Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type i interferons and proinflammatory cytokines

Nature Immunology

Volumn 11, Issue 1, 2010, Pages 70-75

  Tseng, Ping Hui ^a,b   Matsuzawa, Atsushi ^a,c   Zhang, Weizhou ^a   Mino, Takashi ^a   Vignali, Dario A A ^d   Karin, Michael ^a  

^a San Diego   (United States)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c UNIVERSITY OF TOKYO   (Japan)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERFERON; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; AUTACOID; INHIBITOR OF APOPTOSIS PROTEIN; LIPOPOLYSACCHARIDE; MYD88 PROTEIN, MOUSE; TICAM 1 PROTEIN, MOUSE; TICAM-1 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; C57BL MOUSE; CELL LINE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOBLOTTING; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CELL LINE; CYTOKINES; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; INFLAMMATION MEDIATORS; INHIBITOR OF APOPTOSIS PROTEINS; INTERFERON TYPE I; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHORYLATION; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 3; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTOR 4; UBIQUITINATION;

EID: 74049136127     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1819     Document Type: Article

References (43)

1. Banchereau, J. & Pascual, V. Type I Interferon in systemic lupus erythematosus and other autoImmune diseases. Immunity 25, 383-392 (2006). (Pubitemid 44354221)
2. Luo, J.L., Maeda, S., Hsu, L.C., Yagita, H. & Karin, M. Inhibition of NF-KB in cancer cells converts infammation-induced tumor growth mediated by TNFa to TRAIL-mediated tumor regression. Cancer Cell 6, 297-305 (2004).
3. Lin, W.W. & Karin, M. A cytokine-mediated link between innate immunity, infammation, and cancer. J. Clin. Invest. 117, 1175-1183 (2007).
4. Akira, S. & Takeda, K. Toll-like receptor signalling. Nat. Rev. Immunol. 4, 499-511 (2004).
5. Karin, M., Lawrence, T. & Nizet, V. Innate immunity gone awry: linking microbial infections to chronic infammation and cancer. Cell 124, 823-835 (2006).
6. Pasare, C. & Medzhitov, R. Toll-like receptors: linking innate and adaptive immunity. Adv. Exp. Med. Biol. 560, 11-18 (2005).
7. Vogel, S.N., Fitzgerald, K.A. & Fenton, M.J. TLRs: differential adapter utILization by toll-like receptors mediates TLR-specifc patterns of gene expression. Mol. Interv. 3, 466-477 (2003).
8. Doyle, S. et al. IRF3 mediates a TLR3/TLR4-specifc antiviral gene program. Immunity 17, 251-263 (2002).
9. Medzhitov, R. et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor famILy signaling pathways. Mol. Cell 2, 253-258 (1998).
10. 1 promoter in the Toll-like receptor signaling. J. Immunol. 169, 6668-6672 (2002).
11. Hoebe, K. et al. Identifcation of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424, 743-748 (2003).
12. Bin, L.H., Xu, L.G. & Shu, H.B. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J. Biol. Chem. 278, 24526-24532 (2003).
13. Yamamoto, M. et al. TRAM is specifcally involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat. Immunol. 4, 1144-1150 (2003). (Pubitemid 37428043)
14. Fitzgerald, K.A. et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413, 78-83 (2001).
15. Horng, T., Barton, G.M. & Medzhitov, R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat. Immunol. 2, 835-841 (2001). (Pubitemid 34906448)
16. Kawai, T. & Akira, S. TLR signaling. Semin. Immunol. 19, 24-32 (2007).
17. Hacker, H. et al. Specifcity in Toll-like receptor signalling through distinct Effector functions of TRAF3 and TRAF6. Nature 439, 204-207 (2006).
