메뉴 건너뛰기




Volumn 70, Issue 18, 2013, Pages 3391-3404

Muramyl dipeptide responsive pathways in Crohn's disease: From NOD2 and beyond

Author keywords

ATG16L1; Autophagy; Crohn's disease (CD); Inflammasome; Inflammatory bowel disease (IBD); Innate lymfoid cells; Muramyl dipeptide (MDP); NF B; Nucleotide oligomerization domain 2; Paneth cells; Peptidoglycan; Toll like receptor

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 17 ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE; MURAMYL DIPEPTIDE; TRANSCRIPTION FACTOR FOXP3;

EID: 84883449877     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1246-4     Document Type: Review
Times cited : (27)

References (169)
  • 1
    • 33746028777 scopus 로고    scopus 로고
    • Intracellular pattern recognition receptors in the host response
    • 16823444 1:CAS:528:DC%2BD28XmsFWnurk%3D
    • Meylan E, Tschopp J, Karin M (2006) Intracellular pattern recognition receptors in the host response. Nature 442:39-44
    • (2006) Nature , vol.442 , pp. 39-44
    • Meylan, E.1    Tschopp, J.2    Karin, M.3
  • 2
    • 80051764401 scopus 로고    scopus 로고
    • Muramyl dipeptide and its derivatives: Peptide adjuvant in immunological disorders and cancer therapy
    • 22180736 1:CAS:528:DC%2BC3MXhs1ansLrK
    • Ogawa C, Liu YJ, Kobayashi KS (2011) Muramyl dipeptide and its derivatives: peptide adjuvant in immunological disorders and cancer therapy. Curr Bioact Compd 7:180-197
    • (2011) Curr Bioact Compd , vol.7 , pp. 180-197
    • Ogawa, C.1    Liu, Y.J.2    Kobayashi, K.S.3
  • 3
    • 3242771408 scopus 로고    scopus 로고
    • Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation
    • 15090455 1:CAS:528:DC%2BD2cXmtlCku7w%3D
    • Holler E, Rogler G, Herfarth H, Brenmoehl J, Wild PJ, Hahn J, Eissner G, Scholmerich J et al (2004) Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood 104:889-894
    • (2004) Blood , vol.104 , pp. 889-894
    • Holler, E.1    Rogler, G.2    Herfarth, H.3    Brenmoehl, J.4    Wild, P.J.5    Hahn, J.6    Eissner, G.7    Scholmerich, J.8
  • 4
    • 80053055841 scopus 로고    scopus 로고
    • Cutting edge: Crohn's disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality
    • 21849681 1:CAS:528:DC%2BC3MXhtFeksb7E
    • Kim YG, Shaw MH, Warner N, Park JH, Chen F, Ogura Y, Nunez G (2011) Cutting edge: crohn's disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality. J Immunol 187:2849-2852
    • (2011) J Immunol , vol.187 , pp. 2849-2852
    • Kim, Y.G.1    Shaw, M.H.2    Warner, N.3    Park, J.H.4    Chen, F.5    Ogura, Y.6    Nunez, G.7
  • 6
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • 11385576 1:CAS:528:DC%2BD3MXksVShtLY%3D
    • Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C et al (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411:599-603
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3    Lesage, S.4    Cezard, J.P.5    Belaiche, J.6    Almer, S.7    Tysk, C.8
  • 7
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • 11385577 1:CAS:528:DC%2BD3MXksVShur8%3D
    • Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T et al (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411:603-606
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3    Nicolae, D.L.4    Chen, F.F.5    Ramos, R.6    Britton, H.7    Moran, T.8
  • 8
    • 0035895992 scopus 로고    scopus 로고
    • Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB
    • 11087742 1:CAS:528:DC%2BD3MXhtlOqtL8%3D
    • Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G (2001) Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem 276:4812-4818
    • (2001) J Biol Chem , vol.276 , pp. 4812-4818
    • Ogura, Y.1    Inohara, N.2    Benito, A.3    Chen, F.F.4    Yamaoka, S.5    Nunez, G.6
  • 9
    • 79959216005 scopus 로고    scopus 로고
    • Genetics and pathogenesis of inflammatory bowel disease
    • 21677747 1:CAS:528:DC%2BC3MXnsFOrsr4%3D
    • Khor B, Gardet A, Xavier RJ (2011) Genetics and pathogenesis of inflammatory bowel disease. Nature 474:307-317
    • (2011) Nature , vol.474 , pp. 307-317
    • Khor, B.1    Gardet, A.2    Xavier, R.J.3
  • 10
    • 79959271087 scopus 로고    scopus 로고
    • Intestinal homeostasis and its breakdown in inflammatory bowel disease
    • 21677746 1:CAS:528:DC%2BC3MXnsFOqs7g%3D
    • Maloy KJ, Powrie F (2011) Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 474:298-306
    • (2011) Nature , vol.474 , pp. 298-306
    • Maloy, K.J.1    Powrie, F.2
  • 11
    • 84856007744 scopus 로고    scopus 로고
    • Role of genetics in the diagnosis and prognosis of Crohn's disease
    • 22253516 1:CAS:528:DC%2BC38XhslKnsb0%3D
    • Tsianos EV, Katsanos KH, Tsianos VE (2012) Role of genetics in the diagnosis and prognosis of Crohn's disease. World J Gastroenterol 18:105-118
    • (2012) World J Gastroenterol , vol.18 , pp. 105-118
    • Tsianos, E.V.1    Katsanos, K.H.2    Tsianos, V.E.3
  • 13
    • 80052446723 scopus 로고    scopus 로고
    • Peptidoglycan biosynthesis machinery: A rich source of drug targets
    • 21091161 1:CAS:528:DC%2BC3MXhsVGku7zN
    • Gautam A, Vyas R, Tewari R (2011) Peptidoglycan biosynthesis machinery: a rich source of drug targets. Crit Rev Biotechnol 31:295-336
    • (2011) Crit Rev Biotechnol , vol.31 , pp. 295-336
    • Gautam, A.1    Vyas, R.2    Tewari, R.3
  • 15
    • 0037458665 scopus 로고    scopus 로고
    • Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease
    • 12514169 1:CAS:528:DC%2BD3sXht1aqsro%3D
    • Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, Fukase K, Inamura S et al (2003) Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 278:5509-5512
    • (2003) J Biol Chem , vol.278 , pp. 5509-5512
    • Inohara, N.1    Ogura, Y.2    Fontalba, A.3    Gutierrez, O.4    Pons, F.5    Crespo, J.6    Fukase, K.7    Inamura, S.8
  • 16
    • 0030049937 scopus 로고    scopus 로고
    • Structural characteristics of peptidoglycan fragments required to prime mice for induction of anaphylactoid reactions by lipopolysaccharides
    • 8550222 1:CAS:528:DyaK28XntVerug%3D%3D
    • Takada H, Kawabata Y, Kawata S, Kusumoto S (1996) Structural characteristics of peptidoglycan fragments required to prime mice for induction of anaphylactoid reactions by lipopolysaccharides. Infect Immun 64:657-659
    • (1996) Infect Immun , vol.64 , pp. 657-659
    • Takada, H.1    Kawabata, Y.2    Kawata, S.3    Kusumoto, S.4
  • 18
    • 77954418713 scopus 로고    scopus 로고
    • Mycobacteria in Crohn's disease: How innate immune deficiency may result in chronic inflammation
    • 20594136 1:CAS:528:DC%2BC3cXot1aktLw%3D
    • Lalande JD, Behr MA (2010) Mycobacteria in Crohn's disease: how innate immune deficiency may result in chronic inflammation. Expert Rev Clin Immunol 6:633-641
    • (2010) Expert Rev Clin Immunol , vol.6 , pp. 633-641
    • Lalande, J.D.1    Behr, M.A.2
  • 19
    • 84860760507 scopus 로고    scopus 로고
    • Muramyl dipeptide induces NOD2-dependent Ly6C(high) monocyte recruitment to the lungs and protects against influenza virus infection
    • 22590599 1:CAS:528:DC%2BC38Xns1Gms7g%3D
    • Coulombe F, Fiola S, Akira S, Cormier Y, Gosselin J (2012) Muramyl dipeptide induces NOD2-dependent Ly6C(high) monocyte recruitment to the lungs and protects against influenza virus infection. PLoS One 7:e36734
    • (2012) PLoS One , vol.7 , pp. 36734
    • Coulombe, F.1    Fiola, S.2    Akira, S.3    Cormier, Y.4    Gosselin, J.5
