464085 scopus 로고    scopus 로고
    • The two NF-kappaB activation pathways and their role in innate and adaptive immunity
    • DOI 10.1016/j.it.2004.03.008, PII S1471490604001000
    • Bonizzi G, Karin M (2004) The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25:280-288 (Pubitemid 38610351)
    • (2004) Trends in Immunology , vol.25 , Issue.6 , pp. 280-288
    • Bonizzi, G.1    Karin, M.2
  • 127
    • 26444605834 scopus 로고    scopus 로고
    • IKK/NF-kappaB signaling: Balancing life and death - A new approach to cancer therapy
    • DOI 10.1172/JCI26322
    • Luo JL, Kamata H, Karin M (2005) IKK/NF-kappaB signaling: balancing life and death-a new approach to cancer therapy. J Clin Invest 115:2625-2632 (Pubitemid 41434385)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.10 , pp. 2625-2632
    • Luo, J.-L.1    Kamata, H.2    Karin, M.3
  • 128
    • 0842281645 scopus 로고    scopus 로고
    • Cell Death: Critical Control Points
    • DOI 10.1016/S0092-8674(04)00046-7
    • Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116:205-219 (Pubitemid 38167313)
    • (2004) Cell , vol.116 , Issue.2 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 129
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770-776
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 130
    • 0029059060 scopus 로고
    • Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B
    • Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D (1995) Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 376:167-170
    • (1995) Nature , vol.376 , pp. 167-170
    • Beg, A.A.1    Sha, W.C.2    Bronson, R.T.3    Ghosh, S.4    Baltimore, D.5
  • 132
    • 1642553460 scopus 로고    scopus 로고
    • To be, or not to be: NF-kappaB is the answer - Role of Rel/NF-kappaB in the regulation of apoptosis
    • DOI 10.1038/sj.onc.1207230, Apoptosis - Part 2
    • Kucharczak J, Simmons MJ, Fan Y, Gelinas C (2003) To be, or not to be: NF-kappaB is the answer-role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene 22:8961-8982 (Pubitemid 38121698)
    • (2003) Oncogene , vol.22 , Issue.56 REV. ISS. 8 , pp. 8961-8982
    • Kucharczak, J.1    Simmons, M.J.2    Fan, Y.3    Gelinas, C.4
  • 133
    • 1542405935 scopus 로고    scopus 로고
    • 2-terminal Kinase (JNK)
    • DOI 10.1158/0008-5472.CAN-03-3361
    • Zhang Y, Chen F (2004) Reactive oxygen species (ROS), troublemakers between nuclear factor-kappaB (NF-kappaB) and c-Jun NH(2)-terminal kinase (JNK). Cancer Res 64:1902-1905 (Pubitemid 38339430)
    • (2004) Cancer Research , vol.64 , Issue.6 , pp. 1902-1905
    • Zhang, Y.1    Chen, F.2
  • 134
    • 33749076455 scopus 로고    scopus 로고
    • Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes
    • DOI 10.1016/j.bcp.2006.07.003, PII S0006295206004187
    • Wullaert A, Heyninck K, Beyaert R (2006) Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes. Biochem Pharmacol 72:1090-1101 (Pubitemid 44465843)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.9 SPEC. ISS. , pp. 1090-1101
    • Wullaert, A.1    Heyninck, K.2    Beyaert, R.3
  • 137
    • 84864833865 scopus 로고    scopus 로고
    • Th17 response and inflammatory autoimmune diseases
    • Waite JC, Skokos D (2012) Th17 response and inflammatory autoimmune diseases. Int J Inflamm 2012:819467
    • (2012) Int J Inflamm , vol.2012 , pp. 819467
    • Waite, J.C.1    Skokos, D.2
  • 139
    • 41649084155 scopus 로고    scopus 로고
    • At the horizon of innovative therapy in rheumatology: New biologic agents
    • DOI 10.1097/BOR.0b013e3282fa13b4, PII 0000228120080500000008
    • Finckh A, Gabay C (2008) At the horizon of innovative therapy in rheumatology: new biologic agents. Curr Opin Rheumatol 20:269-275 (Pubitemid 351483315)
    • (2008) Current Opinion in Rheumatology , vol.20 , Issue.3 , pp. 269-275
    • Finckh, A.1    Gabay, C.2
  • 140
    • 79958721221 scopus 로고    scopus 로고
    • Th17 cell, the new player of neuroinflammatory process in multiple sclerosis