18. Oganesyan, G. et al. Critical role of TRAF3 in the Toll-like receptor-dependent and-independent antiviral response. Nature 439, 208-211 (2006).
19. Matsuzawa, A. et al. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science 321, 663-668 (2008).
20. Inoue, J., Gohda, J. & Akiyama, T. Characteristics and biological functions of TRAF6. Adv. Exp. Med. Biol. 597, 72-79 (2007).
21. Petersen, S.L. et al. Autocrine TNFa signaling renders human cancer cel ls susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 12, 445-456 (2007).
22. Li, L. et al. A small molecule Smac mimic potentiates TRAIL-and TNFa-mediated cell death. Science 305, 1471-1474 (2004).
23. Vallabhapurapu, S. et al. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-KB signaling. Nat. Immunol. 9, 1364-1370 (2008).
24. Werneburg, B.G., Zoog, S.J., Dang, T.T., Kehry, M.R. & Crute, J.J. Molecular characterization of CD40 signaling intermediates. J. Biol. Chem. 276, 43334-43342 (2001).
25. Kagan, J.C. et al. TRAM couples endocytosis of Toll-like receptor 4 to the induction of Interferon-p. Nat. Immunol. 9, 361-368 (2008).
26. Núñez Miguel, R. et al. A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specifc scaffold for the recruitment of signalling adaptor proteins. PLoS One 2, e788 (2007).
27. Macia, E. et al. Dynasore, a cell-permeable inhibitor of dynamin. Dev. Cell 10, 839-850 (2006).
28. Lamothe, B. et al. Site-specifc Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of IKB kinase activation. J. Biol. Chem. 282, 4102-4112 (2007).
29. Vaux, D.L. & SILke, J. IAPs, RINGs and ubiquitylation. Nat. Rev. Mol. Cell Biol. 6, 287-297 (2005).
30. Li, X., Yang, Y. & Ashwell, J.D. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature 416, 345-347 (2002).
31. Uematsu, S. & Akira, S. Toll-like receptors and type I InterferonS. J. Biol. Chem. 282, 15319-15323 (2007).
32. O'NeILl, L.A. & Bowie, A.G. The famILy of fve: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Rev. Immunol. 7, 353-364 (2007).
33. Pineda, G., Ea, C.K. & Chen, Z.J. Ubiquitination and TRAF signaling. Adv. Exp. Med. Biol. 597, 80-92 (2007).
34. Yamamoto, M. et al. Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in Immune receptor signaling. Nat. Immunol. 7, 962-970 (2006).
35. Sato, S. et al. Essential function for the kinase TAK1 in innate and adaptive Immune responses. Nat. Immunol. 6, 1087-1095 (2005).
36. Kawai, T., Adachi, O., Ogawa, T., Takeda, K. & Akira, S. Unresponsiveness of MyD88-defcient mice to endotoxin. Immunity 11, 115-122 (1999).
37. Keats, J.J. et al. Promiscuous mutations activate the noncanonical NF-κB pathway in multiple myeloma. Cancer Cell 12, 131-144 (2007).
38. Park, J.M. et al. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis-CREB and NF-κB as key regulators. Immunity 23, 319-329 (2005).
39. Micheau, O. & Tschopp, J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114, 181-190 (2003).
40. Lawrence, T., Bebien, M., Liu, G.Y., Nizet, V. & Karin, M. IKKα limits macrophage NF-κB activation and contributes to the resolution of infammation. Nature 434, 1138-1143 (2005).
41. Beaumelle, B.D., Gibson, A. & Hopkins, C.R. Isolation and preliminary characterization of the major membrane boundaries of the endocytic pathway in lymphocytes. J. Cell Biol. 111, 1811-1823 (1990).
42. Johnson, G.L. & Bourne, H.R. Infuence of cholera toxin on the regulation of adenylate cyclase by GTP. Biochem. Biophys. Res. Commun. 78, 792-798 (1977).
43. Iwamura, T. et al. Induction of IRF-3/-7 kinase and NF-κB in response to double-stranded RNA and virus infection: common and unique pathways. Genes Cells 6, 375-388 (2001).