  • 20
    • 44949258242 scopus 로고    scopus 로고
    • How bacteria consume their own exoskeletons (turnover and recycling of cell wall peptidoglycan)
    • 18535144 1:CAS:528:DC%2BD1cXosVahtb0%3D
    • Park JT, Uehara T (2008) How bacteria consume their own exoskeletons (turnover and recycling of cell wall peptidoglycan). Microbiol Mol Biol Rev 72:211-227
    • (2008) Microbiol Mol Biol Rev , vol.72 , pp. 211-227
    • Park, J.T.1    Uehara, T.2
  • 22
    • 44849136632 scopus 로고    scopus 로고
    • Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2
    • 18322214 1:CAS:528:DC%2BD1cXisl2jtr4%3D
    • Marina-Garcia N, Franchi L, Kim YG, Miller D, McDonald C, Boons GJ, Nunez G (2008) Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2. J Immunol 180:4050-4057
    • (2008) J Immunol , vol.180 , pp. 4050-4057
    • Marina-Garcia, N.1    Franchi, L.2    Kim, Y.G.3    Miller, D.4    McDonald, C.5    Boons, G.J.6    Nunez, G.7
  • 23
    • 7644234401 scopus 로고    scopus 로고
    • HPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells
    • 15521010 1:CAS:528:DC%2BD2cXhtVKisrzE
    • Vavricka SR, Musch MW, Chang JE, Nakagawa Y, Phanvijhitsiri K, Waypa TS, Merlin D, Schneewind O et al (2004) hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells. Gastroenterology 127:1401-1409
    • (2004) Gastroenterology , vol.127 , pp. 1401-1409
    • Vavricka, S.R.1    Musch, M.W.2    Chang, J.E.3    Nakagawa, Y.4    Phanvijhitsiri, K.5    Waypa, T.S.6    Merlin, D.7    Schneewind, O.8
  • 24
    • 84858683881 scopus 로고    scopus 로고
    • Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy
    • 22021207
    • Scharl M, Mwinyi J, Fischbeck A, Leucht K, Eloranta JJ, Arikkat J, Pesch T, Kellermeier S et al (2012) Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy. Inflamm Bowel Dis 18:900-912
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 900-912
    • Scharl, M.1    Mwinyi, J.2    Fischbeck, A.3    Leucht, K.4    Eloranta, J.J.5    Arikkat, J.6    Pesch, T.7    Kellermeier, S.8
  • 25
    • 64249166480 scopus 로고    scopus 로고
    • Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation
    • 19299732 1:CAS:528:DC%2BD1MXjsVSjurk%3D
    • Marina-Garcia N, Franchi L, Kim YG, Hu Y, Smith DE, Boons GJ, Nunez G (2009) Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation. J Immunol 182:4321-4327
    • (2009) J Immunol , vol.182 , pp. 4321-4327
    • Marina-Garcia, N.1    Franchi, L.2    Kim, Y.G.3    Hu, Y.4    Smith, D.E.5    Boons, G.J.6    Nunez, G.7
  • 26
    • 69949125920 scopus 로고    scopus 로고
    • PH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling
    • 19570976 1:CAS:528:DC%2BD1MXhtVWqt73J
    • Lee J, Tattoli I, Wojtal KA, Vavricka SR, Philpott DJ, Girardin SE (2009) pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J Biol Chem 284:23818-23829
    • (2009) J Biol Chem , vol.284 , pp. 23818-23829
    • Lee, J.1    Tattoli, I.2    Wojtal, K.A.3    Vavricka, S.R.4    Philpott, D.J.5    Girardin, S.E.6
  • 27
    • 33644508366 scopus 로고    scopus 로고
    • Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity
    • 16467847 1:CAS:528:DC%2BD28Xhs1ertr8%3D
    • Husebye H, Halaas O, Stenmark H, Tunheim G, Sandanger O, Bogen B, Brech A, Latz E et al (2006) Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J 25:683-692
    • (2006) EMBO J , vol.25 , pp. 683-692
    • Husebye, H.1    Halaas, O.2    Stenmark, H.3    Tunheim, G.4    Sandanger, O.5    Bogen, B.6    Brech, A.7    Latz, E.8
  • 28
    • 79960720320 scopus 로고    scopus 로고
    • Molecular mechanism and physiological functions of clathrin-mediated endocytosis
    • 21779028 1:CAS:528:DC%2BC3MXpt1aqtr4%3D
    • McMahon HT, Boucrot E (2011) Molecular mechanism and physiological functions of clathrin-mediated endocytosis. Nat Rev Mol Cell Biol 12:517-533
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 517-533
    • McMahon, H.T.1    Boucrot, E.2
  • 29
    • 34047196224 scopus 로고    scopus 로고
    • Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system
    • 17397264
    • Herskovits AA, Auerbuch V, Portnoy DA (2007) Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system. PLoS Pathog 3:e51
    • (2007) PLoS Pathog , vol.3 , pp. 51
    • Herskovits, A.A.1    Auerbuch, V.2    Portnoy, D.A.3
  • 31
    • 1842430006 scopus 로고    scopus 로고
    • Bacterial invasion: The paradigms of enteroinvasive pathogens
    • 15073367 1:CAS:528:DC%2BD2cXivV2isbk%3D
    • Cossart P, Sansonetti PJ (2004) Bacterial invasion: the paradigms of enteroinvasive pathogens. Science 304:242-248
    • (2004) Science , vol.304 , pp. 242-248
    • Cossart, P.1    Sansonetti, P.J.2
  • 32
    • 80052641505 scopus 로고    scopus 로고
    • Crohn's disease: NOD2, autophagy and ER stress converge
    • 21252204 1:CAS:528:DC%2BC3MXhsV2iurzL
    • Fritz T, Niederreiter L, Adolph T, Blumberg RS, Kaser A (2011) Crohn's disease: NOD2, autophagy and ER stress converge. Gut 60:1580-1588
    • (2011) Gut , vol.60 , pp. 1580-1588
    • Fritz, T.1    Niederreiter, L.2    Adolph, T.3    Blumberg, R.S.4    Kaser, A.5
  • 33
    • 84872404658 scopus 로고    scopus 로고
    • Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases
    • 22908883 1:CAS:528:DC%2BC38XhsFOqurbF
    • Correa RG, Milutinovic S, Reed JC (2012) Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases. Biosci Rep 32:597-608
    • (2012) Biosci Rep , vol.32 , pp. 597-608
    • Correa, R.G.1    Milutinovic, S.2    Reed, J.C.3
  • 34
    • 79651473582 scopus 로고    scopus 로고
    • NF-kappaB in immunobiology
    • 21243012 1:CAS:528:DC%2BC3MXhsVOmurk%3D
    • Hayden MS, Ghosh S (2011) NF-kappaB in immunobiology. Cell Res 21:223-244
    • (2011) Cell Res , vol.21 , pp. 223-244
    • Hayden, M.S.1    Ghosh, S.2
  • 35
    • 78650920066 scopus 로고    scopus 로고
    • Non-canonical NF-kappaB signaling pathway
    • 21173796 1:CAS:528:DC%2BC3MXhtlartw%3D%3D
    • Sun SC (2011) Non-canonical NF-kappaB signaling pathway. Cell Res 21:71-85
    • (2011) Cell Res , vol.21 , pp. 71-85
    • Sun, S.C.1
  • 37
    • 84864815551 scopus 로고    scopus 로고
    • Role of mouse peptidoglycan recognition protein PGLYRP2 in the innate immune response to salmonella enterica serovar typhimurium infection in vivo
    • 22615249 1:CAS:528:DC%2BC38XhtFegsr%2FN
    • Lee J, Geddes K, Streutker C, Philpott DJ, Girardin SE (2012) Role of mouse peptidoglycan recognition protein PGLYRP2 in the innate immune response to salmonella enterica serovar typhimurium infection in vivo. Infect Immun 80:2645-2654
    • (2012) Infect Immun , vol.80 , pp. 2645-2654
    • Lee, J.1    Geddes, K.2    Streutker, C.3    Philpott, D.J.4    Girardin, S.E.5
  • 38
    • 0037379915 scopus 로고    scopus 로고
    • TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells
    • 12671897 1:CAS:528:DC%2BD3sXjsFOju7k%3D
    • Rosenstiel P, Fantini M, Brautigam K, Kuhbacher T, Waetzig GH, Seegert D, Schreiber S (2003) TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells. Gastroenterology 124:1001-1009
    • (2003) Gastroenterology , vol.124 , pp. 1001-1009
    • Rosenstiel, P.1    Fantini, M.2    Brautigam, K.3    Kuhbacher, T.4    Waetzig, G.H.5    Seegert, D.6    Schreiber, S.7
  • 39
    • 84865434771 scopus 로고    scopus 로고
    • The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment
    • 22857257 1:CAS:528:DC%2BC38XhtFChtr3F
