Cellular mechanisms of taste transduction

Annual Review of Physiology

Volumn 61, Issue , 1999, Pages 873-900

  Herness, M Scott ^a   Gilbertson, Timothy A ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Chemical senses; Gustatory; Ion channels; Receptors; Sensory physiology

Indexed keywords

AMINO ACID; CYCLIC AMP; FATTY ACID; GLUTAMIC ACID; INOSITOL TRISPHOSPHATE; ION; ION CHANNEL; NEUROTRANSMITTER;

ACTION POTENTIAL; GUSTATORY NERVOUS SYSTEM; HUMAN; MAMMAL; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SECOND MESSENGER; SENSORY NERVE; SIGNAL TRANSDUCTION; SWEETNESS; TASTE; TASTE BUD;

ACTION POTENTIALS; ANIMALS; NEUROTRANSMITTER AGENTS; RECEPTORS, SENSORY; SIGNAL TRANSDUCTION; TASTE;

EID: 0033034033     PISSN: 00664278     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.physiol.61.1.873     Document Type: Review

References (175)

1. 1. Gilbertson TA, Kinnamon SC. 1996. Making sense of chemicals. Chem. Biol. 3:233-37
2. 2. Spielman AI, Huque T, Whitney G, Brand JG. 1992. The diversity of bitter taste signal transduction mechanisms. In Sensory Transduction, ed. DP Corey, SD Roper, pp. 307-24. New York: Rockefeller Univ. Press
3. 3. Schiffman SS, Gatlin CA. 1993.Sweeteners: state of knowledge review. Neurosci. Biobehav. Rev. 17:313-45
4. 4. Schiffman SS, Gill JM. 1987. Psychophysical and neurophysiological taste responses to glutamate and purinergic compounds. In Umami: A Basic Taste, ed. Y Kawamura, MR Kare, pp. 271-88. New York: Dekker
5. 5. Yamaguchi S. 1991. Basic properties of umami and effects on humans. Physiol. Behav. 49:833-41
6. 6. Drewnowski A. 1997. Taste preferences and food intake. Annu. Rev. Nutr. 17:237-53
7. 7. Mela DJ, Marshall RJ. 1991. Sensory properties and perceptions of fats. In Dietary Fats: Determinants of Preference, Selection and Consumption. ed. DJ Mela, pp. 43-57. New York: Elsevier
8. + channels in taste receptor cells: gustatory cues for dietary fat. Am. J. Physiol. 272:C1203-10
9. 9. Gilbertson TA. 1998. Gustatory mechanisms for the detection of fat. Curr. Opin. Neurobiol. 8:447-52
10. + receptor mechanisms. Chem. Senses 20:37-46
11. 11. Ossebaard CA, Polet IA, Smith DV. 1997. Amiloride effects on taste quality: comparison of single and multiple response category procedures. Chem. Senses 22:267-75
12. 12. Miller IJ. 1995. Anatomy of the peripheral taste system. In Handbook of Olfaction and Gustation, ed. RL Doty, pp. 521-57. New York: Dekker
13. 13. Kolmer W. 1927. Geschmacksorgan. In Handbuch der Mikroskopischen Anatomie des Menschen, Haut und Sinnesorgane, ed. Anonymous, 3:154-91. Berlin: Springer
14. 14. Murray RG, Murray A. 1970. The anatomy and ultrastructure of taste endings. In Taste and Smell in Vertebrates, ed. GEW Wolstenholme, J Knight, pp. 3-30. London: Churchill
15. 15. Delay R, Kinnamon JC, Roper SD. 1986. Ultrastructure of mouse vallate taste buds. II. Cell types and cell lineage. J. Comp. Neurol. 253:242-52
16. 16. Murray RG. 1973. The ultrastructure of taste buds. In The Ultrastructure of Sensory Organs, ed. I Friedemann, pp. 1-81. Amsterdam: North Holland
17. 17. Farbman AI. 1985. Structure of taste buds in foliate papillae of the rhesus monkey, Macaca mulatta. Am. J. Anat. 172:41-56
18. 18. Paran N, Mattern CFT, Henkin R. 1975. Ultrastructure of the taste bud of the human fungiform papilla. Cell Tissue Res. 161:1-10
