-
2
-
-
0034915764
-
Mechanisms underlying ubiquitination
-
Pickart C.M. Mechanisms underlying ubiquitination. Annu Rev Biochem 70 (2001) 503-533
-
(2001)
Annu Rev Biochem
, vol.70
, pp. 503-533
-
-
Pickart, C.M.1
-
3
-
-
34250011799
-
The ubiquitin-proteasome system and its role in inflammatory and autoimmune diseases
-
This article reviews the role of ubiquitination and the proteasome in autoimmunity.
-
Wang J., and Maldonado M.A. The ubiquitin-proteasome system and its role in inflammatory and autoimmune diseases. Cell Mol Immunol 3 (2006) 255-261. This article reviews the role of ubiquitination and the proteasome in autoimmunity.
-
(2006)
Cell Mol Immunol
, vol.3
, pp. 255-261
-
-
Wang, J.1
Maldonado, M.A.2
-
4
-
-
4644285392
-
E3 ubiquitin ligases as T cell anergy factors
-
This article reviews the role of ubiquitination and E3 ligases in T cell homeostasis.
-
Mueller D.L. E3 ubiquitin ligases as T cell anergy factors. Nat Immunol 5 (2004) 883-890. This article reviews the role of ubiquitination and E3 ligases in T cell homeostasis.
-
(2004)
Nat Immunol
, vol.5
, pp. 883-890
-
-
Mueller, D.L.1
-
5
-
-
0036363406
-
Regulation of immune responses by E3 ubiquitin-protein ligases
-
This article reviews the role of ubiquitination and E3 ligases in T cell homeostasis and autoimmunity including Cbl-b, GRAIL, and Itch.
-
Fang N., Fang D., Wang H.Y., Altman A., and Liu Y.C. Regulation of immune responses by E3 ubiquitin-protein ligases. Curr Dir Autoimmun 5 (2002) 161-175. This article reviews the role of ubiquitination and E3 ligases in T cell homeostasis and autoimmunity including Cbl-b, GRAIL, and Itch.
-
(2002)
Curr Dir Autoimmun
, vol.5
, pp. 161-175
-
-
Fang, N.1
Fang, D.2
Wang, H.Y.3
Altman, A.4
Liu, Y.C.5
-
6
-
-
7244227645
-
Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
-
Gallegos A.M., and Bevan M.J. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J Exp Med 200 (2004) 1039-1049
-
(2004)
J Exp Med
, vol.200
, pp. 1039-1049
-
-
Gallegos, A.M.1
Bevan, M.J.2
-
7
-
-
33645071052
-
Central tolerance: good but imperfect
-
Gallegos A.M., and Bevan M.J. Central tolerance: good but imperfect. Immunol Rev 209 (2006) 290-296
-
(2006)
Immunol Rev
, vol.209
, pp. 290-296
-
-
Gallegos, A.M.1
Bevan, M.J.2
-
9
-
-
33750435941
-
Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications
-
Li L., and Boussiotis V.A. Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications. J Mol Med 84 (2006) 887-899
-
(2006)
J Mol Med
, vol.84
, pp. 887-899
-
-
Li, L.1
Boussiotis, V.A.2
-
10
-
-
0346599403
-
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. The Finnish-German APECED Consortium. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
-
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. The Finnish-German APECED Consortium. Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Nat Genet 17 (1997) 399-403
-
(1997)
Nat Genet
, vol.17
, pp. 399-403
-
-
-
11
-
-
34249717868
-
Lessons on immune tolerance from the monogenic disease APS1
-
Devoss J.J., and Anderson MS. Lessons on immune tolerance from the monogenic disease APS1. Curr Opin Genet Dev 17 (2007) 193-200
-
(2007)
Curr Opin Genet Dev
, vol.17
, pp. 193-200
-
-
Devoss, J.J.1
Anderson MS2
-
12
-
-
0037084784
-
Aire deficient mice develop multiple features of APECED phenotype and show altered immune response
-
Ramsey C., Winqvist O., Puhakka L., Halonen M., Moro A., Kampe O., Eskelin P., Pelto-Huikko M., and Peltonen L. Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet 11 (2002) 397-409
-
(2002)
Hum Mol Genet
, vol.11
, pp. 397-409
-
-
Ramsey, C.1
Winqvist, O.2
Puhakka, L.3
Halonen, M.4
Moro, A.5
Kampe, O.6
Eskelin, P.7
Pelto-Huikko, M.8
Peltonen, L.9
-
13
-
-
