-
1
-
-
33746028777
-
Intracellular pattern recognition receptors in the host response
-
16823444 1:CAS:528:DC%2BD28XmsFWnurk%3D
-
Meylan E, Tschopp J, Karin M (2006) Intracellular pattern recognition receptors in the host response. Nature 442:39-44
-
(2006)
Nature
, vol.442
, pp. 39-44
-
-
Meylan, E.1
Tschopp, J.2
Karin, M.3
-
2
-
-
80051764401
-
Muramyl dipeptide and its derivatives: Peptide adjuvant in immunological disorders and cancer therapy
-
22180736 1:CAS:528:DC%2BC3MXhs1ansLrK
-
Ogawa C, Liu YJ, Kobayashi KS (2011) Muramyl dipeptide and its derivatives: peptide adjuvant in immunological disorders and cancer therapy. Curr Bioact Compd 7:180-197
-
(2011)
Curr Bioact Compd
, vol.7
, pp. 180-197
-
-
Ogawa, C.1
Liu, Y.J.2
Kobayashi, K.S.3
-
3
-
-
3242771408
-
Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation
-
15090455 1:CAS:528:DC%2BD2cXmtlCku7w%3D
-
Holler E, Rogler G, Herfarth H, Brenmoehl J, Wild PJ, Hahn J, Eissner G, Scholmerich J et al (2004) Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood 104:889-894
-
(2004)
Blood
, vol.104
, pp. 889-894
-
-
Holler, E.1
Rogler, G.2
Herfarth, H.3
Brenmoehl, J.4
Wild, P.J.5
Hahn, J.6
Eissner, G.7
Scholmerich, J.8
-
4
-
-
80053055841
-
Cutting edge: Crohn's disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality
-
21849681 1:CAS:528:DC%2BC3MXhtFeksb7E
-
Kim YG, Shaw MH, Warner N, Park JH, Chen F, Ogura Y, Nunez G (2011) Cutting edge: crohn's disease-associated Nod2 mutation limits production of proinflammatory cytokines to protect the host from Enterococcus faecalis-induced lethality. J Immunol 187:2849-2852
-
(2011)
J Immunol
, vol.187
, pp. 2849-2852
-
-
Kim, Y.G.1
Shaw, M.H.2
Warner, N.3
Park, J.H.4
Chen, F.5
Ogura, Y.6
Nunez, G.7
-
5
-
-
34548175739
-
Genetic variants in the NOD2/CARD15 gene are associated with early mortality in sepsis patients
-
17558494 1:CAS:528:DC%2BD1cXhtV2lsbbE
-
Brenmoehl J, Herfarth H, Gluck T, Audebert F, Barlage S, Schmitz G, Froehlich D, Schreiber S et al (2007) Genetic variants in the NOD2/CARD15 gene are associated with early mortality in sepsis patients. Intensive Care Med 33:1541-1548
-
(2007)
Intensive Care Med
, vol.33
, pp. 1541-1548
-
-
Brenmoehl, J.1
Herfarth, H.2
Gluck, T.3
Audebert, F.4
Barlage, S.5
Schmitz, G.6
Froehlich, D.7
Schreiber, S.8
-
6
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
11385576 1:CAS:528:DC%2BD3MXksVShtLY%3D
-
Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C et al (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411:599-603
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
Chamaillard, M.2
Zouali, H.3
Lesage, S.4
Cezard, J.P.5
Belaiche, J.6
Almer, S.7
Tysk, C.8
-
7
-
-
0035978533
-
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
-
11385577 1:CAS:528:DC%2BD3MXksVShur8%3D
-
Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T et al (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411:603-606
-
(2001)
Nature
, vol.411
, pp. 603-606
-
-
Ogura, Y.1
Bonen, D.K.2
Inohara, N.3
Nicolae, D.L.4
Chen, F.F.5
Ramos, R.6
Britton, H.7
Moran, T.8
-
8
-
-
0035895992
-
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB
-
11087742 1:CAS:528:DC%2BD3MXhtlOqtL8%3D
-
Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G (2001) Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem 276:4812-4818
-
(2001)
J Biol Chem
, vol.276
, pp. 4812-4818
-
-
Ogura, Y.1
Inohara, N.2
Benito, A.3
Chen, F.F.4
Yamaoka, S.5
Nunez, G.6
-
9
-
-
79959216005
-
Genetics and pathogenesis of inflammatory bowel disease
-
21677747 1:CAS:528:DC%2BC3MXnsFOrsr4%3D
-
Khor B, Gardet A, Xavier RJ (2011) Genetics and pathogenesis of inflammatory bowel disease. Nature 474:307-317
-
(2011)
Nature
, vol.474
, pp. 307-317
-
-
Khor, B.1
Gardet, A.2
Xavier, R.J.3
-
10
-
-
79959271087
-
Intestinal homeostasis and its breakdown in inflammatory bowel disease
-
21677746 1:CAS:528:DC%2BC3MXnsFOqs7g%3D
-
Maloy KJ, Powrie F (2011) Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature 474:298-306
-
(2011)
Nature
, vol.474
, pp. 298-306
-
-
Maloy, K.J.1
Powrie, F.2
-
11
-
-
84856007744
-
Role of genetics in the diagnosis and prognosis of Crohn's disease
-
22253516 1:CAS:528:DC%2BC38XhslKnsb0%3D
-
Tsianos EV, Katsanos KH, Tsianos VE (2012) Role of genetics in the diagnosis and prognosis of Crohn's disease. World J Gastroenterol 18:105-118
-
(2012)
World J Gastroenterol
, vol.18
, pp. 105-118
-
-
Tsianos, E.V.1
Katsanos, K.H.2
Tsianos, V.E.3
-
13
-
-
80052446723
-
Peptidoglycan biosynthesis machinery: A rich source of drug targets
-
21091161 1:CAS:528:DC%2BC3MXhsVGku7zN
-
Gautam A, Vyas R, Tewari R (2011) Peptidoglycan biosynthesis machinery: a rich source of drug targets. Crit Rev Biotechnol 31:295-336
-
(2011)
Crit Rev Biotechnol
, vol.31
, pp. 295-336
-
-
Gautam, A.1
Vyas, R.2
Tewari, R.3
-
14
-
-
0012722659
-
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
-
12527755 1:CAS:528:DC%2BD3sXhvVyqsbs%3D
-
Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, Thomas G, Philpott DJ, Sansonetti PJ (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278:8869-8872
-
(2003)
J Biol Chem
, vol.278
, pp. 8869-8872
-
-
Girardin, S.E.1
Boneca, I.G.2
Viala, J.3
Chamaillard, M.4
Labigne, A.5
Thomas, G.6
Philpott, D.J.7
Sansonetti, P.J.8
-
15
-
-
0037458665
-
Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease
-
12514169 1:CAS:528:DC%2BD3sXht1aqsro%3D
-
Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, Fukase K, Inamura S et al (2003) Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 278:5509-5512
-
(2003)
J Biol Chem
, vol.278
, pp. 5509-5512
-
-
Inohara, N.1
Ogura, Y.2
Fontalba, A.3
Gutierrez, O.4
Pons, F.5
Crespo, J.6
Fukase, K.7
Inamura, S.8
-
16
-
-
0030049937
-
Structural characteristics of peptidoglycan fragments required to prime mice for induction of anaphylactoid reactions by lipopolysaccharides
-
8550222 1:CAS:528:DyaK28XntVerug%3D%3D
-
Takada H, Kawabata Y, Kawata S, Kusumoto S (1996) Structural characteristics of peptidoglycan fragments required to prime mice for induction of anaphylactoid reactions by lipopolysaccharides. Infect Immun 64:657-659
-
(1996)
Infect Immun
, vol.64
, pp. 657-659
-
-
Takada, H.1
Kawabata, Y.2
Kawata, S.3
Kusumoto, S.4
-
17
-
-
68149126054
-
Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide
-
19581406 1:CAS:528:DC%2BD1MXps1enu78%3D
-
Coulombe F, Divangahi M, Veyrier F, de Léséleuc L, Gleason JL, Yang Y, Kelliher MA, Pandey AK et al (2009) Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide. J Exp Med 206(8):1709-1716
-
(2009)
J Exp Med
, vol.206
, Issue.8
, pp. 1709-1716
-
-
Coulombe, F.1
Divangahi, M.2
Veyrier, F.3
De Léséleuc, L.4
Gleason, J.L.5
Yang, Y.6
Kelliher, M.A.7
Pandey, A.K.8
-
18
-
-
77954418713
-
Mycobacteria in Crohn's disease: How innate immune deficiency may result in chronic inflammation
-
20594136 1:CAS:528:DC%2BC3cXot1aktLw%3D
-
Lalande JD, Behr MA (2010) Mycobacteria in Crohn's disease: how innate immune deficiency may result in chronic inflammation. Expert Rev Clin Immunol 6:633-641
-
(2010)
Expert Rev Clin Immunol
, vol.6
, pp. 633-641
-
-
Lalande, J.D.1
Behr, M.A.2
-
19
-
-
84860760507
-
Muramyl dipeptide induces NOD2-dependent Ly6C(high) monocyte recruitment to the lungs and protects against influenza virus infection
-
22590599 1:CAS:528:DC%2BC38Xns1Gms7g%3D
-
