Nanoemulsion Technology for Delivery of Nutraceuticals and Functional-Food Ingredients

Bio-Nanotechnology: A Revolution in Food, Biomedical and Health Sciences

Volumn , Issue , 2013, Pages 667-696

  Sanguansri, Luz ^a   Oliver, Christine M ^a   Leal Calderon, Fernando ^b  

^a CSIRO   (Australia)

^b UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Colloids emulsions; Droplet structure volume fraction; Emulsifier types; Food grade amphiphilic; Functional food ingredients; HPH in production; Nanoemulsion technology; Nutraceutical delivery; Ostwald ripening; Processing requirements

Indexed keywords

EID: 84887198901     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118451915.ch38     Document Type: Chapter

References (128)

1. Acosta, E. (2009). Bioavailability of nanoparticles in nutrient and nutraceutical delivery. Curr. Opin. Colloid Interface Sci., 14, 3-15.
2. Anton, N., Benoit, J.P., Saulnier, P. (2008). Design and production of nanoparticles formulated from nano-emulsion templates-a review. J. Control. Release, 128, 185-199.
3. Anton, N., Vandamme, T.F. (2009). The universality of low-energy nano-emulsification. Int. J. Pharm., 377, 142-147.
4. Bancroft, W.D. (1913). The theory of emulsification, V. J. Phys. Chem., 17, 501-519.
5. Baspinar, Y., Keck, C.M., Borchert, H.-H. (2010). Development of a positively charged prednicarbate nanoemulsion. Int. J. Pharm., 393, 201-208.
6. Bateman, N.E. (1985). Vitamin compositions. UK Patent, number GB2145331.
7. Bateman, N.E., Uccellini, D.A. (1984). Effect of formulation on the bioavailability of retinol, d-α-tocopherol and riboflavine. J. Pharm. Pharmacol., 36, 461-464.
8. BCC Research (2011). Nutraceuticals: global markets and processing technologies. http://www.bccresearch.com/report/nutraceuticals-processing-markets-fod0 13c.html (accessed 07.09.2011).
9. Behrend, O., Ax, K., Schubert, H. (2000). Influence of continuous phase viscosity on emulsification by ultrasound. Ultrason. Sonochem., 7, 77-85.
10. Bhagavan, H.N., Chopra, R.K. (2006). Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic. Res., 40, 445-453.
11. Bouchemal, K., Briancon, S., Perrier, E., Fessi, H. (2004). Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimisation. Int. J. Pharm., 280, 241-251.
12. Charoen, R., Jangchud, A., Jangchud, K., Harnsilawat, T., Naivikul, O., McClements, D.J. (2011). Influence of biopolymer emulsifier type on formation and stability of rice bran oil-in-water emulsions: whey protein, gum arabic, and modified starch. J. Food Sci., 76, E165-E172.
13. Charcosset, C. (2009). Preparation of emulsions and particles by membrane emulsification for the food processing industry. J. Food Eng., 92, 241-249.
14. Cheong, J.N., Tan, C.P. (2010). Palm-based functional lipid nanodispersions: preparation, characterization and stability evaluation. Eur. J. Lipid Sci. Technol., 112, 557-564.
15. Cheong, J.N., Tan, C.P., Man, Y.B.C., Misran, M. (2008). α-Tocopherol nanodispersions: preparation, characterization and stability evaluation. J. Food Eng., 89, 204-209.
16. Choi, A.-J., Kim, C.-J., Cho, Y.-J., Hwang, J.-K., Kim, C.-T. (2011). Characterization of capsaicin-loaded nanoemulsions stabilized with alginate and chitosan by self-assembly. Food Bioprocess Technol., 4, 1119-1126.
17. Chu, B.S., Ichikawa, S., Kanafusa, S., Nakajima, M. (2007a). Preparation and characterization of β-carotene nanodispersions prepared by solvent displacement technique. J. Agric. Food Chem., 55, 6754.
