Nk cell functions restrain T cell responses during viral infections

European Journal of Immunology

Volumn 31, Issue 10, 2001, Pages 3048-3055

  Su, Helen C ^a   Nguyen, Khuong B ^a   Salazar Mather, Thais P ^a   Ruzek, Melanie C ^a   Dalod, Marc Y ^a   Biron, Christine A ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Cell to cell interaction; Immunoregulation; NK cell; T lymphocyte; Viral infection

Indexed keywords

BROXURIDINE; CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; IMMUNOCOMPETENCE; IMMUNOREGULATION; IN VIVO STUDY; LYMPHOCYTE DEPLETION; LYMPHOCYTE FUNCTION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS INFECTION; VIRUS REPLICATION;

ANIMALS; BETA 2-MICROGLOBULIN; BROMODEOXYURIDINE; CELL COMMUNICATION; CYTOMEGALOVIRUS INFECTIONS; INTERFERON TYPE II; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC CHORIOMENINGITIS; MALE; MICE; MICE, INBRED C57BL; MUROMEGALOVIRUS; T-LYMPHOCYTES; VIRUS DISEASES;

EID: 0034777301     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(2001010)31:10<3048::AID-IMMU3048>3.0.CO;2-1     Document Type: Article

References (23)

1. Natural killer cells in antiviral defense: Function and regulation by innate cytokines
2. Requirement for natural killer cell-produced interferon γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration
3. Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells
4. Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo
5. NK cell response to viral infections in β2-microglobulin-deficient mice
6. Perforin gene defects in familial hemophagocytic lymphohistiocytosis
7. Perforin, more than just an effector molecule
8. Characterization of early IL-12, IFN-αβ, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection
9. An absolute and restricted requirement for IL-12 in natural killer cell IFN-γ production and antiviral defense
10. IL-2-dependent NK cell responses discovered in virus-infected β2-microglobulin-deficient mice
11. Natural killer cell activity in lymphocytic chorio-meningitis virus-infected β2-microglobulin-deficient mice
12. + T cell interactions in IFN-γ and IL-4 responses to viral infections: Requirements for IL-2
13. + T lymphocytes in early IFN-γ-dependent resistance to Toxoplasma gondii
14. Triggering of natural killer cells by the costimulatory molecule CD80 (B7-1)
15. Recognition of autologous dendritic cells by human NK cells
16. NK cell trafficking and cytokine expression in splenic compartments after IFN induction and viral infection
17. Virus-triggered acquired immunodeficiency by cytotoxic T cell-dependent destruction of antigen-presenting cells and lymph follicle structure
18. Virus-induced immunosuppression: Immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression
19. A role for perforin in downregulating T cell responses during chronic viral infection
20. + T cells by perforin
21. + T cell homeostasis by perforin and interferon-γ
22. Fas-mediated cytotoxicity by freshly isolated natural killer cells
23. Involvement of Fas ligand and Fas-mediated pathway in the cytotoxicity of human natural killer cells