Coulombe F, Fiola S, Akira S, Cormier Y, Gosselin J (2012) Muramyl dipeptide induces NOD2-dependent Ly6C(high) monocyte recruitment to the lungs and protects against influenza virus infection. PLoS One 7:e36734
-
(2012)
PLoS One
, vol.7
, pp. 36734
-
-
Coulombe, F.1
Fiola, S.2
Akira, S.3
Cormier, Y.4
Gosselin, J.5
-
20
-
-
44949258242
-
How bacteria consume their own exoskeletons (turnover and recycling of cell wall peptidoglycan)
-
18535144 1:CAS:528:DC%2BD1cXosVahtb0%3D
-
Park JT, Uehara T (2008) How bacteria consume their own exoskeletons (turnover and recycling of cell wall peptidoglycan). Microbiol Mol Biol Rev 72:211-227
-
(2008)
Microbiol Mol Biol Rev
, vol.72
, pp. 211-227
-
-
Park, J.T.1
Uehara, T.2
-
21
-
-
34248152308
-
HPepT1 selectively transports muramyl dipeptide but not Nod1-activating muramyl peptides
-
17487240 1:CAS:528:DC%2BD2sXktVSms7w%3D
-
Ismair MG, Vavricka SR, Kullak-Ublick GA, Fried M, Mengin-Lecreulx D, Girardin SE (2006) hPepT1 selectively transports muramyl dipeptide but not Nod1-activating muramyl peptides. Can J Physiol Pharmacol 84:1313-1319
-
(2006)
Can J Physiol Pharmacol
, vol.84
, pp. 1313-1319
-
-
Ismair, M.G.1
Vavricka, S.R.2
Kullak-Ublick, G.A.3
Fried, M.4
Mengin-Lecreulx, D.5
Girardin, S.E.6
-
22
-
-
44849136632
-
Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2
-
18322214 1:CAS:528:DC%2BD1cXisl2jtr4%3D
-
Marina-Garcia N, Franchi L, Kim YG, Miller D, McDonald C, Boons GJ, Nunez G (2008) Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2. J Immunol 180:4050-4057
-
(2008)
J Immunol
, vol.180
, pp. 4050-4057
-
-
Marina-Garcia, N.1
Franchi, L.2
Kim, Y.G.3
Miller, D.4
McDonald, C.5
Boons, G.J.6
Nunez, G.7
-
23
-
-
7644234401
-
HPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells
-
15521010 1:CAS:528:DC%2BD2cXhtVKisrzE
-
Vavricka SR, Musch MW, Chang JE, Nakagawa Y, Phanvijhitsiri K, Waypa TS, Merlin D, Schneewind O et al (2004) hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells. Gastroenterology 127:1401-1409
-
(2004)
Gastroenterology
, vol.127
, pp. 1401-1409
-
-
Vavricka, S.R.1
Musch, M.W.2
Chang, J.E.3
Nakagawa, Y.4
Phanvijhitsiri, K.5
Waypa, T.S.6
Merlin, D.7
Schneewind, O.8
-
24
-
-
84858683881
-
Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy
-
22021207
-
Scharl M, Mwinyi J, Fischbeck A, Leucht K, Eloranta JJ, Arikkat J, Pesch T, Kellermeier S et al (2012) Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy. Inflamm Bowel Dis 18:900-912
-
(2012)
Inflamm Bowel Dis
, vol.18
, pp. 900-912
-
-
Scharl, M.1
Mwinyi, J.2
Fischbeck, A.3
Leucht, K.4
Eloranta, J.J.5
Arikkat, J.6
Pesch, T.7
Kellermeier, S.8
-
25
-
-
64249166480
-
Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation
-
19299732 1:CAS:528:DC%2BD1MXjsVSjurk%3D
-
Marina-Garcia N, Franchi L, Kim YG, Hu Y, Smith DE, Boons GJ, Nunez G (2009) Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation. J Immunol 182:4321-4327
-
(2009)
J Immunol
, vol.182
, pp. 4321-4327
-
-
Marina-Garcia, N.1
Franchi, L.2
Kim, Y.G.3
Hu, Y.4
Smith, D.E.5
Boons, G.J.6
Nunez, G.7
-
26
-
-
69949125920
-
PH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling
-
19570976 1:CAS:528:DC%2BD1MXhtVWqt73J
-
Lee J, Tattoli I, Wojtal KA, Vavricka SR, Philpott DJ, Girardin SE (2009) pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J Biol Chem 284:23818-23829
-
(2009)
J Biol Chem
, vol.284
, pp. 23818-23829
-
-
Lee, J.1
Tattoli, I.2
Wojtal, K.A.3
Vavricka, S.R.4
Philpott, D.J.5
Girardin, S.E.6
-
27
-
-
33644508366
-
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity
-
16467847 1:CAS:528:DC%2BD28Xhs1ertr8%3D
-
Husebye H, Halaas O, Stenmark H, Tunheim G, Sandanger O, Bogen B, Brech A, Latz E et al (2006) Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J 25:683-692
-
(2006)
EMBO J
, vol.25
, pp. 683-692
-
-
Husebye, H.1
Halaas, O.2
Stenmark, H.3
Tunheim, G.4
Sandanger, O.5
Bogen, B.6
Brech, A.7
Latz, E.8
-
28
-
-
79960720320
-
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
-
21779028 1:CAS:528:DC%2BC3MXpt1aqtr4%3D
-
McMahon HT, Boucrot E (2011) Molecular mechanism and physiological functions of clathrin-mediated endocytosis. Nat Rev Mol Cell Biol 12:517-533
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 517-533
-
-
McMahon, H.T.1
Boucrot, E.2
-
29
-
-
34047196224
-
Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system
-
17397264
-
Herskovits AA, Auerbuch V, Portnoy DA (2007) Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system. PLoS Pathog 3:e51
-
(2007)
PLoS Pathog
, vol.3
, pp. 51
-
-
Herskovits, A.A.1
Auerbuch, V.2
Portnoy, D.A.3
-
30
-
-
78650807608
-
Intestinal macrophages and response to microbial encroachment
-
20962772
-
Smith PD, Smythies LE, Shen R, Greenwell-Wild T, Gliozzi M, Wahl SM (2011) Intestinal macrophages and response to microbial encroachment. Mucosal Immunol 4:31-42
-
(2011)
Mucosal Immunol
, vol.4
, pp. 31-42
-
-
Smith, P.D.1
Smythies, L.E.2
Shen, R.3
Greenwell-Wild, T.4
Gliozzi, M.5
Wahl, S.M.6
-
31
-
-
1842430006
-
Bacterial invasion: The paradigms of enteroinvasive pathogens
-
15073367 1:CAS:528:DC%2BD2cXivV2isbk%3D
-
Cossart P, Sansonetti PJ (2004) Bacterial invasion: the paradigms of enteroinvasive pathogens. Science 304:242-248
-
(2004)
Science
, vol.304
, pp. 242-248
-
-
Cossart, P.1
Sansonetti, P.J.2
-
32
-
-
80052641505
-
Crohn's disease: NOD2, autophagy and ER stress converge
-
21252204 1:CAS:528:DC%2BC3MXhsV2iurzL
-
Fritz T, Niederreiter L, Adolph T, Blumberg RS, Kaser A (2011) Crohn's disease: NOD2, autophagy and ER stress converge. Gut 60:1580-1588
-
(2011)
Gut
, vol.60
, pp. 1580-1588
-
-
Fritz, T.1
Niederreiter, L.2
Adolph, T.3
Blumberg, R.S.4
Kaser, A.5
-
33
-
-
84872404658
-
Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases
-
22908883 1:CAS:528:DC%2BC38XhsFOqurbF
-
Correa RG, Milutinovic S, Reed JC (2012) Roles of NOD1 (NLRC1) and NOD2 (NLRC2) in innate immunity and inflammatory diseases. Biosci Rep 32:597-608
-
(2012)
Biosci Rep
, vol.32
, pp. 597-608
-
-
Correa, R.G.1
Milutinovic, S.2
Reed, J.C.3
-
34
-
-
79651473582
-
NF-kappaB in immunobiology
-
21243012 1:CAS:528:DC%2BC3MXhsVOmurk%3D
-
Hayden MS, Ghosh S (2011) NF-kappaB in immunobiology. Cell Res 21:223-244
-
(2011)
Cell Res
, vol.21
, pp. 223-244
-
-
Hayden, M.S.1
Ghosh, S.2
-
35
-
-
78650920066
-
Non-canonical NF-kappaB signaling pathway
-
21173796 1:CAS:528:DC%2BC3MXhtlartw%3D%3D
-
Sun SC (2011) Non-canonical NF-kappaB signaling pathway. Cell Res 21:71-85
-
(2011)
Cell Res
, vol.21
, pp. 71-85
-
-
Sun, S.C.1
-
36
-
-
79955079700
-
Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes
-
20980996 1:CAS:528:DC%2BC3MXkvVCrsrg%3D
-
Duerr CU, Salzman NH, Dupont A, Szabo A, Normark BH, Normark S, Locksley RM, Mellroth P et al (2011) Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes. Mucosal Immunol 4:325-334
-
(2011)
Mucosal Immunol
, vol.4
, pp. 325-334
-
-
Duerr, C.U.1
Salzman, N.H.2
Dupont, A.3
Szabo, A.4
Normark, B.H.5
Normark, S.6
Locksley, R.M.7
Mellroth, P.8
-
37
-
-
84864815551
-
Role of mouse peptidoglycan recognition protein PGLYRP2 in the innate immune response to salmonella enterica serovar typhimurium infection in vivo
-
22615249 1:CAS:528:DC%2BC38XhtFegsr%2FN
-
Lee J, Geddes K, Streutker C, Philpott DJ, Girardin SE (2012) Role of mouse peptidoglycan recognition protein PGLYRP2 in the innate immune response to salmonella enterica serovar typhimurium infection in vivo. Infect Immun 80:2645-2654
-
(2012)
Infect Immun
, vol.80
, pp. 2645-2654
-
-
Lee, J.1
Geddes, K.2
Streutker, C.3
