Age-dependent decreases in DNA methyltransferase levels and low transmethylation micronutrient levels synergize to promote overexpression of genes implicated in autoimmunity and acute coronary syndromes

Experimental Gerontology

Volumn 45, Issue 4, 2010, Pages 312-322

  Li, YePeng ^a   Liu, Ying ^a   Strickland, Faith M ^a   Richardson, Bruce ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

Aging; DNA methylation; Epigenetics; Nutrition; Senescence

Indexed keywords

CD70 ANTIGEN; DNA METHYLTRANSFERASE 1; FOLIC ACID; HOMOCYSTEINE; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; METHIONINE;

ACUTE CORONARY SYNDROME; ADULT; AGE DISTRIBUTION; AGED; AGING; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DNA METHYLATION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MALE; NUTRITION; PRIORITY JOURNAL; T LYMPHOCYTE;

ACUTE CORONARY SYNDROME; ADULT; AGED; AGED, 80 AND OVER; AGING; ANTIGENS, CD28; ANTIGENS, CD70; AUTOIMMUNE DISEASES; CELLS, CULTURED; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DNA MODIFICATION METHYLASES; FEMALE; FOLIC ACID; GENE EXPRESSION REGULATION; HOMOCYSTEINE; HUMANS; MALE; METHIONINE; MICRONUTRIENTS; MIDDLE AGED; RECEPTORS, KIR; T-LYMPHOCYTES;

EID: 77649342230     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2009.12.008     Document Type: Article

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