19. 19. Takeda M, Suzuki Y, Shishido Y. 1985. Effects of colchicine on the ultrastructure of mouse taste buds. Cell Tissue Res. 242:409-16
20. 20. Kinnamon JC, Taylor BJ, Delay RJ, Roper SD. 1985. Ultrastructure of mouse vallate taste buds. I. Taste cells and their associated synapses. J. Comp. Neurol. 235:48-60
21. 21. Murray RG. 1986. The mammalian taste bud type 3 cell: a critical analysis. J. Ultrastruct. Mol. Struct. 95:175-88
22. 22. Royer SM, Kinnamon JC. 1991. HVEM serial-section analysis of rabbit foliate taste buds. 1. Type-III cells and their synapses. J. Comp. Neurol. 306:49-72
23. 23. Beidler LM, Smallmen RL. Renewal of cells within taste buds. J. Cell Biol. 27: 263-72
24. 24. Farbman AI. 1965. Fine structure of the taste buds. J. Ultrastruct. Res. 12:328-50
25. 25. Kinnamon JC. 1987. Organization and innervation of taste buds. In Neurobiology of Taste and Smell, ed. TE Finger, WL Silver, pp. 277-97. New York: Wiley
26. 26. Farbman AI. 1980. Renewal of taste bud cells in rat circumvallate papillae. Cell Tissue Kinet. 13:349-57
27. 27. Murray RG, Murray A. 1971. Relations and possible significance of taste bud cells. Contrib. Sens. Physiol. 5:47-95
28. 28. Pumplin DW, Yu CS, Smith DV. 1997. Light and dark cells of rat vallate taste buds are morphologically distinct cell types. J. Comp. Neurol. 378:389-410
29. 29. Béhé P, DeSimone JA, Avenet P, Lindemann B. 1990. Membrane currents in taste cells of the rat fungiform papilla. Evidence for two types of Ca currents and inhibition of K currents by saccharin. J. Gen. Physiol. 96:1061-84
30. 30. Chen YS, Sun XD, Herness MS. 1996. Characteristics of action potentials and their underlying outward currents in rat taste receptor cells. J. Neurophysiol. 75: 820-31
31. 31. Herness MS, Sun XD. 1995. Voltage-dependent sodium currents recorded from dissociated rat taste cells. J. Membr. Biol. 146:73-84
32. 32. Doolin RE, Gilbertson TA. 1996. Distribution and characterization of functional amiloride-sensitive sodium channels in rat tongue. J. Gen. Physiol. 107:545-54
33. 33. Sun XD, Herness MS. 1996. Characterization of inwardly rectifying potassium currents from dissociated rat taste receptor cells. Am. J. Physiol. 271:C1221-32
34. 34. Chen Y, Herness MS. 1997. Electrophysiological actions of quinine on voltage-dependent currents in dissociated rat taste cells. Pflugers Arch. 434:215-26
35. 35. Sun XD, Herness MS. 1995. Characterization of chloride currents recorded from dissociated rat taste cells. Soc. Neurosci. Abstr. 21:1656 (Abstr.)
36. + conductance in the apical membrane of frog taste cells. Brain Res. 715:79-85
37. 37. Kolesnikov SS, Margolskee RF. 1995. A cyclic-nucleotide-suppressible conductance activated by transducin in taste cells. Nature 376:85-88
38. 38. Misaka T, Kusakabe Y, Emori Y,Gonoi T, Arai S, Abe K. 1997. Taste buds have a cyclic nucleotide-activated channel, CNGgust. J. Biol. Chem. 272:22623-29
39. 39. Akabas MH, Dodd J, Al-Awqati Q. 1990. Identification of electrophysiologically distinct subpopulations of rat taste cells. J. Membr. Biol. 114:71-78
40. 40. Herness MS, Sun XD, Chen Y. 1996. Inhibition of inwardly rectifying potassium currents by G-protein activation in rat taste receptor cells. Soc. Neurosci. Abstr. 22:1826 (Abstr.)