0037112047
-
Projection of an immunological self shadow within the thymus by the aire protein
-
Anderson M.S., Venanzi E.S., Klein L., Chen Z., Berzins S.P., Turley S.J., von Boehmer H., Bronson R., Dierich A., Benoist C., et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 298 (2002) 1395-1401
-
(2002)
Science
, vol.298
, pp. 1395-1401
-
-
Anderson, M.S.1
Venanzi, E.S.2
Klein, L.3
Chen, Z.4
Berzins, S.P.5
Turley, S.J.6
von Boehmer, H.7
Bronson, R.8
Dierich, A.9
Benoist, C.10
-
14
-
-
34147106416
-
Aire-ing self antigen variability and tolerance
-
Holmdahl R. Aire-ing self antigen variability and tolerance. Eur J Immunol 37 (2007) 598-601
-
(2007)
Eur J Immunol
, vol.37
, pp. 598-601
-
-
Holmdahl, R.1
-
16
-
-
1642500086
-
AIRE functions as an E3 ubiquitin ligase
-
Uchida D., Hatakeyama S., Matsushima A., Han H., Ishido S., Hotta H., Kudoh J., Shimizu N., Doucas V., Nakayama K.I., et al. AIRE functions as an E3 ubiquitin ligase. J Exp Med 199 (2004) 167-172
-
(2004)
J Exp Med
, vol.199
, pp. 167-172
-
-
Uchida, D.1
Hatakeyama, S.2
Matsushima, A.3
Han, H.4
Ishido, S.5
Hotta, H.6
Kudoh, J.7
Shimizu, N.8
Doucas, V.9
Nakayama, K.I.10
-
17
-
-
15744397285
-
NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease
-
This article describes the crystal structure of the PHD1 domain of AIRE and confirms its structural similarity to a RING finger domain. Disease-associated point mutations in the PHD1 domain compromise the protein fold responsible for zinc binding, thereby disrupting AIRE function. Interestingly, this group shows that the PHD1 domain is not capable of autoubiquitination.
-
Bottomley M.J., Stier G., Pennacchini D., Legube G., Simon B., Akhtar A., Sattler M., and Musco G. NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease. J Biol Chem 280 (2005) 11505-11512. This article describes the crystal structure of the PHD1 domain of AIRE and confirms its structural similarity to a RING finger domain. Disease-associated point mutations in the PHD1 domain compromise the protein fold responsible for zinc binding, thereby disrupting AIRE function. Interestingly, this group shows that the PHD1 domain is not capable of autoubiquitination.
-
(2005)
J Biol Chem
, vol.280
, pp. 11505-11512
-
-
Bottomley, M.J.1
Stier, G.2
Pennacchini, D.3
Legube, G.4
Simon, B.5
Akhtar, A.6
Sattler, M.7
Musco, G.8
-
18
-
-
4043130957
-
Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner
-
Akiyoshi H., Hatakeyama S., Pitkanen J., Mouri Y., Doucas V., Kudoh J., Tsurugaya K., Uchida D., Matsushima A., Oshikawa K., et al. Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner. J Biol Chem 279 (2004) 33984-33991
-
(2004)
J Biol Chem
, vol.279
, pp. 33984-33991
-
-
Akiyoshi, H.1
Hatakeyama, S.2
Pitkanen, J.3
Mouri, Y.4
Doucas, V.5
Kudoh, J.6
Tsurugaya, K.7
Uchida, D.8
Matsushima, A.9
Oshikawa, K.10
-
19
-
-
1142311548
-
A comparative study of mRNA and protein expression of the autoimmune regulator gene (Aire) in embryonic and adult murine tissues
-
Adamson K.A., Pearce S.H., Lamb J.R., Seckl J.R., and Howie S.E. A comparative study of mRNA and protein expression of the autoimmune regulator gene (Aire) in embryonic and adult murine tissues. J Pathol 202 (2004) 180-187
-
(2004)
J Pathol
, vol.202
, pp. 180-187
-
-
Adamson, K.A.1
Pearce, S.H.2
Lamb, J.R.3
Seckl, J.R.4
Howie, S.E.5
-
20
-
-
32944474710
-
Increased antigen presenting cell-mediated T cell activation in mice and patients without the autoimmune regulator
-
Ramsey C., Hassler S., Marits P., Kampe O., Surh C.D., Peltonen L., and Winqvist O. Increased antigen presenting cell-mediated T cell activation in mice and patients without the autoimmune regulator. Eur J Immunol 36 (2006) 305-317
-
(2006)
