Cell signaling mechanisms of oro-gustatory detection of dietary fat: Advances and challenges

Progress in Lipid Research

Volumn 53, Issue 1, 2014, Pages 82-92

  Gilbertson, Timothy A ^a   Khan, Naim A ^b  

^a UTAH STATE UNIVERSITY   (United States)

^b UNIVERSITÉ DE BOURGOGNE   (France)

Author keywords

Calcium signaling; DRK channels; Fat taste; Obesity; Signal transduction; TRPM channels

Indexed keywords

CALCIUM ION; CD36 ANTIGEN; DELAYED RECTIFIER POTASSIUM CHANNEL; G PROTEIN COUPLED RECEPTOR 120; G PROTEIN COUPLED RECEPTOR 40; TRANSIENT RECEPTOR POTENTIAL CHANNEL M5;

CALCIUM CELL LEVEL; CALCIUM SIGNALING; CD36 GENE; FAT INTAKE; FOOD PREFERENCE; GENE; GENE EXPRESSION; GENE FUNCTION; GENETIC POLYMORPHISM; GPR120 GENE; GPR40 GENE; GUSTATORY NERVOUS SYSTEM; HUMAN; KNOCKOUT MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SENSORY NERVE; SIGNAL TRANSDUCTION; TASTE; TASTE BUD; TPRM5 GENE; TRIGEMINAL NERVE;

CALCIUM SIGNALING; DRK CHANNELS; FAT TASTE; OBESITY; SIGNAL TRANSDUCTION; TRPM CHANNELS;

ANIMALS; DIETARY FATS; HUMANS; MOUTH; OBESITY; POLYMORPHISM, GENETIC; SIGNAL TRANSDUCTION; TASTE PERCEPTION;

EID: 84889801532     PISSN: 01637827     EISSN: 18732194     Source Type: Journal    
DOI: 10.1016/j.plipres.2013.11.001     Document Type: Review

References (121)