    • Jadidi-Niaragh F, Mirshafiey A (2011) Th17 cell, the new player of neuroinflammatory process in multiple sclerosis. Scand J Immunol 74:1-13
    • (2011) Scand J Immunol , vol.74 , pp. 1-13
    • Jadidi-Niaragh, F.1    Mirshafiey, A.2
  • 141
    • 34548651152 scopus 로고    scopus 로고
    • Cutting edge: Opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression
    • Kryczek I, Wei S, Vatan L, Escara-Wilke J, Szeliga W, Keller ET, Zou W (2007) Cutting edge: opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression. J Immunol 179:1423-1426
    • (2007) J Immunol , vol.179 , pp. 1423-1426
    • Kryczek, I.1    Wei, S.2    Vatan, L.3    Escara-Wilke, J.4    Szeliga, W.5    Keller, E.T.6    Zou, W.7
  • 142
    • 75749099362 scopus 로고    scopus 로고
    • Excessive interleukin-1 signaling determines the development of Th1 and Th17 responses in chronic inflammation
    • Joosten LAB (2010) Excessive interleukin-1 signaling determines the development of Th1 and Th17 responses in chronic inflammation. Arthr Rheumatism 62:320-322
    • (2010) Arthr Rheumatism , vol.62 , pp. 320-322
    • Joosten, L.A.B.1
  • 144
    • 67349114782 scopus 로고    scopus 로고
    • FOXP3 and the regulation of Treg/Th17 differentiation
    • Ziegler SF, Buckner JH (2009) FOXP3 and the regulation of Treg/Th17 differentiation. Microbes Infect 11:594-598
    • (2009) Microbes Infect , vol.11 , pp. 594-598
    • Ziegler, S.F.1    Buckner, J.H.2
  • 146
    • 58149357031 scopus 로고    scopus 로고
    • Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice
    • McColl BW, Rothwell NJ, Allan SM (2008) Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice. J Neurosci 28:9451-9462
    • (2008) J Neurosci , vol.28 , pp. 9451-9462
    • McColl, B.W.1    Rothwell, N.J.2    Allan, S.M.3
  • 147
    • 77954549787 scopus 로고
    • Tumour necrosis factor-alphamediates blood-brain barrier damage in HIV-1 infection of the central nervous system
    • Sharief MK, Ciardi M, Thompson EJ, Sorice F, Rossi F, Vullo V, Cirelli A (1992) Tumour necrosis factor-alphamediates blood-brain barrier damage in HIV-1 infection of the central nervous system. Mediators Inflamm 1:191-196
    • (1992) Mediators Inflamm , vol.1 , pp. 191-196
    • Sharief, M.K.1    Ciardi, M.2    Thompson, E.J.3    Sorice, F.4    Rossi, F.5    Vullo, V.6    Cirelli, A.7
  • 149
    • 33947631511 scopus 로고    scopus 로고
    • IL-1beta causes an increase in intestinal epithelial tight junction permeability
    • Al-Sadi RM, Ma TY (2007) IL-1beta causes an increase in intestinal epithelial tight junction permeability. J Immunol 178:4641-4649 (Pubitemid 46492417)
    • (2007) Journal of Immunology , vol.178 , Issue.7 , pp. 4641-4649
    • Al-Sadi, R.M.1    Ma, T.Y.2
  • 150
    • 77957738360 scopus 로고    scopus 로고
    • Gut inflammation in chronic fatigue syndrome
    • Lond
    • Lakhan SE, Kirchgessner A (2010) Gut inflammation in chronic fatigue syndrome. Nutr Metab (Lond) 7:79
    • (2010) Nutr Metab , vol.7 , pp. 79
    • Lakhan, S.E.1    Kirchgessner, A.2
  • 151
    • 47749105350 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 infection increases the in vivo capacity of peripheral monocytes to cross the blood-brain barrier into the brain and the in vivo sensitivity of the blood-brain barrier to disruption by lipopolysaccharide
    • DOI 10.1128/JVI.00768-08
    • Wang H, Sun J, Goldstein H (2008) Human immunodeficiency virus type 1 infection increases the in vivo capacity of peripheral monocytes to cross the blood-brain barrier into the brain and the in vivo sensitivity of the blood-brain barrier to disruption by lipopolysaccharide. J Virol 82:7591-7600 (Pubitemid 352031226)
    • (2008) Journal of Virology , vol.82 , Issue.15 , pp. 7591-7600
    • Wang, H.1    Sun, J.2    Goldstein, H.3
  • 152
    • 83655211771 scopus 로고    scopus 로고
    • Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα
    • Xing B, Bachstetter AD, Eldik LJ (2011) Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα. Mol Neurodegener 6:84