Philpott, D.J.4
Girardin, S.E.5
-
38
-
-
0037379915
-
TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells
-
12671897 1:CAS:528:DC%2BD3sXjsFOju7k%3D
-
Rosenstiel P, Fantini M, Brautigam K, Kuhbacher T, Waetzig GH, Seegert D, Schreiber S (2003) TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells. Gastroenterology 124:1001-1009
-
(2003)
Gastroenterology
, vol.124
, pp. 1001-1009
-
-
Rosenstiel, P.1
Fantini, M.2
Brautigam, K.3
Kuhbacher, T.4
Waetzig, G.H.5
Seegert, D.6
Schreiber, S.7
-
39
-
-
84865434771
-
The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment
-
22857257 1:CAS:528:DC%2BC38XhtFChtr3F
-
Grimes CL, Ariyananda LD, Melnyk JE, O'Shea EK (2012) The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment. J Am Chem Soc 134(33):13535-13537
-
(2012)
J Am Chem Soc
, vol.134
, Issue.33
, pp. 13535-13537
-
-
Grimes, C.L.1
Ariyananda, L.D.2
Melnyk, J.E.3
O'Shea, E.K.4
-
40
-
-
0023266426
-
Fluorescence ratio imaging microscopy: Temporal and spatial measurements of cytoplasmic pH
-
3558476 1:STN:280:DyaL2s7ms1Wluw%3D%3D
-
Bright GR, Fisher GW, Rogowska J, Taylor DL (1987) Fluorescence ratio imaging microscopy: temporal and spatial measurements of cytoplasmic pH. J Cell Biol 104:1019-1033
-
(1987)
J Cell Biol
, vol.104
, pp. 1019-1033
-
-
Bright, G.R.1
Fisher, G.W.2
Rogowska, J.3
Taylor, D.L.4
-
41
-
-
34447504037
-
The NOD2-RICK complex signals from the plasma membrane
-
17355968 1:CAS:528:DC%2BD2sXltFels7Y%3D
-
Lecine P, Esmiol S, Metais JY, Nicoletti C, Nourry C, McDonald C, Nunez G, Hugot JP et al (2007) The NOD2-RICK complex signals from the plasma membrane. J Biol Chem 282:15197-15207
-
(2007)
J Biol Chem
, vol.282
, pp. 15197-15207
-
-
Lecine, P.1
Esmiol, S.2
Metais, J.Y.3
Nicoletti, C.4
Nourry, C.5
McDonald, C.6
Nunez, G.7
Hugot, J.P.8
-
42
-
-
11144289688
-
The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO
-
15620648 1:CAS:528:DC%2BD2cXhtFGhtbzF
-
Abbott DW, Wilkins A, Asara JM, Cantley LC (2004) The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr Biol 14:2217-2227
-
(2004)
Curr Biol
, vol.14
, pp. 2217-2227
-
-
Abbott, D.W.1
Wilkins, A.2
Asara, J.M.3
Cantley, L.C.4
-
44
-
-
35748929941
-
Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti
-
17728323 1:CAS:528:DC%2BD2sXht1Kgs7fJ
-
Sebban-Benin H, Pescatore A, Fusco F, Pascuale V, Gautheron J, Yamaoka S, Moncla A, Ursini MV et al (2007) Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti. Hum Mol Genet 16:2805-2815
-
(2007)
Hum Mol Genet
, vol.16
, pp. 2805-2815
-
-
Sebban-Benin, H.1
Pescatore, A.2
Fusco, F.3
Pascuale, V.4
Gautheron, J.5
Yamaoka, S.6
Moncla, A.7
Ursini, M.V.8
-
45
-
-
78650866071
-
NF-kappaB in the regulation of epithelial homeostasis and inflammation
-
21151201 1:CAS:528:DC%2BC3MXhtlarug%3D%3D
-
Wullaert A, Bonnet MC, Pasparakis M (2011) NF-kappaB in the regulation of epithelial homeostasis and inflammation. Cell Res 21:146-158
-
(2011)
Cell Res
, vol.21
, pp. 146-158
-
-
Wullaert, A.1
Bonnet, M.C.2
Pasparakis, M.3
-
46
-
-
67650724069
-
Regulation and function of NF-kappaB transcription factors in the immune system
-
19302050 1:CAS:528:DC%2BD1MXlsFSlt7o%3D
-
Vallabhapurapu S, Karin M (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 27:693-733
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 693-733
-
-
Vallabhapurapu, S.1
Karin, M.2
-
47
-
-
33745852665
-
Alternative pathways of NF-kappaB activation: A double-edged sword in health and disease
-
16793322 1:CAS:528:DC%2BD28XntFSgsbo%3D
-
Xiao G, Rabson AB, Young W, Qing G, Qu Z (2006) Alternative pathways of NF-kappaB activation: a double-edged sword in health and disease. Cytokine Growth Factor Rev 17:281-293
-
(2006)
Cytokine Growth Factor Rev
, vol.17
, pp. 281-293
-
-
Xiao, G.1
Rabson, A.B.2
Young, W.3
Qing, G.4
Qu, Z.5
-
48
-
-
79953758746
-
A protein interaction network and cell signaling pathways activated by muramyl peptides
-
21063445 1:STN:280:DC%2BC3cbmsVyltg%3D%3D
-
Meshcheriakova EA, Andronova TM, Ivanov VT (2010) A protein interaction network and cell signaling pathways activated by muramyl peptides. Bioorg Khim 36:581-595
-
(2010)
Bioorg Khim
, vol.36
, pp. 581-595
-
-
Meshcheriakova, E.A.1
Andronova, T.M.2
Ivanov, V.T.3
-
49
-
-
33645532087
-
NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway
-
16552041 1:CAS:528:DC%2BD28XjsVWhs7w%3D
-
Pan Q, Kravchenko V, Katz A, Huang S, Ii M, Mathison JC, Kobayashi K, Flavell RA et al (2006) NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway. Infect Immun 74:2121-2127
-
(2006)
Infect Immun
, vol.74
, pp. 2121-2127
-
-
Pan, Q.1
Kravchenko, V.2
Katz, A.3
Huang, S.4
Ii, M.5
Mathison, J.C.6
Kobayashi, K.7
Flavell, R.A.8
-
50
-
-
0141567432
-
Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway
-
12969313 1:CAS:528:DC%2BD3sXotFyrt7Y%3D
-
Weih F, Caamano J (2003) Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway. Immunol Rev 195:91-105
-
(2003)
Immunol Rev
, vol.195
, pp. 91-105
-
-
Weih, F.1
Caamano, J.2
-
51
-
-
54349095688
-
The molecular basis of NOD2 susceptibility mutations in Crohn's disease
-
19079230 1:CAS:528:DC%2BD1cXht1CmsLbO
-
Strober W, Kitani A, Fuss I, Asano N, Watanabe T (2008) The molecular basis of NOD2 susceptibility mutations in Crohn's disease. Mucosal Immunol 1(suppl 1):S5-S9
-
(2008)
Mucosal Immunol
, vol.1
, Issue.SUPPL. 1
-
-
Strober, W.1
Kitani, A.2
Fuss, I.3
Asano, N.4
Watanabe, T.5
-
52
-
-
21144468350
-
Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease
-
15910952
-
van Heel DA, Ghosh S, Butler M, Hunt KA, Lundberg AM, Ahmad T, McGovern DP, Onnie C et al (2005) Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease. Lancet 365:1794-1796
-
(2005)
Lancet
, vol.365
, pp. 1794-1796
-
-
Van Heel, D.A.1
Ghosh, S.2
Butler, M.3
Hunt, K.A.4
Lundberg, A.M.5
Ahmad, T.6
McGovern, D.P.7
Onnie, C.8
-
53
-
-
3442899939
-
NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: Implications for Crohn's disease
-
15214053 1:CAS:528:DC%2BD2cXlslensrY%3D
-
Netea MG, Kullberg BJ, de Jong DJ, Franke B, Sprong T, Naber TH, Drenth JP, van der Meer JW (2004) NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease. Eur J Immunol 34:2052-2059
-
(2004)
Eur J Immunol
, vol.34
, pp. 2052-2059
-
-
Netea, M.G.1
Kullberg, B.J.2
De Jong, D.J.3
Franke, B.4
Sprong, T.5
Naber, T.H.6
Drenth, J.P.7
Van Der Meer, J.W.8
-
55
-
-
77955059513
-
Mechanisms and functions of p38 MAPK signalling
-
20626350 1:CAS:528:DC%2BC3cXovVCnsrg%3D
-
Cuadrado A, Nebreda AR (2010) Mechanisms and functions of p38 MAPK signalling. Biochem J 429:403-417
-
(2010)
Biochem J
, vol.429
, pp. 403-417
-
-
Cuadrado, A.1
Nebreda, A.R.2
-
56
-
-
33847754623
-
The JNK signal transduction pathway
-
17303404 1:CAS:528:DC%2BD2sXjt1Slu7o%3D
-
Weston CR, Davis RJ (2007) The JNK signal transduction pathway. Curr Opin Cell Biol 19:142-149
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 142-149
-
-
Weston, C.R.1
Davis, R.J.2
-
57
-
-
0035066383
-
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
-
11274345 1:CAS:528:DC%2BD3MXislCrsb8%3D
-
Kyriakis JM, Avruch J (2001) Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81:807-869
-
(2001)
Physiol Rev
, vol.81
, pp. 807-869
-
-
Kyriakis, J.M.1
Avruch, J.2
-
58
-
-
74049160438
-
The p38alpha kinase plays a central role in inflammation
-
19747121 1:CAS:528:DC%2BD1MXhsFWisbzO
-
Schieven GL (2009) The p38alpha kinase plays a central role in inflammation. Curr Top Med Chem 9:1038-1048
