Th17 response and inflammatory autoimmune diseases

International Journal of Inflammation

Volumn 2012, Issue , 2012, Pages

  Waite, Janelle C ^a   Skokos, Dimitris ^a  

^a REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CORTICOSTEROID; CYTOKINE; DIGOXIN; GAMMA INTERFERON; HALOFUGINONE; INFLIXIMAB; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 6; IXEKIZUMAB; LEUKEMIA INHIBITORY FACTOR; NONSTEROID ANTIINFLAMMATORY AGENT; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TOCILIZUMAB; USTEKINUMAB;

ADULT ONSET STILL DISEASE; ALLERGIC ENCEPHALOMYELITIS; ARTHRITIS; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CROHN DISEASE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE SEVERITY; DRUG TARGETING; ENTERITIS; HOST RESISTANCE; HUMAN; IMMUNOPATHOGENESIS; INFLAMMATORY DISEASE; INSULIN DEPENDENT DIABETES MELLITUS; LUPUS VULGARIS; LYMPHOCYTE DIFFERENTIATION; MICROBIAL COMMUNITY; MOLECULAR BIOLOGY; MULTIPLE SCLEROSIS; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PSORIASIS; REVIEW; RHEUMATOID ARTHRITIS; TH17 CELL; UVEITIS;

EID: 84864833865     PISSN: 20908040     EISSN: 20420099     Source Type: Journal    
DOI: 10.1155/2012/819467     Document Type: Review

References (102)

1. Harrington L. E., Hatton R. D., Mangan P. R., Turner H., Murphy T. L., Murphy K. M., Weaver C. T., Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nature Immunology 2005 6 11 1123 1132 2-s2.0-27544490377 10.1038/ni1254 (Pubitemid 41541790)
2. Langrish C. L., Chen Y., Blumenschein W. M., Mattson J., Basham B., Sedgwick J. D., McClanahan T., Kastelein R. A., Cua D. J., IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. Journal of Experimental Medicine 2005 201 2 233 240 2-s2.0-13244283212 10.1084/jem.20041257 (Pubitemid 40189432)
3. Park H., Li Z., Yang X. O., Chang S. H., Nurieva R., Wang Y. H., Wang Y., Hood L., Zhu Z., Tian Q., Dong C., A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nature Immunology 2005 6 11 1133 1141 2-s2.0-27544465354 10.1038/ni1261 (Pubitemid 41541791)
4. Chung Y., Chang S. H., Martinez G. J., Yang X. O., Nurieva R., Kang H. S., Ma L., Watowich S. S., Jetten A. M., Tian Q., Dong C., Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 2009 30 4 576 587 2-s2.0-64049089798 10.1016/j.immuni.2009.02.007
5. Hirahara K., Ghoreschi K., Laurence A., Yang X. P., Kanno Y., O'Shea J. J., Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. Cytokine and Growth Factor Reviews 2010 21 6 425 434 2-s2.0-78649689761 10.1016/j.cytogfr.2010.10.006
6. Korn T., Bettelli E., Oukka M., Kuchroo V. K., IL-17 and Th17 cells. Annual Review of Immunology 2009 27 485 517 2-s2.0-61949463911 10.1146/annurev.immunol.021908.132710
7. Sutton C. E., Lalor S. J., Sweeney C. M., Brereton C. F., Lavelle E. C., Mills K. H. G., Interleukin-1 and IL-23 induce innate IL-17 production from γδ T cells, amplifying Th17 responses and autoimmunity. Immunity 2009 31 2 331 341 2-s2.0-68649088121 10.1016/j.immuni.2009.08.001
8. Yang L., Anderson D. E., Baecher-Allan C., Hastings W. D., Bettelli E., Oukka M., Kuchroo V. K., Hafler D. A., IL-21 and TGF- β are required for differentiation of human T(H)17 cells. Nature 2008 454 7202 350 352 2-s2.0-47549112840 10.1038/nature07021
9. Veldhoen M., Hocking R. J., Atkins C. J., Locksley R. M., Stockinger B., TGF β in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006 24 2 179 189 2-s2.0-32244442562 10.1016/j.immuni.2006.01.001 (Pubitemid 43214587)
10. Veldhoen M., Hocking R. J., Flavell R. A., Stockinger B., Signals mediated by transforming growth factor- β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nature Immunology 2006 7 11 1151 1156 2-s2.0-33750142276 10.1038/ni1391 (Pubitemid 44594310)