18. Chu, B.-S., Ichikawa, S., Kanafusa, S., Nakajima, M. (2007b). Preparation of protein-stabilized β-carotene nanodispersions by emulsification-evaporation method. J. Am. Oil Chem. Soc., 84, 1053.
19. Clarke, J., Young, G., Bird, T., Cobiac, L., Topping, D. (2006). Effect of resistant starch, butyrylated starch and tributyrin on colon cancer in rats. J. Gastroenterol. Hepatol., 21, A270.
20. Cornacchia, L., Roos, Y.H. (2011). Stability of β-carotene in protein-stabilized oil-in-water delivery systems. J. Agric. Food Chem., 59, 7013-7020.
21. Coupland, J.N., Weiss, J., Lovy, A., McClements, D.J. (1996). Solubilization kinetics of triacyl glycerol and hydrocarbon emulsion droplets in a micellar solution. J. Food Sci., 61, 1114-1117.
22. Dickinson, E. (2003). Review: hydrocolloids at interfaces and the influence on the properties of dispersed systems. Food Hydrocoll., 17, 25-39.
23. Donsì, F., Senatore, B., Huang, Q., Ferrari, G. (2010). Development of novel pea protein-based nanoemulsions for delivery of nutraceuticals. J. Agric. Food Chem., 58, 10653-10660.
24. Dungan, S.R., Tai, B.H., Gerhardt, N.I. (2003). Transport mechanisms in the micellar solubilization of alkanes in oil-in-water emulsions. Colloids Surf. A, 216, 149-166.
25. Duvoix, A., Blasius, R., Delhalle, S., Schnekenburger, M., Morceau, F., Henry, E., Dicato, M., Diederich, M. (2005). Chemopreventive and therapeutic effects of curcumin. Cancer Lett., 223, 181-190.
26. Edelman, M.J., Bauer, K., Khanwani, S., Tait, N., Trepel, J., Karp, J., Nemieboka, N., Chung, E.J., Van Echo, D. (2003). Clinical and pharmacologic study of tributyrin: an oral butyrate prodrug. Cancer Chemother. Pharmacol., 51, 439-444.
27. Garti, N., Clement, V., Leser, M., Aserin, A., Fanun, M. (1999). Sucrose ester microemulsions. J. Molec. Liq., 80, 253-296.
28. Geerken, M.J., Lammertink, R.H.H., Wessling, M. (2007). Interfacial aspects of water drop formation at micro-engineered orifices. J. Colloid Interface Sci., 312, 460-469.
29. Glatter, O., Orthaber, D., Stradner, A., Scherf, G., Fanun, M., Garti, N. (2001). Sugar-ester nonionic microemulsion: structural characterization. J. Colloid Interface Sci., 241, 215-225.
30. Graves, S., Meleson, K., Wilking, J. (2005). Structure of concentrated emulsions. J. Chem. Phys., 122, 134703/1-6.
31. Gunasekaran, S. (2009). Nutraceutical nanoemulsion encapsulates, delivers ginsenosides. Emerging Food R & D Report. http://fiarticles.com/p/articles/mi_ go2639/is_11_19/ai_n31351493/(accessed 26.09.2011).
32. Guzey, D., McClements, D.J. (2007). Impact of electrostatic interactions on formation and stability of emulsions containing oil droplets coated with β-lactoglobulin-pectin complexes. J. Agric. Food. Chem., 55, 475-485.
33. Han, C. (1997). Screening of anticarcinogenic ingredients in tea polyphenols. Cancer Lett., 114, 153-158.
34. Hargreaves, C. (2006). Facing the functional challenge. NutraCos, 5, 29-30.
35. Hatanaka, J., Kimura, Y., Lai-Fu, Z., Onoue, S., Yamada, S. (2008). Physicochemical and pharmacokinetic characterization of water-soluble coenzyme Q10 formulations. Int. J. Pharm., 363, 112-117.
