Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy

Journal of Immunology

Volumn 181, Issue 3, 2008, Pages 1622-1626

  Lineberry, Neil B ^a   Su, Leon L ^a   Lin, Jack T ^a   Coffey, Greg P ^a   Seroogy, Christine M ^a   Fathman, C Garrison ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 LIGAND; RING FINGER PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; GRAIL PROTEIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ARTICLE; BONE MARROW; CD4+ T LYMPHOCYTE; CHIMERA; CLONAL ANERGY; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; GENE; GENE EXPRESSION REGULATION; GENE RELATED TO ANERGY IN LYMPHOCYTE; HUMAN; HUMAN CELL; LYMPH FOLLICLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; UBIQUITINATION; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CELL MEMBRANE; CYTOLOGY; ENZYMOLOGY; IMMUNOLOGY; LYMPH NODE; METABOLISM; PROTEIN BINDING; T LYMPHOCYTE; UPREGULATION;

ANIMALS; CD40 LIGAND; CELL DIFFERENTIATION; CELL MEMBRANE; CELLS, CULTURED; DOWN-REGULATION; HUMANS; LYMPH NODES; MICE; MICE, INBRED BALB C; PROTEIN BINDING; T-LYMPHOCYTES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; UP-REGULATION;

EID: 49649126399     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.3.1622     Document Type: Article

References (19)

1. Schwartz, R. H. 2003. T cell anergy. Annu. Rev. Immunol. 21: 305-334.
2. Bouneaud, C., P. Kourilsky, and P. Bousso. 2000. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity 13: 829-840.
3. + T-cell anergy. Nat. Rev. Immunol. 7: 599-609.
4. Mueller, D. L. 2004. E3 ubiquitin ligases as T cell anergy factors. Nat. Immunol. 5: 883-890.
5. + T cells. Immunity 18: 535-547.
6. Seroogy, C. M., L. Soares, E. A. Ranheim, L. Su, C. Holness, D. Bloom, and C. G. Fathman. 2004. The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells. J. Immunol. 173: 79-85.
7. Safford, M., S. Collins, M. A. Lutz, A. Allen, C. T. Huang, J. Kowalski, A. Blackford, M. R. Horton, C. Drake, R. H. Schwartz, and J. D. Powell. 2005. Egr-2 and Egr-3 are negative regulators of T cell activation. Nat. Immunol. 6: 472-480.
8. Foy, T. M., A. Aruffo, J. Bajorath, J. E. Buhlmann, and R. J. Noelle. 1996. Immune regulation by CD40 and its ligand GP39. Annu. Rev. Immunol. 14: 591-617.
9. Castle, B. E., K. Kishimoto, C. Stearns, M. L. Brown, and M. R. Kehry. 1993. Regulation of expression of the ligand for CD40 on T helper lymphocytes. J. Immunol. 151: 1777-1788.
10. + T cells. J. Immunol. 151: 2497-2510.
11. Grewal, I. S., and R. A. Flavell. 1998. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16: 111-135.
12. Bowen, F., J. Haluskey, and H. Quill. 1995. Altered CD40 ligand induction in tolerant T lymphocytes. Eur. J. Immunol. 25: 2830-2834.
13. Heissmeyer, V., F. Macian, S. H. Im, R. Varma, S. Feske, K. Venuprasad, H. Gu, Y. C. Liu, M. L. Dustin, and A. Rao. 2004. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat. Immunol. 5: 255-265.
14. Luo, X., and K. Hofmann. 2001. The protease-associated domain: a homology domain associated with multiple classes of proteases. Trends Biochem. Sci. 26: 147-148.
15. Mahon, P., and A. Bateman. 2000. The PA domain: a protease-associated domain. Protein Sci. 9: 1930-1934.
16. Joazeiro, C. A., and A. M. Weissman. 2000. RING finger proteins: mediators of ubiquitin ligase activity. Cell 102: 549-552.
17. Lesley, R., L. M. Kelly, Y. Xu, and J. G. Cyster. 2006. Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival. Proc. Natl. Acad. Sci. USA 103: 10717-10722.
18. Yellin, M. J., K. Sippel, G. Inghirami, L. R. Covey, J. J. Lee, J. Sinning, E. A. Clark, L. Chess, and S. Lederman. 1994. CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40-L. Potential role in regulating helper effector function. J. Immunol. 152: 598-608.
19. Soares, L., C. Seroogy, H. Skrenta, N. Anandasabapathy, P. Lovelace, C. D. Chung, E. Engleman, and C. G. Fathman. 2004. Two isoforms of otubain 1 regulate T cell anergy via GRAIL. Nat. Immunol. 5: 45-54.