11. Das J., Ren G., Zhang L., Roberts A. I., Zhao X., Bothwell A. L. M., Van Kaer L., Shi Y., Das G., Transforming growth factor β is dispensable for the molecular orchestration of Th17 cell differentiation. Journal of Experimental Medicine 2009 206 11 2407 2416 2-s2.0-70449711235 10.1084/jem.20082286
12. Ghoreschi K., Laurence A., Yang X. P., Tato C. M., McGeachy M. J., Konkel J. E., Ramos H. L., Wei L., Davidson T. S., Bouladoux N., Grainger J. R., Chen Q., Kanno Y., Watford W. T., Sun H. W., Eberl G., Shevach E. M., Belkaid Y., Cua D. J., Chen W., O'Shea J. J., Generation of pathogenic T(H) 17 cells in the absence of TGF- β 2 signalling. Nature 2010 467 7318 967 971 2-s2.0-77958584113 10.1038/nature09447
13. Ivanov I. I., McKenzie B. S., Zhou L., Tadokoro C. E., Lepelley A., Lafaille J. J., Cua D. J., Littman D. R., The orphan nuclear receptor ROR γ t directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006 126 6 1121 1133 2-s2.0-33748588423 10.1016/j.cell.2006.07.035 (Pubitemid 44380299)
14. Korn T., Bettelli E., Gao W., Awasthi A., Jäger A., Strom T. B., Oukka M., Kuchroo V. K., IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007 448 7152 484 487 2-s2.0-34547232503 10.1038/nature05970 (Pubitemid 47123515)
15. Nurieva R., Yang X. O., Martinez G., Zhang Y., Panopoulos A. D., Ma L., Schluns K., Tian Q., Watowich S. S., Jetten A. M., Dong C., Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 2007 448 7152 480 483 2-s2.0-34547204946 10.1038/nature05969 (Pubitemid 47123514)
16. Guo L., Wei G., Zhu J., Liao W., Leonard W. J., Zhao K., Paul W., IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proceedings of the National Academy of Sciences of the United States of America 2009 106 32 13463 13468 2-s2.0-69449106110 10.1073/pnas.0906988106
17. Mathur A. N., Chang H. C., Zisoulis D. G., Stritesky G. L., Yu Q., O'Malley J. T., Kapur R., Levy D. E., Kansas G. S., Kaplan M. H., Stat3 and stat4 direct development of IL-17-secreting Th cells. Journal of Immunology 2007 178 8 4901 4907 2-s2.0-34247122412 (Pubitemid 46595272)
18. Wong C. K., Lit L. C. W., Tam L. S., Li E. K. M., Wong P. T. Y., Lam C. W. K., Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity. Clinical Immunology 2008 127 3 385 393 2-s2.0-45249097325 10.1016/j.clim.2008. 01.019
19. Dinarello C. A., IL-18: AtH1-inducing, proinflammatory cytokine and new member of the IL-1 family. Journal of Allergy and Clinical Immunology 1999 103 1 11 24 2-s2.0-0032607876 (Pubitemid 29063184)
20. Reznikov L. L., Kim S. H., Westcott J. Y., Frishman J., Fantuzzi G., Novick D., Rubinstein M., Dinarello C. A., IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN- γ Proceedings of the National Academy of Sciences of the United States of America 2000 97 5 2174 2179 2-s2.0-0034052942 10.1073/pnas.040582597 (Pubitemid 30134041)
21. Weaver C. T., Hatton R. D., Mangan P. R., Harrington L. E., IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annual Review of Immunology 2007 25 821 852 2-s2.0-33847206969 10.1146/annurev.immunol.25. 022106.141557 (Pubitemid 46697925)
22. Gaffen S. L., Structure and signalling in the IL-17 receptor family. Nature Reviews Immunology 2009 9 8 556 567 2-s2.0-68849084891 10.1038/nri2586
23. Ishigame H., Kakuta S., Nagai T., Kadoki M., Nambu A., Komiyama Y., Fujikado N., Tanahashi Y., Akitsu A., Kotaki H., Sudo K., Nakae S., Sasakawa C., Iwakura Y., Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. Immunity 2009 30 1 108 119 2-s2.0-58149231532 10.1016/j.immuni.2008.11.009
24. Kuestner R. E., Taft D. W., Haran A., Brandt C. S., Brender T., Lum K., Harder B., Okada S., Ostrander C. D., Kreindler J. L., Aujla S. J., Reardon B., Moore M., Shea P., Schreckhise R., Bukowski T. R., Presnell S., Guerra-Lewis P., Parrish-Novak J., Ellsworth J. L., Jaspers S., Lewis K. E., Appleby M., Kolls J. K., Rixon M., West J. W., Gao Z., Levin S. D., Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. Journal of Immunology 2007 179 8 5462 5473 2-s2.0-38449094307