36. Hatanaka, J., Chikamori, H., Sato, H., Uchida, S., Debari, K., Onoue, S., Yamada, S. (2010). Physicochemical and pharmacological characterization of α-tocopherol loaded nano-emulsion system. Int. J. Pharm., 396, 188-193.
37. Helfrich, W.Z. (1973). Elastic properties of lipid bilayers-theory and possible experiments. Naturforsch., C28, 693-703.
38. Higuchi, W.I., Misra, J. (1962). Physical degradation of emulsions via the molecular diffusion route and the possible prevention thereof. J. Pharm. Sci., 51, 459-466.
39. Hou, Z., Gao, Y., Yuan, F., Liu, Y., Li, C., Xu, D. (2010). Investigation into the physicochemical stability and rheological properties of β-carotene emulsion stabilized by soybean soluble polysaccharides and chitosan. J. Agric. Food Chem., 58, 8604-8611.
40. Hu, M., McClements, D.J., Decker, E.A. (2003). Impact of whey protein emulsifiers on the oxidative stability of salmon oil-in-water emulsions. J. Agric. Food Chem., 51, 1435-1439.
41. Huang, Q.R., Yu, H.L., Ru, Q.M. (2010). Bioavailability and delivery of nutraceuticals using nanotechnology. J. Food Sci., 75, R50-R57.
42. Huck-Iriart, C., Candal, R., Herrera, M. (2009). Effects of addition of a palmitic sucrose ester on low-trans-fat blends crystallization in bulk and in oil-in-water emulsions. Food Biophys., 4, 158-166.
43. Israelachvili, J. (1992). Intermolecular and Surface Forces, 2nd edn. Academic Press, London.
44. Jafari, S.M., He, Y., Bhandari, B. (2006). Nano-emulsion production by sonication and microfluidization-a comparison. Int. J. Food Prop., 9, 475-485.
45. Jafari, S.M., He, Y., Bhandari, B. (2007). Optimisation of nano-emulsions production by microfluidisation. Eur. Food Res. Technol., 225, 733-742.
46. Jafari, S.M., Assadpoor, E., Bhandari, B., He, Y. (2008a). Nano-particle encapsulation of fish oil by spray drying. Food Res. Int., 41, 172.
47. Jafari, S.M., Assadpoor, E., He, Y., Bhandari, B. (2008b). Re-coalescence of emulsion droplets during high-energy emulsification Food Hydrocoll., 22, 1191.
48. Jiang, Y. (2009). Micro-and nano-encapsulation and controlled-release of phenolic components and others food ingredient. PhD dissertation. Rutgers University, New Brunswick, NJ.
49. Kabalnov, A. (2001). Ostwald ripening and related phenomena. J. Disper. Sci. Technol., 22, 1-12.
50. Kabalnov, A.S., Wennerström, H. (1996). Macroemulsion stability: the oriented wedge theory revisited. Langmuir, 12, 276-292.
51. Kanafusa, S., Chu, B.-S., Nakajima, M. (2007). Factors affecting droplet size of sodium caseinate-stabilized o/w emulsions containing β-carotene. Eur. J. Lipid Sci. Technol., 109, 1039-1041.
52. Katsuda, M.S., McClements, D.J., Miglioranza, L.H.S., Decker, E.A. (2008). Physical and oxidative stability of fish oil-in-water emulsions stabilized with β-lactoglobulin and pectin. J. Agric. Food Chem., 56, 5926-5931.
53. Kawada, H., Kume, T., Matsunaga, T., Iwai, H., Sano, T., Shibayama, M. (2010). Structure and rheology of a self-standing nanoemulsion. Langmuir, 26, 2430-2437.
54. Kim, C.-T., Cho, Y.-J., Kim, N., Kim, C.-J. (2010). The use of nanotechnology in functional food product development. http://www.laboratory-journal.com/science/lebensmittel/use-nanotechnolog y-functional-food-product-development (accessed 28.08.2011).