    • (2011) Mol Neurodegener , vol.6 , pp. 84
    • Xing, B.1    Bachstetter, A.D.2    Eldik, L.J.3
  • 153
    • 34249722703 scopus 로고    scopus 로고
    • Bacterial infections of the central nervous system: A critical role for resident glial cells in the initiation and progression of inflammation
    • DOI 10.2174/157339507780655496
    • Chauhan VS, Marriott I (2007) Bacterial infections of the central nervous system: a critical role for resident glial cells in the initiation and progression of inflammation. Curr Immunol 3:133-143 (Pubitemid 46823010)
    • (2007) Current Immunology Reviews , vol.3 , Issue.2 , pp. 133-143
    • Chauhan, V.S.1    Marriott, I.2
  • 155
    • 33845493421 scopus 로고    scopus 로고
    • Ganglioside molecular mimicry and its pathological roles in Guillain-Barré syndrome and related diseases
    • DOI 10.1128/IAI.00967-06
    • Yu RK, Usuki S, Ariga T (2006) Ganglioside molecular mimicry and its pathological roles in Guillain-Barré syndrome and related diseases. Infect Immun 74:6517-6527 (Pubitemid 44913126)
    • (2006) Infection and Immunity , vol.74 , Issue.12 , pp. 6517-6527
    • Yu, R.K.1    Usuki, S.2    Ariga, T.3
  • 156
    • 0036716770 scopus 로고    scopus 로고
    • Ganglioside mimicry of Campylobacter jejuni lipopolysaccharides determines antiganglioside specificity in rabbits
    • Ang CW, Noordzij PG, de Klerk MA, Endtz HP, van Doorn PA, Laman JD (2002) Ganglioside mimicry of Campylobacter jejuni lipopolysaccharides determines antiganglioside specificity in rabbits. Infect Immun 70:5081-5085
    • (2002) Infect Immun , vol.70 , pp. 5081-5085
    • Ang, C.W.1    Noordzij, P.G.2    De Klerk, M.A.3    Endtz, H.P.4    Van Doorn, P.A.5    Laman, J.D.6
  • 157
    • 0032960310 scopus 로고    scopus 로고
    • The bacterial endotoxin lipopolysaccharide causes rapid inappropriate excitation in rat cortex
    • DOI 10.1046/j.1471-4159.1999.0720652.x
    • Wang YS, White TD (1999) The bacterial endotoxin lipopolysaccharide causes rapid inappropriate excitation in rat cortex. J Neurochem 72:652-660 (Pubitemid 29055227)
    • (1999) Journal of Neurochemistry , vol.72 , Issue.2 , pp. 652-660
    • Wang, Y.S.1    White, T.D.2
  • 158
    • 77954593393 scopus 로고    scopus 로고
    • Bacterial infections and the pathogenesis of autoimmune conditions
    • Sherbet G (2009) Bacterial infections and the pathogenesis of autoimmune conditions. BJMP 2:6-13
    • (2009) BJMP , vol.2 , pp. 6-13
    • Sherbet, G.1
  • 159
    • 79952157789 scopus 로고    scopus 로고
    • The endotoxin-induced neuroinflammation model of Parkinson's disease
    • Tufekci KU, Genc S, Genc K (2011) The endotoxin-induced neuroinflammation model of Parkinson's disease. Parkinsons Dis 2011:487450
    • (2011) Parkinsons Dis , vol.2011 , pp. 487450
    • Tufekci, K.U.1    Genc, S.2    Genc, K.3
  • 160
    • 0030464175 scopus 로고    scopus 로고
    • Multiple sclerosis patients have peripheral blood CD45RO+ B cells and increased intestinal permeability
    • DOI 10.1007/BF02100148
    • Yacyshyn B, Meddings J, Sadowski D, Bowen-Yacyshyn MB (1996) Multiple sclerosis patients have peripheral blood CD45RO + B cells and increased intestinal permeability. Dig Dis Sci 41:2493-2498 (Pubitemid 27041808)
    • (1996) Digestive Diseases and Sciences , vol.41 , Issue.12 , pp. 2493-2498
    • Yacyshyn, B.1    Meddings, J.2    Sadowski, D.3    Bowen-Yacyshyn, M.B.4
  • 162
    • 0030953727 scopus 로고    scopus 로고
    • Increased levels of 4-hydroxynonenal modified proteins in plasma of children with autoimmune diseases
    • DOI 10.1016/S0891-5849(96)00586-2, PII S0891584996005862
    • Grune T, Michel P, Sitte N, Eggert W, Albrecht-Nebe H, Esterbauer H, Siems WG (1997) Increased levels of 4-hydroxynonenal modified proteins in plasma of children with autoimmune diseases. Free Radic Biol Med 23:357-360 (Pubitemid 27276770)
    • (1997) Free Radical Biology and Medicine , vol.23 , Issue.3 , pp. 357-360
    • Grune, T.1    Michel, P.2    Sitte, N.3    Eggert, W.4    Albrecht-Nebe, H.5    Esterbauer, H.6    Siems, W.G.7