    • Grimes CL, Ariyananda LD, Melnyk JE, O'Shea EK (2012) The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment. J Am Chem Soc 134(33):13535-13537
    • (2012) J Am Chem Soc , vol.134 , Issue.33 , pp. 13535-13537
    • Grimes, C.L.1    Ariyananda, L.D.2    Melnyk, J.E.3    O'Shea, E.K.4
  • 40
    • 0023266426 scopus 로고
    • Fluorescence ratio imaging microscopy: Temporal and spatial measurements of cytoplasmic pH
    • 3558476 1:STN:280:DyaL2s7ms1Wluw%3D%3D
    • Bright GR, Fisher GW, Rogowska J, Taylor DL (1987) Fluorescence ratio imaging microscopy: temporal and spatial measurements of cytoplasmic pH. J Cell Biol 104:1019-1033
    • (1987) J Cell Biol , vol.104 , pp. 1019-1033
    • Bright, G.R.1    Fisher, G.W.2    Rogowska, J.3    Taylor, D.L.4
  • 42
    • 11144289688 scopus 로고    scopus 로고
    • The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO
    • 15620648 1:CAS:528:DC%2BD2cXhtFGhtbzF
    • Abbott DW, Wilkins A, Asara JM, Cantley LC (2004) The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr Biol 14:2217-2227
    • (2004) Curr Biol , vol.14 , pp. 2217-2227
    • Abbott, D.W.1    Wilkins, A.2    Asara, J.M.3    Cantley, L.C.4
  • 43
    • 77952316009 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • 20192811 1:CAS:528:DC%2BC3cXlsVSmsL0%3D
    • Kaser A, Zeissig S, Blumberg RS (2010) Inflammatory bowel disease. Annu Rev Immunol 28:573-621
    • (2010) Annu Rev Immunol , vol.28 , pp. 573-621
    • Kaser, A.1    Zeissig, S.2    Blumberg, R.S.3
  • 44
    • 35748929941 scopus 로고    scopus 로고
    • Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti
    • 17728323 1:CAS:528:DC%2BD2sXht1Kgs7fJ
    • Sebban-Benin H, Pescatore A, Fusco F, Pascuale V, Gautheron J, Yamaoka S, Moncla A, Ursini MV et al (2007) Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti. Hum Mol Genet 16:2805-2815
    • (2007) Hum Mol Genet , vol.16 , pp. 2805-2815
    • Sebban-Benin, H.1    Pescatore, A.2    Fusco, F.3    Pascuale, V.4    Gautheron, J.5    Yamaoka, S.6    Moncla, A.7    Ursini, M.V.8
  • 45
    • 78650866071 scopus 로고    scopus 로고
    • NF-kappaB in the regulation of epithelial homeostasis and inflammation
    • 21151201 1:CAS:528:DC%2BC3MXhtlarug%3D%3D
    • Wullaert A, Bonnet MC, Pasparakis M (2011) NF-kappaB in the regulation of epithelial homeostasis and inflammation. Cell Res 21:146-158
    • (2011) Cell Res , vol.21 , pp. 146-158
    • Wullaert, A.1    Bonnet, M.C.2    Pasparakis, M.3
  • 46
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-kappaB transcription factors in the immune system
    • 19302050 1:CAS:528:DC%2BD1MXlsFSlt7o%3D
    • Vallabhapurapu S, Karin M (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 27:693-733
    • (2009) Annu Rev Immunol , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 47
    • 33745852665 scopus 로고    scopus 로고
    • Alternative pathways of NF-kappaB activation: A double-edged sword in health and disease
    • 16793322 1:CAS:528:DC%2BD28XntFSgsbo%3D
    • Xiao G, Rabson AB, Young W, Qing G, Qu Z (2006) Alternative pathways of NF-kappaB activation: a double-edged sword in health and disease. Cytokine Growth Factor Rev 17:281-293
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 281-293
    • Xiao, G.1    Rabson, A.B.2    Young, W.3    Qing, G.4    Qu, Z.5
  • 48
    • 79953758746 scopus 로고    scopus 로고
    • A protein interaction network and cell signaling pathways activated by muramyl peptides
    • 21063445 1:STN:280:DC%2BC3cbmsVyltg%3D%3D
    • Meshcheriakova EA, Andronova TM, Ivanov VT (2010) A protein interaction network and cell signaling pathways activated by muramyl peptides. Bioorg Khim 36:581-595
    • (2010) Bioorg Khim , vol.36 , pp. 581-595
    • Meshcheriakova, E.A.1    Andronova, T.M.2    Ivanov, V.T.3
  • 49
    • 33645532087 scopus 로고    scopus 로고
    • NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway
    • 16552041 1:CAS:528:DC%2BD28XjsVWhs7w%3D
    • Pan Q, Kravchenko V, Katz A, Huang S, Ii M, Mathison JC, Kobayashi K, Flavell RA et al (2006) NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway. Infect Immun 74:2121-2127
    • (2006) Infect Immun , vol.74 , pp. 2121-2127
    • Pan, Q.1    Kravchenko, V.2    Katz, A.3    Huang, S.4    Ii, M.5    Mathison, J.C.6    Kobayashi, K.7    Flavell, R.A.8
  • 50
    • 0141567432 scopus 로고    scopus 로고
    • Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway
    • 12969313 1:CAS:528:DC%2BD3sXotFyrt7Y%3D
    • Weih F, Caamano J (2003) Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway. Immunol Rev 195:91-105
    • (2003) Immunol Rev , vol.195 , pp. 91-105
    • Weih, F.1    Caamano, J.2
  • 51
    • 54349095688 scopus 로고    scopus 로고
    • The molecular basis of NOD2 susceptibility mutations in Crohn's disease
    • 19079230 1:CAS:528:DC%2BD1cXht1CmsLbO
    • Strober W, Kitani A, Fuss I, Asano N, Watanabe T (2008) The molecular basis of NOD2 susceptibility mutations in Crohn's disease. Mucosal Immunol 1(suppl 1):S5-S9
    • (2008) Mucosal Immunol , vol.1 , Issue.SUPPL. 1
    • Strober, W.1    Kitani, A.2    Fuss, I.3    Asano, N.4    Watanabe, T.5
  • 54
    • 79551477677 scopus 로고    scopus 로고
    • MAP kinases in inflammatory bowel disease
    • 21185271 1:CAS:528:DC%2BC3MXhsFOgsbg%3D
    • Coskun M, Olsen J, Seidelin JB, Nielsen OH (2011) MAP kinases in inflammatory bowel disease. Clin Chim Acta 412:513-520
    • (2011) Clin Chim Acta , vol.412 , pp. 513-520
    • Coskun, M.1    Olsen, J.2    Seidelin, J.B.3    Nielsen, O.H.4
  • 55
    • 77955059513 scopus 로고    scopus 로고
    • Mechanisms and functions of p38 MAPK signalling
    • 20626350 1:CAS:528:DC%2BC3cXovVCnsrg%3D
    • Cuadrado A, Nebreda AR (2010) Mechanisms and functions of p38 MAPK signalling. Biochem J 429:403-417
    • (2010) Biochem J , vol.429 , pp. 403-417
    • Cuadrado, A.1    Nebreda, A.R.2
  • 56
    • 33847754623 scopus 로고    scopus 로고
    • The JNK signal transduction pathway
    • 17303404 1:CAS:528:DC%2BD2sXjt1Slu7o%3D
    • Weston CR, Davis RJ (2007) The JNK signal transduction pathway. Curr Opin Cell Biol 19:142-149
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 142-149
    • Weston, C.R.1    Davis, R.J.2
  • 57
    • 0035066383 scopus 로고    scopus 로고
    • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    • 11274345 1:CAS:528:DC%2BD3MXislCrsb8%3D
    • Kyriakis JM, Avruch J (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81:807-869
    • (2001) Physiol Rev , vol.81 , pp. 807-869
    • Kyriakis, J.M.1    Avruch, J.2
  • 58
    • 74049160438 scopus 로고    scopus 로고
    • The p38alpha kinase plays a central role in inflammation
    • 19747121 1:CAS:528:DC%2BD1MXhsFWisbzO
    • Schieven GL (2009) The p38alpha kinase plays a central role in inflammation. Curr Top Med Chem 9:1038-1048
    • (2009) Curr Top Med Chem , vol.9 , pp. 1038-1048
    • Schieven, G.L.1
  • 59
    • 4444253690 scopus 로고    scopus 로고
    • NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
    • 15220916 1:CAS:528:DC%2BD2cXmtVCgtL8%3D
    • Watanabe T, Kitani A, Murray PJ, Strober W (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5:800-808
    • (2004) Nat Immunol , vol.5 , pp. 800-808
    • Watanabe, T.1    Kitani, A.2    Murray, P.J.3    Strober, W.4
  • 60
    • 38849163741 scopus 로고    scopus 로고
    • Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis
    • 18188453 1:CAS:528:DC%2BD1cXhsFOmsrw%3D