Eur J Immunol
, vol.36
, pp. 305-317
-
-
Ramsey, C.1
Hassler, S.2
Marits, P.3
Kampe, O.4
Surh, C.D.5
Peltonen, L.6
Winqvist, O.7
-
21
-
-
34248598295
-
Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
-
Aschenbrenner K., D'Cruz L.M., Vollmann E.H., Hinterberger M., Emmerich J., Swee L.K., Rolink A., and Klein L. Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat Immunol 8 (2007) 351-358
-
(2007)
Nat Immunol
, vol.8
, pp. 351-358
-
-
Aschenbrenner, K.1
D'Cruz, L.M.2
Vollmann, E.H.3
Hinterberger, M.4
Emmerich, J.5
Swee, L.K.6
Rolink, A.7
Klein, L.8
-
22
-
-
0034642499
-
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
-
Bachmaier K., Krawczyk C., Kozieradzki I., Kong Y.Y., Sasaki T., Oliveira-dos-Santos A., Mariathasan S., Bouchard D., Wakeham A., Itie A., et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 403 (2000) 211-216
-
(2000)
Nature
, vol.403
, pp. 211-216
-
-
Bachmaier, K.1
Krawczyk, C.2
Kozieradzki, I.3
Kong, Y.Y.4
Sasaki, T.5
Oliveira-dos-Santos, A.6
Mariathasan, S.7
Bouchard, D.8
Wakeham, A.9
Itie, A.10
-
23
-
-
0034642534
-
Cbl-b regulates the CD28 dependence of T-cell activation
-
Chiang Y.J., Kole H.K., Brown K., Naramura M., Fukuhara S., Hu R.J., Jang I.K., Gutkind J.S., Shevach E., and Gu H. Cbl-b regulates the CD28 dependence of T-cell activation. Nature 403 (2000) 216-220
-
(2000)
Nature
, vol.403
, pp. 216-220
-
-
Chiang, Y.J.1
Kole, H.K.2
Brown, K.3
Naramura, M.4
Fukuhara, S.5
Hu, R.J.6
Jang, I.K.7
Gutkind, J.S.8
Shevach, E.9
Gu, H.10
-
24
-
-
0033680925
-
Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells
-
Krawczyk C., Bachmaier K., Sasaki T., Jones R.G., Snapper S.B., Bouchard D., Kozieradzki I., Ohashi P.S., Alt F.W., and Penninger J.M. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity 13 (2000) 463-473
-
(2000)
Immunity
, vol.13
, pp. 463-473
-
-
Krawczyk, C.1
Bachmaier, K.2
Sasaki, T.3
Jones, R.G.4
Snapper, S.B.5
Bouchard, D.6
Kozieradzki, I.7
Ohashi, P.S.8
Alt, F.W.9
Penninger, J.M.10
-
25
-
-
16844369908
-
CBLB variants in type 1 diabetes and their genetic interaction with CTLA4
-
Bergholdt R., Taxvig C., Eising S., Nerup J., and Pociot F. CBLB variants in type 1 diabetes and their genetic interaction with CTLA4. J Leukoc Biol 77 (2005) 579-585
-
(2005)
J Leukoc Biol
, vol.77
, pp. 579-585
-
-
Bergholdt, R.1
Taxvig, C.2
Eising, S.3
Nerup, J.4
Pociot, F.5
-
26
-
-
34248512113
-
Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b
-
Kitaura Y., Jang I.K., Wang Y., Han Y.C., Inazu T., Cadera E.J., Schlissel M., Hardy R.R., and Gu H. Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b. Immunity 26 (2007) 567-578
-
(2007)
Immunity
, vol.26
, pp. 567-578
-
-
Kitaura, Y.1
Jang, I.K.2
Wang, Y.3
Han, Y.C.4
Inazu, T.5
Cadera, E.J.6
Schlissel, M.7
Hardy, R.R.8
Gu, H.9
-
27
-
-
34147150656
-
Ablation of Cbl-b provides protection against transplanted and spontaneous tumors
-
Chiang J.Y., Jang I.K., Hodes R., and Gu H. Ablation of Cbl-b provides protection against transplanted and spontaneous tumors. J Clin Invest 117 (2007) 1029-1036
-
(2007)
J Clin Invest
, vol.117
, pp. 1029-1036
-
-
Chiang, J.Y.1
Jang, I.K.2
Hodes, R.3
Gu, H.4
-
28
-
-
34547684387
-
E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury
-
Bachmaier K., Toya S., Gao X., Triantafillou T., Garrean S., Park G.Y., Frey R.S., Vogel S., Minshall R., Christman J.W., et al. E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury. Nat Med 13 (2007) 920-926
-
(2007)
Nat Med
, vol.13
, pp. 920-926
-
-
Bachmaier, K.1
Toya, S.2
Gao, X.3
Triantafillou, T.4
Garrean, S.5
Park, G.Y.6
Frey, R.S.7
Vogel, S.8
Minshall, R.9
Christman, J.W.10
-
29
-
-
34247387485
-
Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells
-
