Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients

Clinical and Experimental Immunology

Volumn 129, Issue 1, 2002, Pages 119-124

  Sanchez Margalet V ^a   Martin Romero C ^a   Gonzalez Yanes C ^a   Goberna, R ^a   Rodriguez Bano J ^a   Muniain, M A ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN MACARENA   (Spain)

Author keywords

Cell activation HIV; Leptin receptor; Lymphocytes; PBMC

Indexed keywords

JANUS KINASE; LEPTIN RECEPTOR; STAT PROTEIN; TRANSCRIPTION FACTOR;

ADULT; ARTICLE; BLOOD; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; MONOCYTE; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STIMULUS RESPONSE; T LYMPHOCYTE; WESTERN BLOTTING;

ADOLESCENT; ADULT; CARRIER PROTEINS; CELLS, CULTURED; CHILD; CONCANAVALIN A; FEMALE; GENE EXPRESSION REGULATION; HEPATITIS C; HIV INFECTIONS; HUMANS; LEPTIN; LYMPHOCYTE ACTIVATION; MALE; PHOSPHORYLATION; PHYTOHEMAGGLUTININS; PROTEIN ISOFORMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0036378052     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2002.01900.x     Document Type: Article

References (44)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homolog. Nature 1994; 372:425-32.
2. Maffei M, Fei H, Lee GH et al. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA 1995; 92:6957-60.
3. Masuzaki H, Ogawa Y, Sagawa N et al. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 1997; 3:1029-33.
4. Bado A, Levasseur S, Attoub S et al. The stomach is a source of leptin. Nature 1998; 394:790-3.
5. Flier JS. The adipocyte: storage depot or node on the energy information superhighway? Cell 1995; 80:15-8.
6. Pelleymounter MA, Cullen MJ, Baker MB et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269:540-3.
7. Halaas JL, Gajiwala KS, Maffei M et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269:543-6.
8. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein. evidence for a peripheral signal linking adiposity and central neural networks. Science 1995; 269:546-9.
9. Frederich RC, Löllmann B, Hamann A et al. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. J Clin Invest 1995; 96:1658-63.
10. Ahima RS, Flier JS. Leptin. Annu Rev Physiol 2000; 62:413-37.
11. Madej T, Boguski MS, Bryant SH. Threading analysis suggests that the obese gene product may be a helical cytokine. FEBS Lett 1995; 373:13-8.
12. Tartaglia LA, Dembski M, Weng X et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995; 83:1263-71.
13. Baumann H, Morella KK, White DW et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 1996; 93:8374-8.
14. Lee GH, Proenca R, Montez JM et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379:632-5.
15. Cioffi J, Shafer AW, Zupancic TJ et al. Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat Med 1996; 2:585-8.
16. Bennet BD, Solar GP, Yuan JQ, Mathias J, Thomas GR, Mathews W. A role for leptin and its cognate receptor in hematopoiesis. Curr Biol 1996; 6:1170-80.
17. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998; 394:897-901.
18. Howard JK, Lord GM, Matarese G et al. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J Clin Invest 1999; 104:1051-9.
19. Faggioni R, Jones-Carson J, Reed DA et al. Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18. Proc Natl Acad Sci USA 2000; 97:2367-72.
20. Ozata M, Ozdemir IC, Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab 1999; 84:3686-95.
21. Gainsford T, Willson TA, Metcalf D et al. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA 1996; 93:14564-8.
22. Lee F-YJ, Li Y, Yang EK et al. Phenotypic abnormalities in macrophages from leptin-deficient, obese mice. Am J Pysiol 1999; 276:C386-C394.
23. Loffreda S, Rai R, Yang SQ et al. Leptin regulates proinflammatory immune responses. FASEB J 1998; 12:57-65.
24. Sarraf P, Frederich RC, Turner EM et al. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med 1997; 185:171-5.
25. Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 2000; 68:437-46.
26. Santos-Alvarez J, Goberna R, Sánchez-Margalet V. Human leptin stimulates proliferation and activation of human circulating monocytes. Cell Immunol 1999; 194:6-11.
27. Martín-Romero C, Santos-Alvarez J, Goberna R, Sánchez-Margalet V. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol 2000; 199:15-24.
28. Sanchez-Margalet V, Martin-Romero C. Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway. Cell Immunol 2001; 211:30-6.
29. Martín-Romero C, Sánchez-Margalet V. Human leptin activates PI3K and MAPK pathways in human peripheral blood mononuclear cells: possible role of Sam68. Cell Immunol 2001; 212:83-91.
30. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Scand J Invest 1968; 21:77-89.
31. Lucas M, Sánchez-Margalet V, Sanz A, Solano F. Protein kinase C activation promotes cell survival in mature lymphocytes prone to apoptosis. Biochem Pharmacol 1994; 47:1994.
32. + cells: a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes. J Immunol 1997; 159:574-81.
33. Sung CK, Sanchez-Margalet V, Goldfine ID. Role of p85 subunits of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor, p62 and GTPase-activating protein. J Biol Chem 1994; 269:12503-7.
34. Sánchez-Margalet V, Najib S. Sam68 is a substrate of the insulin receptor and associates with the SH2 domains of p85 PI3K. FEBS Lett 1999; 455:307-10.
35. Jin L, Burguera BG, Couce ME et al. Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of a regulatory role of leptin on pituitary cell proliferation. J Clin Endocrinol Metab 1999; 84:2903-11.
36. Grunfeld C, Zhao C, Fuller J et al. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J Clin Invest 1996; 97:2152-7.
37. Pickup JC, Chusney GD, Mattock MB. The innate immune response and type 2 diabetes: evidence that leptin is associated with a stress-related reaction. Clin Endocrinol 2000; 52:107-12.
38. Lai KN, Leung JC, Lai FM. Soluble interleukin 2 receptor release, interleukin 2 production, and interleukin 2 receptor expression in activated T-lymphocytes in vitro. Pathology 1991; 23:224-8.
39. Breen EC, Rezai AR, Nakajima K et al. Infection with HIV is associated with elevated IL-6 levels and production. J Immunol 1990; 144:480-4.
40. Berman MA, Zaldivar F Jr, Imfeld KL, Kenney JS, Sandborg CL. HIV-1 infection of macrophages promotes long-term survival and sustained release of interleukins 1 alpha and 6. AIDS Res Hum Retroviruses 1994; 10:529-39.
41. Abbate I, Dianzani F, Capobianchi MR. Activation of signal transduction and apoptosis in healthy lymphomonocytes exposed to bystander HIV-1-infected cells. Clin Exper Immnol 2000; 122:374-80.
42. Navikas V, Link J, Persson C et al. Increased mRNA expression of IL-6, IL-10, TNF-alpha, and perforin in blood mononuclear cells in human HIV infection. J Acquir Immune Defic Syndr Hum Retrovirol 1995; 9:484-9.
43. Salazar-Gonzalez JF, Martinez-Maza O, Aziz N et al. Relationship of plasma HIV-RNA levels of TNF-alpha and immune activation products in HIV infection. Clin Immunol Immunopathol 1997; 84:36-45.
44. Sulkowski MS, Chaisson RE, Karp CL, Moore RD, Margolick JB, Quinn TC. The effect of acute infectious illnesses on plasma human immunodeficiency virus (HIV) type 1 load and the expression of serologic markers of immune activation among HIV-infected adults. J Infect Dis 1998; 178:1642-8.