Altered functional B cell subset populations in patients with chronic fatigue syndrome compared to healthy controls

Clinical and Experimental Immunology

Volumn 172, Issue 1, 2013, Pages 73-80

  Bradley, A S ^a   Ford, B ^a   Bansal, A S ^a  

^a EPSOM AND ST HELIER UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

B cells; Chronic fatigue syndrome; Flow cytometry FACS; Myalgic encephalitis (ME)

Indexed keywords

ADULT; AGED; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CHRONIC FATIGUE SYNDROME; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOPHENOTYPING; LYMPHOCYTE; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MALE; PRE B LYMPHOCYTE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

ADULT; AGED; B-LYMPHOCYTE SUBSETS; CASE-CONTROL STUDIES; FATIGUE SYNDROME, CHRONIC; FEMALE; HUMANS; IMMUNITY, HUMORAL; IMMUNOGLOBULINS; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; MALE; MIDDLE AGED;

EID: 84875002274     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12043     Document Type: Article

References (33)

1. Nacul LC, Lacerda EM, Pheby D etal. Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: a repeated cross-sectional study in primary care. BMC Med 2011; 9:1-12.
2. Carruthers BM. Definitions and aetiology of myalgic encephalomyelitis: how the Canadian consensus clinical definition of myalgic encephalomyelitis works. J Clin Pathol 2007; 60:117-119.
3. Holmes GP, Kaplan JE, Gantz NM etal. Chronic fatigue syndrome: a working case definition. Ann Intern Med 1988; 108:387-389.
4. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med 1994; 121:953-959.
5. Sharpe MC, Archard LC, Banatvala JE etal. A report-chronic fatigue syndrome: guidelines for research. J R Soc Med 1991; 84:118-121.
6. Lyall M, Peakman M, Wessely S. A systematic review and critical evaluation of the immunology of chronic fatigue syndrome. J Psychosom Res 2003; 55:79-90.
7. Chew-Graham CA, Cahill G, Dowrick C, Wearden A, Peters S. Using multiple sources of knowledge to reach clinical understanding of chronic fatigue syndrome. Ann Fam Med 2008; 6:340-348.
8. Bansal AS, Bradley AS, Bishop KN, Kiani-Alikhan S, Ford B. Chronic fatigue syndrome, the immune system and viral infection. Brain Behav Immun 2012; 26:24-31.
9. Fluge O, Mella O. Clinical impact of B-cell depletion with the anti-CD20 antibody rituximab in chronic fatigue syndrome: a preliminary case series. BMC Neurol 2009; 9:1-7.
10. Fluge O, Bruland O, Risa K etal. Benefit from B-lymphocyte depletion using the anti-CD20 antibody rituximab in chronic fatigue syndrome. A double-blind and placebo-controlled study. PLOS ONE 2011; 6:e26358.
11. Kessel A, Rosner I, Toubi E. Rituximab: beyond simple B cell depletion. Clin Rev Allergy Immunol 2008; 34:74-79.
12. Klimas NG, Koneru AO. Chronic fatigue syndrome: inflammation, immune function, and neuroendocrine interactions. Curr Rheumatol Rep 2007; 9:482-487.
13. Wessely S, Chalder T, Hirsch S, Wallace P, Wright D. Psychological symptoms, somatic symptoms, and psychiatric disorder in chronic fatigue and chronic fatigue syndrome: a prospective study in the primary care setting. Am J Psychiatry 1996; 153:1050-1059.
14. Powell R, Dolan R, Wessely S. Attributions and self-esteem in depression and chronic fatigue syndromes. J Psychosom Res 1990; 34:665-673.
15. Johnson SK, DeLuca J, Natelson BH. Depression in fatiguing illness: comparing patients with chronic fatigue syndrome, multiple sclerosis and depression. J Affect Disord 1996; 39:21-30.
16. Ferry BL, Jones J, Bateman EA etal. Measurement of peripheral B cell subpopulations in common variable immunodeficiency (CVID) using a whole blood method. Clin Exp Immunol 2005; 140:532-539.
17. Warnatz K, Denz A, Drager R etal. Severe deficiency of switched memory B cells (CD27(+)IgM(-)IgD(-)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease. Blood 2002; 99:1544-1551.
18. Piqueras B, Lavenu-Bombled C, Galicier L etal. Common variable immunodeficiency patient classification based on impaired B cell memory differentiation correlates with clinical aspects. J Clin Immunol 2003; 23:385-400.
19. Wehr C, Kivioja T, Schmitt C etal. The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood 2008; 111:77-85.
20. Mawle AC, Nisenbaum R, Dobbins JG etal. Immune responses associated with chronic fatigue syndrome: a case-control study. J Infect Dis 1997; 175:136-141.
21. Natelson BH, LaManca JJ, Denny TN etal. Immunologic parameters in chronic fatigue syndrome, major depression, and multiple sclerosis. Am J Med 1998; 105:43S-49.
22. Tirelli U, Marotta G, Improta S, Pinto A. Immunological abnormalities in patients with chronic fatigue syndrome. Scand J Immunol 1994; 40:601-608.
23. Chang CM, Warren JL, Engels EA. Chronic fatigue syndrome and subsequent risk of cancer among elderly US adults. Cancer 2012; 118:5929-5936.
24. Yanaba K, Bouaziz JD, Matsushita T, Magro CM, St Clair EW, Tedder TF. B-lymphocyte contributions to human autoimmune disease. Immunol Rev 2008; 223:284-299.
25. Keenan RA, De Riva A, Corleis B etal. Censoring of autoreactive B cell development by the pre-B cell receptor. Science 2008; 321:696-699.
26. Verma S, Waldschmidt TJ. Characterization of splenic CD21hi T2 B cells. Immunol Res 2007; 39:240-248.
27. Dorner T, Giesecke C, Lipsky PE. Mechanisms of B cell autoimmunity in SLE. Arthritis Res Ther 2011; 13:243-283.
28. Lee J, Kuchen S, Fischer R, Chang S, Lipsky PE. Identification and characterization of a human CD5+ pre-naive B cell population. J Immunol 2009; 182:4116-4126.
29. Cuss AK, Avery DT, Cannons JL etal. Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity. J Immunol 2006; 176:1506-1516.
30. Maes M, Mihaylova I, Leunis JC. Increased serum IgM antibodies directed against phosphatidyl inositol (Pi) in chronic fatigue syndrome (CFS) and major depression: evidence that an IgM-mediated immune response against Pi is one factor underpinning the comorbidity between both CFS and depression. Neuro Endocrinol Lett 2007; 28:861-867.
31. Skowera A, Stewart E, Davis ET etal. Anti-nuclear autoantibodies (ANA) in Gulf War-related illness and chronic fatigue syndrome (CFS) patients. Clin Exp Immunol 2002; 129:354-358.
32. Staines DR. Postulated vasoactive neuropeptide autoimmunity in fatigue-related conditions: a brief review and hypothesis. Clin Dev Immunol 2006; 13:25-39.
33. Warnatz K, Schlesier M. Flowcytometric phenotyping of common variable immunodeficiency. Cytometry B Clin Cytom 2008; 74:261-271.