Loeser S., Loser K., Bijker M.S., Rangachari M., van der Burg S.H., Wada T., Beissert S., Melief C.J., and Penninger J.M. Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells. J Exp Med 204 (2007) 879-891
-
(2007)
J Exp Med
, vol.204
, pp. 879-891
-
-
Loeser, S.1
Loser, K.2
Bijker, M.S.3
Rangachari, M.4
van der Burg, S.H.5
Wada, T.6
Beissert, S.7
Melief, C.J.8
Penninger, J.M.9
-
30
-
-
0035555195
-
Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells
-
Fang D., and Liu Y.C. Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. Nat Immunol 2 (2001) 870-875
-
(2001)
Nat Immunol
, vol.2
, pp. 870-875
-
-
Fang, D.1
Liu, Y.C.2
-
31
-
-
0035895959
-
Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells
-
Fang D., Wang H.Y., Fang N., Altman Y., Elly C., and Liu Y.C. Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells. J Biol Chem 276 (2001) 4872-4878
-
(2001)
J Biol Chem
, vol.276
, pp. 4872-4878
-
-
Fang, D.1
Wang, H.Y.2
Fang, N.3
Altman, Y.4
Elly, C.5
Liu, Y.C.6
-
32
-
-
3142782879
-
Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- mice
-
Wohlfert E.A., Callahan M.K., and Clark R.B. Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- mice. J Immunol 173 (2004) 1059-1065
-
(2004)
J Immunol
, vol.173
, pp. 1059-1065
-
-
Wohlfert, E.A.1
Callahan, M.K.2
Clark, R.B.3
-
33
-
-
31144464767
-
Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo
-
Wohlfert E.A., Gorelik L., Mittler R., Flavell R.A., and Clark R.B. Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo. J Immunol 176 (2006) 1316-1320
-
(2006)
J Immunol
, vol.176
, pp. 1316-1320
-
-
Wohlfert, E.A.1
Gorelik, L.2
Mittler, R.3
Flavell, R.A.4
Clark, R.B.5
-
34
-
-
0034307624
-
Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS
-
Lomaga M.A., Henderson J.T., Elia A.J., Robertson J., Noyce R.S., Yeh W.C., and Mak T.W. Tumor necrosis factor receptor-associated factor 6 (TRAF6) deficiency results in exencephaly and is required for apoptosis within the developing CNS. J Neurosci 20 (2000) 7384-7393
-
(2000)
J Neurosci
, vol.20
, pp. 7384-7393
-
-
Lomaga, M.A.1
Henderson, J.T.2
Elia, A.J.3
Robertson, J.4
Noyce, R.S.5
Yeh, W.C.6
Mak, T.W.7
-
35
-
-
0033561039
-
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
-
Lomaga M.A., Yeh W.C., Sarosi I., Duncan G.S., Furlonger C., Ho A., Morony S., Capparelli C., Van G., Kaufman S., et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev 13 (1999) 1015-1024
-
(1999)
Genes Dev
, vol.13
, pp. 1015-1024
-
-
Lomaga, M.A.1
Yeh, W.C.2
Sarosi, I.3
Duncan, G.S.4
Furlonger, C.5
Ho, A.6
Morony, S.7
Capparelli, C.8
Van, G.9
Kaufman, S.10
-
36
-
-
9144220961
-
The role of TRAF6 in signal transduction and the immune response
-
Kobayashi T., Walsh M.C., and Choi Y. The role of TRAF6 in signal transduction and the immune response. Microbes Infect 6 (2004) 1333-1338
-
(2004)
Microbes Infect
, vol.6
, pp. 1333-1338
-
-
Kobayashi, T.1
Walsh, M.C.2
Choi, Y.3
-
37
-
-
2342629277
-
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
-
Sun L., Deng L., Ea C.K., Xia Z.P., and Chen Z.J. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell 14 (2004) 289-301
-
(2004)
Mol Cell
, vol.14
, pp. 289-301
-
-
Sun, L.1
Deng, L.2
Ea, C.K.3
Xia, Z.P.4
Chen, Z.J.5
-
38
-
-
16444377660
-
Dependence of self-tolerance on TRAF6-directed development of thymic stroma
-
Akiyama T., Maeda S., Yamane S., Ogino K., Kasai M., Kajiura F., Matsumoto M., and Inoue J. Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308 (2005) 248-251
-
(2005)
Science
, vol.308
, pp. 248-251
-
-
Akiyama, T.1
Maeda, S.2
Yamane, S.3
Ogino, K.4
Kasai, M.5
Kajiura, F.6
Matsumoto, M.7
Inoue, J.8
-
39
-
-
0141678952
-
TRAF6 is a critical factor for dendritic cell maturation and development