41. 41. Avenet P, Lindemann B. 1991. Noninvasive recording of receptor cell action potentials and sustained currents from single taste buds maintained in the tongue: the response to mucosal NaCl and amiloride. J. Membr. Biol. 124:33-41
42. 42. Cummings TA, Powell J, Kinnamon SC. 1993. Sweet taste transduction in hamster taste cells: evidence for the role of cyclic nucleotides. J. Neurophysiol. 70:2326-36
43. 43. Gilbertson TA, Avenet P, Kinnamon SC, Roper SD. 1992. Proton currents through amiloride-sensitive Na channels in hamster taste cells: role in acid transduction. J. Gen. Physiol. 100:803-24
44. 44. Mackay-Sim A, Delay RJ, Roper SD, Kinnamon SC. 1996. Development of voltage-dependent currents in taste receptor cells. J. Comp. Neurol. 365:278-88
45. 45. Nagai T, Kim DJ, Delay RJ, Roper SD. 1996. Neuromodulation of transduction and signal processing in the end organs of taste. Chem. Senses 21:353-65
46. 46. Obata H, Shimada K, Sakai N, Saito N. 1997. GABAergic neurotransmission in rat taste buds: immunocytochemical study for GABA and GABA transporter subtypes. Mol. Brain Res. 49:29-36
47. 47. Kim DJ, Roper SD. 1995. Localization of serotonin in taste buds: A comparative study in four vertebrates. J. Comp. Neurol. 353:364-70
48. 48. Delay RJ, Taylor R, Roper SD. 1993. Merkel-like basal cells in Necturus taste buds contain serotonin. J. Comp. Neurol. 335:606-13
49. 49. Ewald DA, Roper SD. 1994. Bidirectional synaptic transmission in Necturus taste buds. J. Neurosci. 14:3791-804
50. 50. Delay RJ, Kinnamon SC, Roper SD. 1997. Serotonin modulates voltage-dependent calcium current in Necturus taste cells. J. Neurophysiol. 77:2515-24
51. + current in rat taste receptor cells. NeuroReport 8:3257-61
52. 52. Sun XD, Herness MS. 1996. Cascade of adrenoceptor, G-protein, and cAMP inhibits outward potassium currents in rat taste receptor cells. Soc. Neurosci. Abstr. 22:1826 (Abstr.)
53. 53. Herness MS. 1997. The cAMP cascade affects sodium and chloride currents in rat taste receptor cells. Soc. Neurosci. Abstr. 23:1037 (Abstr.)
54. 54. DeSimone JA, Heck GL, DeSimone SK. 1981. Active ion transport in dog tongue: a possible role in taste. Science 214:1039-41
55. 55. Heck GL, Mierson S, DeSimone JA. 1984. Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway. Science 223:403-5
56. +-transport pathway in rat tongue epithelium. J. Neurophysiol. 76:1297-309
57. 57. Gilbertson TA, Zhang H. 1998. Characterization of sodium transport in gustatory epithelia from the hamster and rat. Chem. Senses 23:283-93
58. 58. Brand JG, Teeter JH, Silver WH. 1985.Inhibition by amiloride of chorda tympani responses evoked by monovalent salts. Brain Res. 334:207-14
59. 59. DeSimone JA, Ferrell F. 1985. Analysis of amiloride inhibition of chorda tympani taste response of rat to NaCl. Am. J. Physiol. 249:R52-61
60. 60. Heck GL, Persuad KC, DeSimone JA. 1989. Direct measurement of translingual epithelial NaCl and KCl currents during the chorda tympani taste response. Biophys. J. 55:843-57
61. + channels in isolated hamster taste cells: enhancement by vasopressin and cAMP. Neuron 10:931-42
62. 62. Gilbertson TA, Fontenot DT. 1998. Distribution of amiloride-sensitive sodium channels in the oral cavity of the hamster. Chem. Senses. 23:495-99