  • 163
    • 50949098933 scopus 로고    scopus 로고
    • Autoimmunity and oxidatively modified autoantigens
    • Kurien BT, Scofield RH (2008) Autoimmunity and oxidatively modified autoantigens. Autoimmun Rev 7:567-573
    • (2008) Autoimmun Rev , vol.7 , pp. 567-573
    • Kurien, B.T.1    Scofield, R.H.2
  • 164
    • 0030757197 scopus 로고    scopus 로고
    • Acute hematopoietic toxicity of aniline in rats
    • DOI 10.1016/S0378-4274(97)00032-5, PII S0378427497000325
    • Khan MF, Wu X, Kaphalia BS, Boor PJ, Ansari GA (1997) Acute hematopoietic toxicity of aniline in rats. Toxicol Lett 92:31-37 (Pubitemid 27289493)
    • (1997) Toxicology Letters , vol.92 , Issue.1 , pp. 31-37
    • Khan, M.F.1    Wu, X.2    Kaphalia, B.S.3    Boor, P.J.4    Ansari, G.A.S.5
  • 165
    • 0028036257 scopus 로고
    • The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: Increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine
    • Weinberg JB, Granger DL, Pisetsky DS, Seldin MF, Misukonis MA, Mason SN, Pippen AM, Ruiz P, Wood ER, Gilkeson GS (1994) The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orally administered NG-monomethyl-L-arginine. J Exp Med 179:651-660
    • (1994) J Exp Med , vol.179 , pp. 651-660
    • Weinberg, J.B.1    Granger, D.L.2    Pisetsky, D.S.3    Seldin, M.F.4    Misukonis, M.A.5    Mason, S.N.6    Pippen, A.M.7    Ruiz, P.8    Wood, E.R.9    Gilkeson, G.S.10
  • 166
    • 33749555820 scopus 로고    scopus 로고
    • Measurement and significance of 3-nitrotyrosine in systemic lupus erythematosus
    • DOI 10.1111/j.1365-3083.2006.01794.x
    • Khan F, Siddiqui AA, Ali R (2006) Measurement and significance of 3-nitrotyrosine in systemic lupus erythematosus. Scand J Immunol 64:507-514 (Pubitemid 44536335)
    • (2006) Scandinavian Journal of Immunology , vol.64 , Issue.5 , pp. 507-514
    • Khan, F.1    Siddiqui, A.A.2    Ali, R.3
  • 167
    • 33645287663 scopus 로고    scopus 로고
    • Antibodies against nitric oxide damaged poly L-tyrosine and 3-nitrotyrosine levels in systemic lupus erythematosus
    • Khan F, Ali R (2006) Antibodies against nitric oxide damaged poly L-tyrosine and 3-nitrotyrosine levels in systemic lupus erythematosus. J Biochem Mol Biol 39:189-196
    • (2006) J Biochem Mol Biol , vol.39 , pp. 189-196
    • Khan, F.1    Ali, R.2
  • 168
    • 33746033343 scopus 로고    scopus 로고
    • Oxidatively modified autoantigens in autoimmune diseases
    • DOI 10.1016/j.freeradbiomed.2006.05.020, PII S0891584906003315
    • Kurien BT, Hensley K, Bachmann M, Scofield RH (2006) Oxidatively modified autoantigens in autoimmune diseases. Free Radic Biol Med 41:549-556 (Pubitemid 44080517)
    • (2006) Free Radical Biology and Medicine , vol.41 , Issue.4 , pp. 549-556
    • Kurien, B.T.1    Hensley, K.2    Bachmann, M.3    Scofield, R.H.4
  • 169
    • 0026647194 scopus 로고
    • Homocysteine remethylation during nitrous oxide exposure of cells cultured in media containing various concentrations of folates
    • Christensen B, Refsum H, Garras A, Ueland PM (1992) Homocysteine remethylation during nitrous oxide exposure of cells cultured in media containing various concentrations of folates. J Pharmacol Exp Ther 261:1096-1105
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 1096-1105
    • Christensen, B.1    Refsum, H.2    Garras, A.3    Ueland, P.M.4
  • 171
    • 77649342230 scopus 로고    scopus 로고
    • Age-dependent decreases in DNA methyltransferase levels and low transmethylation micronutrient levels synergize to promote overexpression of genes implicated in autoimmunity and acute coronary syndromes
    • Li Y, Liu Y, Strickland FM, Richardson B (2010) Age-dependent decreases in DNA methyltransferase levels and low transmethylation micronutrient levels synergize to promote overexpression of genes implicated in autoimmunity and acute coronary syndromes. Exp Gerontol 45:312-322
    • (2010) Exp Gerontol , vol.45 , pp. 312-322