    • Watanabe T, Asano N, Murray PJ, Ozato K, Tailor P, Fuss IJ, Kitani A, Strober W (2008) Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J Clin Invest 118:545-559
    • (2008) J Clin Invest , vol.118 , pp. 545-559
    • Watanabe, T.1    Asano, N.2    Murray, P.J.3    Ozato, K.4    Tailor, P.5    Fuss, I.J.6    Kitani, A.7    Strober, W.8
  • 61
    • 66949138341 scopus 로고    scopus 로고
    • Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2
    • 19464198 1:CAS:528:DC%2BD1MXpsFCntbc%3D
    • Bertrand MJ, Doiron K, Labbe K, Korneluk RG, Barker PA, Saleh M (2009) Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity 30:789-801
    • (2009) Immunity , vol.30 , pp. 789-801
    • Bertrand, M.J.1    Doiron, K.2    Labbe, K.3    Korneluk, R.G.4    Barker, P.A.5    Saleh, M.6
  • 62
    • 79955563439 scopus 로고    scopus 로고
    • Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
    • 21530742 1:CAS:528:DC%2BC3MXlsVGhsL0%3D
    • Strober W, Fuss IJ (2011) Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140:1756-1767
    • (2011) Gastroenterology , vol.140 , pp. 1756-1767
    • Strober, W.1    Fuss, I.J.2
  • 63
    • 79960888630 scopus 로고    scopus 로고
    • The opposing roles of IL-21 and TGFbeta1 in chronic inflammatory bowel disease
    • 21787348 1:CAS:528:DC%2BC3MXpslKqt7w%3D
    • Macdonald TT, Bell I, Monteleone G (2011) The opposing roles of IL-21 and TGFbeta1 in chronic inflammatory bowel disease. Biochem Soc Trans 39:1061-1066
    • (2011) Biochem Soc Trans , vol.39 , pp. 1061-1066
    • Macdonald, T.T.1    Bell, I.2    Monteleone, G.3
  • 66
    • 84868680312 scopus 로고    scopus 로고
    • Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: Unexpected results of a randomised, double-blind placebo-controlled trial
    • 22595313 1:CAS:528:DC%2BC3sXktFOitg%3D%3D
    • Hueber W, Sands BE, Lewitzky S, Vandemeulebroecke M, Reinisch W, Higgins PD, Wehkamp J, Feagan BG et al (2012) Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 61:1693-1700
    • (2012) Gut , vol.61 , pp. 1693-1700
    • Hueber, W.1    Sands, B.E.2    Lewitzky, S.3    Vandemeulebroecke, M.4    Reinisch, W.5    Higgins, P.D.6    Wehkamp, J.7    Feagan, B.G.8
  • 67
    • 65249115914 scopus 로고    scopus 로고
    • A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1
    • 19349988 1:CAS:528:DC%2BD1MXktVKgurw%3D
    • Noguchi E, Homma Y, Kang X, Netea MG, Ma X (2009) A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1. Nat Immunol 10:471-479
    • (2009) Nat Immunol , vol.10 , pp. 471-479
    • Noguchi, E.1    Homma, Y.2    Kang, X.3    Netea, M.G.4    Ma, X.5
  • 68
    • 0033948508 scopus 로고    scopus 로고
    • Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(-/-) mice and intestinal inflammation
    • 10859210 1:CAS:528:DC%2BD3cXks1Kntbw%3D
    • Rennick DM, Fort MM (2000) Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(-/-) mice and intestinal inflammation. Am J Physiol Gastrointest Liver Physiol 278:G829-G833
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.278
    • Rennick, D.M.1    Fort, M.M.2
  • 69
    • 84857365925 scopus 로고    scopus 로고
    • Nod2: A key regulator linking microbiota to intestinal mucosal immunity
    • 1:CAS:528:DC%2BC38Xks1yhsA%3D%3D
    • Biswas A, Petnicki-Ocwieja T, Kobayashi KS (2012) Nod2: a key regulator linking microbiota to intestinal mucosal immunity. J Mol Med (Berl) 90:15-24
    • (2012) J Mol Med (Berl) , vol.90 , pp. 15-24
    • Biswas, A.1    Petnicki-Ocwieja, T.2    Kobayashi, K.S.3
  • 70
    • 2942535858 scopus 로고    scopus 로고
    • Reciprocal cross-talk between Nod2 and TAK1 signaling pathways
    • 15075345 1:CAS:528:DC%2BD2cXksFygtbc%3D
    • Chen CM, Gong Y, Zhang M, Chen JJ (2004) Reciprocal cross-talk between Nod2 and TAK1 signaling pathways. J Biol Chem 279:25876-25882
    • (2004) J Biol Chem , vol.279 , pp. 25876-25882
    • Chen, C.M.1    Gong, Y.2    Zhang, M.3    Chen, J.J.4
  • 71
    • 78149342873 scopus 로고    scopus 로고
    • In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells
    • 20682854 1:CAS:528:DC%2BC3cXhsVKksb7P
    • Courties G, Seiffart V, Presumey J, Escriou V, Scherman D, Zwerina J, Ruiz G, Zietara N et al (2010) In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells. Blood 116:3505-3516
    • (2010) Blood , vol.116 , pp. 3505-3516
    • Courties, G.1    Seiffart, V.2    Presumey, J.3    Escriou, V.4    Scherman, D.5    Zwerina, J.6    Ruiz, G.7    Zietara, N.8
  • 73
    • 80052556040 scopus 로고    scopus 로고
    • Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation
    • 21856952 1:CAS:528:DC%2BC3MXhtFyktb7P
    • Magalhaes JG, Rubino SJ, Travassos LH, Le BL, Duan W, Sellge G, Geddes K, Reardon C et al (2011) Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation. Proc Natl Acad Sci USA 108:14896-14901
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 14896-14901
    • Magalhaes, J.G.1    Rubino, S.J.2    Travassos, L.H.3    Le, B.L.4    Duan, W.5    Sellge, G.6    Geddes, K.7    Reardon, C.8
  • 74
    • 34547097277 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation
    • 17666213 1:CAS:528:DC%2BD2sXotlWktLs%3D
    • Liu YJ (2007) Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation. J Allergy Clin Immunol 120:238-244
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 238-244
    • Liu, Y.J.1
  • 75
    • 0036301998 scopus 로고    scopus 로고
    • Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP
    • 12055625 1:CAS:528:DC%2BD38Xksl2mtbk%3D
    • Soumelis V, Reche PA, Kanzler H, Yuan W, Edward G, Homey B, Gilliet M, Ho S et al (2002) Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol 3:673-680
    • (2002) Nat Immunol , vol.3 , pp. 673-680
    • Soumelis, V.1    Reche, P.A.2    Kanzler, H.3    Yuan, W.4    Edward, G.5    Homey, B.6    Gilliet, M.7    Ho, S.8
  • 76
    • 33646251141 scopus 로고    scopus 로고
    • Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis
    • 16162681 1:CAS:528:DC%2BD28Xksl2hur0%3D
    • Fantini MC, Becker C, Tubbe I, Nikolaev A, Lehr HA, Galle P, Neurath MF (2006) Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis. Gut 55:671-680
    • (2006) Gut , vol.55 , pp. 671-680
    • Fantini, M.C.1    Becker, C.2    Tubbe, I.3    Nikolaev, A.4    Lehr, H.A.5    Galle, P.6    Neurath, M.F.7
  • 78
    • 69449102621 scopus 로고    scopus 로고
    • Increased number of FoxP3+ CD4+ regulatory T cells in inflammatory bowel disease
    • 21479463 1:CAS:528:DC%2BD1cXhtFOitL%2FP
    • Ban H, Andoh A, Shioya M, Nishida A, Tsujikawa T, Fujiyama Y (2008) Increased number of FoxP3+ CD4+ regulatory T cells in inflammatory bowel disease. Mol Med Rep 1:647-650
    • (2008) Mol Med Rep , vol.1 , pp. 647-650
    • Ban, H.1    Andoh, A.2    Shioya, M.3    Nishida, A.4    Tsujikawa, T.5    Fujiyama, Y.6
  • 79
    • 51249084103 scopus 로고    scopus 로고
    • Anti tumour necrosis-alpha therapy increases the number of FOXP3 regulatory T cells in children affected by Crohn's disease
    • 18422560 1:CAS:528:DC%2BD1cXht1ansr3F
    • Ricciardelli I, Lindley KJ, Londei M, Quaratino S (2008) Anti tumour necrosis-alpha therapy increases the number of FOXP3 regulatory T cells in children affected by Crohn's disease. Immunology 125:178-183
    • (2008) Immunology , vol.125 , pp. 178-183
    • Ricciardelli, I.1    Lindley, K.J.2    Londei, M.3    Quaratino, S.4
  • 80
  • 82
    • 0020636609 scopus 로고
    • Stimulating effect of MDP and its adjuvant-active analogues on guinea pig fibroblasts for the production of thymocyte-activating factor
