BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs

Nature

Volumn 491, Issue 7425, 2012, Pages 618-621

  Mathew, Rebecca ^a   Seiler, Michael P ^a   Scanlon, Seth T ^a   Mao, Ai Ping ^a   Constantinides, Michael G ^a   Bertozzi Villa, Clara ^a   Singer, Jeffrey D ^b   Bendelac, Albert ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b PORTLAND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CULLIN 3; HISTONE H2A; PROMYELOCYTIC LEUKEMIA ZINC FINGER; PROTEIN BCL 6; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

CELL ORGANELLE; CHROMOSOME; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC DIFFERENTIATION; IMMUNE SYSTEM; NUMERICAL MODEL; PROTEIN; RODENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; FEMALE; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA; LYMPHOCYTE DIFFERENTIATION; LYMPHOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REGULATORY T LYMPHOCYTE; UBIQUITINATION;

ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINE; CULLIN PROTEINS; DNA-BINDING PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; PROTEIN BINDING; PROTEIN TRANSPORT; T-LYMPHOCYTES; UBIQUITINATION; ZINC FINGERS;

MUS;

EID: 84869866718     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11548     Document Type: Article

References (33)

1. Savage, A. K. et al. The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity 29, 391-403 (2008).
2. Kovalovsky, D. et al. The BTB-zinc finger transcriptional regulatorPLZF controls the development of invariant natural killer T cell effector functions. Nature Immunol. 9, 1055-1064 (2008).
3. Xu, L. et al. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature 425, 316-321 (2003).
4. Furukawa, M., He, Y. J., Borchers, C. & Xiong, Y. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Nature Cell Biol. 5, 1001-1007 (2003).
5. Geyer, R., Wee, S., Anderson, S., Yates, J. & Wolf, D. A. BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases. Mol. Cell 12, 783-790 (2003).
6. Pintard, L., Willems, A. & Peter, M. Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family. EMBO J. 23, 1681-1687 (2004).
7. Zimmerman, E. S., Schulman, B. A. & Zheng, N. Structural assemblyofcullin-RING ubiquitin ligase complexes. Curr. Opin. Struct. Biol. 20, 714-721 (2010).
8. Basso, K. & Dalla-Favera, R. BCL6: master regulator ofthe germinal center reaction and key oncogene in B cell lymphomagenesis. Adv. Immunol. 105, 193-210 (2010).
9. McConnell, M. J. & Licht, J. D. The PLZF gene of t(11;17)-associated APL. Curr. Top. Microbiol. Immunol. 313, 31-48 (2007).
10. Guidez, F. et al. RARa-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia. Proc. Natl Acad. Sci. USA 104, 18694-18699 (2007).
11. Yasui, D., Miyano, M., Cai, S., Varga-Weisz, P. & Kohwi-Shigematsu, T. SATB1 targets chromatin remodelling toregulate genes over long distances. Nature 419, 641-645 (2002).
12. Cai, S., Lee, C. C. & Kohwi-Shigematsu, T. SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Nature Genet. 38, 1278-1288 (2006).
13. Reddy, K. L., Zullo, J. M., Bertolino, E. & Singh, H. Transcriptional repression mediated by repositioning of genes to the nuclear lamina. Nature 452, 243-247 (2008).
14. Zullo, J. M. et al. DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina. Cell 149, 1474-1487 (2012).
15. Ohnuki, H. et al. BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signaling in angiogenesis. Blood 119, 2688-2698 (2012).
16. Savage, A. K., Constantinides, M. G. & Bendelac, A. Promyelocytic leukemia zinc finger turns on the effector T cell program without requirement for agonist TCR signaling. J. Immunol. 186, 5801-5806 (2011).
17. Kwon, J. E. et al. BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase. J. Biol. Chem. 281, 12664-12672 (2006).
18. Wimuttisuk, W. & Singer, J. D. The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer. Mol. Biol. Cell 18, 899-909 (2007).
19. Errington, W. J. et al. Adaptor protein self-assembly drives the control of a Cullin-RING ubiquitin ligase. Structure 20, 1141-1153 (2012).
20. Crotty, S. Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 29, 621-663 (2011).
21. Hyjek, E., Chadburn, A., Liu, Y. F., Cesarman, E. & Knowles, D. M. BCL-6 protein is expressed in precursor T-cell lymphoblastic lymphoma and in prenatal and postnatal thymus. Blood 97, 270-276 (2001).
22. Cdt2 ubiquitin ligase inhibits invasion of a boundary-associated antisilencing factor into heterochromatin. Cell 144, 41-54 (2011).
23. Wang, H. et al. Role of histone H2A ubiquitination in Polycomb silencing. Nature 431, 873-878 (2004).
24. Bosch-Presegué, L. et al. Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection. Mol. Cell 42, 210-223 (2011).
25. Du, Z. et al. DNMT1 stabilityisregulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination. Sci. Signal. 3, ra80 (2010).
26. Hernández-Muñoz, I. et al. Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase. Proc. Natl Acad. Sci. USA 102, 7635-7640 (2005).
27. Hargreaves, D. C. & Crabtree, G. R. ATP-dependent chromatin remodeling: genetics, genomics and mechanisms. Cell Res. 21, 396-420 (2011).
28. Sowa, M. E., Bennett, E. J., Gygi, S. P. & Harper, J. W. Defining the human deubiquitinating enzyme interaction landscape. Cell 138, 389-403 (2009).
29. Beisel, C. & Paro, R. Silencing chromatin: comparing modes and mechanisms. Nature Rev. Genet. 12, 123-135 (2011).
30. McEvoy, J. D., Kossatz, U., Malek, N. & Singer, J. D. Constitutive turnover of cyclin E by Cul3 maintains quiescence. Mol. Cell. Biol. 27, 3651-3666 (2007).
31. Jin, J., Ang, X. L., Shirogane, T. & Wade Harper, J. Identification of substrates for F-box proteins. Methods Enzymol. 399, 287-309 (2005).
32. Rush, J. et al. Immunoaffinity profiling oftyrosine phosphorylation incancer cells. Nature Biotechnol. 23, 94-101 (2005).
33. Benlagha, K., Wei, D. G., Veiga, J., Teyton, L. & Bendelac, A. Characterization of the early stages inthymic NKT cell development. J. Exp. Med. 202, 485-492 (2005).