    • Li, Y.1    Liu, Y.2    Strickland, F.M.3    Richardson, B.4
  • 172
    • 77954548251 scopus 로고    scopus 로고
    • Hypomethylation of IL10 and IL13 promoters in CD4+ T cells of patients with systemic lupus erythematosus
    • Zhao M, Tang J, Gao F, Wu X, Liang Y, Yin H, Lu Q (2010) Hypomethylation of IL10 and IL13 promoters in CD4+ T cells of patients with systemic lupus erythematosus. J Biomed Biotechnol 2010:931018
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 931018
    • Zhao, M.1    Tang, J.2    Gao, F.3    Wu, X.4    Liang, Y.5    Yin, H.6    Lu, Q.7
  • 176
    • 0025666735 scopus 로고
    • Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis
    • Richardson B, Scheinbart L, Strahler J, Gross L, Hanash S, Johnson M (1990) Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 33:1665-1673
    • (1990) Arthritis Rheum , vol.33 , pp. 1665-1673
    • Richardson, B.1    Scheinbart, L.2    Strahler, J.3    Gross, L.4    Hanash, S.5    Johnson, M.6
  • 177
    • 0023001618 scopus 로고
    • Effect of an inhibitor of DNA methylation on T cells. II. 5-Azacytidine induces self-reactivity in antigen-specific T4+ cells
    • Richardson B (1986) Effect of an inhibitor of DNA methylation on T cells. II. 5-Azacytidine induces self-reactivity in antigen-specific T4+ cells. Hum Immunol 17:456-470
    • (1986) Hum Immunol , vol.17 , pp. 456-470
    • Richardson, B.1
  • 179
    • 84896534137 scopus 로고    scopus 로고
    • Activation of the nitric oxide-mitochondrial hyperpolarization-mTOR-Rab4 signaling pathway precedes disease development in lupus T cells
    • Perl A, Telarico T, Singh R, Fernandez D (2010) Activation of the nitric oxide-mitochondrial hyperpolarization-mTOR-Rab4 signaling pathway precedes disease development in lupus T cells. J Immunol 184:93.36
    • (2010) J Immunol , vol.184
    • Perl, A.1    Telarico, T.2    Singh, R.3    Fernandez, D.4
  • 180
    • 78650691031 scopus 로고    scopus 로고
    • Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus
    • Nagy G, Koncz A, Telarico T, Fernandez D, Ersek B, Buzas E, Perl A (2010) Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus. Arthritis Res Ther 12:210
    • (2010) Arthritis Res Ther , vol.12 , pp. 210
    • Nagy, G.1    Koncz, A.2    Telarico, T.3    Fernandez, D.4    Ersek, B.5    Buzas, E.6    Perl, A.7
  • 181
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • DOI 10.1101/gad.1212704
    • Hay N, Sonenberg N (2004) Upstream and downstream of mTOR. Genes Dev 18:1926-1945 (Pubitemid 39071573)
    • (2004) Genes and Development , vol.18 , Issue.16 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 182
    • 83455238260 scopus 로고    scopus 로고
    • mTOR signaling and metabolic regulation of T cells: New potential therapeutic targets in autoimmune diseases
    • Pierdominici M, Vacirca D, Delunardo F, Ortona E (2011) mTOR signaling and metabolic regulation of T cells: new potential therapeutic targets in autoimmune diseases. Curr Pharm Des 17:3888-3897
    • (2011) Curr Pharm des , vol.17 , pp. 3888-3897
    • Pierdominici, M.1    Vacirca, D.2    Delunardo, F.3    Ortona, E.4
  • 184
    • 67650553603 scopus 로고    scopus 로고
    • mTOR: Taking cues from the immune microenvironment
    • Delgoffe GM, Powell JD (2009) mTOR: taking cues from the immune microenvironment. Immunology 127:459-465
    • (2009) Immunology , vol.127 , pp. 459-465
    • Delgoffe, G.M.1    Powell, J.D.2
  • 185
    • 84860187314 scopus 로고    scopus 로고
    • Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo
    • Yurchenko E, Shio MT, Huang TC, Da Silva Martins M, Szyf M, Levings MK, Oliver M, Piccirillo CA (2012) Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo. PLoS ONE 7:e35572
    • (2012) PLoS ONE , vol.7
    • Yurchenko, E.1    Shio, M.T.2    Huang, T.C.3    Da Silva Martins, M.4    Szyf, M.5    Levings, M.K.6    Oliver, M.7    Piccirillo, C.A.8
  • 187
    • 77953720799 scopus 로고    scopus 로고
    • mTOR signaling: A central pathway to pathogenesis in systemic lupus erythematosus?
