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Volumn 39, Issue 1, 2006, Pages 9-19

Multiple sclerosis and virus induced immune responses: Autoimmunity can be primed by molecular mimicry and augmented by bystander activation

Author keywords

Autoimmune diseases; Experimental allergic encephalomyelitis; Immunological models; Myelin proteolipid protein; Virology; Virus diseases

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; BETA1A INTERFERON; BRAIN PROTEIN; FREUND ADJUVANT; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12 ANTIBODY; INTERLEUKIN 23; LISOFYLLINE; VIRUS PROTEIN;

EID: 33745070952     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930500484799     Document Type: Article
Times cited : (108)

References (119)
  • 1
    • 0001983710 scopus 로고
    • Multiple sclerosis. History, definition and general considerations
    • Amsterdam: North-Holland Publishing Company
    • Dejong, RN. (1970) Multiple sclerosis. History, definition and general considerations. In Multiple sclerosis and other demyelinating diseases. (pp. 45-62). Amsterdam: North-Holland Publishing Company.
    • (1970) Multiple Sclerosis and Other Demyelinating Diseases , pp. 45-62
    • Dejong, R.N.1
  • 3
  • 4
    • 0034026912 scopus 로고    scopus 로고
    • Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation
    • Bitsch, A and Schuchardt, J and Bunkowski, S and Kuhlmann, T and Brück, W. (2000) Acute axonal injury in multiple sclerosis. Correlation with demyelination and inflammation Brain, 123, pp. 1174-1183.
    • (2000) Brain , vol.123 , pp. 1174-1183
    • Bitsch, A.1    Schuchardt, J.2    Bunkowski, S.3    Kuhlmann, T.4    Brück, W.5
  • 5
    • 0024536815 scopus 로고
    • T-lymphocyte subsets in the multiple sclerosis lesion
    • Sobel, RA. (1989) T-lymphocyte subsets in the multiple sclerosis lesion Res Immunol, 140, pp. 208-211.
    • (1989) Res Immunol , vol.140 , pp. 208-211
    • Sobel, R.A.1
  • 10
    • 0027313558 scopus 로고
    • Viral infections trigger multiple sclerosis relapses: A prospective seroepidemiological study
    • Andersen, O and Lygner, PE and Bergstrom, T and Andersson, M and Vahlne, A. (1993) Viral infections trigger multiple sclerosis relapses: A prospective seroepidemiological study J Neurol, 240, pp. 417-422.
    • (1993) J Neurol , vol.240 , pp. 417-422
    • Andersen, O.1    Lygner, P.E.2    Bergstrom, T.3    Andersson, M.4    Vahlne, A.5
  • 11
    • 0031776202 scopus 로고    scopus 로고
    • Clinical relapses and disease activity on magnetic resonance imaging associated with viral upper respiratory tract infections in multiple sclerosis
    • Edwards, S and Zvartau, M and Clarke, H and Irving, W and Blumhardt, LD. (1998) Clinical relapses and disease activity on magnetic resonance imaging associated with viral upper respiratory tract infections in multiple sclerosis J Neurol Neurosurg Psychiatry, 64, pp. 736-741.
    • (1998) J Neurol Neurosurg Psychiatry , vol.64 , pp. 736-741
    • Edwards, S.1    Zvartau, M.2    Clarke, H.3    Irving, W.4    Blumhardt, L.D.5
  • 12
    • 0028333890 scopus 로고
    • Influence of infection on exacerbations of multiple sclerosis
    • Panitch, HS. (1994) Influence of infection on exacerbations of multiple sclerosis Ann Neurol, 36(Suppl), pp. S25-S28.
    • (1994) Ann Neurol , vol.36 , Issue.SUPPL.
    • Panitch, H.S.1
  • 13
    • 0021856495 scopus 로고
    • Clinical viral infections and multiple sclerosis
    • Sibley, WA and Bamford, CR and Clark, K. (1985) Clinical viral infections and multiple sclerosis Lancet, 1, pp. 1313-1315.
    • (1985) Lancet , vol.1 , pp. 1313-1315
    • Sibley, W.A.1    Bamford, C.R.2    Clark, K.3
  • 14
    • 0004820549 scopus 로고    scopus 로고
    • Chronic inflammatory and demyelinating diseases
    • Philadelphia and New York: Lippincott-Raven Publishers
    • Johnson, RT. (1998) Chronic inflammatory and demyelinating diseases. In Viral infections of the nervous system2. (pp. 227-263). Philadelphia and New York: Lippincott-Raven Publishers.
    • (1998) Viral Infections of the Nervous System , vol.2 , pp. 227-263
    • Johnson, R.T.1
  • 15
    • 0020560134 scopus 로고
    • Molecular mimicry in virus infection: Crossreaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments
    • Fujinami, RS and Oldstone, MBA and Wroblewska, Z and Frankel, ME and Koprowski, H. (1983) Molecular mimicry in virus infection: Crossreaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments Proc Natl Acad Sci USA, 80, pp. 2346-2350.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 2346-2350
    • Fujinami, R.S.1    Oldstone, M.B.A.2    Wroblewska, Z.3    Frankel, M.E.4    Koprowski, H.5
  • 16
    • 0022375427 scopus 로고
    • Amino acid homology between the encephalitogenic site of myelin basic protein and virus: Mechanism for autoimmunity
    • Fujinami, RS and Oldstone, MBA. (1985) Amino acid homology between the encephalitogenic site of myelin basic protein and virus: Mechanism for autoimmunity Science, 230, pp. 1043-1045.
    • (1985) Science , vol.230 , pp. 1043-1045
    • Fujinami, R.S.1    Oldstone, M.B.A.2
  • 17
    • 0035103878 scopus 로고    scopus 로고
    • Herpes simplex virus-induced keratitis: Evaluation of the role of molecular mimicry in lesion pathogenesis
    • Deshpande, SP and Lee, S and Zheng, M and Song, B and Knipe, D and Kapp, JA and Rouse, BT. (2001) Herpes simplex virus-induced keratitis: Evaluation of the role of molecular mimicry in lesion pathogenesis J Virol, 75, pp. 3077-3088.
    • (2001) J Virol , vol.75 , pp. 3077-3088
    • Deshpande, S.P.1    Lee, S.2    Zheng, M.3    Song, B.4    Knipe, D.5    Kapp, J.A.6    Rouse, B.T.7
  • 18
    • 1842613450 scopus 로고    scopus 로고
    • Microorganisms and autoimmunity: Making the barren field fertile?
    • von Herrath, MG and Fujinami, RS and Whitton, JL. (2003) Microorganisms and autoimmunity: Making the barren field fertile? Nat Rev Microbiol, 1, pp. 151-157.