25. Ho A. W., Gaffen S. L., IL-17RC: a partner in IL-17 signaling and beyond. Seminars in Immunopathology 2010 32 1 33 42 2-s2.0-77949659096 10.1007/s00281-009-0185-0
26. Kolls J. K., Lindén A., Interleukin-17 family members and inflammation. Immunity 2004 21 4 467 476 2-s2.0-5644277476 10.1016/j.immuni. 2004.08.018 (Pubitemid 39370503)
27. Schwarzenberger P., Huang W., Peng Y., Oliver P., Manuel M., Zhang Z., Bagby G., Nelson S., Kolls J. K., Requirement of endogenous stem cell factor and granulocyte-colony- stimulating factor for IL-17-mediated granulopoiesis. Journal of Immunology 2000 164 9 4783 4789 2-s2.0-0034193959 (Pubitemid 30238080)
28. Schwarzenberger P., La Russa V., Miller A., Ye P., Huang W., Zieske A., Nelson S., Bagby G. J., Stoltz D., Mynatt R. L., Spriggs M., Kolls J. K., IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in vivo evaluation of cytokines. Journal of Immunology 1998 161 11 6383 6389 2-s2.0-0032403506 (Pubitemid 28536015)
29. Stark M. A., Huo Y., Burcin T. L., Morris M. A., Olson T. S., Ley K., Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 2005 22 3 285 294 2-s2.0-15244344110 10.1016/j.immuni.2005.01. 011 (Pubitemid 40387471)
30. Codarri L., Gyülvészii G., Tosevski V., Hesske L., Fontana A., Magnenat L., Suter T., Becher B., becher@immunology.uzh.ch ROR γ 3t drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nature Immunology 2011 12 6 560 567 10.1038/ni.2027
31. El-Behi M., Ciric B., Dai H., Yan Y., Cullimore M., Safavi F., Zhang G. X., Dittel B. N., Rostami A., a.m.rostami@jefferson.edu The encephalitogenicity of T(H) 17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nature Immunology 2011 12 6 568 575 10.1038/ni.2031
32. Hou W., Kang H. S., Kim B. S., Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection. Journal of Experimental Medicine 2009 206 2 313 328 2-s2.0-63049129392 10.1084/jem.20082030
33. Stumhofer J. S., Laurence A., Wilson E. H., Huang E., Tato C. M., Johnson L. M., Villarino A. V., Huang Q., Yoshimura A., Sehy D., Saris C. J. M., O'Shea J. J., Hennighausen L., Ernst M., Hunter C. A., Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nature Immunology 2006 7 9 937 945 2-s2.0-33747593830 10.1038/ni1376 (Pubitemid 44263907)
34. Anderson C. F., Stumhofer J. S., Hunter C. A., Sacks D., IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection. Journal of Immunology 2009 183 7 4619 4627 2-s2.0-70449732757 10.4049/jimmunol.0804024
35. Murphy C. A., Langrish C. L., Chen Y., Blumenschein W., McClanahan T., Kastelein R. A., Sedgwick J. D., Cua D. J., Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. Journal of Experimental Medicine 2003 198 12 1951 1957 2-s2.0-0346962972 10.1084/jem.20030896 (Pubitemid 38032126)
36. Nakae S., Nambu A., Sudo K., Iwakura Y., Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. Journal of Immunology 2003 171 11 6173 6177 2-s2.0-0344585384 (Pubitemid 37467240)
37. Ogura H., Murakami M., Okuyama Y., Tsuruoka M., Kitabayashi C., Kanamoto M., Nishihara M., Iwakura Y., Hirano T., Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. Immunity 2008 29 4 628 636 2-s2.0-55049118394 10.1016/j.immuni.2008.07.018
38. Sakaguchi N., Takahashi T., Hata H., Nomura T., Tagami T., Yamazaki S., Sakihama T., Matsutani T., Negishi I., Nakatsuru S., Sakaguchi S., Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature 2003 426 6965 454 460 2-s2.0-0345414139 10.1038/nature02119 (Pubitemid 37490133)