1. A. Drewnowski, J.D. Brunzell, K. Sande, P.H. Iverius, and M.R. Greenwood Sweet tooth reconsidered: taste responsiveness in human obesity Physiol Behav 35 1985 617 622 (Pubitemid 16237717)
2. D.J.D. Mela, and A. Sacchetti Sensory preferences for fats: relationships with diet and body composition Am J Clin Nutr 53 1991 908 915
3. T.A. Gilbertson, T. Yu, and B.P. Shah Gustatory mechanisms for fat detection J.P. Montmayeur, J. le Coutre, Fat detection: taste, texture, and post ingestive effects 2010 CRC Press Boca Raton (FL) 83 104
4. M. Takeda, S. Sawano, M. Imaizumi, and T. Fushiki Preference for corn oil in olfactory-blocked mice in the conditioned place preference test and the two-bottle choice test Life Sci 69 2001 847 854 (Pubitemid 32619197)
5. T. Fukuwatari, K. Shibata, K. Iguchi, T. Saeki, A. Iwata, and K. Tani Role of gustation in the recognition of oleate and triolein in anosmic rats Physiol Behav 78 2003 579 583 (Pubitemid 36628084)
6. G.S. Dramane, S. Akpona, A.M. Simonin, B. Besnard, and N.A. Khan Cell signaling mechanisms of gustatory perception of lipids: can the taste cells be the target of anti-obesity agents? Curr Med Chem 18 2011 3417 3422
7. 2+ signaling in taste bud cells and spontaneous preference for fat: unresolved roles of CD36 and GPR120 Biochimie 2013 10.1016/j.biochi.2013.06.005 pii:S0300-9084(13)00171-5 [Epub ahead of print]
8. M. Tsuruta, T. Kawada, T. Fukuwatari, and T. Fushiki The orosensory recognition of long-chain fatty acids in rats Physiol Behav 66 1999 285 288 (Pubitemid 29206520)
9. A. Chale-Rush, J.R. Burgess, and R.D. Mattes Multiple routes of chemosensitivity to free fatty acids in humans Am J Physiol Gastrointest Liver Physiol 292 2007 G1206 G1212
10. A. Chale-Rush, J.R. Burgess, and R.D. Mattes Evidence for human orosensory (taste?) sensitivity to free fatty acids Chem Senses 32 2007 423 431 (Pubitemid 47079418)
11. R.D. Mattes Effects of linoleic acid on sweet, sour, salty, and bitter taste thresholds and intensity ratings of adults Am J Physiol Gastrointest Liver Physiol 292 2007 G1243 G1248
12. J.A. Nasser, H.R. Kissileff, C.N. Boozer, C.J. Chou, and F.X. Pi-Sunyer PROP taster status and oral fatty acid perception Eat Behav 2 2001 237 245
13. M.M. Kamphuis, W.H. Saris, and M.S. Westerterp-Plantenga The effect of addition of linoleic acid on food intake regulation in linoleic acid tasters and linoleic acid non-tasters Br J Nutr 90 2003 199 206 (Pubitemid 36903418)
14. M.S. Herness, and T.A. Gilbertson Cellular mechanisms of taste transduction Ann Rev Physiol 61 1999 873 900 (Pubitemid 29143196)
15. N. Chaudhari, and S.D. Roper The cell biology of taste J Cell Biol 190 2010 285 296
16. I.J. Miller Anatomy of the peripheral taste system R.L. Doty, Handbook of olfaction and gustation 1995 Marcel Dekker New York 521 547
17. F. Laugerette, P. Passilly-Degrace, B. Patris, I. Niot, M. Febbraio, and J.P. Montmayeur CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions J Clin Invest 115 2005 3177 3184 (Pubitemid 41567582)
18. D. Gaillard, F. Laugerette, N. Darcel, A. El-Yassimi, P. Passilly-Degrace, and A. Hichami The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse FASEB J 22 2008 1458 1468 (Pubitemid 351656786)
19. H. Lawson Food oils and fats: technology, utilization, and nutrition 1995 Chapman & Hall New York
20. T. Kawai, and T. Fushiki Importance of lipolysis in oral cavity for orosensory detection of fat Am J Physiol Regul Integr Comp Physiol 285 2003 R447 R454
21. T. Weiss C.N. Westport, Food oils and their uses 1983 Avi Publishing Co.
22. P. Liu, B.P. Shah, S. Croasdell, and T.A. Gilbertson Transient receptor potential channel type M5 is essential for fat taste J Neurosci 31 2011 8634 8642
23. T. Hiraoka, T. Fukuwatari, M. Imaizumi, and T. Fushiki Effects of oral stimulation with fats on the cephalic phase of pancreatic enzyme secretion in esophagostomized rats Physiol Behav 79 2003 713 717 (Pubitemid 37087965)
24. R.D. Mattes Oral thresholds and suprathreshold intensity ratings for free fatty acids on 3 tongue sites in humans: implications for transduction mechanisms Chem Senses 34 2009 415 423