63. 63. Scott TR, Giza BK. 1990. Coding channels in the taste system of the rat. Science 249:1585-87
64. 64. Giza BK, Scott TR. 1991. The effect of amiloride on taste-evoked activity in the nucleus tractus solitarius of the rat. Brain Res. 550:247-56
65. 65. Hettinger TP, Frank ME. 1990. Specificity of amiloride inhibition of hamster taste responses. Brain Res. 513:24-34
66. 66. Tennison AM. 1992. Amiloride reduces intensity responses of human fungiform papillae. Physiol. Behav. 51:1061-68
67. 67. Gilbertson DM, Gilbertson TA. 1994. Amiloride reduces the aversiveness of acids in preference tests. Physiol. Behav. 56:649-54
68. 68. Garty H, Palmer LG. 1997. Epithelial sodium channels: function, structure and regulation. Physiol. Rev. 77:359-96
69. 69. Li XJ, Blackshaw S, Snyder SH. 1994. Expression and localization of amiloride-sensitive sodium channels indicate a role for non-iaste cells in taste perception. Proc. Natl. Acad. Sci. USA 91:1814-18
70. 70. Simon SA, Holland VF, Benos DJ, Zamphigi GA. 1993. Transcellular and paracellular pathways in lingual epithelia and their influence in taste transduction. Microsc. Res. Tech. 26:196-208
71. 71. Stewart RE, Lasiter PS, Benos DJ, Hill DL. 1995. Immunohistochemical correlates of peripheral gustatory sensitivity to sodium and amiloride. Acta Anat. 153:310-19
72. 72. Formaker BK, Hill DL. 1991. Lack of amiloride sensitivity in SHR and WKY glossopharyngeal taste responses to NaCl. Physiol. Behav. 50:765-69
73. 73. Tonosaki K, Funakoshi M. 1989. Amiloride does not block taste transduction in the mouse (S1C:ICR). Comp. Biochem. Physiol. A 94:659-61
74. 74. Gilbertson TA, Zhang H. 1998. Self-inhibition in amiloride-sensitive sodium channels in taste receptor cells. J. Gen. Physiol. 111:667-77
75. + channels in taste. In Sensory Transduction, ed. DP Corey, SD Roper, pp. 271-79. New York: Rockefeller Univ. Press
76. 76. Gilbertson TA. 1997. Hormonal regulation of salt taste transduction at the level of the receptor cell. Presented at 10th Int. Congr. Endocrinol., San Francisco (Abstr.)
77. 77. Ye Q, Heck GL, DeSimone JA. 1991. The anion paradox in sodium taste reception: resolution by voltage-clamp studies. Science 254:724-26
78. 78. Lewis SA, Wills NK. 1983. Apical membrane permeability and kinetic properties of the sodium pump in rabbit urinary bladder. J. Physiol. 341:169-84
79. 79. Elliot EJ, Simon SA. 1990. The anion in salt taste. A possible role for paracellular pathways. Brain Res. 535:9-17
80. 80. McPheeters M, Roper SD. 1985. Amiloride does not block taste transduction in the mudpuppy, Necturus maculosus. Chem. Senses 10:341-52
81. 81. Tonosaki K, Funakoshi M. 1984. Intracellular taste cell responses of mouse. Comp. Biochem. Physiol. A 78:651-56
82. 82. Settle R, Meehan K, Williams GR, Doty RL, Sisley AC. 1986. Chemosensory properties of sour tastants. Physiol. Behav. 36:619-23
83. 83. Kinnamon SC, Dionne VE, Beam KG. 1988. Apical localization of K channels in taste cells provides the basis for sour taste transduction. Proc. Natl. Acad. Sci. USA 85:7023-27
84. 84. Hille B. 1992. Ionic Channels of Excitable Membranes. Sunderland, MA: Sinauer. 607 pp.