    • Fernandez D, Perl A (2010) mTOR signaling: a central pathway to pathogenesis in systemic lupus erythematosus? Discov Med 9:173-178
    • (2010) Discov Med , vol.9 , pp. 173-178
    • Fernandez, D.1    Perl, A.2
  • 189
    • 34347389223 scopus 로고    scopus 로고
    • Leptin in autoimmunity: Many questions, some answers
    • DOI 10.1111/j.1399-0039.2007.00886.x
    • Matarese G, Leiter EH, La Cava A (2007) Leptin in autoimmunity: many questions, some answers. Tissue Antigens 70:87-95 (Pubitemid 47024837)
    • (2007) Tissue Antigens , vol.70 , Issue.2 , pp. 87-95
    • Matarese, G.1    Leiter, E.H.2    La, C.A.3
  • 190
    • 0035195887 scopus 로고    scopus 로고
    • Leptin regulation of the immune response and the immunodeficiency of malnutrition
    • DOI 10.1096/fj.01-0431rev
    • Faggioni R, Feingold KR, Grunfeld C (2001) Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 15:2565-2571 (Pubitemid 33131083)
    • (2001) FASEB Journal , vol.15 , Issue.14 , pp. 2565-2571
    • Faggioni, R.1    Feingold, K.R.2    Grunfeld, C.3
  • 191
    • 2142748041 scopus 로고    scopus 로고
    • Stimulatory effect of leptin on nitric oxide production is impaired in dietary-induced obesity
    • Bettowski J, Wojcicka G, Jamroz A (2003) Stimulatory effect of leptin on nitric oxide production is impaired in dietary-induced obesity. Obes Res 11:1571-1580 (Pubitemid 41127343)
    • (2003) Obesity Research , vol.11 , Issue.12 , pp. 1571-1580
    • Beltowski, J.1    Wojcicka, G.2    Jamroz, A.3
  • 194
    • 0034628016 scopus 로고    scopus 로고
    • Human leptin enhances activation and proliferation of human circulating T lymphocytes
    • DOI 10.1006/cimm.1999.1594
    • Martin-Romero C, Santos-Alvarez J, Goberna R, Sanchez-Margalet V (2000) Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol 199:15-24 (Pubitemid 30118591)
    • (2000) Cellular Immunology , vol.199 , Issue.1 , pp. 15-24
    • Martin-Romero, C.1    Santos-Alvarez, J.2    Goberna, R.3    Sanchez-Margalet, V.4
  • 195
    • 38549161031 scopus 로고    scopus 로고
    • Leptin promotes cell survival and activates Jurkat T lymphocytes by stimulation of mitogen-activated protein kinase
    • DOI 10.1111/j.1365-2249.2007.03563.x
    • Fernandez-Riejos P, Goberna R, Sanchez-Margalet V (2008) Leptin promotes cell survival and activates Jurkat T lymphocytes by stimulation ofmitogen-activated protein kinase. Clin Exp Immunol 151:505-518 (Pubitemid 351160721)
    • (2008) Clinical and Experimental Immunology , vol.151 , Issue.3 , pp. 505-518
    • Fernandez-Riejos, P.1    Goberna, R.2    Sanchez-Margalet, V.3
  • 196
    • 0036378052 scopus 로고    scopus 로고
    • Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients
    • Sanchez-Margalet V, Martin-Romero C, Gonzalez-Yanes C, Goberna R, Rodriguez-Bano J, Muniain MA (2002) Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients. Clin Exp Immunol 129:119-124
    • (2002) Clin Exp Immunol , vol.129 , pp. 119-124
    • Sanchez-Margalet, V.1    Martin-Romero, C.2    Gonzalez-Yanes, C.3    Goberna, R.4    Rodriguez-Bano, J.5    Muniain, M.A.6
  • 199
    • 34547860034 scopus 로고    scopus 로고
    • Leptin-mediated cytokine release and migration of eosinophils: Implications for immunopathophysiology of allergic inflammation
    • DOI 10.1002/eji.200636866
    • Wong CK, Cheung PF, Lam CW (2007) Leptin-mediated cytokine release and migration of eosinophils: implications for immunopathophysiology of allergic inflammation. Eur J Immunol 37:2337-2348 (Pubitemid 47250225)
    • (2007) European Journal of Immunology , vol.37 , Issue.8 , pp. 2337-2348
    • Wong, C.K.1    Cheung, P.F.-Y.2    Lam, C.W.-K.3
  • 200
    • 62849114121 scopus 로고    scopus 로고
    • Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway
    • Mattioli B, Giordani L, Quaranta MG, Viora M (2009) Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway. FEBS Lett 583:1102-1106
    • (2009) FEBS Lett , vol.583 , pp. 1102-1106
    • Mattioli, B.1    Giordani, L.2    Quaranta, M.G.3    Viora, M.4
  • 201
    • 45449099469 scopus 로고    scopus 로고
    • Cytokine-producing B lymphocytes-key regulators of immunity
    • Lund FE (2008) Cytokine-producing B lymphocytes-key regulators of immunity. Curr Opin Immunol 20:332-338