-
(2009)
Curr Top Med Chem
, vol.9
, pp. 1038-1048
-
-
Schieven, G.L.1
-
59
-
-
4444253690
-
NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
-
15220916 1:CAS:528:DC%2BD2cXmtVCgtL8%3D
-
Watanabe T, Kitani A, Murray PJ, Strober W (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5:800-808
-
(2004)
Nat Immunol
, vol.5
, pp. 800-808
-
-
Watanabe, T.1
Kitani, A.2
Murray, P.J.3
Strober, W.4
-
60
-
-
38849163741
-
Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis
-
18188453 1:CAS:528:DC%2BD1cXhsFOmsrw%3D
-
Watanabe T, Asano N, Murray PJ, Ozato K, Tailor P, Fuss IJ, Kitani A, Strober W (2008) Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J Clin Invest 118:545-559
-
(2008)
J Clin Invest
, vol.118
, pp. 545-559
-
-
Watanabe, T.1
Asano, N.2
Murray, P.J.3
Ozato, K.4
Tailor, P.5
Fuss, I.J.6
Kitani, A.7
Strober, W.8
-
61
-
-
66949138341
-
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2
-
19464198 1:CAS:528:DC%2BD1MXpsFCntbc%3D
-
Bertrand MJ, Doiron K, Labbe K, Korneluk RG, Barker PA, Saleh M (2009) Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity 30:789-801
-
(2009)
Immunity
, vol.30
, pp. 789-801
-
-
Bertrand, M.J.1
Doiron, K.2
Labbe, K.3
Korneluk, R.G.4
Barker, P.A.5
Saleh, M.6
-
62
-
-
79955563439
-
Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
-
21530742 1:CAS:528:DC%2BC3MXlsVGhsL0%3D
-
Strober W, Fuss IJ (2011) Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140:1756-1767
-
(2011)
Gastroenterology
, vol.140
, pp. 1756-1767
-
-
Strober, W.1
Fuss, I.J.2
-
63
-
-
79960888630
-
The opposing roles of IL-21 and TGFbeta1 in chronic inflammatory bowel disease
-
21787348 1:CAS:528:DC%2BC3MXpslKqt7w%3D
-
Macdonald TT, Bell I, Monteleone G (2011) The opposing roles of IL-21 and TGFbeta1 in chronic inflammatory bowel disease. Biochem Soc Trans 39:1061-1066
-
(2011)
Biochem Soc Trans
, vol.39
, pp. 1061-1066
-
-
Macdonald, T.T.1
Bell, I.2
Monteleone, G.3
-
64
-
-
35348948374
-
Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells
-
17919942
-
van Beelen AJ, Zelinkova Z, Taanman-Kueter EW, Muller FJ, Hommes DW, Zaat SA, Kapsenberg ML, de Jong EC (2007) Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 27:660-669
-
(2007)
Immunity
, vol.27
, pp. 660-669
-
-
Van Beelen, A.J.1
Zelinkova, Z.2
Taanman-Kueter, E.W.3
Muller, F.J.4
Hommes, D.W.5
Zaat, S.A.6
Kapsenberg, M.L.7
De Jong, E.C.8
-
65
-
-
79960131814
-
Identification of an innate T helper type 17 response to intestinal bacterial pathogens
-
21666695 1:CAS:528:DC%2BC3MXnsVWqsb4%3D
-
Geddes K, Rubino SJ, Magalhaes JG, Streutker C, Le BL, Cho JH, Robertson SJ, Kim CJ et al (2011) Identification of an innate T helper type 17 response to intestinal bacterial pathogens. Nat Med 17:837-844
-
(2011)
Nat Med
, vol.17
, pp. 837-844
-
-
Geddes, K.1
Rubino, S.J.2
Magalhaes, J.G.3
Streutker, C.4
Le, B.L.5
Cho, J.H.6
Robertson, S.J.7
Kim, C.J.8
-
66
-
-
84868680312
-
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: Unexpected results of a randomised, double-blind placebo-controlled trial
-
22595313 1:CAS:528:DC%2BC3sXktFOitg%3D%3D
-
Hueber W, Sands BE, Lewitzky S, Vandemeulebroecke M, Reinisch W, Higgins PD, Wehkamp J, Feagan BG et al (2012) Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial. Gut 61:1693-1700
-
(2012)
Gut
, vol.61
, pp. 1693-1700
-
-
Hueber, W.1
Sands, B.E.2
Lewitzky, S.3
Vandemeulebroecke, M.4
Reinisch, W.5
Higgins, P.D.6
Wehkamp, J.7
Feagan, B.G.8
-
67
-
-
65249115914
-
A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1
-
19349988 1:CAS:528:DC%2BD1MXktVKgurw%3D
-
Noguchi E, Homma Y, Kang X, Netea MG, Ma X (2009) A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1. Nat Immunol 10:471-479
-
(2009)
Nat Immunol
, vol.10
, pp. 471-479
-
-
Noguchi, E.1
Homma, Y.2
Kang, X.3
Netea, M.G.4
Ma, X.5
-
68
-
-
0033948508
-
Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(-/-) mice and intestinal inflammation
-
10859210 1:CAS:528:DC%2BD3cXks1Kntbw%3D
-
Rennick DM, Fort MM (2000) Lessons from genetically engineered animal models. XII. IL-10-deficient (IL-10(-/-) mice and intestinal inflammation. Am J Physiol Gastrointest Liver Physiol 278:G829-G833
-
(2000)
Am J Physiol Gastrointest Liver Physiol
, vol.278
-
-
Rennick, D.M.1
Fort, M.M.2
-
69
-
-
84857365925
-
Nod2: A key regulator linking microbiota to intestinal mucosal immunity
-
1:CAS:528:DC%2BC38Xks1yhsA%3D%3D
-
Biswas A, Petnicki-Ocwieja T, Kobayashi KS (2012) Nod2: a key regulator linking microbiota to intestinal mucosal immunity. J Mol Med (Berl) 90:15-24
-
(2012)
J Mol Med (Berl)
, vol.90
, pp. 15-24
-
-
Biswas, A.1
Petnicki-Ocwieja, T.2
Kobayashi, K.S.3
-
70
-
-
2942535858
-
Reciprocal cross-talk between Nod2 and TAK1 signaling pathways
-
15075345 1:CAS:528:DC%2BD2cXksFygtbc%3D
-
Chen CM, Gong Y, Zhang M, Chen JJ (2004) Reciprocal cross-talk between Nod2 and TAK1 signaling pathways. J Biol Chem 279:25876-25882
-
(2004)
J Biol Chem
, vol.279
, pp. 25876-25882
-
-
Chen, C.M.1
Gong, Y.2
Zhang, M.3
Chen, J.J.4
-
71
-
-
78149342873
-
In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells
-
20682854 1:CAS:528:DC%2BC3cXhsVKksb7P
-
Courties G, Seiffart V, Presumey J, Escriou V, Scherman D, Zwerina J, Ruiz G, Zietara N et al (2010) In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells. Blood 116:3505-3516
-
(2010)
Blood
, vol.116
, pp. 3505-3516
-
-
Courties, G.1
Seiffart, V.2
Presumey, J.3
Escriou, V.4
Scherman, D.5
Zwerina, J.6
Ruiz, G.7
Zietara, N.8
-
72
-
-
80053572564
-
NOD2 regulation of micrornas [Abstract]
-
Brain O, Allan P, Pichulik T, Khatamzas E, Simpson P, Jewell D, Simmons A (2011) NOD2 regulation of micrornas [Abstract]. Gut 60:A37
-
(2011)
Gut
, vol.60
, pp. 37
-
-
Brain, O.1
Allan, P.2
Pichulik, T.3
Khatamzas, E.4
Simpson, P.5
Jewell, D.6
Simmons, A.7
-
73
-
-
80052556040
-
Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation
-
21856952 1:CAS:528:DC%2BC3MXhtFyktb7P
-
Magalhaes JG, Rubino SJ, Travassos LH, Le BL, Duan W, Sellge G, Geddes K, Reardon C et al (2011) Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation. Proc Natl Acad Sci USA 108:14896-14901
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 14896-14901
-
-
Magalhaes, J.G.1
Rubino, S.J.2
Travassos, L.H.3
Le, B.L.4
Duan, W.5
Sellge, G.6
Geddes, K.7
Reardon, C.8
-
74
-
-
34547097277
-
Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation
-
17666213 1:CAS:528:DC%2BD2sXotlWktLs%3D
-
Liu YJ (2007) Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation. J Allergy Clin Immunol 120:238-244
-
(2007)
J Allergy Clin Immunol
, vol.120
, pp. 238-244
-
-
Liu, Y.J.1
-
75
-
-
0036301998
-
Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP
-
12055625 1:CAS:528:DC%2BD38Xksl2mtbk%3D
-
Soumelis V, Reche PA, Kanzler H, Yuan W, Edward G, Homey B, Gilliet M, Ho S et al (2002) Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol 3:673-680
-
(2002)
Nat Immunol
, vol.3
, pp. 673-680
-
-
Soumelis, V.1
Reche, P.A.2
Kanzler, H.3
Yuan, W.4
Edward, G.5
Homey, B.6
Gilliet, M.7
Ho, S.8
-
76
-
-
33646251141
-
Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis
-
16162681 1:CAS:528:DC%2BD28Xksl2hur0%3D
-
Fantini MC, Becker C, Tubbe I, Nikolaev A, Lehr HA, Galle P, Neurath MF (2006) Transforming growth factor beta induced FoxP3+ regulatory T cells suppress Th1 mediated experimental colitis. Gut 55:671-680
-
(2006)
Gut
, vol.55
, pp. 671-680
-
-
Fantini, M.C.1
Becker, C.2
Tubbe, I.3
Nikolaev, A.4