39. Hirota K., Hashimoto M., Yoshitomi H., Tanaka S., Nomura T., Yamaguchi T., Iwakura Y., Sakaguchi N., Sakaguchi S., T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis. Journal of Experimental Medicine 2007 204 1 41 47 2-s2.0-33846456970 10.1084/jem.20062259 (Pubitemid 46148754)
40. Iwakura Y., Saijo S., Kioka Y., Nakayama-Yamada J., Itagaki K., Tosu M., Asano M., Kanai Y., Kakimoto K., Autoimmunity induction by human T cell leukemia virus type 1 in transgenic mice that develop chronic inflammatory arthropathy resembling rheumatoid arthritis in humans. Journal of Immunology 1995 155 3 1588 1598 2-s2.0-0029148912
41. Iwakura Y., Nakae S., Saijo S., Ishigame H., The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunological Reviews 2008 226 1 57 79 2-s2.0-55149113836 10.1111/j.1600-065X.2008.00699.x
42. O'Connor W. Jr., Kamanaka M., Booth C. J., Town T., Nakae S., Iwakura Y., Kolls J. K., Flavell R. A., A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nature Immunology 2009 10 6 603 609 2-s2.0-65749091607 10.1038/ni.1736
43. Leppkes M., Becker C., Ivanov I. I., Hirth S., Wirtz S., Neufert C., Pouly S., Murphy A. J., Valenzuela D. M., Yancopoulos G. D., Becher B., Littman D. R., Neurath M. F., ROR γ -expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology 2009 136 1 257 267 2-s2.0-59849114998 10.1053/j.gastro.2008.10. 018
44. Ogawa A., Andoh A., Araki Y., Bamba T., Fujiyama Y., Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clinical Immunology 2004 110 1 55 62 2-s2.0-0842324613 10.1016/j.clim.2003.09. 013 (Pubitemid 38177420)
45. Yang X. O., Seon H. C., Park H., Nurieva R., Shah B., Acero L., Wang Y. H., Schluns K. S., Broaddus R. R., Zhu Z., Dong C., Regulation of inflammatory responses by IL-17F. Journal of Experimental Medicine 2008 205 5 1063 1075 2-s2.0-43549110961 10.1084/jem.20071978 (Pubitemid 351679682)
46. Ito R., Kita M., Shin-Ya M., Kishida T., Urano A., Takada R., Sakagami J., Imanishi J., Iwakura Y., Okanoue T., Yoshikawa T., Kataoka K., Mazda O., Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice. Biochemical and Biophysical Research Communications 2008 377 1 12 16 2-s2.0-54449102022 10.1016/j.bbrc.2008.09.019
47. Zenewicz L. A., Yancopoulos G. D., Valenzuela D. M., Murphy A. J., Stevens S., Flavell R. A., Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 2008 29 6 947 957 2-s2.0-57449090428 10.1016/j.immuni.2008.11.003
48. Huber S., Gagliani N., Esplugues E., O'Connor W., Huber F., Chaudhry A., Kamanaka M., Kobayashi Y., Booth C., Rudensky A., Roncarolo M., Battaglia M., Flavell R., richard.flavell@yale.edu Th17 cells express interleukin-10 receptor and are controlled by Foxp3- and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity 2011 34 4 554 565 10.1016/j.immuni. 2011.01.020
49. Chaudhry A., Samstein R., Treuting P., Liang Y., Pils M., Heinrich J. M., Jack R., Wunderlich F. T., Brüning J., Müller W., Rudensky A., rudenska@mskcc.org Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity 2011 34 4 566 578 10.1016/j.immuni.2011.03.018
50. Chen Y., Haines C., Gutcher I., Hochweller K., Blumenschein W., McClanahan T., Hämmerling G., Li M., Cua D., McGeachy M., mandy.mcgeachy@merck.com Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2. Immunity 2011 34 3 409 421 10.1016/j.immuni.2011.02.011
51. Pandiyan P., Conti H. R., Zheng L., Peterson A. C., Mathern D. R., Hernández-Santos N., Edgerton M., Gaffen S. L., Lenardo M. J., CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. Immunity 2011 34 3 422 434
52. Lowes M. A., Kikuchi T., Fuentes-Duculan J., Cardinale I., Zaba L. C., Haider A. S., Bowman E. P., Krueger J. G., Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. Journal of Investigative Dermatology 2008 128 5 1207 1211 2-s2.0-42149087160 10.1038/sj.jid.5701213 (Pubitemid 351543220)