    • (2008) Curr Opin Immunol , vol.20 , pp. 332-338
    • Lund, F.E.1
  • 202
    • 0030741166 scopus 로고    scopus 로고
    • Production of cytokines by human B cells in health and disease
    • Pistoia V (1997) Production of cytokines by human B cells in health and disease. Immunol Today 18:343-350
    • (1997) Immunol Today , vol.18 , pp. 343-350
    • Pistoia, V.1
  • 203
    • 30744458329 scopus 로고    scopus 로고
    • A case for regulatory B cells
    • Mizoguchi A, Bhan AK (2006) A case for regulatory B cells. J Immunol 176:705-710 (Pubitemid 43099663)
    • (2006) Journal of Immunology , vol.176 , Issue.2 , pp. 705-710
    • Mizoguchi, A.1    Bhan, A.K.2
  • 204
    • 77950070632 scopus 로고    scopus 로고
    • Effector and regulatory B cells: Modulators of CD4(+) T cell immunity
    • Lund FE, Randall TD (2010) Effector and regulatory B cells: modulators of CD4(+) T cell immunity. Nat Rev Immunol 10:236-247
    • (2010) Nat Rev Immunol , vol.10 , pp. 236-247
    • Lund, F.E.1    Randall, T.D.2
  • 206
    • 34247638346 scopus 로고    scopus 로고
    • B cell depletion therapy in autoimmune diseases
    • Sanz I, Anolik JH, Looney RJ (2007) B cell depletion therapy in autoimmune diseases. Front Biosci 12:2546-2567
    • (2007) Front Biosci , vol.12 , pp. 2546-2567
    • Sanz, I.1    Anolik, J.H.2    Looney, R.J.3
  • 207
    • 77950327120 scopus 로고    scopus 로고
    • Rituximab in autoimmune hematologic diseases: Not just a matter of B cells
    • Stasi R (2010) Rituximab in autoimmune hematologic diseases: not just a matter of B cells. Semin Hematol 47:170-179
    • (2010) Semin Hematol , vol.47 , pp. 170-179
    • Stasi, R.1
  • 208
    • 18944370055 scopus 로고    scopus 로고
    • Regulation of IFN-gamma production by B effector 1 cells: Essential roles for T-bet and the IFN-gamma receptor
    • Harris DP, Goodrich S, Gerth AJ, Peng SL, Lund FE (2005) Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor. J Immunol 174:6781-6790 (Pubitemid 40705641)
    • (2005) Journal of Immunology , vol.174 , Issue.11 , pp. 6781-6790
    • Harris, D.P.1    Goodrich, S.2    Gerth, A.J.3    Peng, S.L.4    Lund, F.E.5
  • 209
    • 28244458933 scopus 로고    scopus 로고
    • Cutting Edge: The development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor alpha, and Th2 cells
    • Harris DP, Goodrich S, Mohrs K, Mohrs M, Lund FE (2005) Cutting edge: the development of IL-4-producing B cells (B effector 2 cells) is controlled by IL-4, IL-4 receptor alpha, and Th2 cells. J Immunol 175:7103-7107 (Pubitemid 41713402)
    • (2005) Journal of Immunology , vol.175 , Issue.11 , pp. 7103-7107
    • Harris, D.P.1    Goodrich, S.2    Mohrs, K.3    Mohrs, M.4    Lund, F.E.5
  • 211
    • 1542514778 scopus 로고    scopus 로고
    • Distinct Profiles of Human B Cell Effector Cytokines: A Role in Immune Regulation?
    • Duddy ME, Alter A, Bar-Or A (2004) Distinct profiles of human B cell effector cytokines: a role in immune regulation? J Immunol 172:3422-3427 (Pubitemid 38337921)
    • (2004) Journal of Immunology , vol.172 , Issue.6 , pp. 3422-3427
    • Duddy, M.E.1    Alter, A.2    Bar-Or, A.3
  • 214
    • 50949128658 scopus 로고    scopus 로고
    • Intrinsic TGF-beta 1 regulation of B cells
    • Gros MJ, Naquet P, Guinamard RR (2008) Intrinsic TGF-beta 1 regulation of B cells. J Immunol 180:8153-8158
    • (2008) J Immunol , vol.180 , pp. 8153-8158
    • Gros, M.J.1    Naquet, P.2    Guinamard, R.R.3
  • 215
    • 43049156086 scopus 로고    scopus 로고
    • + Phenotype Controls T Cell-Dependent Inflammatory Responses
    • DOI 10.1016/j.immuni.2008.03.017, PII S1074761308001933
    • Yanaba K, Bouaziz JD, Haas KM, Poe JC, Fujimoto M, Tedder TF (2008) A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 28:639-650 (Pubitemid 351636247)
    • (2008) Immunity , vol.28 , Issue.5 , pp. 639-650
    • Yanaba, K.1    Bouaziz, J.-D.2    Haas, K.M.3    Poe, J.C.4    Fujimoto, M.5    Tedder, T.F.6
  • 216
    • 37849044394 scopus 로고    scopus 로고
    • The 'short' history of regulatory B cells
    • Mauri C, Ehrenstein MR (2008) The 'short' history of regulatory B cells. Trends Immunol 29:34-40
    • (2008) Trends Immunol , vol.29 , pp. 34-40
    • Mauri, C.1    Ehrenstein, M.R.2
  • 217