85. 85. Thomas RC. 1984. Experimental displacement of intracellular pH and the mechanism of its subsequent recovery. J. Physiol. 354:3P-22P
86. 86. Lyall V, Biber TU. 1994. Potential-induced changes in intracellular pH. Am. J. Physiol. 266:F685-96
87. + channels in Necturus taste cells: modulation by intracellular factors and taste stimuli. J. Gen. Physiol. 99:591-613
88. 88. Bigiani A, Roper SD. 1994. Reduction of electrical coupling between Necturus taste receptor cells: a possible role in acid taste. Neurosci. Lett. 176:212-16
89. 89. Okada Y, Miyamoto T, Sato T. 1987. Cation dependence of frog gustatory neural responses to acid stimuli. Comp. Biochem. Physiol. A 88:487-90
90. 90. Okada Y, Miyamoto T, Sato T. 1994. Activation of a cation conductance by acetic acid in taste cells isolated from the bull-frog. J. Exp. Biol. 187:19-32
91. 91. Miyamoto T, Okada Y, Sato T. 1988. Ionic basis of receptor potential of frog taste cells induced by acid stimuli. J. Physiol. 405:699-711
92. 92. Akisaka T, Oda M. 1978. Taste buds in the vallate papillae of the rat studied with freeze-fracture preparation. Arch. Histol. Jpn. 41:87-98
93. 93. Palmer LG. 1987. Ion selectivity of epithelial Na channels. J. Membr. Biol. 96: 97-106
94. 94. Smith DV, Liu H, Vogt M. 1996. Responses of gustatory cells in the nucleus of the solitary tract of the hamster after NaCl or amiloride adaptation. J. Neurophysiol. 76:47-58
95. 95. Rehnberg BG, Hettinger TP, Frank ME. 1992. Salivary ions and neural taste responses in the hamster. Chem. Senses 17: 179-90
96. 96. Harris DE, Gilbertson DM, Monroe WT, Kinnamon SC, Gilbertson TA. 1994. Contribution of amiloride-sensitive pathways to acid transduction in rats. Chem. Senses 19:431-32 (Abstr.)
97. 97. Beidler LM. 1967. Anion influences of taste receptor response. In Olfaction and Taste II, ed. T Hayashi, pp. 509-35. New-York: Pergamon
98. 98. Ganzevles PGJ, Kroeze JHA. 1987. Effects of adaptation and cross-adaptation to common ions on sourness intensity. Physiol. Behav. 40:641-46
99. 99. Simon SA, Garvin JL. 1985. Salt and acid studies on canine lingual epithelium. Am. J. Physiol. 249:C398-408
100. 100. Price S. 1973. Phosphodiesterase in tongue epithelium: activation by bitter taste stimuli. Nature 241:54-55
101. 101. Kurihara K. 1972. Inhibition of cyclic 3′,5′-nucleotide phosphodiesterase in bovine taste papillae by bitter taste stimuli. FEBS Lett. 27:279-81
102. 102. McLaughlin S, McKinnon PJ, Margolskee RF. 1992. Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature 357:563-69
103. 103. Spielman AI. 1998. Gustducin and its role in taste. J. Dent. Res. 77:539-44
104. 104. Ruiz-Avila L, McLaughlin SK, Wildman D, McKinnon PJ, Robichon A, Spickofsky N, Margolskee RF. 1995. Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells. Nature 376:80-85
105. 105. McLaughlin SK, McKinnon PJ, Spickofsky N, Danho W, Margolskee RF. 1994. Molecular cloning of G proteins and phosphodiesterases from rat taste cells. Physiol. Behav. 56:1157-64
106. 106. Ming D, Ruiz-Avila L, Margolskee RF. 1998. Characterization of solubilization of bitter-responsive receptors that couple to gustducin. Proc. Natl Acad. Sci. USA 95:8933-38
107. 107. Wong GT, Gannon KS, Margolskee RF. 1996. Transduction of bitter and sweet taste by gustducin. Nature 381:796-800
108. 108. Akabas MH. 1988. A bitter substance induces a rise in intracellular calcium in a subpopulation of rat taste cells. Science 242:1047-49