53. van der Fits L., Mourits S., Voerman J. S. A., Kant M., Boon L., Laman J. D., Cornelissen F., Mus A. M., Florencia E., Prens E. P., Lubberts E., Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. Journal of Immunology 2009 182 9 5836 5845 2-s2.0-66949162673 10.4049/jimmunol.0802999
54. Hedrick M. N., Lonsdorf A. S., Shirakawa A. K., Lee C. C. R., Liao F., Singh S. P., Zhang H. H., Grinberg A., Love P. E., Hwang S. T., Farber J. M., CCR6 is required for IL-23-induced psoriasis-like inflammation in mice. Journal of Clinical Investigation 2009 119 8 2317 2329 2-s2.0-68849104003 10.1172/JCI37378
55. Lindroos J., Svensson L., Norsgaard H., Lovato P., Moller K., Hagedorn P. H., Olsen G. M., Labuda T., tord.labuda@leo-pharma.com IL-23-mediated epidermal hyperplasia is dependent on IL-6. Journal of Investigative Dermatology 2011 131 5 1110 1118 10.1038/jid.2010.432
56. Rizzo H. L., Kagami S., Phillips K. G., Kurtz S. E., Jacques S. L., Blauvelt A., blauvean@ohsu.edu IL-23-mediated psoriasis-like epidermal hyperplasia is dependent on IL-17A. Journal of Immunology 2011 186 3 1495 1502 10.4049/jimmunol.1001001
57. Nakajima K., Kanda T., Takaishi M., Shiga T., Miyoshi K., Nakajima H., Kamijima R., Tarutani M., Benson J. M., Elloso M. M., Gutshall L. L., Naso M. F., Iwakura Y., DiGiovanni J., Sano S., sano.derma@kochi-u.ac.jp Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model. Journal of Immunology 2011 186 7 4481 4489 10.4049/jimmunol.1000148
58. Nakajima A., Matsuki T., Komine M., Asahina A., Horai R., Nakae S., Ishigame H., Kakuta S., Saijo S., Iwakura Y., TNF, but not IL-6 and IL-17, is crucial for the development of T cell-independent psoriasis-like dermatitis in Il1rn-/- mice. Journal of Immunology 2010 185 3 1887 1893 2-s2.0-77956404314 10.4049/jimmunol.1001227
59. Ciric B., El-behi M., Cabrera R., Zhang G. X., Rostami A., IL-23 drives pathogenic IL-17-producing CD8+ T cells. Journal of Immunology 2009 182 9 5296 5305 2-s2.0-66949180111 10.4049/jimmunol.0900036
60. Emamaullee J. A., Davis J., Merani S., Toso C., Elliott J. F., Thiesen A., Shapiro A. M. J., Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice. Diabetes 2009 58 6 1302 1311 2-s2.0-66649113381 10.2337/db08-1113
61. Ivanov I. I., Frutos R. D. L., Manel N., Yoshinaga K., Rifkin D. B., Sartor R. B., Finlay B. B., Littman D. R., Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host and Microbe 2008 4 4 337 349 2-s2.0-53349173070 10.1016/j.chom.2008.09.009
62. Wu H. J., Ivanov I. I., Darce J., Hattori K., Shima T., Umesaki Y., Littman D. R., Benoist C., Mathis D., Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 2010 32 6 815 827 2-s2.0-77953913586 10.1016/j.immuni.2010.06.001
63. Abdollahi-Roodsaz S., Joosten L. A. B., Koenders M. I., Devesa I., Roelofs M. F., Radstake T. R. D. J., Heuvelmans-Jacobs M., Akira S., Nicklin M. J. H., Ribeiro-Dias F., van den Berg W. B., Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. Journal of Clinical Investigation 2008 118 1 205 216 2-s2.0-38149048556 10.1172/JCI32639
64. Yoshitomi H., Sakaguchi N., Kobayashi K., Brown G. D., Tagami T., Sakihama T., Hirota K., Tanaka S., Nomura T., Miki I., Gordon S., Akira S., Nakamura T., Sakaguchi S., A role for fungal β -glucans and their receptor dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. Journal of Experimental Medicine 2005 201 6 949 960 2-s2.0-20244373339 10.1084/jem.20041758 (Pubitemid 40524464)
65. Sundrud M. S., Koralov S. B., Feuerer M., Calado D. P., Kozhaya A. E., Rhule-Smith A., Lefebvre R. E., Unutmaz D., Mazitschek R., Waldner H., Whitman M., Keller T., Rao A., Halofuginone inhibits th17 cell differentiation by activating the amino acid starvation response. Science 2009 324 5932 1334 1338 2-s2.0-66749107425 10.1126/science.1172638
