Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs

International Journal of Pharmaceutics

Volumn 353, Issue 1-2, 2008, Pages 270-276

  Mou, Dongsheng ^a   Chen, Huabing ^a   Du, Danrong ^a   Mao, Chengwen ^a   Wan, Jiangling ^a   Xu, Huibi ^a   Yang, Xiangliang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Camphor; Menthol; Methyl salicylate; Nanoemulsion; Topical delivery

Indexed keywords

CAMPHOR; CARBOMER; COSURFACTANT; MENTHOL; PHOSPHATIDYLCHOLINE; POLOXAMER; POLYSORBATE 80; PROPYLENE GLYCOL; SALICYLIC ACID METHYL ESTER; SOYBEAN OIL; SURFACTANT; THICKENING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DRUG PENETRATION; DRUG STABILITY; EMULSION; GAS CHROMATOGRAPHY; HYDROGEL; IN VITRO STUDY; LIPOPHILICITY; MALE; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SPECTROSCOPY; TOPICAL TREATMENT; TRANSMISSION ELECTRON MICROSCOPY; VISCOSITY;

ADMINISTRATION, TOPICAL; DRUG DELIVERY SYSTEMS; DRUG STABILITY; EMULSIONS; HYDROGEL; NANOPARTICLES; PERMEABILITY; SOLUBILITY;

EID: 40149108427     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.11.051     Document Type: Article

References (32)