109. 109. Hwang PM, Verma A, Bredt DS, Snyder SH. 1990. Localization of phosphatidylinositol signaling components in rat taste cells: role in bitter taste transduction. Proc. Natl. Acad. Sci. USA 87:7395-99
110. 110. Spielman AI, Huque T, Nagai H, Whitney G, Brand JG. 1994. Generation of inositol phosphates in bitter taste transduction. Physiol. Behav. 56:1149-55
111. 111. Spielman AI, Nagai H, Sunavala G, Dasso M, Breer H, et al. 1996. Rapid kinetics of second messenger production in bitter taste. Am. J. Physiol. 270:C926-31
112. 112. Ogura T, Mackay-Sim A, Kinnamon SC. 1997. Bitter taste transduction of denatonium in the mudpuppy Necturus maculosus. J. Neurosci. 17:3580-87
113. 113. Orola CN, Yamashita T, Harada N, Amano H, Ohtani M, Kumazawa T. 1992. Intracellular free calcium concentrations in single taste receptor cells in guinea pig. Acta Otolaryngol. 112:120-27
114. 114. Tsunenari T, Hayashi Y, Orita M, Kurahashi T, Kaneko A, Mori T. 1996. A quinine-activated cationic conductance in vertebrate taste receptor cells. J. Gen. Physiol. 108:515-23
115. 115. Okada Y. 1988. Ionic mechanisms of generation of receptor potential in response to quinine in frog taste cell. Brain Res. 450:295-307
116. 116. Abe K, Kusakabe Y, Tanemura K, Emori Y, Arai S. 1993. Multiple genes for G protein-coupled receptors and their expression in lingual epithelia. FEBS Lett. 316:253-56
117. 117. Kusakabe Y, Abe K, Tanemura K, Emori Y, Arai S. 1996. GUST27 and closely related G-protein-coupled receptors are localized in taste buds together with Gi-protein α-subunit. Chem. Senses 21:335-40
118. 118. Striem B, Naim M, Lindemann B. 1991. Generation of cyclic AMP in taste buds of the rat circumvallate papilla in response to sucrose. Cell. Physiol. Biochem. 1:46-54
119. 2+ in response to sugars and non-sugar sweeteners in transduction of sweet taste in the rat. J. Physiol. 490:325-36
120. 120. Dib K, Wrisez F, Jamali AE, Lambert B, Correze C. 1997. Sodium saccharin inhibits adenylyl cyclase activity in non-taste cells. Cell. Signal. 9:431-38
121. 121. Okada Y, Miyamoto T, Sato T. 1987. Depolarization induced by injection of cyclic nucleotides into frog taste cell. Biochim. Biophys. Acta 904:187-90
122. 122. Avenet P, Hofmann F, Lindemann B. 1988. Transduction in taste receptor cells requires cAMP dependent protein kinase. Nature 331:351-54
123. 123. Tonosaki K, Funakoshi M. 1988. Cyclic nucleotides may mediate taste transduction. Nature 331:354-56
124. + current. J. Neurophysiol. 75:1256-63
125. 125. Uchida Y, Sato T. 1997. Intracellular calcium increase in gerbil taste cell by amino acid sweeteners. Chem. Senses 22:83-91
126. + currents in response to two types of sweeteners in sweet taste transduction of gerbil taste cells. Chem. Senses 22: 163-69
127. 127. Brand JG, Teeter JH, Kumazawa T, Huque T, Bayley DL. 1991. Transduction mechanisms for the taste of amino acids. Physiol. Behav. 49:899-904
128. 128. Caprio J, Brand JG, Teeter JH, Valentincic T, Kalinoski DL, et al. 1993. The taste system of the channel catfish: from biophysics to behavior. Trends Neurosci. 16:192-97
129. 129. Teeter JH, Kumazawa T, Brand JG, Kalinoski DL, Honda E, Smutzer G. 1992. Amino acid receptor channels in taste cells. In Sensory Transduction. Society of General Physiologists, 45th Annu. Symp., ed. DP Corey, SD Roper, pp. 291-306. New York: Rockefeller Univ. Press
130. 130. Teeter JH, Brand JG, Kumazawa T. 1990. A stimulus-activated conductance in isolated taste epithelial membranes. Biophys. J. 58:253-59