25. R.D. Mattes Accumulating evidence supports a taste component for free fatty acids in humans Physiol Behav 104 2011 624 663
26. C.A. Running, R.D. Mattes, and R.M. Tucker Fat taste in humans: sources of within- and between-subject variability Prog Lipid Res 52 2013 438 445
27. B. Kulkarni, V.K.V. Wood, and R.D. Mattes Quantitative and qualitative analyses of human salivary NEFA with gas-chromatography and mass spectrometry Front Physiol 3 2012 328 10.3389/fphys.2012.00328
28. B. Kulkarni, and R.D. Mattes Evidence for presence of nonesterified fatty acids as potential gustatory signaling molecules in humans Chem Senses 38 2013 119 127
29. R.M. Tucker, and R.D. Mattes Are free fatty acids effective taste stimuli in humans? Presented at the symposium "the taste for fat: new discoveries on the role of fat in sensory perception, metabolism, sensory pleasure and beyond" held at the Institute of Food Technologists 2011 Annual Meeting, New Orleans, LA, June 12, 2011 J Food Sci 77 2012 S148 S151
30. N.A. Abumrad, M.R. El-Maghrabi, E.Z. Amri, E. Lopez, and P.A. Grimaldi Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36 J Biol Chem 268 1993 17665 17668 (Pubitemid 23260267)
31. D.E. Greenwalt, R.H. Lipsky, C.F. Ockenhouse, H. Ikeda, N.N. Tandon, and G.A. Jamieson Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine Blood 80 1992 1105 1115
32. R.L. Silverstein, and M. Febbraio CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior Sci Signal 2 2009 re3
33. A.G. Baillie, C.T. Coburn, and N.A. Abumrad Reversible binding of long-chain fatty acids to purified FAT, the adipose CD36 homologue J Membr Biol 153 1996 75 81 (Pubitemid 26323623)
34. T. Fukuwatari, T. Kawada, M. Tsuruta, T. Hiraoka, T. Iwanaga, and E. Sugimoto Expression of the putative membrane fatty acid transporter (FAT) in taste buds of the circumvallate papillae in rats FEBS Lett 414 1997 461 464 (Pubitemid 27389417)
35. A. Sclafani, K. Ackroff, and N.A. Abumrad CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice Am J Physiol Regul Integr Comp Physiol 293 2007 R1823 R1832
36. P.J. Simons, J.A. Kummer, J.J. Luiken, and L. Boon Apical CD36 immunolocalization in human and porcine taste buds from circumvallate and foliate papillae Acta Histochem 113 2011 839 843
37. H. Ozdener, K.K. Yee, J. Cao, J.G. Brand, J.H. Teeter, and N.E. Rawson Characterization and long-term maintenance of rat taste cells in culture Chem Senses 31 2006 279 290
38. K.L. Keller, L.C. Liang, J. Sakimura, D. May, C. van Belle, and C. Breen Common variants in the CD36 gene are associated with oral fat perception, fat preferences, and obesity in African Americans Obesity (Silver Spring) 20 2012 1066 1073
39. M. Von Zastrow Mechanisms regulating membrane trafficking of G protein-coupled receptors in the endocytic pathway Life Sci 74 2003 217 224 (Pubitemid 37357053)
40. B. Lindemann Receptors and transduction in taste Nature 413 2001 219 225 (Pubitemid 32867887)
41. C. Cartoni, K. Yasumatsu, T. Ohkuri, N. Shigemura, R. Yoshida, and N. Godinot Taste preference for fatty acids is mediated by GPR40 and GPR120 J Neurosci 30 2010 8376 8382
42. M.M. Galindo, N. Voigt, J. Stein, J. van Lengerich, J.D. Raguse, and T. Hofmann G protein-coupled receptors in human fat taste perception Chem Senses 37 2012 123 139
43. A. Hirasawa, T. Hara, S. Katsuma, T. Adachi, and G. Tsujimoto Free fatty acid receptors and drug discovery Biol Pharm Bull 31 2008 1847 1851
44. R.L. Dobbins, L.S. Szczepaniak, J. Myhill, Y. Tamura, H. Uchino, and A. Giacca The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats Diabetes 51 2002 1825 1833 (Pubitemid 34564295)
45. W. El-Assaad, J. Buteau, M.L. Peyot, C. Nolan, R. Roduit, and S. Hardy Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death Endocrinology 144 2003 4154 4163 (Pubitemid 37088771)
46. M. Manco, A. Bertuzzi, S. Salinari, A. Scarfone, M. Calvani, and A.V. Greco The ingestion of saturated fatty acid triacylglycerols acutely affects insulin secretion and insulin sensitivity in human subjects Br J Nutr 92 2004 895 903 (Pubitemid 40028850)