Lehr, H.A.5
Galle, P.6
Neurath, M.F.7
-
77
-
-
79954527727
-
Increase of regulatory T cells in ileal mucosa of untreated pediatric Crohn's disease patients
-
21281255 1:CAS:528:DC%2BC3MXks1ahsLg%3D
-
Reikvam DH, Perminow G, Lyckander LG, Gran JM, Brandtzaeg P, Vatn M, Carlsen HS (2011) Increase of regulatory T cells in ileal mucosa of untreated pediatric Crohn's disease patients. Scand J Gastroenterol 46:550-560
-
(2011)
Scand J Gastroenterol
, vol.46
, pp. 550-560
-
-
Reikvam, D.H.1
Perminow, G.2
Lyckander, L.G.3
Gran, J.M.4
Brandtzaeg, P.5
Vatn, M.6
Carlsen, H.S.7
-
78
-
-
69449102621
-
Increased number of FoxP3+ CD4+ regulatory T cells in inflammatory bowel disease
-
21479463 1:CAS:528:DC%2BD1cXhtFOitL%2FP
-
Ban H, Andoh A, Shioya M, Nishida A, Tsujikawa T, Fujiyama Y (2008) Increased number of FoxP3+ CD4+ regulatory T cells in inflammatory bowel disease. Mol Med Rep 1:647-650
-
(2008)
Mol Med Rep
, vol.1
, pp. 647-650
-
-
Ban, H.1
Andoh, A.2
Shioya, M.3
Nishida, A.4
Tsujikawa, T.5
Fujiyama, Y.6
-
79
-
-
51249084103
-
Anti tumour necrosis-alpha therapy increases the number of FOXP3 regulatory T cells in children affected by Crohn's disease
-
18422560 1:CAS:528:DC%2BD1cXht1ansr3F
-
Ricciardelli I, Lindley KJ, Londei M, Quaratino S (2008) Anti tumour necrosis-alpha therapy increases the number of FOXP3 regulatory T cells in children affected by Crohn's disease. Immunology 125:178-183
-
(2008)
Immunology
, vol.125
, pp. 178-183
-
-
Ricciardelli, I.1
Lindley, K.J.2
Londei, M.3
Quaratino, S.4
-
80
-
-
20444434616
-
Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease
-
15940622 1:CAS:528:DC%2BD2MXlvFKlsLo%3D
-
Maul J, Loddenkemper C, Mundt P, Berg E, Giese T, Stallmach A, Zeitz M, Duchmann R (2005) Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease. Gastroenterology 128:1868-1878
-
(2005)
Gastroenterology
, vol.128
, pp. 1868-1878
-
-
Maul, J.1
Loddenkemper, C.2
Mundt, P.3
Berg, E.4
Giese, T.5
Stallmach, A.6
Zeitz, M.7
Duchmann, R.8
-
81
-
-
77953637385
-
The pathogen recognition receptor NOD2 regulates human FOXP3+ T cell survival
-
20483763 1:CAS:528:DC%2BC3cXmvFejt70%3D
-
Rahman MK, Midtling EH, Svingen PA, Xiong Y, Bell MP, Tung J, Smyrk T, Egan LJ et al (2010) The pathogen recognition receptor NOD2 regulates human FOXP3+ T cell survival. J Immunol 184:7247-7256
-
(2010)
J Immunol
, vol.184
, pp. 7247-7256
-
-
Rahman, M.K.1
Midtling, E.H.2
Svingen, P.A.3
Xiong, Y.4
Bell, M.P.5
Tung, J.6
Smyrk, T.7
Egan, L.J.8
-
82
-
-
0020636609
-
Stimulating effect of MDP and its adjuvant-active analogues on guinea pig fibroblasts for the production of thymocyte-activating factor
-
6602206 1:CAS:528:DyaL3sXksFWlt7c%3D
-
Iribe H, Koga T, Kotani S, Kusumoto S, Shiba T (1983) Stimulating effect of MDP and its adjuvant-active analogues on guinea pig fibroblasts for the production of thymocyte-activating factor. J Exp Med 157:2190-2195
-
(1983)
J Exp Med
, vol.157
, pp. 2190-2195
-
-
Iribe, H.1
Koga, T.2
Kotani, S.3
Kusumoto, S.4
Shiba, T.5
-
83
-
-
84860241737
-
Innate immune dysfunction in inflammatory bowel disease
-
22324936 1:CAS:528:DC%2BC38XpsFOms7w%3D
-
Gersemann M, Wehkamp J, Stange EF (2012) Innate immune dysfunction in inflammatory bowel disease. J Intern Med 271:421-428
-
(2012)
J Intern Med
, vol.271
, pp. 421-428
-
-
Gersemann, M.1
Wehkamp, J.2
Stange, E.F.3
-
84
-
-
78049450786
-
The protein Nod2: An innate receptor more complex than previously assumed
-
20643110 1:CAS:528:DC%2BC3cXhtlKrs7%2FK
-
Lecat A, Piette J, Legrand-Poels S (2010) The protein Nod2: an innate receptor more complex than previously assumed. Biochem Pharmacol 80:2021-2031
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 2021-2031
-
-
Lecat, A.1
Piette, J.2
Legrand-Poels, S.3
-
85
-
-
0038109983
-
Crohn's disease and the NOD2 gene: A role for paneth cells
-
12851870 1:CAS:528:DC%2BD3sXmtVWqtbs%3D
-
Lala S, Ogura Y, Osborne C, Hor SY, Bromfield A, Davies S, Ogunbiyi O, Nunez G et al (2003) Crohn's disease and the NOD2 gene: a role for paneth cells. Gastroenterology 125:47-57
-
(2003)
Gastroenterology
, vol.125
, pp. 47-57
-
-
Lala, S.1
Ogura, Y.2
Osborne, C.3
Hor, S.Y.4
Bromfield, A.5
Davies, S.6
Ogunbiyi, O.7
Nunez, G.8
-
86
-
-
10744222688
-
Expression of NOD2 in Paneth cells: A possible link to Crohn's ileitis
-
14570728 1:CAS:528:DC%2BD3sXpsFyksrc%3D
-
Ogura Y, Lala S, Xin W, Smith E, Dowds TA, Chen FF, Zimmermann E, Tretiakova M et al (2003) Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis. Gut 52:1591-1597
-
(2003)
Gut
, vol.52
, pp. 1591-1597
-
-
Ogura, Y.1
Lala, S.2
Xin, W.3
Smith, E.4
Dowds, T.A.5
Chen, F.F.6
Zimmermann, E.7
Tretiakova, M.8
-
87
-
-
0034252293
-
Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria
-
11248802 1:CAS:528:DC%2BD3cXlsFOmur4%3D
-
Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ (2000) Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol 1:113-118
-
(2000)
Nat Immunol
, vol.1
, pp. 113-118
-
-
Ayabe, T.1
Satchell, D.P.2
Wilson, C.L.3
Parks, W.C.4
Selsted, M.E.5
Ouellette, A.J.6
-
88
-
-
7244257312
-
NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
-
15479689 1:CAS:528:DC%2BD2cXhtVajtrvK
-
Wehkamp J, Harder J, Weichenthal M, Schwab M, Schaffeler E, Schlee M, Herrlinger KR, Stallmach A et al (2004) NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 53:1658-1664
-
(2004)
Gut
, vol.53
, pp. 1658-1664
-
-
Wehkamp, J.1
Harder, J.2
Weichenthal, M.3
Schwab, M.4
Schaffeler, E.5
Schlee, M.6
Herrlinger, K.R.7
Stallmach, A.8
-
89
-
-
66649111859
-
Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype
-
19433600 1:CAS:528:DC%2BD1MXmvFantL4%3D
-
Bevins CL, Stange EF, Wehkamp J (2009) Decreased Paneth cell defensin expression in ileal Crohn's disease is independent of inflammation, but linked to the NOD2 1007fs genotype. Gut 58:882-883
-
(2009)
Gut
, vol.58
, pp. 882-883
-
-
Bevins, C.L.1
Stange, E.F.2
Wehkamp, J.3
-
90
-
-
79955555098
-
Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease
-
21530740 1:CAS:528:DC%2BC3MXlsVGhsL8%3D
-
Kaser A, Blumberg RS (2011) Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease. Gastroenterology 140:1738-1747
-
(2011)
Gastroenterology
, vol.140
, pp. 1738-1747
-
-
Kaser, A.1
Blumberg, R.S.2
-
91
-
-
29144483937
-
Reduced Paneth cell alpha-defensins in ileal Crohn's disease
-
16330776 1:CAS:528:DC%2BD2MXhtlersrrI
-
Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E et al (2005) Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proc Natl Acad Sci USA 102:18129-18134
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 18129-18134
-
-
Wehkamp, J.1
Salzman, N.H.2
Porter, E.3
Nuding, S.4
Weichenthal, M.5
Petras, R.E.6
Shen, B.7
Schaeffeler, E.8
-
92
-
-
84860136921
-
Abnormal activation of autophagy-induced crinophagy in paneth cells from patients with Crohn's disease
-
22285936
-
Thachil E, Hugot JP, Arbeille B, Paris R, Grodet A, Peuchmaur M, Codogno P, Barreau F et al (2012) Abnormal activation of autophagy-induced crinophagy in paneth cells from patients with Crohn's disease. Gastroenterology 142:1097-1099
-
(2012)
Gastroenterology
, vol.142
, pp. 1097-1099
-
-
Thachil, E.1
Hugot, J.P.2
Arbeille, B.3
Paris, R.4
Grodet, A.5
Peuchmaur, M.6
Codogno, P.7
Barreau, F.8
-
93
-
-
13244292161
-
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
-
15692051 1:CAS:528:DC%2BD2MXpt1Wqtw%3D%3D
-
Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nunez G, Flavell RA (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307:731-734