131. 131. Finger TE, Bryant BP, Kalinoski DL, Teeter JH, Böttger B, et al. 1996. Differential localization of putative amino acid receptors in taste buds of the channel catfish, Ictalurus punctatus. J. Comp. Neurol. 373:129-38
132. i in cell ensembles: application to the study of glutamate taste in mice. Biophys. J. 71: 1057-70
133. 133. Chaudhari N, Yang H, Lamp C, Delay E, Cartford C, et al. 1996. The taste of monosodium glutamate: membrane receptors in taste buds. J. Neurosci. 16: 3817-26
134. 134. Bigiani A, Delay RJ, Chaudhari N, Kinnamon SC, Roper SD. 1997. Responses to glutamate in rat taste cells. J. Neurophysiol. 77:3048-59
135. 135. Hamosh M, Burns WA. 1977. Lipolytic activity of human lingual glands (Ebner). Lab. Invest. 37:603-8
136. 136. Field RB, Spielman AI, Hand AR. 1989. Purification of lingual amylase from serous glands of rat tongue and characterization of rat lingual amylase and lingual lipase. J. Dent. Res. 68:139-45
137. 137. Kock K, Bläker M, Schmale H. 1992. Postnatal development of von Ebner's glands: accumulation of a protein of the lipocalin superfamily in taste papillae of rat tongue. Cell Tissue Res. 267:313-20
138. 138. Kock K, Ahlers C, Schmale H. 1994. Structural organization of the genes for rat von Ebner's gland proteins 1 and 2 reveals their close relationship to lipocalins. Eur. J. Biochem. 221:905-16
139. + channel in taste cells: the primary target for fatty acid inhibition. Chem. Senses (Abstr.). In press
140. + channel (Kv1.5) by polyunsaturated fatty acids. Proc. Natl. Acad. Sci. USA 91: 1937-44
141. 141. Fukuwatari T, Kawada T, Tsuruta M, Hiraoka T, Iwanaga T, et al. 1997. Expression of the putative membrane fatty acid transporter (FAT) in taste buds of the circumvallate papillae in rats. FEBS Lett. 414:461-64
142. 142. Fushiki T, Kawada T, Fukuwatari T. 1997. From the viewpoint of food and nutrition: Why is fat delicious? Chem. Senses 22:332 (Abstr.)
143. 143. Ramirez I. 1992. Chemoreception for fat: Do rats sense triglycerides directly? Appetite 18:193-206
144. 144. Smith DV, Frank ME. 1993. Sensory coding by peripheral taste fibers. In Mechanisms of Taste Transduction, ed. SA Simon, SD Roper, pp. 295-338. Boca Raton, FL: CRC
145. 145. Kinnamon JC, Sherman TA, Roper SD. 1988. Ultrastructure of mouse vallate taste buds. III. Patterns of synaptic connectivity. J. Comp. Neurol. 270:1-10
146. 146. Roper SD. 1992. The microphysiology of peripheral taste organs. J. Neurosci. 12: 1127-34
147. 147. Sweazey RD, Smith DV. 1987. Convergence onto hamster medullary taste neurons. Brain Res. 408:173-84
148. 148. Smith DV, Travers JB. 1979. A metric for the breadth of tuning of gustatory neurons. Chem. Senses Flav. 4:215-29
149. 149. Travers JB, Smith DV. 1979. Gustatory sensitivities in neurons of the hamster nucleus tractus solitarius. Sens. Process. 3: 1-26
150. 150. Van Buskirk RL, Smith DV. 1981. Taste sensitivity of hamster parabrachial pontine neurons. J. Gen. Physiol. 45:144-71
151. 151. Ozeki M, Sato M. 1972. Responses of gustatory cells in the tongue of rat to stimuli representing four taste qualities. Comp. Biochem. Physiol. A 41:391-407
152. 152. Sato T. 1972. Multiple sensitivity of single taste cells of the frog tongue to four basic stimuli. J. Cell Physiol. 80:207-18
153. 153. Daniels C, Kinnamon SC. 1995. Specificity of hamster fungiform taste cells. Chem. Senses 20:687 (Abstr.)
