Mass Spectrometric and Mutational Analyses Reveal Lys-6-linked Polyubiquitin Chains Catalyzed by BRCA1-BARD1 Ubiquitin Ligase

Journal of Biological Chemistry

Volumn 279, Issue 6, 2004, Pages 3916-3924

  Nishikawa, Hiroyuki ^a   Ooka, Seido ^a   Sato, Ko ^a   Arima, Kei ^a   Okamoto, Joji ^a   Klevit, Rachel E ^b   Fukuda, Mamoru ^a   Ohta, Tomohiko ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ENZYME INHIBITION; ENZYMES; MASS SPECTROMETRY; TUMORS;

MUTATIONS; OVARIAN CANCER;

BIOCHEMISTRY;

BRCA1 ASSOCIATED RING DOMAIN PROTEIN 1; BRCA1 PROTEIN; GENE PRODUCT; LYSINE; POLYUBIQUITIN; PROTEASOME; PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER SUSCEPTIBILITY; CATALYSIS; CHEMICAL ANALYSIS; DNA REPAIR; ENDOCYTOSIS; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE MUTATION; GENETIC ANALYSIS; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

AMINO ACID SEQUENCE; BRCA1 PROTEIN; CARRIER PROTEINS; CELL LINE; HUMANS; LYSINE; MASS SPECTROMETRY; MUTAGENESIS, SITE-DIRECTED; PEPTIDE HYDROLASES; POLYUBIQUITIN; PROTEASOME ENDOPEPTIDASE COMPLEX; RECOMBINANT PROTEINS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA;

EID: 1042278177     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M308540200     Document Type: Article

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