    • 6602206 1:CAS:528:DyaL3sXksFWlt7c%3D
    • Iribe H, Koga T, Kotani S, Kusumoto S, Shiba T (1983) Stimulating effect of MDP and its adjuvant-active analogues on guinea pig fibroblasts for the production of thymocyte-activating factor. J Exp Med 157:2190-2195
    • (1983) J Exp Med , vol.157 , pp. 2190-2195
    • Iribe, H.1    Koga, T.2    Kotani, S.3    Kusumoto, S.4    Shiba, T.5
  • 83
    • 84860241737 scopus 로고    scopus 로고
    • Innate immune dysfunction in inflammatory bowel disease
    • 22324936 1:CAS:528:DC%2BC38XpsFOms7w%3D
    • Gersemann M, Wehkamp J, Stange EF (2012) Innate immune dysfunction in inflammatory bowel disease. J Intern Med 271:421-428
    • (2012) J Intern Med , vol.271 , pp. 421-428
    • Gersemann, M.1    Wehkamp, J.2    Stange, E.F.3
  • 84
    • 78049450786 scopus 로고    scopus 로고
    • The protein Nod2: An innate receptor more complex than previously assumed
    • 20643110 1:CAS:528:DC%2BC3cXhtlKrs7%2FK
    • Lecat A, Piette J, Legrand-Poels S (2010) The protein Nod2: an innate receptor more complex than previously assumed. Biochem Pharmacol 80:2021-2031
    • (2010) Biochem Pharmacol , vol.80 , pp. 2021-2031
    • Lecat, A.1    Piette, J.2    Legrand-Poels, S.3
  • 86
    • 10744222688 scopus 로고    scopus 로고
    • Expression of NOD2 in Paneth cells: A possible link to Crohn's ileitis
    • 14570728 1:CAS:528:DC%2BD3sXpsFyksrc%3D
    • Ogura Y, Lala S, Xin W, Smith E, Dowds TA, Chen FF, Zimmermann E, Tretiakova M et al (2003) Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. Gut 52:1591-1597
    • (2003) Gut , vol.52 , pp. 1591-1597
    • Ogura, Y.1    Lala, S.2    Xin, W.3    Smith, E.4    Dowds, T.A.5    Chen, F.F.6    Zimmermann, E.7    Tretiakova, M.8
  • 87
    • 0034252293 scopus 로고    scopus 로고
    • Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria
    • 11248802 1:CAS:528:DC%2BD3cXlsFOmur4%3D
    • Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ (2000) Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol 1:113-118
    • (2000) Nat Immunol , vol.1 , pp. 113-118
    • Ayabe, T.1    Satchell, D.P.2    Wilson, C.L.3    Parks, W.C.4    Selsted, M.E.5    Ouellette, A.J.6
  • 88
    • 7244257312 scopus 로고    scopus 로고
    • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
    • 15479689 1:CAS:528:DC%2BD2cXhtVajtrvK
    • Wehkamp J, Harder J, Weichenthal M, Schwab M, Schaffeler E, Schlee M, Herrlinger KR, Stallmach A et al (2004) NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 53:1658-1664
    • (2004) Gut , vol.53 , pp. 1658-1664
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3    Schwab, M.4    Schaffeler, E.5    Schlee, M.6    Herrlinger, K.R.7    Stallmach, A.8
  • 89
    • 66649111859 scopus 로고    scopus 로고
    • Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype
    • 19433600 1:CAS:528:DC%2BD1MXmvFantL4%3D
    • Bevins CL, Stange EF, Wehkamp J (2009) Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype. Gut 58:882-883
    • (2009) Gut , vol.58 , pp. 882-883
    • Bevins, C.L.1    Stange, E.F.2    Wehkamp, J.3
  • 90
    • 79955555098 scopus 로고    scopus 로고
    • Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease
    • 21530740 1:CAS:528:DC%2BC3MXlsVGhsL8%3D
    • Kaser A, Blumberg RS (2011) Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease. Gastroenterology 140:1738-1747
    • (2011) Gastroenterology , vol.140 , pp. 1738-1747
    • Kaser, A.1    Blumberg, R.S.2
  • 93
  • 95
    • 27444444603 scopus 로고    scopus 로고
    • Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease
    • 15928043
    • van Heel DA, Ghosh S, Hunt KA, Mathew CG, Forbes A, Jewell DP, Playford RJ (2005) Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease. Gut 54:1553-1557
    • (2005) Gut , vol.54 , pp. 1553-1557
    • Van Heel, D.A.1    Ghosh, S.2    Hunt, K.A.3    Mathew, C.G.4    Forbes, A.5    Jewell, D.P.6    Playford, R.J.7
  • 96
    • 84862733209 scopus 로고    scopus 로고
    • Nod2 improves barrier function of intestinal epithelial cells via enhancement of TLR responses
    • 22750073 1:CAS:528:DC%2BC38XhtVOisLfE
    • Hiemstra IH, Bouma G, Geerts D, Kraal G, den Haan JM (2012) Nod2 improves barrier function of intestinal epithelial cells via enhancement of TLR responses. Mol Immunol 52:264-272
    • (2012) Mol Immunol , vol.52 , pp. 264-272
    • Hiemstra, I.H.1    Bouma, G.2    Geerts, D.3    Kraal, G.4    Den Haan, J.M.5
  • 97
    • 77949471940 scopus 로고    scopus 로고
    • Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients
    • 20232407
    • Kosovac K, Brenmoehl J, Holler E, Falk W, Schoelmerich J, Hausmann M, Rogler G (2010) Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients. Inflamm Bowel Dis 16:1311-1321
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1311-1321
    • Kosovac, K.1    Brenmoehl, J.2    Holler, E.3    Falk, W.4    Schoelmerich, J.5    Hausmann, M.6    Rogler, G.7
  • 98
    • 84855845985 scopus 로고    scopus 로고
    • Host genetics and environmental factors regulate ecological succession of the mouse colon tissue-associated microbiota
    • 22272321 1:CAS:528:DC%2BC38XhslKmtrg%3D
    • Smith P, Siddharth J, Pearson R, Holway N, Shaxted M, Butler M, Clark N, Jamontt J et al (2012) Host genetics and environmental factors regulate ecological succession of the mouse colon tissue-associated microbiota. PLoS One 7:e30273
    • (2012) PLoS One , vol.7 , pp. 30273
    • Smith, P.1    Siddharth, J.2    Pearson, R.3    Holway, N.4    Shaxted, M.5    Butler, M.6    Clark, N.7    Jamontt, J.8
  • 99
    • 39149094587 scopus 로고    scopus 로고
    • The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands
    • 18261938 1:CAS:528:DC%2BD1cXisVehurs%3D
    • Kim YG, Park JH, Shaw MH, Franchi L, Inohara N, Nunez G (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28:246-257
    • (2008) Immunity , vol.28 , pp. 246-257
    • Kim, Y.G.1    Park, J.H.2    Shaw, M.H.3    Franchi, L.4    Inohara, N.5    Nunez, G.6
  • 101
    • 58149189054 scopus 로고    scopus 로고
    • NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity
    • 18981137 1:CAS:528:DC%2BD1cXhtlaisrvE
    • Divangahi M, Mostowy S, Coulombe F, Kozak R, Guillot L, Veyrier F, Kobayashi KS, Flavell RA et al (2008) NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity. J Immunol 181:7157-7165
    • (2008) J Immunol , vol.181 , pp. 7157-7165
    • Divangahi, M.1    Mostowy, S.2    Coulombe, F.3    Kozak, R.4    Guillot, L.5    Veyrier, F.6    Kobayashi, K.S.7    Flavell, R.A.8
  • 103
    • 84867807929 scopus 로고    scopus 로고
    • Innate lymphoid cell interactions with microbiota: Implications for intestinal health and disease
    • 23084357 1:CAS:528:DC%2BC38XhsFeqsrnK
    • Sonnenberg GF, Artis D (2012) Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease. Immunity 37:601-610
    • (2012) Immunity , vol.37 , pp. 601-610
    • Sonnenberg, G.F.1    Artis, D.2
  • 104
    • 84859384082 scopus 로고    scopus 로고
    • Innate lymphoid cells: Emerging insights in development, lineage relationships, and function
    • 22224763 1:CAS:528:DC%2BC38XmsVKmurY%3D
    • Spits H, Cupedo T (2012) Innate lymphoid cells: emerging insights in development, lineage relationships, and function. Annu Rev Immunol 30:647-675
    • (2012) Annu Rev Immunol , vol.30 , pp. 647-675
    • Spits, H.1    Cupedo, T.2
  • 105
    • 79961012464 scopus 로고    scopus 로고