1. Bivas-Benita M., Oudshoorn M., Romeijn S., van Meijgaarden K., Koerten H., and van der Meulen H. Cationic submicron emulsions for pulmonary DNA immunization. J. Control. Release 100 (2004) 145-155
2. Bondoc Jr. L.L., and Fitzpatrick S. Size distribution analysis of recombinant adenovirus using disc centrifugation. J. Ind. Microbiol. Biotechnol. 20 (1998) 317-322
3. Buszello K., and Müller B.W. Emulsions as drug delivery systems. In: Nielloud F., and Marti-Mestres G. (Eds). Pharmaceutical Emulsions and Suspensions (2000), Marcel Dekker, New York 191-228
4. Capek I. Degradation of kinetically-stable o/w emulsions. Adv. Colloid Interface Sci. 107 (2004) 125-155
5. Chen H., Chang X., Du D., Liu W., Weng T., Yang Y., Xu H., and Yang X. Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting. J. Control. Release 110 (2006) 296-306
6. Chen H., Chang X., Du D., Li J., Xu H., and Yang X. Microemulsion-based hydrogel formulation of ibuprofen for topical delivery. Int. J. Pharm. 315 (2006) 52-58
7. Chen H., Chang X., Weng T., Zhao X., Gao Z., Yang Y., Xu H., and Yang X. A study of microemulsion systems for transdermal delivery of triptolide. J. Control. Release 98 (2004) 427-436
8. Elizalde O., Leal G.P., and Leiza J.R. Particle size distribution measurements of polymeric dispersions: a comparative study. Part. Part. Syst. Charact. 17 (2000) 236-243
9. Lapasin R., Grassi M., and Coceani N. Effects of polymer addition on the rheology of o/w microemulsions. Rheol. Acta 40 (2001) 185-192
10. Maestrelli F., González-Rodríguez M.L., Rabasco A.M., and Mura P. Effect of preparation technique on the properties of liposomes encapsulating ketoprofen-cyclodextrin complexes aimed for transdermal delivery. Int. J. Pharm. 31 (2006) 53-60
11. Moshfeghi A.A., and Peyman G.A. Micro- and nanoparticulates. Adv. Drug Deliv. Rev. 57 (2005) 2047-2052
12. Nicolaos G., Crauste-Manciet S., Farinotti R., and Brossard D. Improvement of cefpodoxime proxetil oral absorption in rats by an oil-in-water submicron emulsion. Int. J. Pharm. 263 (2003) 165-171
13. Peltola S., Saarinen-Savolainen P., Kiesvaara J., Suhonen T.M., and Urtti A. Microemulsions for topical delivery of estradiol. Int. J. Pharm. 254 (2003) 99-107
14. Rabinovich-Guilatt L., Couvreur P., Lambert G., and Dubernet C. Cationic vectors in ocular drug delivery. J. Drug Target 12 (2004) 623-633
15. Rosen H., and Abribat T. The rise and rise of drug delivery. Nat. Rev. Drug Discov. 4 (2005) 381-385
16. Sajjadi S. Effect of mixing protocol on formation of fine emulsionsk. Chem. Eng. Sci. 61 (2006) 3009-3017
17. Santos-Magalhäes N.S., Pontes A., Pereira V.M.W., and Caetano M.N.P. Colloidal carriers for benzathine penicillin G: nanoemulsions and nanocapsules. Int. J. Pharm. 208 2000 (2000) 71-80
18. Service R.F. Nanotechnology grows up. Science 304 (2005) 1732-1734
19. Solans C., Esquena J., Forgiarini A., Morales D., Usón N., and Izquierdo P. Nanoemulsions: formation and properties. In: Shah D., Moudgil B., and Mittal K.L. (Eds). Surfactants in Solution: Fundamentals and Applications, Surfactant Science Series (2002), Marcel Dekker, New York 525-554
20. Solans C., Izquierdo P., Nolla J., Azemar N., and Garcia-Celma M.J. Nano-emulsions. Curr. Opin. Colloid Interface Sci. 10 (2005) 102-110
21. Sonneville-Aubrun O., Simonnet J.-T., and L'Alloret F. Nanoemulsions: a new vehicle for skincare products. Adv. Colloid Interface Sci. 108-109 (2004) 145-149
22. Sznitowska M., Dabrowska E.A., and Janicki S. Solubilizing potential of submicron emulsions and aqueous dispersions of lecithin. Int. J. Pharm. 246 (2002) 203-206
23. Sznitowska M., Janicki S., Dabrowska E., and Zurowska-Pryczkowska K. Submicron emulsions as drug carriers: studies on destabilization potential of various drugs European. J. Pharm. Sci. 12 (2001) 175-179
24. Tadros T., Izquierdo P., Esquena J., and Solans C. Formation and stability of nano-emulsions. Adv. Colloid Interface Sci. 108-109 (2004) 303-318
25. Tamilvanan S. Oil-in-water lipid emulsions: implications for parenteral and ocular delivering systems. Prog. Lipid Res. 43 (2004) 489-533
26. Tamilvanan S., Schmitd S., Müller R.H., and Benita S. In vitro adsorption of plasma proteins onto the surface (charges) modified-submicron emulsions for intravenous administration. Eur. J. Pharm. Biopharm. 59 (2005) 1-7
27. Valdez J.S., Martin D.K., and Mayersohn M. Sensitive and selective gas chromatographic methods for the quantitation of camphor, menthol and methyl salicylate from human plasma. J. Chromatogr. B 729 1999 (1999) 163-171
28. Vleeschauwer D.D., and der Meeren P.V. Colloid chemical stability and interfacial properties of mixed phospholipid-non-ionic surfactant stabilized oil-in-water emulsions. Colloid Surf. A: Physicochem. Eng. Asp. 152 (1999) 59-66
29. Wu H., Ramachandran C., Weiner N.D., and Roessler B.J. Topical transport of hydrophilic compounds using water-in-oil nanoemulsions. Int. J. Pharm. 220 (2001) 63-75
30. Yilmaz E., and Borchert H.-H. Effect of lipid-containing, positively charged nanoemulsions on skin hydration, elasticity and erythema-an in vivo study. Int. J. Pharm. 307 (2006) 232-238
31. Youenang Piemi M.P., Korner D., Benita S., and Marty J.-P. Positively and negatively charged submicron emulsions for enhanced topical delivery of antifungal drugs. J. Control. Release 58 (1999) 177-187
32. 2/polystyrene nanocomposite particles via miniemulsion polymerization. Langmuir 21 (2005) 2124-2128