55. Kuo, F., Subramanian, B.K., Kotyla, T., Wilson, T.A., Yoganathan, S., Nicolosi, R.J. (2008). Nanoemulsions of an anti-oxidant synergy formulation containing gamma tocopherol have enhanced bioavailability and anti-inflammatory properties. Int. J. Pharm., 363, 206-213.
56. Leal-Calderon, F., Schmitt, V., Bibette, J. (2007). Emulsion Science: Basic Principles, 2nd edn. Springer, New York.
57. Lee, S.J., McClements, D.J. (2010). Fabrication of protein-stabilized nanoemulsions using a combined ho-mogenization and amphiphilic solvent dissolution/evaporation approach. Food Hydrocoll., 24, 560-569.
58. Lee, S.J., Choi, S.J., Li, Y., Decker, E.A., McClements, D.J. (2011a). Protein-stabilized nanoemulsions and emulsions: comparison of physico-chemical stability, lipid oxidation and lipase digestibility J. Agric. Food Chem., 59, 415.
59. Lee, Y.-J., Kwon, M., Kim, T.-H., Kim, K., Jeong, S.-H., Chang, H.-R. (2011b). Pharmacokinetic characterization of nano-emulsion vitamin A, D and E (LaVita) in rats Korean J. Environ. Agric., 30, 196.
60. Lemlich, R. (1978). Prediction of changes in bubble size distribution due to interbubble gas diffusion in foam. Ind. Eng. Chem. Fundam., 17, 89-93.
61. Leong, T.S.H., Wooster, T.J., Kentish, S.E., Ashokkumar, M. (2009). Minimising oil droplet size using ultrasonic emulsification. Ultrason. Sonochem., 16, 721-727.
62. Li, P.H., Chiang, B.H. (2012). Process optimisation and stability of d-limonene-in-water nanoemulsions prepared by ultrasonic emulsification using response surface methodology. Ultrason. Sonochem., 19, 192-197.
63. Li, Y., Maux, S.L., Xiao, H., McClements, D.J. (2009). Emulsion-based delivery systems for tributyrin, a potential colon cancer preventative agent. J. Agric. Food Chem., 57, 9243-9249.
64. Lifshitz, I.M., Slyozov, V.V. (1961). The kinetics of precipitation from supersaturated solid solutions. J. Phys. Chem. Solids, 19, 35-50.
65. Lin, D., Zhang, X., Wang, Z. (2005). Nano emulsion containing ginsenoside, preparation method and usage. Chinese Patent, number CN1626101.
66. Lin, W., Hong, J.-L., Shen, G., Wu, R.T., Wang, Y., Huang, M.-T., Newmark, H.L., Huang, Q., Khor, T.O., Heimbach, T., Kong, A.-N. (2011). Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition. Biopharm. Drug Dispos., 32, 65-75.
67. Maiti, K., Mukherjee, K., Gantait, A., Saha, B.P., Mukherjee, P.K. (2007). Curcumin-phospholipid complex: preparation, therapeutic evaluation and pharmacokinetic study in rats. Int. J. Pharm., 330, 155-163.
68. Mao, L., Xu, D., Yang, J., Yuan, F., Gao, Y., Zhao, J. (2009). Effects of small and large molecule emulsifiers on the characteristics of β-carotene nanoemulsions prepared by high pressure homogenization. Food Technol. Biotechnol., 47, 336-342.
69. Mason, T. (1995). Rheology of monodisperse emulsions. PhD dissertation. Princeton University, Princeton, NJ.
70. Mason, T.G., Bibette, J., Weitz, D.A. (1995). Elasticity of compressed emulsions. Phys. Rev. Lett., 75, 2051-2054.
71. Mason, T.G., Krall, A.H., Gang, H., Bibette, J., Weitz, D.A. (1996). Monodisperse emulsions: properties and uses. In Encyclopedia of Emulsion Technology, P. Becher (ed.), Marcel Dekker, New York, pp. 299-336.