-
(2005)
Science
, vol.307
, pp. 731-734
-
-
Kobayashi, K.S.1
Chamaillard, M.2
Ogura, Y.3
Henegariu, O.4
Inohara, N.5
Nunez, G.6
Flavell, R.A.7
-
94
-
-
70349468054
-
Nod2 is required for the regulation of commensal microbiota in the intestine
-
19805227 1:CAS:528:DC%2BD1MXhtFyjsLfN
-
Petnicki-Ocwieja T, Hrncir T, Liu YJ, Biswas A, Hudcovic T, Tlaskalova-Hogenova H, Kobayashi KS (2009) Nod2 is required for the regulation of commensal microbiota in the intestine. Proc Natl Acad Sci USA 106:15813-15818
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 15813-15818
-
-
Petnicki-Ocwieja, T.1
Hrncir, T.2
Liu, Y.J.3
Biswas, A.4
Hudcovic, T.5
Tlaskalova-Hogenova, H.6
Kobayashi, K.S.7
-
95
-
-
27444444603
-
Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease
-
15928043
-
van Heel DA, Ghosh S, Hunt KA, Mathew CG, Forbes A, Jewell DP, Playford RJ (2005) Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease. Gut 54:1553-1557
-
(2005)
Gut
, vol.54
, pp. 1553-1557
-
-
Van Heel, D.A.1
Ghosh, S.2
Hunt, K.A.3
Mathew, C.G.4
Forbes, A.5
Jewell, D.P.6
Playford, R.J.7
-
96
-
-
84862733209
-
Nod2 improves barrier function of intestinal epithelial cells via enhancement of TLR responses
-
22750073 1:CAS:528:DC%2BC38XhtVOisLfE
-
Hiemstra IH, Bouma G, Geerts D, Kraal G, den Haan JM (2012) Nod2 improves barrier function of intestinal epithelial cells via enhancement of TLR responses. Mol Immunol 52:264-272
-
(2012)
Mol Immunol
, vol.52
, pp. 264-272
-
-
Hiemstra, I.H.1
Bouma, G.2
Geerts, D.3
Kraal, G.4
Den Haan, J.M.5
-
97
-
-
77949471940
-
Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients
-
20232407
-
Kosovac K, Brenmoehl J, Holler E, Falk W, Schoelmerich J, Hausmann M, Rogler G (2010) Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients. Inflamm Bowel Dis 16:1311-1321
-
(2010)
Inflamm Bowel Dis
, vol.16
, pp. 1311-1321
-
-
Kosovac, K.1
Brenmoehl, J.2
Holler, E.3
Falk, W.4
Schoelmerich, J.5
Hausmann, M.6
Rogler, G.7
-
98
-
-
84855845985
-
Host genetics and environmental factors regulate ecological succession of the mouse colon tissue-associated microbiota
-
22272321 1:CAS:528:DC%2BC38XhslKmtrg%3D
-
Smith P, Siddharth J, Pearson R, Holway N, Shaxted M, Butler M, Clark N, Jamontt J et al (2012) Host genetics and environmental factors regulate ecological succession of the mouse colon tissue-associated microbiota. PLoS One 7:e30273
-
(2012)
PLoS One
, vol.7
, pp. 30273
-
-
Smith, P.1
Siddharth, J.2
Pearson, R.3
Holway, N.4
Shaxted, M.5
Butler, M.6
Clark, N.7
Jamontt, J.8
-
99
-
-
39149094587
-
The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands
-
18261938 1:CAS:528:DC%2BD1cXisVehurs%3D
-
Kim YG, Park JH, Shaw MH, Franchi L, Inohara N, Nunez G (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28:246-257
-
(2008)
Immunity
, vol.28
, pp. 246-257
-
-
Kim, Y.G.1
Park, J.H.2
Shaw, M.H.3
Franchi, L.4
Inohara, N.5
Nunez, G.6
-
100
-
-
78649957904
-
Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model
-
20921147 1:CAS:528:DC%2BC3MXhtlCgu7s%3D
-
Geddes K, Rubino S, Streutker C, Cho JH, Magalhaes JG, Le BL, Selvanantham T, Girardin SE et al (2010) Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model. Infect Immun 78:5107-5115
-
(2010)
Infect Immun
, vol.78
, pp. 5107-5115
-
-
Geddes, K.1
Rubino, S.2
Streutker, C.3
Cho, J.H.4
Magalhaes, J.G.5
Le, B.L.6
Selvanantham, T.7
Girardin, S.E.8
-
101
-
-
58149189054
-
NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity
-
18981137 1:CAS:528:DC%2BD1cXhtlaisrvE
-
Divangahi M, Mostowy S, Coulombe F, Kozak R, Guillot L, Veyrier F, Kobayashi KS, Flavell RA et al (2008) NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity. J Immunol 181:7157-7165
-
(2008)
J Immunol
, vol.181
, pp. 7157-7165
-
-
Divangahi, M.1
Mostowy, S.2
Coulombe, F.3
Kozak, R.4
Guillot, L.5
Veyrier, F.6
Kobayashi, K.S.7
Flavell, R.A.8
-
102
-
-
84861634889
-
The nucleotide synthesis enzyme CAD inhibits NOD2 antibacterial function in human intestinal epithelial cells
-
22387394 1:CAS:528:DC%2BC38XnslSnurg%3D
-
Richmond AL, Kabi A, Homer CR, Marina-Garcia N, Nickerson KP, Nesvizhskii AI, Sreekumar A, Chinnaiyan AM et al (2012) The nucleotide synthesis enzyme CAD inhibits NOD2 antibacterial function in human intestinal epithelial cells. Gastroenterology 142:1483-1492
-
(2012)
Gastroenterology
, vol.142
, pp. 1483-1492
-
-
Richmond, A.L.1
Kabi, A.2
Homer, C.R.3
Marina-Garcia, N.4
Nickerson, K.P.5
Nesvizhskii, A.I.6
Sreekumar, A.7
Chinnaiyan, A.M.8
-
103
-
-
84867807929
-
Innate lymphoid cell interactions with microbiota: Implications for intestinal health and disease
-
23084357 1:CAS:528:DC%2BC38XhsFeqsrnK
-
Sonnenberg GF, Artis D (2012) Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease. Immunity 37:601-610
-
(2012)
Immunity
, vol.37
, pp. 601-610
-
-
Sonnenberg, G.F.1
Artis, D.2
-
104
-
-
84859384082
-
Innate lymphoid cells: Emerging insights in development, lineage relationships, and function
-
22224763 1:CAS:528:DC%2BC38XmsVKmurY%3D
-
Spits H, Cupedo T (2012) Innate lymphoid cells: emerging insights in development, lineage relationships, and function. Annu Rev Immunol 30:647-675
-
(2012)
Annu Rev Immunol
, vol.30
, pp. 647-675
-
-
Spits, H.1
Cupedo, T.2
-
105
-
-
79961012464
-
Activation of cytokine-producing and antitumor activities of natural killer cells and macrophages by engagement of Toll-like and NOD-like receptors
-
20682587 1:CAS:528:DC%2BC3MXhtFGisrvE
-
Qiu F, Maniar A, Diaz MQ, Chapoval AI, Medvedev AE (2011) Activation of cytokine-producing and antitumor activities of natural killer cells and macrophages by engagement of Toll-like and NOD-like receptors. Innate Immun 17:375-387
-
(2011)
Innate Immun
, vol.17
, pp. 375-387
-
-
Qiu, F.1
Maniar, A.2
Diaz, M.Q.3
Chapoval, A.I.4
Medvedev, A.E.5
-
106
-
-
44849110066
-
Activation of human NK cells by the bacterial pathogen-associated molecular pattern muramyl dipeptide
-
18322218 1:CAS:528:DC%2BD1cXisl2jtro%3D
-
Athie-Morales V, O'Connor GM, Gardiner CM (2008) Activation of human NK cells by the bacterial pathogen-associated molecular pattern muramyl dipeptide. J Immunol 180:4082-4089
-
(2008)
J Immunol
, vol.180
, pp. 4082-4089
-
-
Athie-Morales, V.1
O'Connor, G.M.2
Gardiner, C.M.3
-
107
-
-
35348932070
-
Intracellular NOD-like receptors in host defense and disease
-
17967410 1:CAS:528:DC%2BD2sXht1ygur%2FE
-
Kanneganti TD, Lamkanfi M, Nunez G (2007) Intracellular NOD-like receptors in host defense and disease. Immunity 27:549-559
-
(2007)
Immunity
, vol.27
, pp. 549-559
-
-
Kanneganti, T.D.1
Lamkanfi, M.2
Nunez, G.3
-
108
-
-
21044457217
-
Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: Monoacylated MDP confers TLR2/TLR4 activation
-
15905553 1:CAS:528:DC%2BD2MXkt1Omur4%3D
-
Uehori J, Fukase K, Akazawa T, Uematsu S, Akira S, Funami K, Shingai M, Matsumoto M et al (2005) Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation. J Immunol 174:7096-7103
-
(2005)
J Immunol
, vol.174
, pp. 7096-7103
-
-
Uehori, J.1
Fukase, K.2
Akazawa, T.3
Uematsu, S.4
Akira, S.5
Funami, K.6
Shingai, M.7
Matsumoto, M.8
-
109
-
-
78650183459
-
Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by Toll-like receptor 2
-
21055975 1:CAS:528:DC%2BC3cXhsVCms7%2FJ
-
Crellin NK, Trifari S, Kaplan CD, Satoh-Takayama N, Di Santo JP, Spits H (2010) Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by Toll-like receptor 2. Immunity 33:752-764