    • (2003) Nat Rev Microbiol , vol.1 , pp. 151-157
    • von Herrath, M.G.1    Fujinami, R.S.2    Whitton, J.L.3
  • 20
    • 0020551984 scopus 로고
    • Isolation of myelin basic protein-reactive T-cell lines from normal human blood
    • Burns, J and Rosenzweig, A and Zweiman, B and Lisak, RP. (1983) Isolation of myelin basic protein-reactive T-cell lines from normal human blood Cell Immunol, 81, pp. 435-440.
    • (1983) Cell Immunol , vol.81 , pp. 435-440
    • Burns, J.1    Rosenzweig, A.2    Zweiman, B.3    Lisak, R.P.4
  • 21
    • 0021019539 scopus 로고
    • Expansion of antigen-specific T cells from cerebrospinal fluid of patients with multiple sclerosis
    • Richert, JR and McFarlin, DE and Rose, JW and McFarland, HF and Greenstein, JI. (1983) Expansion of antigen-specific T cells from cerebrospinal fluid of patients with multiple sclerosis J Neuroimmunol, 5, pp. 317-324.
    • (1983) J Neuroimmunol , vol.5 , pp. 317-324
    • Richert, J.R.1    McFarlin, D.E.2    Rose, J.W.3    McFarland, H.F.4    Greenstein, J.I.5
  • 22
    • 0024334453 scopus 로고
    • Response of human T lymphocyte lines to myelin basic protein: Association of dominant epitopes with HLA class II restriction molecules
    • Chou, YK and Vainiene, M and Whitham, R and Bourdette, D and Chou, CH and Hashim, G and Offner, H and Vandenbark, AA. (1989) Response of human T lymphocyte lines to myelin basic protein: Association of dominant epitopes with HLA class II restriction molecules J Neurosci Res, 23, pp. 207-216.
    • (1989) J Neurosci Res , vol.23 , pp. 207-216
    • Chou, Y.K.1    Vainiene, M.2    Whitham, R.3    Bourdette, D.4    Chou, C.H.5    Hashim, G.6    Offner, H.7    Vandenbark, A.A.8
  • 23
    • 0024997357 scopus 로고
    • Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals
    • Martin, R and Jaraquemada, D and Flerlage, M and Richert, J and Whitaker, J and Long, EO and McFarlin, DE and McFarland, HF. (1990) Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals J Immunol, 145, pp. 540-548.
    • (1990) J Immunol , vol.145 , pp. 540-548
    • Martin, R.1    Jaraquemada, D.2    Flerlage, M.3    Richert, J.4    Whitaker, J.5    Long, E.O.6    McFarlin, D.E.7    McFarland, H.F.8
  • 24
    • 0025188659 scopus 로고
    • Myelin basic protein-specific T lymphocyte lines from MS patients and healthy individuals
    • Pette, M and Fujita, K and Kitze, B and Whitaker, JN and Albert, E and Kappos, L and Wekerle, H. (1990) Myelin basic protein-specific T lymphocyte lines from MS patients and healthy individuals Neurology, 40, pp. 1770-1776.
    • (1990) Neurology , vol.40 , pp. 1770-1776
    • Pette, M.1    Fujita, K.2    Kitze, B.3    Whitaker, J.N.4    Albert, E.5    Kappos, L.6    Wekerle, H.7
  • 25
    • 0025325226 scopus 로고
    • Shared human T cell receptor Vβ usage to immunodominant regions of myelin basic protein
    • Wucherpfennig, KW and Ota, K and Endo, N and Seidman, JG and Rosenzweig, A and Weiner, HL and Hafler, DA. (1990) Shared human T cell receptor Vβ usage to immunodominant regions of myelin basic protein Science, 248, pp. 1016-1019.
    • (1990) Science , vol.248 , pp. 1016-1019
    • Wucherpfennig, K.W.1    Ota, K.2    Endo, N.3    Seidman, J.G.4    Rosenzweig, A.5    Weiner, H.L.6    Hafler, D.A.7
  • 26
    • 0025013169 scopus 로고
    • Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-γ
    • Olsson, T and Zhi, WW and Hojeberg, B and Kostulas, V and Jiang, YP and Anderson, G and Ekre, HP and Link, H. (1990) Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-γ J Clin Investig, 86, pp. 981-985.
    • (1990) J Clin Investig , vol.86 , pp. 981-985
    • Olsson, T.1    Zhi, W.W.2    Hojeberg, B.3    Kostulas, V.4    Jiang, Y.P.5    Anderson, G.6    Ekre, H.P.7    Link, H.8
  • 27
    • 0029888979 scopus 로고    scopus 로고
    • Two models for multiple sclerosis: Experimental allergic encephalomyelitis and Theiler's murine encephalomyelitis virus
    • Tsunoda, I and Fujinami, RS. (1996) Two models for multiple sclerosis: Experimental allergic encephalomyelitis and Theiler's murine encephalomyelitis virus J Neuropathol Exp Neurol, 55, pp. 673-686.
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 673-686
    • Tsunoda, I.1    Fujinami, R.S.2
  • 28
    • 0033519264 scopus 로고    scopus 로고
    • Infection with a recombinant vaccinia virus encoding myelin proteolipid protein causes suppression of chronic relapsing-remitting experimental allergic encephalomyelitis
    • Wang, L-Y and Theil, DJ and Whitton, JL and Fujinami, RS. (1999) Infection with a recombinant vaccinia virus encoding myelin proteolipid protein causes suppression of chronic relapsing-remitting experimental allergic encephalomyelitis J Neuroimmunol, 96, pp. 148-157.
    • (1999) J Neuroimmunol , vol.96 , pp. 148-157
    • Wang, L.-Y.1    Theil, D.J.2    Whitton, J.L.3    Fujinami, R.S.4
  • 29
    • 0027333348 scopus 로고
    • Tickling the TCR: Selective T-cell functions stimulated by altered peptide ligands
    • Evavold, BD and Sloan-Lancaster, J and Allen, PM. (1993) Tickling the TCR: Selective T-cell functions stimulated by altered peptide ligands Immunol Today, 14, pp. 602-609.
    • (1993) Immunol Today , vol.14 , pp. 602-609
    • Evavold, B.D.1    Sloan-Lancaster, J.2    Allen, P.M.3
  • 31
    • 0025754853 scopus 로고
    • Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response
    • Oldstone, MBA and Nerenberg, M and Southern, P and Price, J and Lewicki, H. (1991) Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response Cell, 65, pp. 319-331.
