Pharmacokinetics of dietary cancer chemopreventive compound dibenzoylmethane in rats and the impact of nanoemulsion and genetic knockout of Nrf2 on its disposition

Biopharmaceutics and Drug Disposition

Volumn 32, Issue 2, 2011, Pages 65-75

  Lin, Wen ^a   Hong, Jin Liern ^a   Shen, Guoxiang ^a   Wu, Rachel T ^a   Wang, Yuwen ^b   Huang, Mou Tuan ^a   Newmark, Harold L ^a   Huang, Qingrong ^b   Khor, Tin Oo ^a   Heimbach, Tycho ^c   Kong, Ah Ng ^a  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Dibenzoylmethane; Nanotechnology based drug delivery system; Nrf2 genotype

Indexed keywords

ANTINEOPLASTIC AGENT; DIBENZOYLMETHANE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; WATER OIL CREAM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DETOXIFICATION; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SOLUBILITY; GENE INACTIVATION; GENOTYPE; IN VIVO STUDY; LIVER BLOOD FLOW; MALE; MOUSE; NANOEMULSION; NONHUMAN; PLASMA CLEARANCE; RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTICARCINOGENIC AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHALCONES; DOSE-RESPONSE RELATIONSHIP, DRUG; EMULSIONS; HALF-LIFE; INJECTIONS, INTRAVENOUS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NANOPARTICLES; NANOTECHNOLOGY; NF-E2-RELATED FACTOR 2; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; TISSUE DISTRIBUTION;

EID: 79952024052     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.734     Document Type: Article

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