    • Activation of cytokine-producing and antitumor activities of natural killer cells and macrophages by engagement of Toll-like and NOD-like receptors
    • 20682587 1:CAS:528:DC%2BC3MXhtFGisrvE
    • Qiu F, Maniar A, Diaz MQ, Chapoval AI, Medvedev AE (2011) Activation of cytokine-producing and antitumor activities of natural killer cells and macrophages by engagement of Toll-like and NOD-like receptors. Innate Immun 17:375-387
    • (2011) Innate Immun , vol.17 , pp. 375-387
    • Qiu, F.1    Maniar, A.2    Diaz, M.Q.3    Chapoval, A.I.4    Medvedev, A.E.5
  • 106
    • 44849110066 scopus 로고    scopus 로고
    • Activation of human NK cells by the bacterial pathogen-associated molecular pattern muramyl dipeptide
    • 18322218 1:CAS:528:DC%2BD1cXisl2jtro%3D
    • Athie-Morales V, O'Connor GM, Gardiner CM (2008) Activation of human NK cells by the bacterial pathogen-associated molecular pattern muramyl dipeptide. J Immunol 180:4082-4089
    • (2008) J Immunol , vol.180 , pp. 4082-4089
    • Athie-Morales, V.1    O'Connor, G.M.2    Gardiner, C.M.3
  • 107
    • 35348932070 scopus 로고    scopus 로고
    • Intracellular NOD-like receptors in host defense and disease
    • 17967410 1:CAS:528:DC%2BD2sXht1ygur%2FE
    • Kanneganti TD, Lamkanfi M, Nunez G (2007) Intracellular NOD-like receptors in host defense and disease. Immunity 27:549-559
    • (2007) Immunity , vol.27 , pp. 549-559
    • Kanneganti, T.D.1    Lamkanfi, M.2    Nunez, G.3
  • 108
    • 21044457217 scopus 로고    scopus 로고
    • Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: Monoacylated MDP confers TLR2/TLR4 activation
    • 15905553 1:CAS:528:DC%2BD2MXkt1Omur4%3D
    • Uehori J, Fukase K, Akazawa T, Uematsu S, Akira S, Funami K, Shingai M, Matsumoto M et al (2005) Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation. J Immunol 174:7096-7103
    • (2005) J Immunol , vol.174 , pp. 7096-7103
    • Uehori, J.1    Fukase, K.2    Akazawa, T.3    Uematsu, S.4    Akira, S.5    Funami, K.6    Shingai, M.7    Matsumoto, M.8
  • 109
    • 78650183459 scopus 로고    scopus 로고
    • Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by Toll-like receptor 2
    • 21055975 1:CAS:528:DC%2BC3cXhsVCms7%2FJ
    • Crellin NK, Trifari S, Kaplan CD, Satoh-Takayama N, Di Santo JP, Spits H (2010) Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by Toll-like receptor 2. Immunity 33:752-764
    • (2010) Immunity , vol.33 , pp. 752-764
    • Crellin, N.K.1    Trifari, S.2    Kaplan, C.D.3    Satoh-Takayama, N.4    Di Santo, J.P.5    Spits, H.6
  • 110
    • 84857444876 scopus 로고    scopus 로고
    • Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense
    • 22306017 1:CAS:528:DC%2BC38XhslCktbc%3D
    • Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, Flavell RA, Littman DR et al (2012) Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity 36:276-287
    • (2012) Immunity , vol.36 , pp. 276-287
    • Kinnebrew, M.A.1    Buffie, C.G.2    Diehl, G.E.3    Zenewicz, L.A.4    Leiner, I.5    Hohl, T.M.6    Flavell, R.A.7    Littman, D.R.8
  • 111
    • 77953910523 scopus 로고    scopus 로고
    • Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue
    • 20620944 1:CAS:528:DC%2BC3cXovVahur4%3D
    • Hughes T, Becknell B, Freud AG, McClory S, Briercheck E, Yu J, Mao C, Giovenzana C et al (2010) Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue. Immunity 32:803-814
    • (2010) Immunity , vol.32 , pp. 803-814
    • Hughes, T.1    Becknell, B.2    Freud, A.G.3    McClory, S.4    Briercheck, E.5    Yu, J.6    Mao, C.7    Giovenzana, C.8
  • 113
    • 79955030498 scopus 로고    scopus 로고
    • Border patrol: Regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
    • 21502992 1:CAS:528:DC%2BC3MXkvVKqsLg%3D
    • Sonnenberg GF, Fouser LA, Artis D (2011) Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat Immunol 12:383-390
    • (2011) Nat Immunol , vol.12 , pp. 383-390
    • Sonnenberg, G.F.1    Fouser, L.A.2    Artis, D.3
  • 114
    • 73849151394 scopus 로고    scopus 로고
    • NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    • 19966812 1:CAS:528:DC%2BD1MXhsFWksb3L
    • Cooney R, Baker J, Brain O, Danis B, Pichulik T, Allan P, Ferguson DJ, Campbell BJ et al (2010) NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 16:90-97
    • (2010) Nat Med , vol.16 , pp. 90-97
    • Cooney, R.1    Baker, J.2    Brain, O.3    Danis, B.4    Pichulik, T.5    Allan, P.6    Ferguson, D.J.7    Campbell, B.J.8
  • 116
    • 34247566585 scopus 로고    scopus 로고
    • A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5
    • 17484864 1:CAS:528:DC%2BD2sXmsVymsrY%3D
    • Prescott NJ, Fisher SA, Franke A, Hampe J, Onnie CM, Soars D, Bagnall R, Mirza MM et al (2007) A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. Gastroenterology 132:1665-1671
    • (2007) Gastroenterology , vol.132 , pp. 1665-1671
    • Prescott, N.J.1    Fisher, S.A.2    Franke, A.3    Hampe, J.4    Onnie, C.M.5    Soars, D.6    Bagnall, R.7    Mirza, M.M.8
  • 117
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • 17200669 1:CAS:528:DC%2BD2sXpvFerug%3D%3D
    • Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G et al (2007) A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39:207-211
    • (2007) Nat Genet , vol.39 , pp. 207-211
    • Hampe, J.1    Franke, A.2    Rosenstiel, P.3    Till, A.4    Teuber, M.5    Huse, K.6    Albrecht, M.7    Mayr, G.8
  • 118
    • 73849121209 scopus 로고    scopus 로고
    • Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    • 19898471 1:CAS:528:DC%2BD1MXhtlOrur3L
    • Travassos LH, Carneiro LA, Ramjeet M, Hussey S, Kim YG, Magalhaes JG, Yuan L, Soares F et al (2010) Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 11:55-62
    • (2010) Nat Immunol , vol.11 , pp. 55-62
    • Travassos, L.H.1    Carneiro, L.A.2    Ramjeet, M.3    Hussey, S.4    Kim, Y.G.5    Magalhaes, J.G.6    Yuan, L.7    Soares, F.8
  • 119
    • 33244472793 scopus 로고    scopus 로고
    • Signalling pathways and molecular interactions of NOD1 and NOD2
    • 16493424 1:CAS:528:DC%2BD28XlsVeksw%3D%3D
    • Strober W, Murray PJ, Kitani A, Watanabe T (2006) Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol 6:9-20
    • (2006) Nat Rev Immunol , vol.6 , pp. 9-20
    • Strober, W.1    Murray, P.J.2    Kitani, A.3    Watanabe, T.4
  • 120
    • 0033968625 scopus 로고    scopus 로고
    • Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
    • 10607756 1:CAS:528:DC%2BD3cXotVKltA%3D%3D
    • Takeuchi O, Takeda K, Hoshino K, Adachi O, Ogawa T, Akira S (2000) Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int Immunol 12:113-117
    • (2000) Int Immunol , vol.12 , pp. 113-117
    • Takeuchi, O.1    Takeda, K.2    Hoshino, K.3    Adachi, O.4    Ogawa, T.5    Akira, S.6
  • 121
    • 0033565407 scopus 로고    scopus 로고
    • Signaling events induced by lipopolysaccharide-activated toll-like receptor 2
    • 10395652 1:CAS:528:DyaK1MXksVegtLg%3D
    • Yang RB, Mark MR, Gurney AL, Godowski PJ (1999) Signaling events induced by lipopolysaccharide-activated toll-like receptor 2. J Immunol 163:639-643
    • (1999) J Immunol , vol.163 , pp. 639-643
    • Yang, R.B.1    Mark, M.R.2    Gurney, A.L.3    Godowski, P.J.4
  • 122
    • 80053561363 scopus 로고    scopus 로고
    • Expression of TRAF6 and pro-inflammatory cytokines through activation of TLR2, TLR4, NOD1, and NOD2 in human periodontal ligament fibroblasts