    • (1991) Cell , vol.65 , pp. 319-331
    • Oldstone, M.B.A.1    Nerenberg, M.2    Southern, P.3    Price, J.4    Lewicki, H.5
  • 32
    • 0030066265 scopus 로고    scopus 로고
    • Virus-induced autoimmune disease: Transgenic approach to mimic insulin-dependent diabetes mellitus and multiple sclerosis
    • Oldstone, MBA and von Herrath, MG and Evans, CF and Horwitz, MS. (1996) Virus-induced autoimmune disease: Transgenic approach to mimic insulin-dependent diabetes mellitus and multiple sclerosis Curr Top Microbiol Immunol, 206, pp. 67-83.
    • (1996) Curr Top Microbiol Immunol , vol.206 , pp. 67-83
    • Oldstone, M.B.A.1    von Herrath, M.G.2    Evans, C.F.3    Horwitz, M.S.4
  • 33
    • 0036185313 scopus 로고    scopus 로고
    • Regulation of virally induced autoimmunity and immunopathology: Contribution of LCMV transgenic models to understanding autoimmune insulin-dependent diabetes mellitus
    • von Herrath, MG. (2002) Regulation of virally induced autoimmunity and immunopathology: Contribution of LCMV transgenic models to understanding autoimmune insulin-dependent diabetes mellitus Curr Top Microbiol Immunol, 263, pp. 145-175.
    • (2002) Curr Top Microbiol Immunol , vol.263 , pp. 145-175
    • von Herrath, M.G.1
  • 34
    • 0035230967 scopus 로고    scopus 로고
    • Is activation of autoreactive lymphocytes always detrimental? Viral infections and regulatory circuits in autoimmunity
    • von Herrath, MG and Oldstone, MBA and Homann, D and Christen, U. (2001) Is activation of autoreactive lymphocytes always detrimental? Viral infections and regulatory circuits in autoimmunity Curr Dir Autoimmun, 4, pp. 91-122.
    • (2001) Curr Dir Autoimmun , vol.4 , pp. 91-122
    • von Herrath, M.G.1    Oldstone, M.B.A.2    Homann, D.3    Christen, U.4
  • 35
    • 0029551987 scopus 로고
    • Coexpression of B7-1 and viral ("self") transgenes in pancreatic β cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes
    • von Herrath, MG and Guerder, S and Lewicki, H and Flavell, RA and Oldstone, MBA. (1995) Coexpression of B7-1 and viral ("self") transgenes in pancreatic β cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes Immunity, 3, pp. 727-738.
    • (1995) Immunity , vol.3 , pp. 727-738
    • von Herrath, M.G.1    Guerder, S.2    Lewicki, H.3    Flavell, R.A.4    Oldstone, M.B.A.5
  • 36
    • 0031051747 scopus 로고    scopus 로고
    • Interferon-γ is essential for destruction of β cells and development of insulin-dependent diabetes mellitus
    • von Herrath, MG and Oldstone, MBA. (1997) Interferon-γ is essential for destruction of β cells and development of insulin-dependent diabetes mellitus J Exp Med, 185, pp. 531-539.
    • (1997) J Exp Med , vol.185 , pp. 531-539
    • von Herrath, M.G.1    Oldstone, M.B.A.2
  • 37
    • 0031171380 scopus 로고    scopus 로고
    • Pathological changes in the islet milieu precede infiltration of islets and destruction of β-cells by autoreactive lymphocytes in a transgenic model of virus-induced IDDM
    • von Herrath, MG and Holz, A. (1997) Pathological changes in the islet milieu precede infiltration of islets and destruction of β-cells by autoreactive lymphocytes in a transgenic model of virus-induced IDDM J Autoimmun, 10, pp. 231-238.
    • (1997) J Autoimmun , vol.10 , pp. 231-238
    • von Herrath, M.G.1    Holz, A.2
  • 38
    • 0034712898 scopus 로고    scopus 로고
    • Consequences of cross-reactive and bystander CTL responses during viral infections
    • Welsh, RM and McNally, JM and Brehm, MA and Selin, LK. (2000) Consequences of cross-reactive and bystander CTL responses during viral infections Virology, 270, pp. 4-8.
    • (2000) Virology , vol.270 , pp. 4-8
    • Welsh, R.M.1    McNally, J.M.2    Brehm, M.A.3    Selin, L.K.4
  • 39
    • 0036301672 scopus 로고    scopus 로고
    • T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens
    • Brehm, MA and Pinto, AK and Daniels, KA and Schneck, JP and Welsh, RM and Selin, LK. (2002) T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens Nat Immunol, 3, pp. 627-634.
    • (2002) Nat Immunol , vol.3 , pp. 627-634
    • Brehm, M.A.1    Pinto, A.K.2    Daniels, K.A.3    Schneck, J.P.4    Welsh, R.M.5    Selin, L.K.6
  • 41
    • 0032476684 scopus 로고    scopus 로고
    • Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations
    • Selin, LK and Varga, SM and Wong, IC and Welsh, RM. (1998) Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations J Exp Med, 188, pp. 1705-1715.
    • (1998) J Exp Med , vol.188 , pp. 1705-1715
    • Selin, L.K.1    Varga, S.M.2    Wong, I.C.3    Welsh, R.M.4
  • 42
    • 33644965745 scopus 로고    scopus 로고
    • TMEV and neuroantigens: Myelin genes and proteins, molecular mimicry, epitope spreading, and autoantibody-mediated remyelination
    • New York: Springer
    • Tsunoda, I and Fujinami, RS. (2005) TMEV and neuroantigens: Myelin genes and proteins, molecular mimicry, epitope spreading, and autoantibody-mediated remyelination. In Experimental models of multiple sclerosis. New York: Springer.
    • (2005) Experimental Models of Multiple Sclerosis
    • Tsunoda, I.1    Fujinami, R.S.2
  • 43
    • 0000681669 scopus 로고    scopus 로고
    • Theiler's murine encephalomyelitis virus
    • Chichester: John Wiley & Sons Ltd
    • Tsunoda, I and Fujinami, RS. (1999) Theiler's murine encephalomyelitis virus. In Persistent viral infections. (pp. 517-536). Chichester: John Wiley & Sons Ltd.
    • (1999) Persistent Viral Infections , pp. 517-536
    • Tsunoda, I.1    Fujinami, R.S.2
  • 44
    • 0023739322 scopus 로고
    • Monoclonal antibody defines determinant between Theiler's virus and lipid-like structures
    • Fujinami, RS and Zurbriggen, A and Powell, HC. (1988) Monoclonal antibody defines determinant between Theiler's virus and lipid-like structures J Neuroimmunol, 20, pp. 25-32.