-
(2010)
Immunity
, vol.33
, pp. 752-764
-
-
Crellin, N.K.1
Trifari, S.2
Kaplan, C.D.3
Satoh-Takayama, N.4
Di Santo, J.P.5
Spits, H.6
-
110
-
-
84857444876
-
Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense
-
22306017 1:CAS:528:DC%2BC38XhslCktbc%3D
-
Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, Flavell RA, Littman DR et al (2012) Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity 36:276-287
-
(2012)
Immunity
, vol.36
, pp. 276-287
-
-
Kinnebrew, M.A.1
Buffie, C.G.2
Diehl, G.E.3
Zenewicz, L.A.4
Leiner, I.5
Hohl, T.M.6
Flavell, R.A.7
Littman, D.R.8
-
111
-
-
77953910523
-
Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue
-
20620944 1:CAS:528:DC%2BC3cXovVahur4%3D
-
Hughes T, Becknell B, Freud AG, McClory S, Briercheck E, Yu J, Mao C, Giovenzana C et al (2010) Interleukin-1beta selectively expands and sustains interleukin-22+ immature human natural killer cells in secondary lymphoid tissue. Immunity 32:803-814
-
(2010)
Immunity
, vol.32
, pp. 803-814
-
-
Hughes, T.1
Becknell, B.2
Freud, A.G.3
McClory, S.4
Briercheck, E.5
Yu, J.6
Mao, C.7
Giovenzana, C.8
-
112
-
-
38849141814
-
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
-
18172556 1:CAS:528:DC%2BD1cXhsFOmsr8%3D
-
Sugimoto K, Ogawa A, Mizoguchi E, Shimomura Y, Andoh A, Bhan AK, Blumberg RS, Xavier RJ et al (2008) IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest 118:534-544
-
(2008)
J Clin Invest
, vol.118
, pp. 534-544
-
-
Sugimoto, K.1
Ogawa, A.2
Mizoguchi, E.3
Shimomura, Y.4
Andoh, A.5
Bhan, A.K.6
Blumberg, R.S.7
Xavier, R.J.8
-
113
-
-
79955030498
-
Border patrol: Regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
-
21502992 1:CAS:528:DC%2BC3MXkvVKqsLg%3D
-
Sonnenberg GF, Fouser LA, Artis D (2011) Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat Immunol 12:383-390
-
(2011)
Nat Immunol
, vol.12
, pp. 383-390
-
-
Sonnenberg, G.F.1
Fouser, L.A.2
Artis, D.3
-
114
-
-
73849151394
-
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
-
19966812 1:CAS:528:DC%2BD1MXhsFWksb3L
-
Cooney R, Baker J, Brain O, Danis B, Pichulik T, Allan P, Ferguson DJ, Campbell BJ et al (2010) NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 16:90-97
-
(2010)
Nat Med
, vol.16
, pp. 90-97
-
-
Cooney, R.1
Baker, J.2
Brain, O.3
Danis, B.4
Pichulik, T.5
Allan, P.6
Ferguson, D.J.7
Campbell, B.J.8
-
115
-
-
72549117022
-
Role of ATG16L1 Thr300Ala polymorphism in inflammatory bowel disease: A study in the Spanish population and a meta-analysis
-
19575361
-
Marquez A, Nunez C, Martinez A, Mendoza JL, Taxonera C, Fernandez-Arquero M, Diaz-Rubio M, de la Concha EG et al (2009) Role of ATG16L1 Thr300Ala polymorphism in inflammatory bowel disease: a study in the Spanish population and a meta-analysis. Inflamm Bowel Dis 15:1697-1704
-
(2009)
Inflamm Bowel Dis
, vol.15
, pp. 1697-1704
-
-
Marquez, A.1
Nunez, C.2
Martinez, A.3
Mendoza, J.L.4
Taxonera, C.5
Fernandez-Arquero, M.6
Diaz-Rubio, M.7
De La Concha, E.G.8
-
116
-
-
34247566585
-
A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5
-
17484864 1:CAS:528:DC%2BD2sXmsVymsrY%3D
-
Prescott NJ, Fisher SA, Franke A, Hampe J, Onnie CM, Soars D, Bagnall R, Mirza MM et al (2007) A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. Gastroenterology 132:1665-1671
-
(2007)
Gastroenterology
, vol.132
, pp. 1665-1671
-
-
Prescott, N.J.1
Fisher, S.A.2
Franke, A.3
Hampe, J.4
Onnie, C.M.5
Soars, D.6
Bagnall, R.7
Mirza, M.M.8
-
117
-
-
33846627302
-
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
-
17200669 1:CAS:528:DC%2BD2sXpvFerug%3D%3D
-
Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G et al (2007) A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39:207-211
-
(2007)
Nat Genet
, vol.39
, pp. 207-211
-
-
Hampe, J.1
Franke, A.2
Rosenstiel, P.3
Till, A.4
Teuber, M.5
Huse, K.6
Albrecht, M.7
Mayr, G.8
-
118
-
-
73849121209
-
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
-
19898471 1:CAS:528:DC%2BD1MXhtlOrur3L
-
Travassos LH, Carneiro LA, Ramjeet M, Hussey S, Kim YG, Magalhaes JG, Yuan L, Soares F et al (2010) Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 11:55-62
-
(2010)
Nat Immunol
, vol.11
, pp. 55-62
-
-
Travassos, L.H.1
Carneiro, L.A.2
Ramjeet, M.3
Hussey, S.4
Kim, Y.G.5
Magalhaes, J.G.6
Yuan, L.7
Soares, F.8
-
119
-
-
33244472793
-
Signalling pathways and molecular interactions of NOD1 and NOD2
-
16493424 1:CAS:528:DC%2BD28XlsVeksw%3D%3D
-
Strober W, Murray PJ, Kitani A, Watanabe T (2006) Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol 6:9-20
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 9-20
-
-
Strober, W.1
Murray, P.J.2
Kitani, A.3
Watanabe, T.4
-
120
-
-
0033968625
-
Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
-
10607756 1:CAS:528:DC%2BD3cXotVKltA%3D%3D
-
Takeuchi O, Takeda K, Hoshino K, Adachi O, Ogawa T, Akira S (2000) Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int Immunol 12:113-117
-
(2000)
Int Immunol
, vol.12
, pp. 113-117
-
-
Takeuchi, O.1
Takeda, K.2
Hoshino, K.3
Adachi, O.4
Ogawa, T.5
Akira, S.6
-
121
-
-
0033565407
-
Signaling events induced by lipopolysaccharide-activated toll-like receptor 2
-
10395652 1:CAS:528:DyaK1MXksVegtLg%3D
-
Yang RB, Mark MR, Gurney AL, Godowski PJ (1999) Signaling events induced by lipopolysaccharide-activated toll-like receptor 2. J Immunol 163:639-643
-
(1999)
J Immunol
, vol.163
, pp. 639-643
-
-
Yang, R.B.1
Mark, M.R.2
Gurney, A.L.3
Godowski, P.J.4
-
122
-
-
80053561363
-
Expression of TRAF6 and pro-inflammatory cytokines through activation of TLR2, TLR4, NOD1, and NOD2 in human periodontal ligament fibroblasts
-
21457942 1:CAS:528:DC%2BC3MXht1Gnu7bO
-
Tang L, Zhou XD, Wang Q, Zhang L, Wang Y, Li XY, Huang DM (2011) Expression of TRAF6 and pro-inflammatory cytokines through activation of TLR2, TLR4, NOD1, and NOD2 in human periodontal ligament fibroblasts. Arch Oral Biol 56:1064-1072
-
(2011)
Arch Oral Biol
, vol.56
, pp. 1064-1072
-
-
Tang, L.1
Zhou, X.D.2
Wang, Q.3
Zhang, L.4
Wang, Y.5
Li, X.Y.6
Huang, D.M.7
-
123
-
-
77950343791
-
Pattern recognition receptors and inflammation
-
20303872 1:CAS:528:DC%2BC3cXlsVSgu74%3D
-
Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140:805-820
-
(2010)
Cell
, vol.140
, pp. 805-820
-
-
Takeuchi, O.1
Akira, S.2
-
124
-
-
80051987703
-
Crosstalk in NF-kappaB signaling pathways
-
21772278 1:CAS:528:DC%2BC3MXptV2it7g%3D
-
Oeckinghaus A, Hayden MS, Ghosh S (2011) Crosstalk in NF-kappaB signaling pathways. Nat Immunol 12:695-708
-
(2011)
Nat Immunol
, vol.12
, pp. 695-708
-
-
Oeckinghaus, A.1
Hayden, M.S.2
Ghosh, S.3
-
125
-
-
77951260924
-
The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
-
20404851 1:CAS:528:DC%2BC3cXkvFSjsrc%3D
-
Kawai T, Akira S (2010) The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11:373-384
-
(2010)
Nat Immunol
, vol.11
, pp. 373-384
-
-
Kawai, T.1
Akira, S.2
-
126
-
-
80052723769
-
Cellular and molecular mechanisms in the two major forms of inflammatory bowel disease
-
21681604 1:CAS:528:DC%2BC3MXhtVKltrjL
-
Bene L, Falus A, Baffy N, Fulop AK (2011) Cellular and molecular mechanisms in the two major forms of inflammatory bowel disease. Pathol Oncol Res 17:463-472
-
(2011)
Pathol Oncol Res
, vol.17
, pp. 463-472
-
-
Bene, L.1
Falus, A.2
Baffy, N.3
Fulop, A.K.4
-
127
-
-
77954050569
-
Signaling pathways associated with inflammatory bowel disease
-
20001899 1:CAS:528:DC%2BC3cXms1egs7g%3D
-