66. Huh J. R., Leung M. W.L., Huang P., Ryan D. A., Krout M. R., Malapaka R. R.V., Chow J., Manel N., Ciofani M., Kim S. V., Cuesta A., Santori F. R., Lafaille J. J., Xu H. E., Gin D. Y., Rastinejad F., Littman D. R., Dan.Littman@med.nyu.edu Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing ROR γ 3t activity. Nature 2011 472 7344 486 490 10.1038/nature09978
67. Awasthi A., Kuchroo V., vkuchroo@rics.bwh.harvard.edu Value added: neural progenitor cells suppress inflammation and autoimmunity. Immunity 2011 35 2 156 157 10.1016/j.immuni.2011.08.005
68. Cao W., Yang Y., Wang Z., Liu A., Fang L., Wu F., Hong J., Shi Y., Leung S., Dong C., Zhang J., jingwu.z.zang@gsk.com Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease. Immunity 2011 35 2 273 284 10.1016/j.immuni.2011.06.011
69. Agarwal S., Misra R., Aggarwal A., Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases. Journal of Rheumatology 2008 35 3 515 519 2-s2.0-40649083317 (Pubitemid 351374430)
70. Liu F. C., Chang D. M., Lai J. H., Lin C. K., Chen H. C., Hou T. Y., Kuo S. Y., Autoimmune hepatitis with raised alpha-fetoprotein level as the presenting symptoms of systemic lupus erythematosus: a case report. Rheumatology International 2007 27 5 489 491 2-s2.0-33847118908 10.1007/s00296-006-0242-0 (Pubitemid 46294987)
71. Wong C. K., Ho C. Y., Li E. K., Lam C. W. K., Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus. Lupus 2000 9 8 589 593 2-s2.0-0033772374
72. Chabaud M., Fossiez F., Taupin J. L., Miossec P., Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines. Journal of Immunology 1998 161 1 409 414 2-s2.0-0031802932 (Pubitemid 28285549)
73. Venken K., Hellings N., Hensen K., Rummens J. L., Stinissen P., Memory CD4+CD127high T cells from patients with multiple sclerosis produce IL-17 in response to myelin antigens. Journal of Neuroimmunology 2010 226 1-2 185 191 2-s2.0-77956338425 10.1016/j.jneuroim.2010.05.025
74. Kebir H., Ifergan I., Alvarez J. I., Bernard M., Poirier J., Arbour N., Duquette P., Prat A., Preferential recruitment of interferon- γ -expressing TH17 cells in multiple sclerosis. Annals of Neurology 2009 66 3 390 402 2-s2.0-70350052626 10.1002/ana.21748
75. Segal B. M., Constantinescu C. S., Raychaudhuri A., Kim L., Fidelus-Gort R., Kasper L. H., Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study. The Lancet Neurology 2008 7 9 796 804 2-s2.0-48849087125 10.1016/S1474-4422(08) 70173-X
76. Patel A. M., aarat.patel@chp.edu Moreland L. W., Interleukin-6 inhibition for treatment of rheumatoid arthritis: a review of tocilizumab therapy. Drug Design, Development and Therapy 2010 4 263 278 10.2147/DDDT.S14099
77. Geyer M., Müller-Ladner U., Actual status of antiinterleukin-1 therapies in rheumatic diseases. Current Opinion in Rheumatology 2010 22 3 246 251 2-s2.0-77950258225 10.1097/BOR.0b013e3283373fa0
78. Genovese M. C., van den Bosch F., Roberson S. A., Bojin S., Biagini I. M., Ryan P., Sloan-Lancaster J., LY2439821, a humanized anti-interleukin-17 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, double-blind, placebo-controlled, proof-of-concept study. Arthritis and Rheumatism 2010 62 4 929 939 2-s2.0-77950535421 10.1002/art.27334
79. Res P. C. M., Piskin G., de Boer O. J., van der Loos C. M., Teeling P., Bos J. D., Teunissen M. B. M., Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis. PLoS ONE 2010 5 11 2-s2.0-78649666553 10.1371/journal.pone.0014108 e14108
80. Wilson N. J., Boniface K., Chan J. R., McKenzie B. S., Blumenschein W. M., Mattson J. D., Basham B., Smith K., Chen T., Morel F., Lecron J. C., Kastelein R. A., Cua D. J., McClanahan T. K., Bowman E. P., Malefyt R. D. W., Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nature Immunology 2007 8 9 950 957 2-s2.0-34548133583 10.1038/ni1497 (Pubitemid 47300009)