    • (1988) J Neuroimmunol , vol.20 , pp. 25-32
    • Fujinami, R.S.1    Zurbriggen, A.2    Powell, H.C.3
  • 45
    • 0025299640 scopus 로고
    • Monoclonal antibody to Theiler's murine encephalomyelitis virus defines a determinant on myelin and oligodendrocytes, and augments demyelination in experimental allergic encephalomyelitis
    • Yamada, M and Zurbriggen, A and Fujinami, RS. (1990) Monoclonal antibody to Theiler's murine encephalomyelitis virus defines a determinant on myelin and oligodendrocytes, and augments demyelination in experimental allergic encephalomyelitis J Exp Med, 171, pp. 1893-1907.
    • (1990) J Exp Med , vol.171 , pp. 1893-1907
    • Yamada, M.1    Zurbriggen, A.2    Fujinami, R.S.3
  • 46
    • 0031754296 scopus 로고    scopus 로고
    • Early cytokine responses to viral infections and their roles in shaping endogenous cellular immunity
    • Biron, CA and Cousens, LP and Ruzek, MC and Su, HC and Salazar-Mather, TP. (1998) Early cytokine responses to viral infections and their roles in shaping endogenous cellular immunity Adv Exp Med Biol, 452, pp. 143-149.
    • (1998) Adv Exp Med Biol , vol.452 , pp. 143-149
    • Biron, C.A.1    Cousens, L.P.2    Ruzek, M.C.3    Su, H.C.4    Salazar-Mather, T.P.5
  • 47
    • 0033009888 scopus 로고    scopus 로고
    • Natural killer cells in antiviral defense: Function and regulation by innate cytokines
    • Biron, CA and Nguyen, KB and Pien, GC and Cousens, LP and Salazar-Mather, TP. (1999) Natural killer cells in antiviral defense: Function and regulation by innate cytokines Annu Rev Immunol, 17, pp. 189-220.
    • (1999) Annu Rev Immunol , vol.17 , pp. 189-220
    • Biron, C.A.1    Nguyen, K.B.2    Pien, G.C.3    Cousens, L.P.4    Salazar-Mather, T.P.5
  • 48
    • 0032191176 scopus 로고    scopus 로고
    • Role of early cytokines, including alpha and beta interferons (IFN-αβ), in innate and adaptive immune responses to viral infections
    • Biron, CA. (1998) Role of early cytokines, including alpha and beta interferons (IFN-αβ), in innate and adaptive immune responses to viral infections Semin Immunol, 10, pp. 383-390.
    • (1998) Semin Immunol , vol.10 , pp. 383-390
    • Biron, C.A.1
  • 49
    • 0031017252 scopus 로고    scopus 로고
    • Interferon-α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection
    • Cousens, LP and Orange, JS and Su, HC and Biron, CA. (1997) Interferon-α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection Proc Natl Acad Sci USA, 94, pp. 634-639.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 634-639
    • Cousens, L.P.1    Orange, J.S.2    Su, H.C.3    Biron, C.A.4
  • 50
    • 0030271360 scopus 로고    scopus 로고
    • Interferon beta in multiple sclerosis
    • Arnason, BGW. (1996) Interferon beta in multiple sclerosis Clin Immunol Immunopathol, 81, pp. 1-11.
    • (1996) Clin Immunol Immunopathol , vol.81 , pp. 1-11
    • Arnason, B.G.W.1
  • 51
    • 0031722187 scopus 로고    scopus 로고
    • In vivo dynamics of anti-viral CD8 T cell responses to different epitopes. An evaluation of bystander activation in primary and secondary responses to viral infection
    • Murali-Krishna, K and Altman, JD and Suresh, M and Sourdive, D and Zajac, A and Ahmed, R. (1998) In vivo dynamics of anti-viral CD8 T cell responses to different epitopes. An evaluation of bystander activation in primary and secondary responses to viral infection Adv Exp Med Biol, 452, pp. 123-142.
    • (1998) Adv Exp Med Biol , vol.452 , pp. 123-142
    • Murali-Krishna, K.1    Altman, J.D.2    Suresh, M.3    Sourdive, D.4    Zajac, A.5    Ahmed, R.6
  • 52
    • 0033843272 scopus 로고    scopus 로고
    • Evolution of the CD8 T-cell repertoire during infections
    • Lin, MY and Selin, LK and Welsh, RM. (2000) Evolution of the CD8 T-cell repertoire during infections Microbes Infect, 2, pp. 1025-1039.
    • (2000) Microbes Infect , vol.2 , pp. 1025-1039
    • Lin, M.Y.1    Selin, L.K.2    Welsh, R.M.3
  • 53
    • 0035809316 scopus 로고    scopus 로고
    • Assessing CD8 T cell number and dysfunction in the presence of antigen
    • Welsh, RM. (2001) Assessing CD8 T cell number and dysfunction in the presence of antigen J Exp Med, 193, pp. F19-F22.
    • (2001) J Exp Med , vol.193
    • Welsh, R.M.1
  • 54
    • 0028970060 scopus 로고
    • Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri, G. (1995) Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity Annu Rev Immunol, 13, pp. 251-276.
    • (1995) Annu Rev Immunol , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 55
    • 0029096181 scopus 로고
    • Requirement for natural killer cell-produced interferon γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration
    • Orange, JS and Wang, B and Terhorst, C and Biron, CA. (1995) Requirement for natural killer cell-produced interferon γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration J Exp Med, 182, pp. 1045-1056.
    • (1995) J Exp Med , vol.182 , pp. 1045-1056
    • Orange, J.S.1    Wang, B.2    Terhorst, C.3    Biron, C.A.4
  • 57
    • 0037378748 scopus 로고    scopus 로고
    • Activated, but not resting, T cells can be recognized and killed by syngeneic NK cells
    • Rabinovich, BA and Li, J and Shannon, J and Hurren, R and Chalupny, J and Cosman, D and Miller, RG. (2003) Activated, but not resting, T cells can be recognized and killed by syngeneic NK cells J Immunol, 170, pp. 3572-3576.
    • (2003) J Immunol , vol.170 , pp. 3572-3576
    • Rabinovich, B.A.1    Li, J.2    Shannon, J.3    Hurren, R.4    Chalupny, J.5    Cosman, D.6    Miller, R.G.7
  • 58
    • 18844385230 scopus 로고    scopus 로고
    • Mechanism of natural killer (NK) cell regulatory role in experimental autoimmune encephalomyelitis
    • Xu, W and Fazekas, G and Hara, H and Tabira, T. (2005) Mechanism of natural killer (NK) cell regulatory role in experimental autoimmune encephalomyelitis J Neuroimmunol, 163, pp. 24-30.
