Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

EMBO Molecular Medicine

Volumn 5, Issue 8, 2013, Pages 1278-1295

  Damgaard, Rune Busk ^a   Fiil, Berthe Katrine ^a   Speckmann, Carsten ^b   Yabal, Monica ^c   Stadt, Udo zur ^d   Bekker Jensen, Simon ^a   Jost, Philipp J ^c   Ehl, Stephan ^b   Mailand, Niels ^a   Gyrd Hansen, Mads ^a  

^a University of Copenhagen   (Denmark)

^b UNIVERSITY OF FREIBURG   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

BIR2; NOD2; Smac mimetic compounds; XIAP; XLP2

Indexed keywords

BACULOVIRUS VECTOR; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; IMMUNOSUPPRESSIVE AGENT; RITUXIMAB; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; X LINKED INHIBITOR OF APOPTOSIS BIR2;

APOPTOSIS; ARTICLE; AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME; BINDING SITE; GENE; HUMAN; INNATE IMMUNITY; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; RING FINGER MOTIF; UBIQUITINATION; X CHROMOSOME LINKED DISORDER; XLP2 GENE;

BIR2; NOD2; SMAC MIMETIC COMPOUNDS; XIAP; XLP2;

APOPTOSIS; BINDING SITES; CELL LINE, TUMOR; HEK293 CELLS; HUMANS; INFLAMMATION; MUTATION, MISSENSE; NOD2 SIGNALING ADAPTOR PROTEIN; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASE 2; SIGNAL TRANSDUCTION; UBIQUITIN; UBIQUITINATION; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84880774323     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201303090     Document Type: Article

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