72. Mason, T.G., Wilking, J.N., Meleson, K., Chang, C.B., Graves, S.M. (2006). J. Phys. Condens. Matter. 18, R635-R666.
73. McClements, D. J. (2005). Food Emulsions: Principles, Practice, and Techniques, 2nd edn. CRC Press, Boca Raton, FL.
74. McClements, D.J. (2011). Edible nanoemulsions: fabrication, properties, and functional performance. Soft Matter, 7, 2297-2316.
75. McClements, D.J., Dungan, S.R. (1995). Light scattering study of solubilization of emulsion droplets by non-ionic surfactants. Colloids Surf. A., 104, 127-135.
76. McClements, D.J., Li, Y. (2010). Structured emulsion-based delivery systems: controlling the digestion and release of lipophilic food components. Adv. Colloid Interface Sci., 159, 213-228.
77. McClements, D.J., Decker, E.A., Park, Y., Weiss, J. (2009). Structural design principles for delivery of bioactive components in nutraceuticals and functional foods. Crit. Rev. Food Sci. Nutr., 49, 577-606.
78. Miller, C.A. (1988). Spontaneous emulsification produced by diffusion-a review. Colloids Surf., 29, 89-102.
79. Morisco, C., Trimarco, B., Condorelli, M. (1993). Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multicenter randomized study. Clin. Investig., 71 (8 Suppl.), S134-S136.
80. Mou, D., Chen, H., Du, D., Mao, C., Wan, J., Xu, H., Yang, X. (2008). Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs. Int. J. Pharm., 353, 270-276.
81. Nam, Y.S., Kim, J.W., Shim, J., Han, S.H., Kim, H.K. (2010). Nanosized emulsions stabilized by semisolid polymer interphase. Langmuir, 26, 13039-13043.
82. Narayan, M., Berliner, L.J. (1997). Fatty acids and retinoids bind independently and simultaneously to β-lactoglobulin. Biochemistry, 36, 1906-1911.
83. Nicolosi, R., Shea, T. (2009). Anti-oxidant synergy formulation nanoemulsions to treat cancer. US Patent, number US0306198 A1.
84. Nicolosi, R., Wilson, T. (2008). Compositions and methods for making and using nanoemulsions. Patent application, WO2008010788.
85. Parker, R.S., Swanson, J.E., You, C.-S., Edwards, A.J., Huang, T. (1999). Bioavailability of carotenoids in human subjects. Proc. Nutr. Soc., 58, 155-162.
86. Peng, L.C., Liu, C.H., Kwan, C.C., Huang, K.F. (2010). Optimization of water-in-oil nanoemulsions by mixed surfactants. Colloids Surf. A, 370, 136-142.
87. Pinnamaneni, S., Das, N.G., Das, S.K. (2003). Comparison of oil-in-water emulsions manufactured by microfluidization and homogenization. Pharmazie, 58 (8), 554-558.
88. Princen, H.M. (1983). Rheology of foams and highly concentrated emulsions I. Elastic properties and yield stress of a cylindrical model system. J. Colloid Interface Sci., 91, 160-175.
89. Princen, H.M. (1986). Osmotic pressure of foams and highly concentrated emulsions. 1. Theoretical considerations. Langmuir, 2, 519-524.
90. Princen, H.M., Kiss, A.D. (1986). Rheology of foams and highly concentrated emulsions: III. Static shear modulus. J. Colloid Interface Sci., 112, 427-437.
91. Qian, C., McClements, D.J. (2011). Formation of nanoemulsions stabilized by model food-grade emulsifiers using high-pressure homogenization: factors affecting particle size. Food Hydrocoll., 25, 1000-1008.
92. Quintanilla-Carvajal, M.X., Camacho-Diaz, B.H., Meraz-Torres, L.S., Chanona-Perez, J.J., Alamilla-Beltran, L., Jimenez-Aparicio, A., Gutierrez-Lopez, G. (2010). Nanoencapsulation: a new trend in food engineering processing. Food Eng. Rev., 2, 39-50.
93. Rao, J., McClements, D.J. (2010). Stabilization of phase inversion temperature nanoemulsions by surfactant displacement. J. Agric. Food Chem., 58, 7059-7066.