    • (2005) J Neuroimmunol , vol.163 , pp. 24-30
    • Xu, W.1    Fazekas, G.2    Hara, H.3    Tabira, T.4
  • 60
    • 0035863835 scopus 로고    scopus 로고
    • Roles of TNF-related apoptosis-inducing ligand in experimental autoimmune encephalomyelitis
    • Hilliard, B and Wilmen, A and Seidel, C and Liu, TS and Goke, R and Chen, Y. (2001) Roles of TNF-related apoptosis-inducing ligand in experimental autoimmune encephalomyelitis J Immunol, 166, pp. 1314-1319.
    • (2001) J Immunol , vol.166 , pp. 1314-1319
    • Hilliard, B.1    Wilmen, A.2    Seidel, C.3    Liu, T.S.4    Goke, R.5    Chen, Y.6
  • 62
    • 0029929032 scopus 로고    scopus 로고
    • Characterization of early IL-12, IFN-αβ, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection
    • Orange, JS and Biron, CA. (1996) Characterization of early IL-12, IFN-αβ, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection J Immunol, 156, pp. 4746-4756.
    • (1996) J Immunol , vol.156 , pp. 4746-4756
    • Orange, J.S.1    Biron, C.A.2
  • 63
    • 0028808594 scopus 로고
    • Natural killer cell activity in lymphocytic choriomeningitis virus-infected beta 2-microglobulin-deficient mice
    • Zajac, AJ and Muller, D and Pederson, K and Frelinger, JA and Quinn, DG. (1995) Natural killer cell activity in lymphocytic choriomeningitis virus-infected beta 2-microglobulin-deficient mice Int Immunol, 7, pp. 1545-1556.
    • (1995) Int Immunol , vol.7 , pp. 1545-1556
    • Zajac, A.J.1    Muller, D.2    Pederson, K.3    Frelinger, J.A.4    Quinn, D.G.5
  • 64
    • 0030890603 scopus 로고    scopus 로고
    • Mouse CD1-specific NK1 T cells: Development, specificity, and function
    • Bendelac, A and Rivera, MN and Park, SH and Roark, JH. (1997) Mouse CD1-specific NK1 T cells: Development, specificity, and function Annu Rev Immunol, 15, pp. 535-562.
    • (1997) Annu Rev Immunol , vol.15 , pp. 535-562
    • Bendelac, A.1    Rivera, M.N.2    Park, S.H.3    Roark, J.H.4
  • 68
    • 0343618469 scopus 로고    scopus 로고
    • Differential expression of NK T cell Vα24JαQ invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy
    • Illés, Z and Kondo, T and Newcombe, J and Oka, N and Tabira, T and Yamamura, T. (2000) Differential expression of NK T cell Vα24JαQ invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy J Immunol, 164, pp. 4375-4381.
    • (2000) J Immunol , vol.164 , pp. 4375-4381
    • Illés, Z.1    Kondo, T.2    Newcombe, J.3    Oka, N.4    Tabira, T.5    Yamamura, T.6
  • 69
    • 0036135559 scopus 로고    scopus 로고
    • Natural killer T cells restricted by the monomorphic MHC class 1b CD1d1 molecules behave like inflammatory cells
    • Mempel, M and Ronet, C and Suarez, F and Gilleron, M and Puzo, G and Van Kaer, L and Lehuen, A and Kourilsky, P and Gachelin, G. (2002) Natural killer T cells restricted by the monomorphic MHC class 1b CD1d1 molecules behave like inflammatory cells J Immunol, 168, pp. 365-371.
    • (2002) J Immunol , vol.168 , pp. 365-371
    • Mempel, M.1    Ronet, C.2    Suarez, F.3    Gilleron, M.4    Puzo, G.5    Van Kaer, L.6    Lehuen, A.7    Kourilsky, P.8    Gachelin, G.9
  • 70
    • 0029121325 scopus 로고
    • Selective reduction of T cells bearing invariant Vα24JαQ antigen receptor in patients with systemic sclerosis
    • Sumida, T and Sakamoto, A and Murata, H and Makino, Y and Takahashi, H and Yoshida, S and Nishioka, K and Iwamoto, I and Taniguchi, M. (1995) Selective reduction of T cells bearing invariant Vα24JαQ antigen receptor in patients with systemic sclerosis J Exp Med, 182, pp. 1163-1168.
    • (1995) J Exp Med , vol.182 , pp. 1163-1168
    • Sumida, T.1    Sakamoto, A.2    Murata, H.3    Makino, Y.4    Takahashi, H.5    Yoshida, S.6    Nishioka, K.7    Iwamoto, I.8    Taniguchi, M.9
  • 73
    • 0035025559 scopus 로고    scopus 로고
    • Dysfunction of T cell receptor AV24AJ18+, BV11+ double-negative regulatory natural killer T cells in autoimmune diseases
    • Kojo, S and Adachi, Y and Keino, H and Taniguchi, M and Sumida, T. (2001) Dysfunction of T cell receptor AV24AJ18+, BV11+ double-negative regulatory natural killer T cells in autoimmune diseases Arthritis Rheum, 44, pp. 1127-1138.
    • (2001) Arthritis Rheum , vol.44 , pp. 1127-1138
    • Kojo, S.1    Adachi, Y.2    Keino, H.3    Taniguchi, M.4    Sumida, T.5
  • 76
    • 0035956538 scopus 로고    scopus 로고
    • Interferon beta-lb is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial
    • (The UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group)
    • Paty, DW and Li, DK. (2001) Interferon beta-lb is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial Neurology, 57, pp. S10-S15. (The UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group)
    • (2001) Neurology , vol.57
    • Paty, D.W.1    Li, D.K.2
  • 77
    • 22044436956 scopus 로고    scopus 로고
    • Interferon β-1a in MS: Results following development of neutralizing antibodies in PRISMS
    • Francis, GS and Rice, GP and Alsop, JC. (2005) Interferon β-1a in MS: Results following development of neutralizing antibodies in PRISMS Neurology, 65, pp. 48-55.
    • (2005) Neurology , vol.65 , pp. 48-55
    • Francis, G.S.1    Rice, G.P.2    Alsop, J.C.3
  • 78
    • 0023126661 scopus 로고
    • Exacerbations of multiple sclerosis in patients treated with gamma interferon
    • Panitch, HS and Hirsch, RL and Haley, AS and Johnson, KP. (1987) Exacerbations of multiple sclerosis in patients treated with gamma interferon Lancet, 1, pp. 893-895.
    • (1987) Lancet , vol.1 , pp. 893-895
    • Panitch, H.S.1    Hirsch, R.L.2    Haley, A.S.3    Johnson, K.P.4
  • 79
    • 0023705457 scopus 로고
    • Treatment of multiple sclerosis with various interferons: The cons
    • Johnson, KP. (1988) Treatment of multiple sclerosis with various interferons: The cons Neurology, 38, pp. 62-65.