47. M. Manco, G. Mingrone, A.V. Greco, E. Capristo, D. Gniuli, and A. Gaetano Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides Metab Clin Exp 49 2000 220 224 (Pubitemid 30090887)
48. S.B. Tove Toxicity of saturated fat J Nutr 84 1964 237 243
49. C.P. Briscoe, M. Tadayyon, J.L. Andrews, W.G. Benson, J.K. Chambers, and M.M. Eilert The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids J Biol Chem 278 2003 11303 11311 (Pubitemid 36792687)
50. D.Y. Oh, and W.S. Lagakos The role of G-protein-coupled receptors in mediating the effect of fatty acids on inflammation and insulin sensitivity Curr Opin Clin Nutr Metab Care 14 2011 322 327
51. C. Venkataraman, and F. Kuo The G-protein coupled receptor, GPR84 regulates IL-4 production by T lymphocytes in response to CD3 crosslinking Immunol Lett 101 2005 144 153 (Pubitemid 41368072)
52. J. Wang, X. Wu, N. Simonavicius, H. Tian, and L. Ling Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84 J Biol Chem 281 2006 34457 34464 (Pubitemid 46036653)
53. Liu Y, Gilbertson TA. Medium chain fatty acid transduction in mouse taste cells is TRPM5-independent. Association for Chemoreception Sciences XXXIV Annual Meeting. Huntington Beach, CA; 2012.
54. Liu Y, Gilbertson TA. Ligand specificity of orphan G protein-coupled receptor 84. Association for Chemoreception Sciences XXXVnd Annual Meeting. Huntington Beach, CA; 2013.
55. C.N. Serhan, and N. Chiang Resolution phase lipid mediators of inflammation: agonists of resolution Curr Opin Pharmacol 6 2013 90 10.1016/j.coph.2013.05.012 pii:S1471-4892(13)00072-6 [Epub ahead of print]
56. J.V. Busik, W.J. Esselman, and G.E. Reid Examining the role of lipid mediators in diabetic retinopathy Clin Lipidol 7 2012 661 675
57. S.W. Wong, M.-J. Kwon, A.M.K. Choi, H.-P. Kim, K. Nakahira, and D.H. Hwang Fatty acids modulate toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner J Biol Chem 284 2009 384 392
58. K.M. Eyster The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemist Adv Physiol Educ 31 2007 5 16
59. F.A. Monsalve, R.D. Pyarasani, F. Delgado-Lopez, and R. Moore-Carrasco Peroxisome proliferator-activated receptor targets for the treatment of metabolic diseases Mediators Inflamm 2013 2013 549627
60. N.A. Khan Polyunsaturated fatty acids in the modulation of T-cell signalling Prostaglandins Leukot Essent Fatty Acids 82 2010 179 187
61. S.B. Russo, J.S. Ross, and L.A. Cowart Sphingolipids in obesity, type 2 diabetes, and metabolic disease Handb Exp Pharmacol 216 2013 373 401
62. T.A. Gilbertson, and J.D. Boughter Taste transduction: appetizing times in gustation Neuroreport 14 2003 905 911 (Pubitemid 36829762)
63. N.A. Khan, and P. Besnard Oro-sensory perception of dietary lipids: new insights into the fat taste transduction Biochim Biophys Acta 1791 2009 149 155
64. S.D. Roper Cell communication in taste buds Cell Mol Life Sci 63 2006 1494 1500 (Pubitemid 44156746)
65. M.J. Berridge Unlocking the secrets of cell signaling Annu Rev Physiol 67 2005 1 21 (Pubitemid 40404483)
66. J.W. Putney Jr TRP, inositol 1,4,5-trisphosphate receptors, and capacitative calcium entry Proc Natl Acad Sci U S A 96 1999 14669 14671
67. P.B. Liu, P. Shah, S. Croasdell, and T.A. Gilbertson Transient receptor potential channel type M5 is essential for fat taste J Neurosci 31 2011 8634 8642
68. A. El-Yassimi, A. Hichami, P. Besnard, and N.A. Khan Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells J Biol Chem 283 2008 12949 12959
69. A. Hirasawa, K. Tsumaya, T. Awaji, S. Katsuma, T. Adachi, and M. Yamada Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 Nat Med 11 2005 90 94 (Pubitemid 40215843)
70. G. Babnigg, S.R. Bowersox, and M.L. Villereal The role of pp60 c-src in the regulation of calcium entry via store-operated calcium channels J Biol Chem 272 1997 29434 29437
71. M.M. Huang, J.B. Bolen, J.W. Barnwell, S.J. Shattil, and J.S. Brugge Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets Proc Natl Acad Sci U S A 88 1991 7844 7848 (Pubitemid 21915251)
72. H.A. Bull, P.M. Brickel, and P.M. Dowd Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells FEBS Lett 351 1994 41 44
73. 2+ channel activation J Biol Chem 282 2007 29448 29456 (Pubitemid 350043387)