94. Rao, J., McClements, D.J. (2012). Lemon oil solubilization in mixed surfactant solutions: rationalizing microemulsion & nanoemulsion formation. Food Hydrocoll., 26, 268-276.
95. Relkin, P., Jung, J.-M., Ollivon, M. (2009). Factors affecting vitamin degradation in oil-in-water nano-emulsions. J. Therm. Anal. Calorim., 98, 13-18.
96. Ribeiro, H.S., Guerrero, J.M.M., Briviba, K., Rechkemmer, G., Schuchmann, H.P., Schubert, H. (2006). Cellular uptake of carotenoid-loaded oil-in-water emulsions in colon carcinoma cells in vitro. J. Agric. Food Chem., 54, 9366-9369.
97. Roberts, R.L., Green, J., Lewis, B. (2009). Lutein and zeaxanthin in eye and skin health. Clin. Dermatol., 27, 195-201.
98. Ru, Q., Yu, H., Huang, Q. (2010). Encapsulation of epigallocatechin-3-gallate (EGCG) using oil-in-water submicrometer emulsions stabilized by ι-carrageenan and β-lactoglobulin. J. Agric. Food Chem., 58, 10373-10391.
99. Sadtler, V., Guely, M., Marchal, P., Choplin, L. (2004). Shear-induced phase transitions in sucrose ester surfactant. J. Colloid Interface Sci., 270, 270-275.
100. Sagalowicz, L., Leser, M.E. (2010). Delivery systems for liquid food products. Curr. Opin. Colloid Interface Sci., 115, 61-72.
101. Schubert, H., Ax, K. (2003). Engineering food emulsions. In Texture in Food, B.M. McKenna, D. Kilcast (eds), Woodhead, Cambridge, pp. 183-200.
102. Shah, P., Bhalodia, D., Shelat, P. (2010). Nanoemulsion: a pharmaceutical review. Sys. Rev Pharm., 1, 24-32.
103. Shinoda, K., Saito, H. (1968). The effect of temperature on the phase equilibrium and the types of dispersions of the ternary system composed of water, cyclohexane and nonionic surfactant. J. Colloid Interface Sci., 26, 70-74.
104. Shukat, R., Relkin, P. (2011). Lipid nanoparticles as vitamin matrix carriers in liquid food systems: on the role of high-pressure homogenisation, droplet size and adsorbed materials. Colloids Surf. B, 86, 119-124.
105. Silva, H.D., Cerqueira, M.A., Souza, B.W.S., Ribeiro, C., Avides, M.C., Quintas, M.A.C., Coimbra, J.S.R., Carneiro-da-Cunha, M.G., Vicente, A.A. (2011). Nanoemulsions of β-carotene using a high-energy emulsification-evaporation technique. J. Food Eng., 102, 130-135.
106. Singletary, K., MacDonald, C., Iovinelli, M., Fisher, C.,Wallig, M. (1998). Effect of the beta-diketones diferuloylmethane (curcumin) and dibenzoylmethane on rat mammary DNA adducts and tumors induced by 7,12-dimethylbenz[a]anthracene. Carcinogenesis, 19, 1039-1043.
107. Szuts, A., Budai-Szucs, M., Eros, I., Otomo, N., Szab ó-Révész, P. (2010). Study of gel-forming properties of sucrose esters for thermosensitive drug delivery systems. Int. J. Pharm., 393, 132-137.
108. Tadros, T., Izquierdo, R., Esquena, J., Solans, C. (2004). Formation and stability of nanoemulsions Adv. Colloid Interface Sci., 108-109, 303-318.
109. Tan, C.P., Nakajima, M. (2005). Effect of polyglycerol esters of fatty acids on physicochemical properties and stability of β-carotene nanodispersions prepared by emulsification/evaporation method. J. Sci. Food Agric., 85, 121-126.
110. Velikov, K.P., Pelan, E. (2008). Colloidal delivery systems for micronutrients and nutraceuticals. Soft Matter, 4, 1964-1980.