    • (1988) Neurology , vol.38 , pp. 62-65
    • Johnson, K.P.1
  • 80
    • 0023221133 scopus 로고
    • Treatment of multiple sclerosis with gamma interferon: Exacerbations associated with activation of the immune system
    • Panitch, HS and Hirsch, RL and Schindler, J and Johnson, KP. (1987) Treatment of multiple sclerosis with gamma interferon: Exacerbations associated with activation of the immune system Neurology, 37, pp. 1097-1102.
    • (1987) Neurology , vol.37 , pp. 1097-1102
    • Panitch, H.S.1    Hirsch, R.L.2    Schindler, J.3    Johnson, K.P.4
  • 81
    • 0000986861 scopus 로고
    • Treatment and management of multiple sclerosis
    • London: Churchill Livingstone
    • Compston, A. (1988) Treatment and management of multiple sclerosis. In McAlpine's multiple sclerosis3. (pp. 435-498). London: Churchill Livingstone.
    • (1988) McAlpine's Multiple Sclerosis , vol.3 , pp. 435-498
    • Compston, A.1
  • 82
    • 0004716474 scopus 로고    scopus 로고
    • The effects of interferon-β on cytokines and immune responses
    • New York: Marcel Dekker
    • Reichman, P. (1997) The effects of interferon-β on cytokines and immune responses. In Interferon therapy of multiple sclerosis. (pp. 161-191). New York: Marcel Dekker.
    • (1997) Interferon Therapy of Multiple Sclerosis , pp. 161-191
    • Reichman, P.1
  • 83
    • 0021846171 scopus 로고
    • The effect of recombinant α2-interferon on defective natural killer cell activity in multiple sclerosis
    • Hirsch, RL and Johnson, KP. (1985) The effect of recombinant α2-interferon on defective natural killer cell activity in multiple sclerosis Neurology, 35, pp. 597-600.
    • (1985) Neurology , vol.35 , pp. 597-600
    • Hirsch, R.L.1    Johnson, K.P.2
  • 84
    • 0020517754 scopus 로고
    • Natural killer cell activity in patients with multiple sclerosis given α interferon
    • Rice, GPA and Casali, P and Merigan, TC and Oldstone, MBA. (1983) Natural killer cell activity in patients with multiple sclerosis given α interferon Ann Neurol, 14, pp. 333-338.
    • (1983) Ann Neurol , vol.14 , pp. 333-338
    • Rice, G.P.A.1    Casali, P.2    Merigan, T.C.3    Oldstone, M.B.A.4
  • 85
    • 0023677710 scopus 로고
    • Multiple sclerosis: Involvement of interferons in lesion pathogenesis
    • Traugott, U and Lebon, P. (1988) Multiple sclerosis: Involvement of interferons in lesion pathogenesis Ann Neurol, 24, pp. 243-251.
    • (1988) Ann Neurol , vol.24 , pp. 243-251
    • Traugott, U.1    Lebon, P.2
  • 86
    • 0029410743 scopus 로고
    • Interferon-γ-induced oligodendrocyte cell death: Implications for the pathogenesis of multiple sclerosis
    • Vartanian, T and Li, Y and Zhao, M and Stefansson, K. (1995) Interferon-γ-induced oligodendrocyte cell death: Implications for the pathogenesis of multiple sclerosis Mol Med, 1, pp. 732-743.
    • (1995) Mol Med , vol.1 , pp. 732-743
    • Vartanian, T.1    Li, Y.2    Zhao, M.3    Stefansson, K.4
  • 87
    • 0029950889 scopus 로고    scopus 로고
    • Interferon-β1b treatment decreases tumor necrosis factor-α and increases interleukin-6 production in multiple sclerosis
    • Brod, SA and Marshall, GD, Jr and Henninger, EM and Sriram, S and Khan, M and Wolinsky, JS. (1996) Interferon-β1b treatment decreases tumor necrosis factor-α and increases interleukin-6 production in multiple sclerosis Neurology, 46, pp. 1633-1638.
    • (1996) Neurology , vol.46 , pp. 1633-1638
    • Brod, S.A.1    Marshall Jr., G.D.2    Henninger, E.M.3    Sriram, S.4    Khan, M.5    Wolinsky, J.S.6
  • 88
    • 0842278239 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist, soluble tumor necrosis factor-α receptor type I and II, and soluble E-selectin serum levels in multiple sclerosis patients receiving weekly intramuscular injections of interferon-β1a
    • Perini, P and Tiberio, M and Sivieri, S and Facchinetti, A and Biasi, G and Gallo, P. (2000) Interleukin-1 receptor antagonist, soluble tumor necrosis factor-α receptor type I and II, and soluble E-selectin serum levels in multiple sclerosis patients receiving weekly intramuscular injections of interferon-β1a Eur Cytokine Netw, 11, pp. 81-86.
    • (2000) Eur Cytokine Netw , vol.11 , pp. 81-86
    • Perini, P.1    Tiberio, M.2    Sivieri, S.3    Facchinetti, A.4    Biasi, G.5    Gallo, P.6
  • 89
    • 0034256059 scopus 로고    scopus 로고
    • Multiple sclerosis: Pro- and anti-inflammatory cytokines and metalloproteinases are affected differentially by treatment with IFN-β
    • Ozenci, V and Kouwenhoven, M and Teleshova, N and Pashenkov, M and Fredrikson, S and Link, H. (2000) Multiple sclerosis: Pro- and anti-inflammatory cytokines and metalloproteinases are affected differentially by treatment with IFN-β J Neuroimmunol, 108, pp. 236-243.
    • (2000) J Neuroimmunol , vol.108 , pp. 236-243
    • Ozenci, V.1    Kouwenhoven, M.2    Teleshova, N.3    Pashenkov, M.4    Fredrikson, S.5    Link, H.6
  • 90
    • 0033118470 scopus 로고    scopus 로고
    • Interferon (IFN)-β treatment enhances CD95 and interleukin 10 expression but reduces interferon-γ producing T cells in MS patients
    • Rep, MHG and Schrijver, HM and van Lopik, T and Hintzen, RQ and Roos, MTL and Adèr, HJ and Polman, CH and van Lier, RAW. (1999) Interferon (IFN)-β treatment enhances CD95 and interleukin 10 expression but reduces interferon-γ producing T cells in MS patients J Neuroimmunol, 96, pp. 92-100.