74. G. Dramane, S. Abdoul-Azize, A. Hichami, T. Vögtle, S. Akpona, and C. Chouabe STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice J Clin Invest 122 2012 2267 2282
75. 2+ selectivity of Orai1/Orai3 heteromeric channel Proc Natl Acad Sci U S A 106 2009 19623 19628
76. C.A. Perez, L. Huang, M. Rong, J.A. Kozak, A.K. Preuss, and H. Zhang A transient receptor potential channel expressed in taste receptor cells Nat Neurosci 5 2002 1169 1176 (Pubitemid 35247176)
77. Y. Zhang, M.A. Hoon, J. Chandrashekar, K.L. Mueller, B. Cook, and D. Wu Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways Cell 112 2003 293 301 (Pubitemid 36183651)
78. 2 regulate the taste transduction ion channel TRPM5 Proc Natl Acad Sci U S A 100 2003 15160 15165 (Pubitemid 37518033)
79. A. Sclafani, S. Zukerman, J.I. Glendinning, and R.F. Margolskee Fat and carbohydrate preferences in mice. The contribution of alpha-gustducin and Trpm5 taste-signaling proteins Am J Physiol Regul Integr Comp Physiol 293 2007 R1504 R1513
80. H. Oike, M. Wakamori, Y. Mori, H. Nakanishi, R. Taguchi, and T. Misaka Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells Biochim Biophys Acta 1761 2006 1078 1084 (Pubitemid 44354293)
81. B.P. Shah, P. Liu, T. Yu, D.R. Hansen, and T.A. Gilbertson TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1 Am J Physiol Cell Physiol 302 2012 C210 C219
82. + channels in taste receptor cells: gustatory cues for dietary fat Am J Physiol 272 1997 C1203 C1210
83. + channels in taste cells provides the basis for sour taste transduction Proc Natl Acad Sci U S A 85 1988 7023 7027
84. + current J Neurophysiol 75 1996 1256 1263 (Pubitemid 26087490)
85. + channels in anterior rat taste buds Am J Physiol 289 2005 C868 C880
86. M.C. McKay, and J.F. Worley III. Linoleic acid both enhances activation and blocks Kv1.5 and Kv2.1 channels by two separate mechanisms Am J Physiol Cell Physiol 281 2001 C1277 C1284
87. + channel Am J Physiol 274 1998 C149 C160
88. T.A. Gilbertson Role of the taste system in ingestive behavior. Studies in NaCl and fatty acid transduction Ann N Y Acad Sci 855 1998 860 867 (Pubitemid 29110088)
89. T. Yu, B.P. Shah, D.R. Hansen, M. Park-York, and T.A. Gilbertson Activation of oral trigeminal neurons by fatty acids is dependent upon intracellular calcium Pflugers Arch 464 2012 227 237
90. S. Abdoul-Azize, F. Atek-Maebarki, A. Bitam, H. Sadou, E.A. Koceïr, and N.A. Khan Oro-gustatory perception of dietary lipids and calcium signaling in taste bud cells are altered in nutritionally obesity-prone Psammomys obesus PLoS One 8 2013 e68532 10.1371/journal.pone.0068532
91. R.D. Mattes Oral fatty acid signaling and intestinal lipid processing: support and supposition Physiol Behav 105 2011 27 35
92. F. Bellisle Glutamate and the UMAMI taste: sensory, metabolic, nutritional and behavioural considerations. A review of the literature published in the last 10 years Neurosci Biobehav Rev 23 1999 423 438 (Pubitemid 29053216)
93. W. Kim, N.A. Khan, D.N. McMurray, I.A. Prior, N. Wang, and R.S. Chapkin Regulatory activity of polyunsaturated fatty acids in T-cell signaling Prog Lipid Res 49 2010 250 261
94. A. Bonin, and N.A. Khan Regulation of calcium signalling by docosahexaenoic acid in human T-cells. Implication of CRAC channels J Lipid Res 41 2000 277 284 (Pubitemid 30117869)
95. M. Chevrot, A. Bernard, D. Ancel, M. Buttet, C. Martin, and S. Abdoul-Azize Obesity alters the gustatory perception of lipids in the mouse: plausible involvement of the lingual CD36 J Lipid Res 54 2013 2485 2494
96. X.J. Zhang, L.H. Zhou, X. Ban, D.X. Liu, W. Jiang, and X.M. Liu Decreased expression of CD36 in circumvallate taste buds of high-fat diet induced obese rats Acta Histochem 113 2011 663 667
97. K.S. Curtis, E.G. Krause, and R.J. Contreras Altered NaCl taste responses precede increased NaCl ingestion during Na(+) deprivation Physiol Behav 72 2001 743 749 (Pubitemid 32406223)
98. J.I. Glendinning, J. Gillman, H. Zamer, R.F. Margolskee, and A. Sclafani The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice Physiol Behav 107 2012 50 58
99. M.Y. Pepino, L. Love-Gregory, S. Klein, and N.A. Abumrad The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects J Lipid Res 53 2012 561 566