111. Vishwanathan, R., Wilson, T.A., Nicolosi, R.J. (2009). Bioavailability of a nanoemulsion of lutein is greater than a lutein supplement. Nano Biomed. Eng., 1, 39-49.
112. Vyas, T.K., Shahiwala, A., Amiji, M.M. (2008). Improved oral bioavailability and brain transport of saquinavir upon administration in novel nanoemulsion formulations. Int. J. Pharm., 347, 93-101.
113. Wagner, C. (1961). Theorie der alterung von niederschlagen durch umlosen (Ostwald-reifung). Z. Elektrochem., 65, 581-591.
114. Wajda, R. (2004). Nanosolve-a new type of technique for the solubilization of lipophilic actives such as coenzyme Q10 or omega-3 fatty acids. Innov. Food Technol., 8, 32-33.
115. Wajda, R. (2006). Emulsive water soluble concentrates. US Patent, number US0159633 A1.
116. Wajda, R., Zirkel, J., Schaffer, T. (2007). Increase of bioavailability of coenzyme Q10 and vitamin E. J. Med. Food, 10, 731-734.
117. Wang, X., Jiang, Y., Wang, Y.-W., Huang, M.-T., Ho, C.-T., Huang, Q. (2008). Enhancing anti-inflammation activity of curcumin through O/W nanoemulsions. Food Chem., 108, 419-424.
118. Weiss, J., McClements, D.J. (2000a). Influence of Ostwald ripening on rheology of oil-in-water emulsions containing electrostatically stabilized droplets Langmuir, 16, 2145.
119. Weiss, J., McClements, D.J. (2000b). Mass transport phenomena in oil-in-water emulsions containing surfactant micelles: solubilization Langmuir, 16, 5879.
120. Weiss, J., McClements, D.J. (2001). Color changes in hy-drocarbon oil-in-water emulsions caused by Ostwald ripening. J. Agric. Food Chem., 49, 4372-4377.
121. Weiss, J., Coupland, J., Brathwaite, D., McClements, D.J. (1997). Influence of molecular structure of hydrocarbon emulsion droplets on their solubilization in nonionic surfactant micelles. Colloids Surf. A, 121, 53-60.
122. Weiss, J., Canceliere, C., McClements, D.J. (2000). Mass transport phenomena in oil-in-water emulsions containing surfactant micelles: Ostwald ripening. Langmuir, 16, 6833-6839.
123. Wilking, J.N., Mason, T.G. (2007). Irreversible shear-induced vitrifiation of droplets into elastic nanoemulsions by extreme rupturing Phys. Rev. E Stat. Nonlin. Soft Matter Phys., 75, 041407.
124. Wooster, T.J., Golding, M., Sanguansri, P. (2008). Impact of oil type on nano emulsion formation and Ostwald ripening stability. Langmuir, 24, 12758-12765.
125. Wulff-P é rez, M., Torcello-G ó mez, A., G á lvez-Ru í z, M.J., Mart í n-Rodr í guez, A. (2009). Stability of emulsions for parenteral feeding: preparation and characterization of o/w nanoemulsions with natural oils and Pluronic f68 as surfactant. Food Hydrocoll., 23, 1096-1102.
126. Yin, L.-J., Kobayashi, I., Nakajima, M. (2008). Effect of polyglycerol esters of fatty acids on the physicochemical properties and stability of β-carotene emulsions during digestion in simulated gastric fluid. Food Biophysics, 3, 213-218.
127. Yuan, Y., Gao, Y., Mao, L., Zhao, J. (2008a). Optimisation of conditions for the preparation of β-carotene nanoemulsions using response surface methodology Food Chem., 107, 1300.
128. Yuan, Y., Gao, Y., Zhao, J., Mao, L. (2008b). Characterization and stability evaluation of β-carotene nanoemulsions prepared by high pressure homogenization under various emulsifying conditions Food Res. Int., 41, 61.