-
Kobayashi T., Walsh P.T., Walsh M.C., Speirs K.M., Chiffoleau E., King C.G., Hancock W.W., Caamano J.H., Hunter C.A., Scott P., et al. TRAF6 is a critical factor for dendritic cell maturation and development. Immunity 19 (2003) 353-363
-
(2003)
Immunity
, vol.19
, pp. 353-363
-
-
Kobayashi, T.1
Walsh, P.T.2
Walsh, M.C.3
Speirs, K.M.4
Chiffoleau, E.5
King, C.G.6
Hancock, W.W.7
Caamano, J.H.8
Hunter, C.A.9
Scott, P.10
-
40
-
-
0034644474
-
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
-
Deng L., Wang C., Spencer E., Yang L., Braun A., You J., Slaughter C., Pickart C., and Chen Z.J. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103 (2000) 351-361
-
(2000)
Cell
, vol.103
, pp. 351-361
-
-
Deng, L.1
Wang, C.2
Spencer, E.3
Yang, L.4
Braun, A.5
You, J.6
Slaughter, C.7
Pickart, C.8
Chen, Z.J.9
-
41
-
-
21644449560
-
The TRAF6-NF kappa B signaling pathway in autoimmunity: not just inflammation
-
Thomas R. The TRAF6-NF kappa B signaling pathway in autoimmunity: not just inflammation. Arthritis Res Ther 7 (2005) 170-173
-
(2005)
Arthritis Res Ther
, vol.7
, pp. 170-173
-
-
Thomas, R.1
-
42
-
-
0345016454
-
TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease
-
Chiffoleau E., Kobayashi T., Walsh M.C., King C.G., Walsh P.T., Hancock W.W., Choi Y., and Turka L.A. TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease. J Immunol 171 (2003) 5751-5759
-
(2003)
J Immunol
, vol.171
, pp. 5751-5759
-
-
Chiffoleau, E.1
Kobayashi, T.2
Walsh, M.C.3
King, C.G.4
Walsh, P.T.5
Hancock, W.W.6
Choi, Y.7
Turka, L.A.8
-
43
-
-
33748460821
-
TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis
-
This article reports on a murine conditional deletion of Traf6 used to study TRAF6's role in T cell homeostasis. These mutants develop severe T cell-mediated autoimmune disease, suggesting a novel role for TRAF6 in peripheral tolerance and autoimmunity.
-
King C.G., Kobayashi T., Cejas P.J., Kim T., Yoon K., Kim G.K., Chiffoleau E., Hickman S.P., Walsh P.T., Turka L.A., et al. TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med 12 (2006) 1088-1092. This article reports on a murine conditional deletion of Traf6 used to study TRAF6's role in T cell homeostasis. These mutants develop severe T cell-mediated autoimmune disease, suggesting a novel role for TRAF6 in peripheral tolerance and autoimmunity.
-
(2006)
Nat Med
, vol.12
, pp. 1088-1092
-
-
King, C.G.1
Kobayashi, T.2
Cejas, P.J.3
Kim, T.4
Yoon, K.5
Kim, G.K.6
Chiffoleau, E.7
Hickman, S.P.8
Walsh, P.T.9
Turka, L.A.10
-
44
-
-
0034107671
-
Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo
-
Borlado L.R., Redondo C., Alvarez B., Jimenez C., Criado L.M., Flores J., Marcos M.A., Martinez A.C., Balomenos D., and Carrera A.C. Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo. FASEB J 14 (2000) 895-903
-
(2000)
FASEB J
, vol.14
, pp. 895-903
-
-
Borlado, L.R.1
Redondo, C.2
Alvarez, B.3
Jimenez, C.4
Criado, L.M.5
Flores, J.6
Marcos, M.A.7
Martinez, A.C.8
Balomenos, D.9
Carrera, A.C.10
-
45
-
-
0041975825
-
Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma
-
Rathmell J.C., Elstrom R.L., Cinalli R.M., and Thompson C.B. Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. Eur J Immunol 33 (2003) 2223-2232
-
(2003)
Eur J Immunol
, vol.33
, pp. 2223-2232
-
-
Rathmell, J.C.1
Elstrom, R.L.2
Cinalli, R.M.3
Thompson, C.B.4
-
46
-
-
0035399612
-
Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation
-
Parsons M.J., Jones R.G., Tsao M.S., Odermatt B., Ohashi P.S., and Woodgett J.R. Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation. J Immunol 167 (2001) 42-48
-
(2001)
J Immunol
, vol.167
, pp. 42-48
-
-
Parsons, M.J.1
Jones, R.G.2
Tsao, M.S.3
Odermatt, B.4