154. 154. Monroe WT, Smith DV, Gilbertson TA. 1996. The MU chamber: a new method to record electrophysiological responses of taste receptor cells to gustatory stimuli. Chem. Senses 21:644-45 (Abstr.)
155. 155. Smith DV, McBurney DH. 1969. Gustatory cross-adaptation: Does a single mechanism code the salty taste? J. Exp. Psychol. 80:101-5
156. 156. Smith DV, van der Klaauw NJ. 1995. The perception of saltiness is eliminated by NaCl adaptation: implications for gustatory transduction and coding. Chem. Senses 20:545-57
157. 157. Sato T, Beidler LM. 1997. Broad tuning of rat taste cells for the four basic taste stimuli. Chem. Senses 22:287-93
158. 158. Bacon AW, Miles JS, Schiffman SS. 1994. Effects of race on perception of fat alone and in combination with sugar. Physiol. Behav. 55:603-6
159. 159. Johnson SL, McPhee L, Birch LL. 1991. Conditioned preferences: Young children prefer flavors associated with high dietary fat. Physiol. Behav. 50:1245-51
160. + channel is made of three homologous subunits. Nature 367:463-67
161. + channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning. Proc. Natl. Acad. Sci. USA 91:247-51
162. + channel are differentially regulated by aldosterone. J. Biol. Chem. 269:13736-39
163. 163. Li XJ, Xu RH, Guggino WB, Snyder SH. 1995. Alternatively spliced forms of the alpha subunit of the epithelial sodium channel: distinct sites for amiloride binding and channel pore. Mol. Pharmacol. 47:1133-40
164. 164. Stewart RE, Hill DL. 1993. The developing gustatory system: functional, morphological and behavioral perspectives. Mechanisms of Taste Transduclion, ed. SA Simon, SD Roper, pp. 127-58. Boca Raton, FL: CRC
165. 165. Herness MS. 1992. Aldosterone increases the amiloride-sensitivity of the rat gustatory neural response to NaCl. Comp. Biochem. Physiol. A 103:269-73
166. 166. Okada Y, Miyamoto T, Sato T. 1990. Aldosterone increases gustatory neural response to NaCl in frog. Comp. Biochem. Physiol. A 97:535-36
167. 167. Okada Y, Miyamoto T, Sato T. 1991. Vasopressin increases frog gustatory neural responses elicited by NaCl and HCl. Comp. Biochem. Physiol. A 100:693-96
168. 168. Lindemann B. 1984. Fluctuation analysis of sodium channels in epithelia. Annu. Rev. Physiol. 46:497-515
169. + channels in A6 cells, a regulatory role for protein kinase C. Am. J. Physiol 256:F1094-103
170. +current in salivary duct cells by extracellular sodium. J. Membr. Biol. 150:133-41
171. o guanine nucleotide-binding regulatory protein. Proc. Natl. Acad. Sci. USA 93:8107-11
172. 172. Fuchs W. Larsen EH, Lindemann B. 1977. Current-voltage curve of sodium channels and concentration dependence of sodium permeability on frog skin. J. Physiol. 267: 137-66
173. 173. Luger A, Turnheim K. 1981. Modification of cation permeability of rabbit descending colon by sulphydryl reagents. J. Physiol. 317:49-66
174. 174. Matsuo R, Yamamoto T. 1992. Effects of inorganic constituents of saliva on taste responses of the rat chorda tympani nerve. Brain Res. 583:71-80
175. 175. Nakamura K, Norgren R. 1991. Gustatory responses of neurons in the nucleus of the solitary tract of behaving rats. J. Neurophysiol. 66:1232-48