81. Gottlieb A., Menter A., Mendelsohn A., Shen Y. K., Li S., Guzzo C., Fretzin S., Kunynetz R., Kavanaugh A., Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial. The Lancet 2009 373 9664 633 640 2-s2.0-60249084148 10.1016/S0140-6736(09)60140-9
82. Griffiths C. E.M., christopher.griffiths@manchester.ac.uk Comparing biological therapies in psoriasis: implications for clinical practice. Journal of the European Academy of Dermatology and Venereology 2010 24 supplement 6 10 14 10.1111/j.1468-3083.2010.03831.x
83. Duerr R. H., Taylor K. D., Brant S. R., Rioux J. D., Silverberg M. S., Daly M. J., Steinhart A. H., Abraham C., Regueiro M., Griffiths A., Dassopoulos T., Bitton A., Yang H., Targan S., Datta L. W., Kistner E. O., Schumm L. P., Lee A. T., Gregersen P. K., Barmada M. M., Rotter J. I., Nicolae D. L., Cho J. H., A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006 314 5804 1461 1463 2-s2.0-33845340501 10.1126/science.1135245 (Pubitemid 44871953)
84. Annunziato F., Cosmi L., Santarlasci V., Maggi L., Liotta F., Mazzinghi B., Parente E., Filì L., Ferri S., Frosali F., Giudici F., Romagnani P., Parronchi P., Tonelli F., Maggi E., Romagnani S., Phenotypic and functional features of human Th17 cells. Journal of Experimental Medicine 2007 204 8 1849 1861 2-s2.0-34547734621 10.1084/jem.20070663 (Pubitemid 47240944)
85. Kleinschek M. A., Boniface K., Sadekova S., Grein J., Murphy E. E., Turner S. P., Raskin L., Desai B., Faubion W. A., De Malefyt R. W., Pierce R. H., McClanahan T., Kastelein R. A., Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation. Journal of Experimental Medicine 2009 206 3 525 534 2-s2.0-63449133361 10.1084/jem.20081712
86. Leonardi C. L., Kimball A. B., Papp K. A., Yeilding N., Guzzo C., Wang Y., Li S., Dooley L. T., Gordon K. B., Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1). The Lancet 2008 371 9625 1665 1674 2-s2.0-43449111187 10.1016/S0140-6736(08) 60725-4 (Pubitemid 351671883)
87. Nair R. P., Duffin K. C., Helms C., Ding J., Stuart P. E., Goldgar D., Gudjonsson J. E., Li Y., Tejasvi T., Feng B. J., Ruether A., Schreiber S., Weichenthal M., Gladman D., Rahman P., Schrodi S. J., Prahalad S., Guthery S. L., Fischer J., Liao W., Kwok P. Y., Menter A., Lathrop G. M., Wise C. A., Begovich A. B., Voorhees J. J., Elder J. T., Krueger G. G., Bowcock A. M., Abecasis G. R., Genome-wide scan reveals association of psoriasis with IL-23 and NF- κ B pathways. Nature Genetics 2009 41 2 199 204 2-s2.0-59149106117 10.1038/ng.311
88. Huber A. M., Gaboury I., Cabral D. A., Lang B., Ni A., Stephure D., Taback S., Dent P., Ellsworth J., LeBlanc C., Saint-Cyr C., Scuccimarri R., Hay J., Lentle B., Matzinger M., Shenouda N., Moher D., Rauch F., Siminoski K., Ward L. M., Feber J., Halton J., Roth J., Kloiber R., Lewis V., Midgley J., Miettunen P., Dix D. B., Houghton K., Nadel H. R., White C., Clarson C., Stein R., Cairney E., Filler G., Grimmer J., Sparrow K., Cummings E., Fernandez C., O'Brien K., Ross A., Atkinson S., Arora S., Barr R., Coblentz C., Webber C., Rodd C., Abish S., Bell L., Glorieux F., Alos N., Dubois J., Laverdière C., Phan V., Couch R., Pinsk M., Wilson B., Grant R., Charron M., Hebert D., Blydt-Hansen T., Israels S., Oen K., Reed M., Prevalent vertebral fractures among children initiating glucocorticoid therapy for the treatment of rheumatic disorders. Arthritis Care and Research 2010 62 4 516 526 2-s2.0-77950372125 10.1002/acr.20171
89. Taleb S., Romain M., Ramkhelawon B., Uyttenhove C., Pasterkamp G., Herbin O., Esposito B., Perez N., Yasukawa H., Van Snick J., Yoshimura A., Tedgui A., Mallat Z., Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis. Journal of Experimental Medicine 2009 206 10 2067 2077 2-s2.0-70350433833 10.1084/jem.20090545