Ohashi, P.S.5
Woodgett, J.R.6
-
47
-
-
0037396674
-
GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells
-
Anandasabapathy N., Ford G.S., Bloom D., Holness C., Paragas V., Seroogy C., Skrenta H., Hollenhorst M., Fathman C.G., and Soares L. GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. Immunity 18 (2003) 535-547
-
(2003)
Immunity
, vol.18
, pp. 535-547
-
-
Anandasabapathy, N.1
Ford, G.S.2
Bloom, D.3
Holness, C.4
Paragas, V.5
Seroogy, C.6
Skrenta, H.7
Hollenhorst, M.8
Fathman, C.G.9
Soares, L.10
-
48
-
-
2942707976
-
The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells
-
Seroogy C.M., Soares L., Ranheim E.A., Su L., Holness C., Bloom D., and Fathman C.G. The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells. J Immunol 173 (2004) 79-85
-
(2004)
J Immunol
, vol.173
, pp. 79-85
-
-
Seroogy, C.M.1
Soares, L.2
Ranheim, E.A.3
Su, L.4
Holness, C.5
Bloom, D.6
Fathman, C.G.7
-
49
-
-
34248151591
-
GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype
-
MacKenzie D.A., Schartner J., Lin J., Timmel A., Jennens-Clough M., Fathman C.G., and Seroogy C.M. GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype. J Biol Chem 282 (2007) 9696-9702
-
(2007)
J Biol Chem
, vol.282
, pp. 9696-9702
-
-
MacKenzie, D.A.1
Schartner, J.2
Lin, J.3
Timmel, A.4
Jennens-Clough, M.5
Fathman, C.G.6
Seroogy, C.M.7
-
50
-
-
33751583077
-
A novel E3 ubiquitin ligase substrate screen identifies Rho guanine dissociation inhibitor as a substrate of gene related to anergy in lymphocytes
-
This article describes a novel prokaryotic method that can be used to screen for E3 ligase substrates. RhoGDIα and β are identified as the first known substrates of the E3 ligase GRAIL, linking T cell anergy to alterations in the actin cytoskeleton.
-
Su L., Lineberry N., Huh Y., Soares L., and Fathman C.G. A novel E3 ubiquitin ligase substrate screen identifies Rho guanine dissociation inhibitor as a substrate of gene related to anergy in lymphocytes. J Immunol 177 (2006) 7559-7566. This article describes a novel prokaryotic method that can be used to screen for E3 ligase substrates. RhoGDIα and β are identified as the first known substrates of the E3 ligase GRAIL, linking T cell anergy to alterations in the actin cytoskeleton.
-
(2006)
J Immunol
, vol.177
, pp. 7559-7566
-
-
Su, L.1
Lineberry, N.2
Huh, Y.3
Soares, L.4
Fathman, C.G.5
-
51
-
-
0031915677
-
The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice
-
Perry W.L., Hustad C.M., Swing D.A., O'Sullivan T.N., Jenkins N.A., and Copeland N.G. The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Nat Genet 18 (1998) 143-146
-
(1998)
Nat Genet
, vol.18
, pp. 143-146
-
-
Perry, W.L.1
Hustad, C.M.2
Swing, D.A.3
O'Sullivan, T.N.4
Jenkins, N.A.5
Copeland, N.G.6
-
52
-
-
0036197639
-
Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation
-
Fang D., Elly C., Gao B., Fang N., Altman Y., Joazeiro C., Hunter T., Copeland N., Jenkins N., and Liu Y.C. Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. Nat Immunol 3 (2002) 281-287
-
(2002)
Nat Immunol
, vol.3
, pp. 281-287
-
-
Fang, D.1
Elly, C.2
Gao, B.3
Fang, N.4
Altman, Y.5
Joazeiro, C.6
Hunter, T.7
Copeland, N.8
Jenkins, N.9
Liu, Y.C.10
-
53
-
-
34249293370
-
The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance
-
This article reviews the phenotype of Itch-deficient mice, as well as the role of the E3 ligase function of Itch in T cell functions, tolerance, and autoimmunity.
-
Liu YC. The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance. Semin Immunol 19 (2007) 197-205. This article reviews the phenotype of Itch-deficient mice, as well as the role of the E3 ligase function of Itch in T cell functions, tolerance, and autoimmunity.