    • 80054793227 scopus 로고    scopus 로고
    • Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study
    • Fluge O, Bruland O, Risa K, Storstein A, Kristoffersen EK, Sapkota D, Næss H, Dahl O, Nyland H, Mella O (2011) Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study. PLoS ONE 6:e26358
    • (2011) PLoS ONE , vol.6
    • Fluge, O.1    Bruland, O.2    Risa, K.3    Storstein, A.4    Kristoffersen, E.K.5    Sapkota, D.6    Næss, H.7    Dahl, O.8    Nyland, H.9    Mella, O.10
  • 218
    • 27444441270 scopus 로고    scopus 로고
    • Update on rituximab
    • Eisenberg R (2005) Update on rituximab. Ann Rheum Dis 64:iv55-iv57
    • (2005) Ann Rheum Dis , vol.64
    • Eisenberg, R.1
  • 223
    • 33751085414 scopus 로고    scopus 로고
    • Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients
    • DOI 10.1016/j.jneuroim.2006.06.029, PII S0165572806002700
    • Cross AH, Stark JL, Lauber J, Ramsbottom MJ, Lyons JA (2006) Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients. J Neuroimmunol 180:63-70 (Pubitemid 44767709)
    • (2006) Journal of Neuroimmunology , vol.180 , Issue.1-2 , pp. 63-70
    • Cross, A.H.1    Stark, J.L.2    Lauber, J.3    Ramsbottom, M.J.4    Lyons, J.-A.5
  • 224
    • 43149122203 scopus 로고    scopus 로고
    • Rituximab in a patient with multiple sclerosis - Effect on B cells, plasma cells and intrathecal IgG synthesis
    • DOI 10.1111/j.1600-0404.2007.00958.x
    • Petereit HF, Moeller-Hartmann W, Reske D, Rubbert A (2008) Rituximab in a patient with multiple sclerosis-effect on B cells, plasma cells and intrathecal IgG synthesis. Acta Neurol Scand 117:399-403 (Pubitemid 351643667)
    • (2008) Acta Neurologica Scandinavica , vol.117 , Issue.6 , pp. 399-403
    • Petereit, H.F.1    Moeller-Hartmann, W.2    Reske, D.3    Rubbert, A.4
  • 225
    • 84887869907 scopus 로고    scopus 로고
    • Potential impact of B cells on T cell function in multiple sclerosis
    • Ireland S, Monson N (2011) Potential impact of B cells on T cell function in multiple sclerosis. Mult Scler Int 2011:423971
    • (2011) Mult Scler Int , vol.2011 , pp. 423971
    • Ireland, S.1    Monson, N.2
  • 226
    • 0029671317 scopus 로고    scopus 로고
    • Regulation of NF-kappa B activation in T helper 1 and T helper 2 cells
    • Lederer JA, Liou JS, Kim S, Rice N, Lichtman AH (1996) Regulation of NF-kappa B activation in T helper 1 and T helper 2 cells. J Immunol 156:56-63
    • (1996) J Immunol , vol.156 , pp. 56-63
    • Lederer, J.A.1    Liou, J.S.2    Kim, S.3    Rice, N.4    Lichtman, A.H.5
  • 227
    • 11244254238 scopus 로고    scopus 로고
    • Rituximab (chimeric anti-CD20 monoclonal antibody) inhibits the constitutive nuclear factor-kappaB signaling pathway in non-Hodgkin's lymphoma B-cell lines: Role in sensitization to chemotherapeutic drug-induced apoptosis
    • Jazirehi AR, Huerta-Yepez S, Cheng G, Bonavida B (2005) Rituximab (chimeric anti-CD20 monoclonal antibody) inhibits the constitutive nuclear factor-{kappa}B signaling pathway in non-Hodgkin's lymphoma B-cell lines: role in sensitization to chemotherapeutic drug-induced apoptosis. Cancer Res 65:264-276 (Pubitemid 40070818)
    • (2005) Cancer Research , vol.65 , Issue.1 , pp. 264-276
    • Jazirehi, A.R.1    Huerta-Yepez, S.2    Cheng, G.3    Bonavida, B.4
  • 229
    • 39049115197 scopus 로고    scopus 로고
    • The B cell-old player, new position on the team
    • McFarland HF (2008) The B cell-old player, new position on the team. N Engl J Med 358:664-665
    • (2008) N Engl J Med , vol.358 , pp. 664-665
    • McFarland, H.F.1
  • 231
    • 13444274684 scopus 로고    scopus 로고
    • Effect of rituximab on the peripheral blood and cerebrospinal fluid B cells in patients with primary progressive multiple sclerosis
    • DOI 10.1001/archneur.62.2.258
    • Monson NL, Cravens PD, Frohman EM, Hawker K, Racke MK (2005) Effect of rituximab on the peripheral blood and cerebrospinal fluid B cells in patients with primary progressive multiple sclerosis. Arch Neurol 62:258-264 (Pubitemid 40204747)
    • (2005) Archives of Neurology , vol.62 , Issue.2 , pp. 258-264
    • Monson, N.L.1    Cravens, P.D.2    Frohman, E.M.3    Hawker, K.4    Racke, M.K.5


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