    • (1999) J Neuroimmunol , vol.96 , pp. 92-100
    • Rep, M.H.G.1    Schrijver, H.M.2    van Lopik, T.3    Hintzen, R.Q.4    Roos, M.T.L.5    Adèr, H.J.6    Polman, C.H.7    van Lier, R.A.W.8
  • 92
    • 0034665289 scopus 로고    scopus 로고
    • IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-γ by NK cells
    • Shi, F-D and Takeda, K and Akira, S and Sarvetnick, N and Ljunggren, H-G. (2000) IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-γ by NK cells J Immunol, 165, pp. 3099-3104.
    • (2000) J Immunol , vol.165 , pp. 3099-3104
    • Shi, F.-D.1    Takeda, K.2    Akira, S.3    Sarvetnick, N.4    Ljunggren, H.-G.5
  • 93
    • 0032989060 scopus 로고    scopus 로고
    • Interferon β modulates experimental autoimmune encephalomyelitis by altering the pattern of cytokine secretion
    • Yasuda, CL and al Sabbagh, A and Oliveira, EC and Diaz-Bardales, BM and Garcia, AA and Santos, LM. (1999) Interferon β modulates experimental autoimmune encephalomyelitis by altering the pattern of cytokine secretion Immunol Invest, 28, pp. 115-126.
    • (1999) Immunol Invest , vol.28 , pp. 115-126
    • Yasuda, C.L.1    al Sabbagh, A.2    Oliveira, E.C.3    Diaz-Bardales, B.M.4    Garcia, A.A.5    Santos, L.M.6
  • 94
    • 0031926095 scopus 로고    scopus 로고
    • Role of interleukin-12 in primary influenza virus infection
    • Monteiro, JM and Harvey, C and Trinchieri, G. (1998) Role of interleukin-12 in primary influenza virus infection J Virol, 72, pp. 4825-4831.
    • (1998) J Virol , vol.72 , pp. 4825-4831
    • Monteiro, J.M.1    Harvey, C.2    Trinchieri, G.3
  • 95
    • 0031957982 scopus 로고    scopus 로고
    • In vivo production of cytokines and β (C-C) chemokines in human recurrent herpes simplex lesions - Do herpes simplex virus-infected keratinocytes contribute to their production?
    • Mikloska, Z and Danis, VA and Adams, S and Lloyd, AR and Adrian, DL and Cunningham, AL. (1998) In vivo production of cytokines and β (C-C) chemokines in human recurrent herpes simplex lesions - do herpes simplex virus-infected keratinocytes contribute to their production? J Infect Dis, 177, pp. 827-838.
    • (1998) J Infect Dis , vol.177 , pp. 827-838
    • Mikloska, Z.1    Danis, V.A.2    Adams, S.3    Lloyd, A.R.4    Adrian, D.L.5    Cunningham, AL.6
  • 96
    • 0033058394 scopus 로고    scopus 로고
    • Measles: Immunosuppression, interleukin-12, and complement receptors
    • Karp, CL. (1999) Measles: Immunosuppression, interleukin-12, and complement receptors Immunol Rev, 168, pp. 91-101.
    • (1999) Immunol Rev , vol.168 , pp. 91-101
    • Karp, C.L.1
  • 97
    • 0023794099 scopus 로고
    • Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations?
    • Beck, J and Rondot, P and Catinot, L and Falcoff, E and Kirchner, H and Wietzerbin, J. (1988) Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations? Acta Neurol Scand, 78, pp. 318-323.
    • (1988) Acta Neurol Scand , vol.78 , pp. 318-323
    • Beck, J.1    Rondot, P.2    Catinot, L.3    Falcoff, E.4    Kirchner, H.5    Wietzerbin, J.6
  • 98
    • 0027491655 scopus 로고
    • + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming
    • + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming Proc Natl Acad Sci USA, 90, pp. 10188-10192.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10188-10192
    • Seder, R.A.1    Gazzinelli, R.2    Sher, A.3    Paul, W.E.4
  • 99
    • 0027409793 scopus 로고
    • Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
    • Manetti, R and Parronchi, P and Giudizi, MG and Piccinni, M-P and Maggi, E and Trinchieri, G and Romagnani, S. (1993) Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells J Exp Med, 177, pp. 1199-1204.
    • (1993) J Exp Med , vol.177 , pp. 1199-1204
    • Manetti, R.1    Parronchi, P.2    Giudizi, M.G.3    Piccinni, M.-P.4    Maggi, E.5    Trinchieri, G.6    Romagnani, S.7
  • 100
    • 0027422313 scopus 로고
    • + T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent
    • + T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent Int Immunol, 5, pp. 1119-1128.
    • (1993) Int Immunol , vol.5 , pp. 1119-1128
    • Macatonia, S.E.1    Hsieh, C.-S.2    Murphy, K.M.3    O'Garra, A.4
  • 101
    • 8044250881 scopus 로고    scopus 로고
    • Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    • Szabo, SJ and Dighe, AS and Gubler, U and Murphy, KM. (1997) Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells J Exp Med, 185, pp. 817-824.
    • (1997) J Exp Med , vol.185 , pp. 817-824
    • Szabo, S.J.1    Dighe, A.S.2    Gubler, U.3    Murphy, K.M.4
  • 103
    • 0028966091 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
    • Leonard, JP and Waldburger, KE and Goldman, SJ. (1995) Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12 J Exp Med, 181, pp. 381-386.
    • (1995) J Exp Med , vol.181 , pp. 381-386
    • Leonard, J.P.1    Waldburger, K.E.2    Goldman, S.J.3
  • 104
    • 0027454052 scopus 로고
    • Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen
    • Brocke, S and Gaur, A and Piercy, C and Gautam, A and Gijbels, K and Fathman, CG and Steinman, L. (1993) Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen Nature, 365, pp. 642-644.
    • (1993) Nature , vol.365 , pp. 642-644
    • Brocke, S.1    Gaur, A.2    Piercy, C.3    Gautam, A.4    Gijbels, K.5    Fathman, C.G.6    Steinman, L.7
  • 105
    • 0032211092 scopus 로고    scopus 로고
    • Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis
    • Constantinescu, CS and Wysocka, M and Hilliard, B and Ventura, ES and Lavi, E and Trinchieri, G and Rostami, A. (1998) Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis J Immunol, 161, pp. 5097-5104.
    • (1998) J Immunol , vol.161 , pp. 5097-5104
    • Constantinescu, C.S.1    Wysocka, M.2    Hilliard, B.3    Ventura, E.S.4    Lavi, E.5    Trinchieri, G.6    Rostami, A.7
  • 106
    • 0032534750 scopus 로고    scopus 로고
    • Prevention of experimental allergic encephalomyelitis via inhibition of IL-12 signaling and IL-12-mediated Th1 differentiation: An effect of the novel anti-inflammatory drug lisofylline
    • Bright, JJ and Du, C and Coon, M and Sriram, S and Klaus, SJ. (1998) Prevention of experimental allergic encephalomyelitis via inhibition of IL-12 signaling and IL-12-mediated Th1 differentiation: An effect of the novel anti-inflammatory drug lisofylline J Immunol, 161, pp. 7015-7022.