-
(2007)
Semin Immunol
, vol.19
, pp. 197-205
-
-
Liu YC1
-
54
-
-
0034331549
-
Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4
-
Jolliffe C.N., Harvey K.F., Haines B.P., Parasivam G., and Kumar S. Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. Biochem J 351 Pt 3 (2000) 557-565
-
(2000)
Biochem J
, vol.351
, Issue.PART 3
, pp. 557-565
-
-
Jolliffe, C.N.1
Harvey, K.F.2
Haines, B.P.3
Parasivam, G.4
Kumar, S.5
-
55
-
-
0037088688
-
N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein
-
Harvey K.F., Shearwin-Whyatt L.M., Fotia A., Parton R.G., and Kumar S. N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J Biol Chem 277 (2002) 9307-9317
-
(2002)
J Biol Chem
, vol.277
, pp. 9307-9317
-
-
Harvey, K.F.1
Shearwin-Whyatt, L.M.2
Fotia, A.3
Parton, R.G.4
Kumar, S.5
-
56
-
-
33845386442
-
Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation
-
-/- mice. Ndfip1 was first identified as binding partner for another E3 ligase, Nedd4.
-
-/- mice. Ndfip1 was first identified as binding partner for another E3 ligase, Nedd4.
-
(2006)
Immunity
, vol.25
, pp. 929-940
-
-
Oliver, P.M.1
Cao, X.2
Worthen, G.S.3
Shi, P.4
Briones, N.5
MacLeod, M.6
White, J.7
Kirby, P.8
Kappler, J.9
Marrack, P.10
-
57
-
-
33748065322
-
The E3 ubiquitin ligase Itch controls the protein stability of p63
-
Rossi M., Aqeilan R.I., Neale M., Candi E., Salomoni P., Knight R.A., Croce C.M., and Melino G. The E3 ubiquitin ligase Itch controls the protein stability of p63. Proc Natl Acad Sci U S A 103 (2006) 12753-12758
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 12753-12758
-
-
Rossi, M.1
Aqeilan, R.I.2
Neale, M.3
Candi, E.4
Salomoni, P.5
Knight, R.A.6
Croce, C.M.7
Melino, G.8
-
58
-
-
15444367709
-
The ubiquitin-protein ligase Itch regulates p73 stability
-
Rossi M., De Laurenzi V., Munarriz E., Green D.R., Liu Y.C., Vousden K.H., Cesareni G., and Melino G. The ubiquitin-protein ligase Itch regulates p73 stability. EMBO J 24 (2005) 836-848
-
(2005)
EMBO J
, vol.24
, pp. 836-848
-
-
Rossi, M.1
De Laurenzi, V.2
Munarriz, E.3
Green, D.R.4
Liu, Y.C.5
Vousden, K.H.6
Cesareni, G.7
Melino, G.8
-
59
-
-
32044447161
-
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover
-
Chang L., Kamata H., Solinas G., Luo J.L., Maeda S., Venuprasad K., Liu Y.C., and Karin M. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 124 (2006) 601-613
-
(2006)
Cell
, vol.124
, pp. 601-613
-
-
Chang, L.1
Kamata, H.2
Solinas, G.3
Luo, J.L.4
Maeda, S.5
Venuprasad, K.6
Liu, Y.C.7
Karin, M.8
-
60
-
-
21144438325
-
A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
-
The E3 ligase Roquin was isolated in this systematic screen of the mouse genome designed to identify novel single genes involved in autoimmunity. In the absence of Roquin, mRNAs for ICOS and RANTES (among other molecules) are upregulated. It is proposed that Roquin binds to RNA-protein complexes to alter post-transcriptional protein expression, representing a unique method of E3 ligase-mediated regulation.
-
Vinuesa C.G., Cook M.C., Angelucci C., Athanasopoulos V., Rui L., Hill K.M., Yu D., Domaschenz H., Whittle B., Lambe T., et al. A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435 (2005) 452-458. The E3 ligase Roquin was isolated in this systematic screen of the mouse genome designed to identify novel single genes involved in autoimmunity. In the absence of Roquin, mRNAs for ICOS and RANTES (among other molecules) are upregulated. It is proposed that Roquin binds to RNA-protein complexes to alter post-transcriptional protein expression, representing a unique method of E3 ligase-mediated regulation.