    • 21457942 1:CAS:528:DC%2BC3MXht1Gnu7bO
    • Tang L, Zhou XD, Wang Q, Zhang L, Wang Y, Li XY, Huang DM (2011) Expression of TRAF6 and pro-inflammatory cytokines through activation of TLR2, TLR4, NOD1, and NOD2 in human periodontal ligament fibroblasts. Arch Oral Biol 56:1064-1072
    • (2011) Arch Oral Biol , vol.56 , pp. 1064-1072
    • Tang, L.1    Zhou, X.D.2    Wang, Q.3    Zhang, L.4    Wang, Y.5    Li, X.Y.6    Huang, D.M.7
  • 123
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • 20303872 1:CAS:528:DC%2BC3cXlsVSgu74%3D
    • Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140:805-820
    • (2010) Cell , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 124
    • 80051987703 scopus 로고    scopus 로고
    • Crosstalk in NF-kappaB signaling pathways
    • 21772278 1:CAS:528:DC%2BC3MXptV2it7g%3D
    • Oeckinghaus A, Hayden MS, Ghosh S (2011) Crosstalk in NF-kappaB signaling pathways. Nat Immunol 12:695-708
    • (2011) Nat Immunol , vol.12 , pp. 695-708
    • Oeckinghaus, A.1    Hayden, M.S.2    Ghosh, S.3
  • 125
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • 20404851 1:CAS:528:DC%2BC3cXkvFSjsrc%3D
    • Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11:373-384
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 126
    • 80052723769 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms in the two major forms of inflammatory bowel disease
    • 21681604 1:CAS:528:DC%2BC3MXhtVKltrjL
    • Bene L, Falus A, Baffy N, Fulop AK (2011) Cellular and molecular mechanisms in the two major forms of inflammatory bowel disease. Pathol Oncol Res 17:463-472
    • (2011) Pathol Oncol Res , vol.17 , pp. 463-472
    • Bene, L.1    Falus, A.2    Baffy, N.3    Fulop, A.K.4
  • 127
    • 77954050569 scopus 로고    scopus 로고
    • Signaling pathways associated with inflammatory bowel disease
    • 20001899 1:CAS:528:DC%2BC3cXms1egs7g%3D
    • Wei J, Feng J (2010) Signaling pathways associated with inflammatory bowel disease. Recent Pat Inflamm Allergy Drug Discov 4:105-117
    • (2010) Recent Pat Inflamm Allergy Drug Discov , vol.4 , pp. 105-117
    • Wei, J.1    Feng, J.2
  • 128
    • 33745775434 scopus 로고    scopus 로고
    • Mechanisms of disease: Pathogenesis of Crohn's disease and ulcerative colitis
    • 16819502 1:CAS:528:DC%2BD28XnslKjs7o%3D
    • Sartor RB (2006) Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 3:390-407
    • (2006) Nat Clin Pract Gastroenterol Hepatol , vol.3 , pp. 390-407
    • Sartor, R.B.1
  • 129
    • 42549167131 scopus 로고    scopus 로고
    • The effect of NOD2 activation on TLR2-mediated cytokine responses is dependent on activation dose and NOD2 genotype
    • 18340358 1:CAS:528:DC%2BD1cXkvFyksL0%3D
    • Borm ME, van Bodegraven AA, Mulder CJ, Kraal G, Bouma G (2008) The effect of NOD2 activation on TLR2-mediated cytokine responses is dependent on activation dose and NOD2 genotype. Genes Immun 9:274-278
    • (2008) Genes Immun , vol.9 , pp. 274-278
    • Borm, M.E.1    Van Bodegraven, A.A.2    Mulder, C.J.3    Kraal, G.4    Bouma, G.5
  • 131
    • 84887619697 scopus 로고    scopus 로고
    • The essential adaptors of innate immune signaling
    • Chen H, Jiang Z (2012) The essential adaptors of innate immune signaling. Protein Cell
    • (2012) Protein Cell
    • Chen, H.1    Jiang, Z.2
  • 132
    • 79958746242 scopus 로고    scopus 로고
    • Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections
    • 21669398 1:CAS:528:DC%2BC3MXnsVykt7o%3D
    • Kim YG, Park JH, Reimer T, Baker DP, Kawai T, Kumar H, Akira S, Wobus C et al (2011) Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections. Cell Host Microbe 9:496-507
    • (2011) Cell Host Microbe , vol.9 , pp. 496-507
    • Kim, Y.G.1    Park, J.H.2    Reimer, T.3    Baker, D.P.4    Kawai, T.5    Kumar, H.6    Akira, S.7    Wobus, C.8
  • 133
    • 84867222865 scopus 로고    scopus 로고
    • Respiratory syncytial virus infection augments NOD2 signaling in an IFN-beta-dependent manner in human primary cells
    • 22730064 1:CAS:528:DC%2BC38Xht1Wrt7vK
    • Vissers M, Remijn T, Oosting M, de Jong DJ, Diavatopoulos DA, Hermans PW, Ferwerda G (2012) Respiratory syncytial virus infection augments NOD2 signaling in an IFN-beta-dependent manner in human primary cells. Eur J Immunol 42:2727-2735
    • (2012) Eur J Immunol , vol.42 , pp. 2727-2735
    • Vissers, M.1    Remijn, T.2    Oosting, M.3    De Jong, D.J.4    Diavatopoulos, D.A.5    Hermans, P.W.6    Ferwerda, G.7
  • 134
    • 66749174867 scopus 로고    scopus 로고
    • The inflammasomes: Guardians of the body
    • 19302040 1:CAS:528:DC%2BD1MXlsFSlsbc%3D
    • Martinon F, Mayor A, Tschopp J (2009) The inflammasomes: guardians of the body. Annu Rev Immunol 27:229-265
    • (2009) Annu Rev Immunol , vol.27 , pp. 229-265
    • Martinon, F.1    Mayor, A.2    Tschopp, J.3
  • 136
    • 84860001887 scopus 로고    scopus 로고
    • Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction
    • 22520462 1:CAS:528:DC%2BC38XlvFygs70%3D
    • Meinzer U, Barreau F, Esmiol-Welterlin S, Jung C, Villard C, Leger T, Ben-Mkaddem S, Berrebi D et al (2012) Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction. Cell Host Microbe 11:337-351
    • (2012) Cell Host Microbe , vol.11 , pp. 337-351
    • Meinzer, U.1    Barreau, F.2    Esmiol-Welterlin, S.3    Jung, C.4    Villard, C.5    Leger, T.6    Ben-Mkaddem, S.7    Berrebi, D.8
  • 137
    • 84858677223 scopus 로고    scopus 로고
    • Sensing and reacting to microbes through the inflammasomes
    • 22430785 1:CAS:528:DC%2BC38XktFSgsbY%3D
    • Franchi L, Munoz-Planillo R, Nunez G (2012) Sensing and reacting to microbes through the inflammasomes. Nat Immunol 13:325-332
    • (2012) Nat Immunol , vol.13 , pp. 325-332
    • Franchi, L.1    Munoz-Planillo, R.2    Nunez, G.3
  • 138
    • 72849115852 scopus 로고    scopus 로고
    • Inflammasomes: Too big to miss
    • 19955661 1:CAS:528:DC%2BD1MXhsFCit7vK
    • Stutz A, Golenbock DT, Latz E (2009) Inflammasomes: too big to miss. J Clin Invest 119:3502-3511
    • (2009) J Clin Invest , vol.119 , pp. 3502-3511
    • Stutz, A.1    Golenbock, D.T.2    Latz, E.3
  • 139
    • 60749104683 scopus 로고    scopus 로고
    • The inflammasome: A caspase-1-activation platform that regulates immune responses and disease pathogenesis
    • 19221555 1:CAS:528:DC%2BD1MXhvFKjtLo%3D
    • Franchi L, Eigenbrod T, Munoz-Planillo R, Nunez G (2009) The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 10:241-247
    • (2009) Nat Immunol , vol.10 , pp. 241-247
    • Franchi, L.1    Eigenbrod, T.2    Munoz-Planillo, R.3    Nunez, G.4
  • 140
    • 84855989829 scopus 로고    scopus 로고
    • Inflammasomes in health and disease
    • 22258606 1:CAS:528:DC%2BC38Xps1GmsA%3D%3D
    • Strowig T, Henao-Mejia J, Elinav E, Flavell R (2012) Inflammasomes in health and disease. Nature 481:278-286
    • (2012) Nature , vol.481 , pp. 278-286
    • Strowig, T.1    Henao-Mejia, J.2    Elinav, E.3    Flavell, R.4
  • 141
    • 58049200723 scopus 로고    scopus 로고
    • Function of Nod-like receptors in microbial recognition and host defense
    • 19120480 1:CAS:528:DC%2BD1MXhsFGls7zL
    • Franchi L, Warner N, Viani K, Nunez G (2009) Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev 227:106-128
    • (2009) Immunol Rev , vol.227 , pp. 106-128
    • Franchi, L.1    Warner, N.2    Viani, K.3    Nunez, G.4
  • 144
    • 63649145255 scopus 로고    scopus 로고
    • AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    • 19158676 1:CAS:528:DC%2BD1MXht1eht78%3D
    • Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES (2009) AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458:509-513
    • (2009) Nature , vol.458 , pp. 509-513
    • Fernandes-Alnemri, T.1    Yu, J.W.2    Datta, P.3    Wu, J.4    Alnemri, E.S.5
  • 145
  • 147
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • 12191486 1:CAS:528:DC%2BD38XmslyrurY%3D
    • Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10:417-426
    • (2002) Mol Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 148
    • 45549093755 scopus 로고    scopus 로고
    • A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
    • 18511561 1:CAS:528:DC%2BD1cXntF2ru7k%3D
    • Hsu LC, Ali SR, McGillivray S, Tseng PH, Mariathasan S, Humke EW, Eckmann L, Powell JJ et al (2008) A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci USA 105:7803-7808
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7803-7808
    • Hsu, L.C.1    Ali, S.R.2    McGillivray, S.3    Tseng, P.H.4    Mariathasan, S.5    Humke, E.W.6    Eckmann, L.7    Powell, J.J.8
  • 150
    • 7944232105 scopus 로고    scopus 로고
    • Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome
    • 15530394 1:CAS:528:DC%2BD2cXpsVOrtr8%3D
    • Martinon F, Agostini L, Meylan E, Tschopp J (2004) Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol 14:1929-1934
    • (2004) Curr Biol , vol.14 , pp. 1929-1934
    • Martinon, F.1    Agostini, L.2    Meylan, E.3    Tschopp, J.4
  • 151
    • 70249110860 scopus 로고    scopus 로고
    • Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation
    • 19542372 1:CAS:528:DC%2BD1MXotFWgt7w%3D
    • Franchi L, Eigenbrod T, Nunez G (2009) Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J Immunol 183:792-796
    • (2009) J Immunol , vol.183 , pp. 792-796
    • Franchi, L.1    Eigenbrod, T.2    Nunez, G.3
  • 152
    • 77749270973 scopus 로고    scopus 로고
    • Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor
    • 19812205 1:CAS:528:DC%2BD1MXht1ymtbfK
    • Harder J, Franchi L, Munoz-Planillo R, Park JH, Reimer T, Nunez G (2009) Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor. J Immunol 183:5823-5829
    • (2009) J Immunol , vol.183 , pp. 5823-5829
    • Harder, J.1    Franchi, L.2    Munoz-Planillo, R.3    Park, J.H.4    Reimer, T.5    Nunez, G.6
  • 154
    • 84859877626 scopus 로고    scopus 로고
    • The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1beta and IL-18 production
    • 22529966 1:CAS:528:DC%2BC38Xmtlyqsb0%3D
    • Verma D, Sarndahl E, Andersson H, Eriksson P, Fredrikson M, Jonsson JI, Lerm M, Soderkvist P (2012) The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1beta and IL-18 production. PLoS One 7:e34977
    • (2012) PLoS One , vol.7 , pp. 34977
    • Verma, D.1    Sarndahl, E.2    Andersson, H.3    Eriksson, P.4    Fredrikson, M.5    Jonsson, J.I.6    Lerm, M.7    Soderkvist, P.8
  • 155
    • 1642285783 scopus 로고    scopus 로고
    • NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    • 15030775 1:CAS:528:DC%2BD2cXis1Kht78%3D
    • Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J (2004) NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20:319-325
    • (2004) Immunity , vol.20 , pp. 319-325
    • Agostini, L.1    Martinon, F.2    Burns, K.3    McDermott, M.F.4    Hawkins, P.N.5    Tschopp, J.6
  • 156
    • 33845890803 scopus 로고    scopus 로고
    • Inflammasome adaptors and sensors: Intracellular regulators of infection and inflammation
    • 17186029 1:CAS:528:DC%2BD28XhtlChtL7M
    • Mariathasan S, Monack DM (2007) Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol 7:31-40
    • (2007) Nat Rev Immunol , vol.7 , pp. 31-40
    • Mariathasan, S.1    Monack, D.M.2
  • 157
    • 77953105781 scopus 로고    scopus 로고
    • Extraintestinal manifestations of inflammatory bowel disease: Epidemiology, diagnosis, and management
    • 20166813
    • Larsen S, Bendtzen K, Nielsen OH (2010) Extraintestinal manifestations of inflammatory bowel disease: epidemiology, diagnosis, and management. Ann Med 42:97-114
    • (2010) Ann Med , vol.42 , pp. 97-114
    • Larsen, S.1    Bendtzen, K.2    Nielsen, O.H.3
  • 161
    • 22544453861 scopus 로고    scopus 로고
    • Muramyl dipeptide enhances osteoclast formation induced by lipopolysaccharide, IL-1 alpha, and TNF-alpha through nucleotide-binding oligomerization domain 2-mediated signaling in osteoblasts
    • 16034140 1:CAS:528:DC%2BD2MXmtlWisro%3D
    • Yang S, Takahashi N, Yamashita T, Sato N, Takahashi M, Mogi M, Uematsu T, Kobayashi Y et al (2005) Muramyl dipeptide enhances osteoclast formation induced by lipopolysaccharide, IL-1 alpha, and TNF-alpha through nucleotide-binding oligomerization domain 2-mediated signaling in osteoblasts. J Immunol 175:1956-1964
    • (2005) J Immunol , vol.175 , pp. 1956-1964
    • Yang, S.1    Takahashi, N.2    Yamashita, T.3    Sato, N.4    Takahashi, M.5    Mogi, M.6    Uematsu, T.7    Kobayashi, Y.8
  • 162
    • 77954842857 scopus 로고    scopus 로고
    • Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication
    • 20500518 1:CAS:528:DC%2BC3cXhtVCktbvP
    • Motani K, Kawase K, Imamura R, Kinoshita T, Kushiyama H, Suda T (2010) Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication. Cancer Sci 101:1822-1827
    • (2010) Cancer Sci , vol.101 , pp. 1822-1827
    • Motani, K.1    Kawase, K.2    Imamura, R.3    Kinoshita, T.4    Kushiyama, H.5    Suda, T.6
  • 163
  • 165
    • 18644384436 scopus 로고    scopus 로고
    • The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm
    • 15761471 1:CAS:528:DC%2BD2MXkvVSrtL4%3D
    • Bender LM, Morgan MJ, Thomas LR, Liu ZG, Thorburn A (2005) The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm. Cell Death Differ 12:473-481
    • (2005) Cell Death Differ , vol.12 , pp. 473-481
    • Bender, L.M.1    Morgan, M.J.2    Thomas, L.R.3    Liu, Z.G.4    Thorburn, A.5
  • 166
    • 78650654512 scopus 로고    scopus 로고
    • Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD
    • 20943999 1:CAS:528:DC%2BC3cXhtlOhsbbM
    • Hindryckx P, De VM, Jacques P, Ferdinande L, Peeters H, Olievier K, Bogaert S, Brinkman B et al (2010) Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD. J Immunol 185:6306-6316
    • (2010) J Immunol , vol.185 , pp. 6306-6316
    • Hindryckx, P.1    De, V.M.2    Jacques, P.3    Ferdinande, L.4    Peeters, H.5    Olievier, K.6    Bogaert, S.7    Brinkman, B.8
  • 168
    • 70649085135 scopus 로고    scopus 로고
    • Evidence for impaired CARD15 signalling in Crohn's disease without disease linked variants
    • 19907652
    • Seidelin JB, Broom OJ, Olsen J, Nielsen OH (2009) Evidence for impaired CARD15 signalling in Crohn's disease without disease linked variants. PLoS One 4:e7794
    • (2009) PLoS One , vol.4 , pp. 7794
    • Seidelin, J.B.1    Broom, O.J.2    Olsen, J.3    Nielsen, O.H.4
  • 169
    • 37649013801 scopus 로고    scopus 로고
    • Chronic stimulation of Nod2 mediates tolerance to bacterial products
    • 18032608 1:CAS:528:DC%2BD1cXisVOhsw%3D%3D
    • Hedl M, Li J, Cho JH, Abraham C (2007) Chronic stimulation of Nod2 mediates tolerance to bacterial products. Proc Natl Acad Sci USA 104:19440-19445
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19440-19445
    • Hedl, M.1    Li, J.2    Cho, J.H.3    Abraham, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.