Emulsion-based delivery systems for tributyrin, a potential colon cancer preventative agent

Journal of Agricultural and Food Chemistry

Volumn 57, Issue 19, 2009, Pages 9243-9249

  Li, Yan ^a   Le Maux, Solene ^a   Xiao, Hang ^a   McClements, David Julian ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Cell culture; Colon cancer; Emulsions; Ostwald ripening; Tributyrin

Indexed keywords

ANTINEOPLASTIC AGENT; CORN OIL; TRIACYLGLYCEROL; TRIBUTYRIN;

ARTICLE; CELL STRAIN HT29; COLON TUMOR; DRUG DELIVERY SYSTEM; DRUG STABILITY; EMULSION; HUMAN; SOLUBILITY;

ANTICARCINOGENIC AGENTS; COLONIC NEOPLASMS; CORN OIL; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; HT29 CELLS; HUMANS; SOLUBILITY; TRIGLYCERIDES;

ZEA MAYS;

EID: 70349921010     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf901836f     Document Type: Article

References (24)

1. Johnson, T.; Lund, E. K. Review article: nutrition, obesity and colorectal cancer. Aliment. Pharmacol. Ther. 2007, 26 (2), 161-181. (Pubitemid 46985501)
2. Jemal, A.; Siegel, R.; Ward, E.; Murray, T.; Xu, J. Q.; Smigal, C.; Thun, M. J., Cancer statistics, 2006. Ca-Cancer J. Clin. 2006, 56(2), 106-130.
3. Pan, M. H.; Ho, C. T. Chemopreventive effects of natural dietary compounds on cancer development. Chem. Soc. Rev. 2008, 37 (11), 2558-2574.
4. Key, T.; Schatzkin, A.; Willett, W. C.; Allen, N. E.; Spencer, E. A.; Travis, R. C. In Diet, Nutrition and the Prevention of Cancer; Joint WHO/FAO Expert Consultation Meeting on Diet, Nutrition and the Prevention of Chronic Diseases, Geneva, Switzerland, Jan 28-Feb 1, 2002; WHO: Geneva, Switzerland, 2002; pp 187-200.
5. Edelman, M. J.; Bauer, K.; Khanwani, S.; Tait, N.; Trepel, J.; Karp, J.; Nemieboka, N.; Chung, E. J.; Van Echo, D. Clinical and pharmacologic study of tributyrin: an oral butyrate prodrug. Cancer Chemother. Pharmacol. 2003, 51 (5), 439-444.
6. Hamer, H. M.; Jonkers, D.; Venema, K.; Vanhoutvin, S.; Troost, F. J.; Brummer, R. J. Review article: the role of butyrate on colonic function. Aliment. Pharmacol. Ther. 2008, 27 (2), 104-119.
7. Wong, J. M. W.; de Souza, R.; Kendall, C. W. C.; Emam, A.; Jenkins, D. J. A. Colonic health: fermentation and short chain fatty acids. J. Clin. Gastroenterol. 2006, 40 (3), 235-243. (Pubitemid 44309560)
8. Wong, J. M. W.; Jenkins, D. J. A. Carbohydrate digestibility and metabolic effects. J. Nutr. 2007, 137(11), 2539S-2546S.
9. Clarke, J.; Bird, T.; Topping, D.; Young, G.; Cobiac, L. Effect of resistant starch, butyrylated starch and tributyrin on colon cancer in rats. J. Gastroenterol. Hepatol. 2006, 21, A270-A270.
10. Su, J.; He, L.; Zhang, N. N.; Ho, P. C. Evaluation of tributyrin lipid emulsion with affinity to low-density lipoprotein: Pharmacokinetics in adult male Wistar rats and cellular activity on Caco-2 and HepG2 cell lines. J. Pharmacol. Exp. Ther. 2006, 316 (1), 62-70.
11. Su, J.; Ho, P. C. Preparation of tributyrin emulsion and characterization of the binding of the emulsion particles to low-density lipoprotein in vitro. J. Pharm. Sci. 2004, 93 (1), 1755-1765.
12. Wooster, T. J.; Golding, M.; Sanguansri, P. Impact of oil type on nanoemulsion formation and Ostwald ripening stability. Langmuir 2008, 24, 12758-12765.
13. Kabalnov, A. S.; Shchukin, E. D. Ostwald ripening theory-applications to fluorocarbon emulsion stability. Adv. Colloid Interface Sci. 1992, 38, 69-97.
14. Kabalnov, A. S.; Pertzov, A. V.; Shchukin, E. D. Ostwald ripening in 2-component disperse phase systems-application to emulsion stability. Colloids Surf. 1987, 24 (1), 19-32.
15. Taylor, P. Ostwald ripening in emulsions. Adv. Colloid Interface Sci, 1998, 75(2), 107-163.
16. Coupland, J. N.; Weiss, J.; Lovy, A.; McClements, D. J. Solubilization kinetics of triacyl glycerol and hydrocarbon emulsion droplets in a micellar solution. J. Food Sci. 1996, 61 (6), 1114-1117.
17. Dimitrijevic, D.; Shaw, A. J.; Florence, A. T. Effects of some nonionic surfactants on transepithelial permeability in Caco-2 cells. J. Pharm. Pharmacol. 2000, 52 (2), 157-162.
18. Ingels, F. M.; Augustijns, P. F. Biological, pharmaceutical, and analytical considerations with respect to the transport media used in the absorption screening system, Caco-2. J. Pharm. Sci, 2003, 92 (8), 1545-1558.
19. Boulenc, X.; Breul, T.; Gautier, J. C.; Saudemon, P.; Joyeux, H.; Roques, C.; Berger, Y.; Fabre, G. Sodium lauryl sulfate increases tiludronate paracellular transport using human epithelial Caco-2 monolayers. Int. J. Pharm. 1995,123 (1), 71-83.
20. McClements, D. J.; Decker, E. A.; Park, Y. Controlling lipid bioavailability through physicochemical and structural approaches. Crit. Rev. Food Sci. Nutr. 2009, 49 (1), 48-67.
21. Porter, C. J. H.; Wasan, K. M. Lipid-based systems for the enhanced delivery of poorly water soluble drugs. Adv. Drug Delivery Rev. 2008, 60(6), 615-616.
22. Pouton, C. W. Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. Eur. J. Pharm. Sci. 2006, 29 (3-4), 278-287.
23. McClements, D. J.; Decker, E. A.; Weiss, J. Emulsion-based delivery systems for lipophilioc bioactive components. J. Food Sci. 2007, 72 (8), R109-R124. (Pubitemid 47583566)
24. Mun, S.; Decker, E. A.; Park, Y.; Weiss, J.; McClements, D. J. Influence of interfacial composition on in vitro digestibility of emulsified lipids: potential mechanism for chitosan's ability to inhibit fat digestion. Food Biophys. 2006, 1 (1), 21-29.