-
(2005)
Nature
, vol.435
, pp. 452-458
-
-
Vinuesa, C.G.1
Cook, M.C.2
Angelucci, C.3
Athanasopoulos, V.4
Rui, L.5
Hill, K.M.6
Yu, D.7
Domaschenz, H.8
Whittle, B.9
Lambe, T.10
-
61
-
-
4143137360
-
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction
-
Jeon M.S., Atfield A., Venuprasad K., Krawczyk C., Sarao R., Elly C., Yang C., Arya S., Bachmaier K., Su L., et al. Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity 21 (2004) 167-177
-
(2004)
Immunity
, vol.21
, pp. 167-177
-
-
Jeon, M.S.1
Atfield, A.2
Venuprasad, K.3
Krawczyk, C.4
Sarao, R.5
Elly, C.6
Yang, C.7
Arya, S.8
Bachmaier, K.9
Su, L.10
-
62
-
-
27244459060
-
A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling
-
Heissmeyer V., Macian F., Varma R., Im S.H., Garcia-Cozar F., Horton H.F., Byrne M.C., Feske S., Venuprasad K., Gu H., et al. A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling. Novartis Found Symp 267 (2005) 165-174
-
(2005)
Novartis Found Symp
, vol.267
, pp. 165-174
-
-
Heissmeyer, V.1
Macian, F.2
Varma, R.3
Im, S.H.4
Garcia-Cozar, F.5
Horton, H.F.6
Byrne, M.C.7
Feske, S.8
Venuprasad, K.9
Gu, H.10
-
63
-
-
12144290293
-
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
-
This article describes the signaling events in T cell anergy. The E3 ligases Cbl-b, Itch, GRAIL, and Tsg101 are upregulated upon sustained calcium-calcineurin-induced T cell anergy and coordinate in function to compromise TCR-mediated signaling.
-
Heissmeyer V., Macian F., Im S.H., Varma R., Feske S., Venuprasad K., Gu H., Liu Y.C., Dustin M.L., and Rao A. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol 5 (2004) 255-265. This article describes the signaling events in T cell anergy. The E3 ligases Cbl-b, Itch, GRAIL, and Tsg101 are upregulated upon sustained calcium-calcineurin-induced T cell anergy and coordinate in function to compromise TCR-mediated signaling.
-
(2004)
Nat Immunol
, vol.5
, pp. 255-265
-
-
Heissmeyer, V.1
Macian, F.2
Im, S.H.3
Varma, R.4
Feske, S.5
Venuprasad, K.6
Gu, H.7
Liu, Y.C.8
Dustin, M.L.9
Rao, A.10
-
64
-
-
1642299050
-
PKCtheta signals activation versus tolerance in vivo
-
Berg-Brown N.N., Gronski M.A., Jones R.G., Elford A.R., Deenick E.K., Odermatt B., Littman D.R., and Ohashi P.S. PKCtheta signals activation versus tolerance in vivo. J Exp Med 199 (2004) 743-752
-
(2004)
J Exp Med
, vol.199
, pp. 743-752
-
-
Berg-Brown, N.N.1
Gronski, M.A.2
Jones, R.G.3
Elford, A.R.4
Deenick, E.K.5
Odermatt, B.6
Littman, D.R.7
Ohashi, P.S.8
-
65
-
-
33751103681
-
Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection
-
Chang X., Chen L., Wen J., Godfrey V.L., Qiao G., Hussien Y., Zhang J., and Gao J.X. Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection. Clin Immunol 121 (2006) 274-285
-
(2006)
Clin Immunol
, vol.121
, pp. 274-285
-
-
Chang, X.1
Chen, L.2
Wen, J.3
Godfrey, V.L.4
Qiao, G.5
Hussien, Y.6
Zhang, J.7
Gao, J.X.8
-
68
-
-
33847032974
-
The proteasome and its inhibitors in immune regulation and immune disorders
-
Nencioni A., Grunebach F., Patrone F., Ballestrero A., and Brossart P. The proteasome and its inhibitors in immune regulation and immune disorders. Crit Rev Immunol 26 (2006) 487-498
-
(2006)
Crit Rev Immunol
, vol.26
, pp. 487-498
-
-
Nencioni, A.1
Grunebach, F.2
Patrone, F.3
Ballestrero, A.4
Brossart, P.5
-
69
-
-
33845520806
-
Proteasome inhibitors: antitumor effects and beyond
-
This article reviews the use of proteasome inhibitors as effective anticancer therapeutics and potential antiautoimmune therapeutics. The mechanism of proteasome inhibitor action is not well understood, particularly with respect to autoimmune and inflammatory disorders. Current theories are discussed.
-
Nencioni A., Grunebach F., Patrone F., Ballestrero A., and Brossart P. Proteasome inhibitors: antitumor effects and beyond. Leukemia 21 (2007) 30-36. This article reviews the use of proteasome inhibitors as effective anticancer therapeutics and potential antiautoimmune therapeutics. The mechanism of proteasome inhibitor action is not well understood, particularly with respect to autoimmune and inflammatory disorders. Current theories are discussed.
-
(2007)
Leukemia
, vol.21
, pp. 30-36
-
-
Nencioni, A.1
Grunebach, F.2
Patrone, F.3
Ballestrero, A.4
Brossart, P.5
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