100. S.D. Primeaux, H.D. Braymer, and G.A. Bray CD36 mRNA in the gastrointestinal tract is differentially regulated by dietary fat intake in obesity-prone and obesity-resistant rats Dig Dis Sci 58 2013 363 370
101. A. Ichimura, A. Hirasawa, O. Poulain-Godefroy, A. Bonnefond, T. Hara, and L. Yengo Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human Nature 483 2012 350 354
102. J.E. Stewart, C. Feinle-Bisset, and R.S. Keast Fatty acid detection during food consumption and digestion: associations with ingestive behavior and obesity Prog Lipid Res 50 2011 225 233
103. J.E. Stewart, R.V. Seimon, B. Otto, R.S. Keast, P.M. Clifton, and C. Feinle-Bisset Marked differences in gustatory and gastrointestinal sensitivity to oleic acid between lean and obese men Am J Clin Nutr 93 2011 703 711
104. J.E. Stewart, and R.S. Keast Recent fat intake modulates fat taste sensitivity in lean and overweight subjects Int J Obes (Lond) 36 2012 834 842
105. J.E. Stewart, L.P. Newman, and R.S. Keast Oral sensitivity to oleic acid is associated with fat intake and body mass index Clin Nutr 30 2011 838 844
106. L.M. Bartoshuck, K. Rennert, J. Rodin, and J.C. Stevens Effects of temperature on the perceived sweetness of sucrose Physiol Behav 28 2001 905 910
107. K. Hoebe, P. Georgel, S. Rutschmann, X. Du, S. Mudd, and K. Crozat CD36 is a sensor of diacylglycerides Nature 433 2005 523 527 (Pubitemid 40204309)
108. R. Benton, K.S. Vannice, and L.B. Vosshall An essential role for a CD36-related receptor in pheromone detection in Drosophila Nature 450 2007 289 293 (Pubitemid 350100549)
109. C. Martin, P. Passilly-Degrace, D. Gaillard, J.F. Merlin, M. Chevrot, and P. Besnard The lipid-sensor candidates CD36 and GPR120 are differentially regulated by dietary lipids in mouse taste buds: impact on spontaneous fat preference PLoS One 6 8 2011 e24014
110. D.W. Pittman, C.E. Labban, A.A. Anderson, and H.E. O'connor Linoleic and oleic acids alter the licking responses to sweet, salt, sour, and bitter tastants in rats Chem Senses 31 2006 835 843 (Pubitemid 44742418)
111. + currents in primary cultured rat pancreatic beta-cells by linoleic acids Endocrinology 147 2006 674 682 (Pubitemid 43112982)
112. T.A. Gilbertson, L. Liu, I. Kim, C.A. Burks, and D.R. Hansen Fatty acid responses in taste cells from obesity-prone and -resistant rats Physiol Behav 86 2005 681 690 (Pubitemid 41728986)
113. C. Martin, P. Passilly-Degrace, M. Chevrot, D. Ancel, S.M. Sparks, and D.J. Drucker Lipid-mediated release of GLP-1 by mouse taste buds from circumvallate papillae: putative involvement of GPR120 and impact on taste sensitivity J Lipid Res 53 2012 2256 2265
114. A. Drewnowski, and M.R. Greenwood Cream and sugar: human preferences for high-fat foods Physiol Behav 30 1983 629 633 (Pubitemid 13036236)
115. C.D. Dotson, S.D. Roper, and A.C. Spector PLC-beta2-independent behavioral avoidance of prototypical bitter-tasting ligands Chem Senses 30 2005 593 600 (Pubitemid 41300632)
116. C. Hisatsune, K. Yasumatsu, H. Takahashi-Iwanaga, N. Ogawa, Y. Kuroda, and R. Yoshida Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor J Biol Chem 282 2007 37225 37231
117. S.R. Crystal, and K.L. Teff Tasting fat: cephalic phase hormonal responses and food intake in restrained and unrestrained eaters Physiol Behav 89 2006 213 220
118. R.B. Heath, R. Jones, K.N. Fryan, and M.D. Robertson Vagal stimulation exaggerates the inhibitory ghrelin response to oral fat in humans J Endocrinol 180 2004 273 281 (Pubitemid 38312608)
119. A. Schafmayer, N.R. Pompino, and H. Kohler Vagal influence on cholecystokinin and neurotensin release in conscious dogs Scand J Gastroenterol 23 1988 315 320
120. Q. Sun, A. Hirasawa, T. Hara, I. Kimura, T. Adachi, and T. Awaji Structure-activity relationships of GPR120 agonists based on a docking simulation Mol Pharmacol 78 2010 804 810
121. N. Godinot, K. Yasumatsu, M.E. Barcos, N. Pineau, M. Ledda, and F. Viton Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice Neuroscience 2013 10.1016/J Neurosci 2013.06.043 pii:S0306-4522(13)00549-6 [Epub ahead of print]