90. Kisand K., Boe Wolff A. S., Podkrajšek K. T., Tserel L., Link M., Kisand K. V., Ersvaer E., Perheentupa J., Erichsen M. M., Bratanic N., Meloni A., Cetani F., Perniola R., Ergun-Longmire B., Maclaren N., Krohn K. J. E., Pura M., Schalke B., Ströbel P., Leite M. I., Battelino T., Husebye E. S., Peterson P., Willcox N., Meager A., Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. Journal of Experimental Medicine 2010 207 2 299 308 2-s2.0-77149147477 10.1084/jem.20091669
91. Bywaters E. G., Still's disease in the adult. Annals of the Rheumatic Diseases 1971 30 2 121 133 2-s2.0-0015030792
92. Ohta A., Yamaguchi M., Kaneoka H., Nagayoshi T., Hiida M., Adult Still's disease: review of 228 cases from the literature. Journal of Rheumatology 1988 14 6 1139 1146 2-s2.0-0023851479 (Pubitemid 18049931)
93. Chen D. Y., Lan J. L., Lin F. J., Hsieh T. Y., Proinflammatory cytokine profiles in sera and pathological tissues of patients with active untreated adult onset still's disease. Journal of Rheumatology 2004 31 11 2189 2198 2-s2.0-7544248841
94. Chen D. Y., Lan J. L., Lin F. J., Hsieh T. Y., Wen M. C., Predominance of Th1 cytokine in peripheral blood and pathological tissues of patients with active untreated adult onset Still's disease. Annals of the Rheumatic Diseases 2004 63 10 1300 1306 2-s2.0-4644253851 10.1136/ard.2003.013680 (Pubitemid 39273513)
95. Choi J. H., Suh C. H., Lee Y. M., Suh Y. J., Lee S. K., Kim S. S., Nahm D. H., Park H. S., Serum cytokine profiles in patients with adult onset Still's disease. Journal of Rheumatology 2003 30 11 2422 2427 2-s2.0-0242609036
96. Kawashima M., Yamamura M., Taniai M., Yamauchi H., Tanimoto T., Kurimoto M., Miyawaki S., Amano T., Takeuchi T., Makino H., Levels of interleukin-18 and its binding inhibitors in the blood circulation of patients with adult-onset Still's disease. Arthritis and Rheumatism 2001 44 3 550 560 2-s2.0-0035080102 10.1002/1529-0131(200103)44:3550::AID-ANR103>3.0.CO;2-5 (Pubitemid 32234613)
97. Chen D. Y., Chen Y. M., Lan J. L., Lin C. C., Chen H. H., Hsieh C. W., Potential role of th17 cells in the pathogenesis of adult-onset Still's disease. Rheumatology 2010 49 12 2305 2312 2-s2.0-78549270112 10.1093/rheumatology/ keq284 keq284
98. Yang J., Chu Y., Yang X., Gao D., Zhu L., Yang X., Wan L., Li M., Th17 and natural treg cell population dynamics in systemic lupus erythematosus. Arthritis and Rheumatism 2009 60 5 1472 1483 2-s2.0-66049151440 10.1002/art.24499
99. Jen H. Y., Chuang Y. H., Lin S. C., Chiang B. L., Yang Y. H., yan0126@ms15.hinet.net Increased serum interleukin-17 and peripheral Th17 cells in children with acute Henoch-Schönlein purpura. Pediatric Allergy and Immunology 2011 22 8 862 868 10.1111/j.1399-3038.2011.01198.x
100. Chang H., Hanawa H., Yoshida T., Hayashi M., Liu H., Ding L., Otaki K., Hao K., Yoshida K., Kato K., Toba K., Kodama M., Maruyama H., Miyazaki J., Aizawa Y., Alteration of IL-17 related protein expressions in experimental autoimmune myocarditis and inhibition of IL-17 by IL-10-Ig fusion gene transfer. Circulation Journal 2008 72 5 813 819 2-s2.0-44149105863 10.1253/circj.72.813 (Pubitemid 351716688)
101. Su Z., Sun C., Zhou C., HMGB 1 blockade attenuates experimental autoimmune myocarditis possibly by suppressing Th17-cell expansion. European Journal of Immunology 2011 41 12 3586 3595 10.1002/eji.201141879
102. Valaperti A., Marty R. R., Kania G., Germano D., Mauermann N., Dirnhofer S., Leimenstoll B., Blyszczuk P., Dong C., Mueller C., Hunziker L., Eriksson U., CD11b+ monocytes abrogate Th17 CD4+ T cell-mediated experimental autoimmune myocarditis. Journal of Immunology 2008 180 4 2686 2695 2-s2.0-42149133146