    • (1998) J Immunol , vol.161 , pp. 7015-7022
    • Bright, J.J.1    Du, C.2    Coon, M.3    Sriram, S.4    Klaus, S.J.5
  • 107
    • 0034193032 scopus 로고    scopus 로고
    • Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis
    • Pagenstecher, A and Lassmann, S and Carson, MJ and Kincaid, CL and Stalder, AK and Campbell, IL. (2000) Astrocyte-targeted expression of IL-12 induces active cellular immune responses in the central nervous system and modulates experimental allergic encephalomyelitis J Immunol, 164, pp. 4481-4492.
    • (2000) J Immunol , vol.164 , pp. 4481-4492
    • Pagenstecher, A.1    Lassmann, S.2    Carson, M.J.3    Kincaid, C.L.4    Stalder, A.K.5    Campbell, I.L.6
  • 109
    • 0037238897 scopus 로고    scopus 로고
    • A unique role for IL-23 in promoting cellular immunity
    • Lankford, CS and Frucht, DM. (2003) A unique role for IL-23 in promoting cellular immunity J Leukoc Biol, 73, pp. 49-56.
    • (2003) J Leukoc Biol , vol.73 , pp. 49-56
    • Lankford, C.S.1    Frucht, D.M.2
  • 111
    • 0036677420 scopus 로고    scopus 로고
    • Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
    • Becher, B and Durell, BG and Noelle, RJ. (2002) Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12 J Clin Investig, 110, pp. 493-497.
    • (2002) J Clin Investig , vol.110 , pp. 493-497
    • Becher, B.1    Durell, B.G.2    Noelle, R.J.3
  • 112
    • 0037114150 scopus 로고    scopus 로고
    • IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
    • Gran, B and Zhang, G-X and Yu, S and Li, J and Chen, X-H and Ventura, ES and Kamoun, M and Rostami, A. (2003) IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination J Immunol, 169, pp. 7104-7110.
    • (2003) J Immunol , vol.169 , pp. 7104-7110
    • Gran, B.1    Zhang, G.-X.2    Yu, S.3    Li, J.4    Chen, X.-H.5    Ventura, E.S.6    Kamoun, M.7    Rostami, A.8
  • 113
    • 0037442020 scopus 로고    scopus 로고
    • Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system
    • Zhang, G-X and Gran, B and Yu, S and Li, J and Siglienti, I and Chen, X and Kamoun, M and Rostami, A. (2003) Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system J Immunol, 170, pp. 2153-2160.
    • (2003) J Immunol , vol.170 , pp. 2153-2160
    • Zhang, G.-X.1    Gran, B.2    Yu, S.3    Li, J.4    Siglienti, I.5    Chen, X.6    Kamoun, M.7    Rostami, A.8
  • 114
    • 1242263952 scopus 로고    scopus 로고
    • Inhibiting cytokines of the interleukin-12 family: Recent advances and novel challenges
    • Vandenbroeck, K and Alloza, I and Gadina, M and Matthys, P. (2004) Inhibiting cytokines of the interleukin-12 family: Recent advances and novel challenges J Pharm Pharmacol, 56, pp. 145-160.
    • (2004) J Pharm Pharmacol , vol.56 , pp. 145-160
    • Vandenbroeck, K.1    Alloza, I.2    Gadina, M.3    Matthys, P.4
  • 115
    • 17844385539 scopus 로고    scopus 로고
    • IL-27 subunits and its receptor (WSX-1) mRNAs are markedly up-regulated in inflammatory cells in the CNS during experimental autoimmune encephalomyelitis
    • Li, J and Gran, B and Zhang, GX and Rostami, A and Kamoun, M. (2005) IL-27 subunits and its receptor (WSX-1) mRNAs are markedly up-regulated in inflammatory cells in the CNS during experimental autoimmune encephalomyelitis J Neurol Sci, 232, pp. 3-9.
    • (2005) J Neurol Sci , vol.232 , pp. 3-9
    • Li, J.1    Gran, B.2    Zhang, G.X.3    Rostami, A.4    Kamoun, M.5
  • 116
    • 0034917817 scopus 로고    scopus 로고
    • Viruses can silently prime for and trigger central nervous system autoimmune disease
    • Theil, DJ and Tsunoda, I and Rodriguez, F and Whitton, JL and Fujinami, RS. (2001) Viruses can silently prime for and trigger central nervous system autoimmune disease J NeuroVirol, 7, pp. 220-227.
    • (2001) J NeuroVirol , vol.7 , pp. 220-227
    • Theil, D.J.1    Tsunoda, I.2    Rodriguez, F.3    Whitton, J.L.4    Fujinami, R.S.5
  • 117
    • 10644298017 scopus 로고    scopus 로고
    • Are virus infections triggers for autoimmune disease?
    • Libbey, JE and Fujinami, RS. (2002) Are virus infections triggers for autoimmune disease? Clin Microbiol News Lett, 24, pp. 73-76.
    • (2002) Clin Microbiol News Lett , vol.24 , pp. 73-76
    • Libbey, J.E.1    Fujinami, R.S.2
  • 118
    • 0031835347 scopus 로고    scopus 로고
    • Wild isolates of murine cytomegalovirus induce myocarditis and antibodies that cross-react with virus and cardiac myosin
    • Fairweather, D and Lawson, CM and Chapman, AJ and Brown, CMS and Booth, TWM and Papadimitriou, JM and Shellam, GR. (1998) Wild isolates of murine cytomegalovirus induce myocarditis and antibodies that cross-react with virus and cardiac myosin Immunology, 94, pp. 263-270.
    • (1998) Immunology , vol.94 , pp. 263-270
    • Fairweather, D.1    Lawson, C.M.2    Chapman, A.J.3    Brown, C.M.S.4    Booth, T.W.M.5    Papadimitriou, J.M.6    Shellam, G.R.7
  • 119
    • 0026530150 scopus 로고
    • Mouse cytomegalovirus infection induces antibodies which cross-react with virus and cardiac myosin: A model for the study of molecular mimicry in the pathogenesis of viral myocarditis
    • Lawson, CM and O'Donoghue, HL and Reed, WD. (1992) Mouse cytomegalovirus infection induces antibodies which cross-react with virus and cardiac myosin: A model for the study of molecular mimicry in the pathogenesis of viral myocarditis Immunology, 75, pp. 513-519.
    • (1992) Immunology , vol.75 , pp. 513-519
    • Lawson, C.M.1    O'Donoghue, H.L.2    Reed, W.D.3


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