Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins

Nature Immunology

Volumn 5, Issue 3, 2004, Pages 255-265

  Heissmeyer, Vigo ^a   Macián, Fernando ^a,e   Im, Sin Hyeog ^a,f   Varma, Rajat ^b   Feske, Stefan ^a   Venuprasad, K ^c   Gu, Hua ^d   Liu, Yun Cai ^c   Dustin, Michael L ^b   Rao, Anjana ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^d College of Physicians and Surgeons ^*  (United States)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^f Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCIUM ION; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MESSENGER RNA; PHOSPHOLIPASE C; PROTEIN KINASE C; T LYMPHOCYTE RECEPTOR; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE NEDD4; DNA BINDING PROTEIN; ISOENZYME; ITCH PROTEIN, MOUSE; NEDD4 UBIQUITIN PROTEIN LIGASES; PHOSPHOLIPASE C GAMMA; PRKCQ PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CALCIUM SIGNALING; CELL ADHESION; CELL MEMBRANE; CELL SELECTION; COMPLEX FORMATION; CONTROLLED STUDY; ENDOSOME; ENZYME DEFICIENCY; ENZYME DEGRADATION; ENZYME SUBSTRATE; GENETIC TRANSCRIPTION; IMMUNOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SYNAPSE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UBIQUITINATION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL CULTURE; CLONAL ANERGY; GENETICS; METABOLISM; PHYSIOLOGY; UPREGULATION;

ANIMALS; CALCINEURIN; CALCIUM SIGNALING; CELLS, CULTURED; CLONAL ANERGY; DNA-BINDING PROTEINS; ISOENZYMES; MICE; MICE, INBRED BALB C; PHOSPHOLIPASE C; PHOSPHOLIPASE C GAMMA; PROTEIN KINASE C; RNA, MESSENGER; T-LYMPHOCYTES; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINS; UP-REGULATION;

EID: 12144290293     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni1047     Document Type: Article

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