Wei J, Feng J (2010) Signaling pathways associated with inflammatory bowel disease. Recent Pat Inflamm Allergy Drug Discov 4:105-117
-
(2010)
Recent Pat Inflamm Allergy Drug Discov
, vol.4
, pp. 105-117
-
-
Wei, J.1
Feng, J.2
-
128
-
-
33745775434
-
Mechanisms of disease: Pathogenesis of Crohn's disease and ulcerative colitis
-
16819502 1:CAS:528:DC%2BD28XnslKjs7o%3D
-
Sartor RB (2006) Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 3:390-407
-
(2006)
Nat Clin Pract Gastroenterol Hepatol
, vol.3
, pp. 390-407
-
-
Sartor, R.B.1
-
129
-
-
42549167131
-
The effect of NOD2 activation on TLR2-mediated cytokine responses is dependent on activation dose and NOD2 genotype
-
18340358 1:CAS:528:DC%2BD1cXkvFyksL0%3D
-
Borm ME, van Bodegraven AA, Mulder CJ, Kraal G, Bouma G (2008) The effect of NOD2 activation on TLR2-mediated cytokine responses is dependent on activation dose and NOD2 genotype. Genes Immun 9:274-278
-
(2008)
Genes Immun
, vol.9
, pp. 274-278
-
-
Borm, M.E.1
Van Bodegraven, A.A.2
Mulder, C.J.3
Kraal, G.4
Bouma, G.5
-
130
-
-
70349459620
-
Activation of innate immune antiviral responses by Nod2
-
19701189 1:CAS:528:DC%2BD1MXhtVaksrrP
-
Sabbah A, Chang TH, Harnack R, Frohlich V, Tominaga K, Dube PH, Xiang Y, Bose S (2009) Activation of innate immune antiviral responses by Nod2. Nat Immunol 10:1073-1080
-
(2009)
Nat Immunol
, vol.10
, pp. 1073-1080
-
-
Sabbah, A.1
Chang, T.H.2
Harnack, R.3
Frohlich, V.4
Tominaga, K.5
Dube, P.H.6
Xiang, Y.7
Bose, S.8
-
131
-
-
84887619697
-
The essential adaptors of innate immune signaling
-
Chen H, Jiang Z (2012) The essential adaptors of innate immune signaling. Protein Cell
-
(2012)
Protein Cell
-
-
Chen, H.1
Jiang, Z.2
-
132
-
-
79958746242
-
Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections
-
21669398 1:CAS:528:DC%2BC3MXnsVykt7o%3D
-
Kim YG, Park JH, Reimer T, Baker DP, Kawai T, Kumar H, Akira S, Wobus C et al (2011) Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections. Cell Host Microbe 9:496-507
-
(2011)
Cell Host Microbe
, vol.9
, pp. 496-507
-
-
Kim, Y.G.1
Park, J.H.2
Reimer, T.3
Baker, D.P.4
Kawai, T.5
Kumar, H.6
Akira, S.7
Wobus, C.8
-
133
-
-
84867222865
-
Respiratory syncytial virus infection augments NOD2 signaling in an IFN-beta-dependent manner in human primary cells
-
22730064 1:CAS:528:DC%2BC38Xht1Wrt7vK
-
Vissers M, Remijn T, Oosting M, de Jong DJ, Diavatopoulos DA, Hermans PW, Ferwerda G (2012) Respiratory syncytial virus infection augments NOD2 signaling in an IFN-beta-dependent manner in human primary cells. Eur J Immunol 42:2727-2735
-
(2012)
Eur J Immunol
, vol.42
, pp. 2727-2735
-
-
Vissers, M.1
Remijn, T.2
Oosting, M.3
De Jong, D.J.4
Diavatopoulos, D.A.5
Hermans, P.W.6
Ferwerda, G.7
-
134
-
-
66749174867
-
The inflammasomes: Guardians of the body
-
19302040 1:CAS:528:DC%2BD1MXlsFSlsbc%3D
-
Martinon F, Mayor A, Tschopp J (2009) The inflammasomes: guardians of the body. Annu Rev Immunol 27:229-265
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 229-265
-
-
Martinon, F.1
Mayor, A.2
Tschopp, J.3
-
136
-
-
84860001887
-
Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction
-
22520462 1:CAS:528:DC%2BC38XlvFygs70%3D
-
Meinzer U, Barreau F, Esmiol-Welterlin S, Jung C, Villard C, Leger T, Ben-Mkaddem S, Berrebi D et al (2012) Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction. Cell Host Microbe 11:337-351
-
(2012)
Cell Host Microbe
, vol.11
, pp. 337-351
-
-
Meinzer, U.1
Barreau, F.2
Esmiol-Welterlin, S.3
Jung, C.4
Villard, C.5
Leger, T.6
Ben-Mkaddem, S.7
Berrebi, D.8
-
137
-
-
84858677223
-
Sensing and reacting to microbes through the inflammasomes
-
22430785 1:CAS:528:DC%2BC38XktFSgsbY%3D
-
Franchi L, Munoz-Planillo R, Nunez G (2012) Sensing and reacting to microbes through the inflammasomes. Nat Immunol 13:325-332
-
(2012)
Nat Immunol
, vol.13
, pp. 325-332
-
-
Franchi, L.1
Munoz-Planillo, R.2
Nunez, G.3
-
138
-
-
72849115852
-
Inflammasomes: Too big to miss
-
19955661 1:CAS:528:DC%2BD1MXhsFCit7vK
-
Stutz A, Golenbock DT, Latz E (2009) Inflammasomes: too big to miss. J Clin Invest 119:3502-3511
-
(2009)
J Clin Invest
, vol.119
, pp. 3502-3511
-
-
Stutz, A.1
Golenbock, D.T.2
Latz, E.3
-
139
-
-
60749104683
-
The inflammasome: A caspase-1-activation platform that regulates immune responses and disease pathogenesis
-
19221555 1:CAS:528:DC%2BD1MXhvFKjtLo%3D
-
Franchi L, Eigenbrod T, Munoz-Planillo R, Nunez G (2009) The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 10:241-247
-
(2009)
Nat Immunol
, vol.10
, pp. 241-247
-
-
Franchi, L.1
Eigenbrod, T.2
Munoz-Planillo, R.3
Nunez, G.4
-
140
-
-
84855989829
-
Inflammasomes in health and disease
-
22258606 1:CAS:528:DC%2BC38Xps1GmsA%3D%3D
-
Strowig T, Henao-Mejia J, Elinav E, Flavell R (2012) Inflammasomes in health and disease. Nature 481:278-286
-
(2012)
Nature
, vol.481
, pp. 278-286
-
-
Strowig, T.1
Henao-Mejia, J.2
Elinav, E.3
Flavell, R.4
-
141
-
-
58049200723
-
Function of Nod-like receptors in microbial recognition and host defense
-
19120480 1:CAS:528:DC%2BD1MXhsFGls7zL
-
Franchi L, Warner N, Viani K, Nunez G (2009) Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev 227:106-128
-
(2009)
Immunol Rev
, vol.227
, pp. 106-128
-
-
Franchi, L.1
Warner, N.2
Viani, K.3
Nunez, G.4
-
142
-
-
40449140937
-
The NLR gene family: A standard nomenclature
-
18341998 1:CAS:528:DC%2BD1cXjvFeks7o%3D
-
Ting JP, Lovering RC, Alnemri ES, Bertin J, Boss JM, Davis BK, Flavell RA, Girardin SE et al (2008) The NLR gene family: a standard nomenclature. Immunity 28:285-287
-
(2008)
Immunity
, vol.28
, pp. 285-287
-
-
Ting, J.P.1
Lovering, R.C.2
Alnemri, E.S.3
Bertin, J.4
Boss, J.M.5
Davis, B.K.6
Flavell, R.A.7
Girardin, S.E.8
-
143
-
-
60749136484
-
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
-
19158679
-
Burckstummer T, Baumann C, Bluml S, Dixit E, Durnberger G, Jahn H, Planyavsky M, Bilban M et al (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol 10:266-272
-
(2009)
Nat Immunol
, vol.10
, pp. 266-272
-
-
Burckstummer, T.1
Baumann, C.2
Bluml, S.3
Dixit, E.4
Durnberger, G.5
Jahn, H.6
Planyavsky, M.7
Bilban, M.8
-
144
-
-
63649145255
-
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
-
19158676 1:CAS:528:DC%2BD1MXht1eht78%3D
-
Fernandes-Alnemri T, Yu JW, Datta P, Wu J, Alnemri ES (2009) AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458:509-513
-
(2009)
Nature
, vol.458
, pp. 509-513
-
-
Fernandes-Alnemri, T.1
Yu, J.W.2
Datta, P.3
Wu, J.4
Alnemri, E.S.5
-
145
-
-
60749104535
-
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
-
19131592 1:CAS:528:DC%2BD1MXitVyntr8%3D
-
Roberts TL, Idris A, Dunn JA, Kelly GM, Burnton CM, Hodgson S, Hardy LL, Garceau V et al (2009) HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 323:1057-1060
-
(2009)
Science
, vol.323
, pp. 1057-1060
-
-
Roberts, T.L.1
Idris, A.2
Dunn, J.A.3
Kelly, G.M.4
Burnton, C.M.5
Hodgson, S.6
Hardy, L.L.7
Garceau, V.8
-
146
-
-
63649133278
-
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
-
19158675 1:CAS:528:DC%2BD1MXht1ehu7w%3D
-
Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA (2009) AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458:514-518
-
(2009)
Nature
, vol.458
, pp. 514-518
-
-
Hornung, V.1
Ablasser, A.2
Charrel-Dennis, M.3
Bauernfeind, F.4
Horvath, G.5
Caffrey, D.R.6
Latz, E.7
Fitzgerald, K.A.8
-
147
-
-
0036671894
-
The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
-
12191486 1:CAS:528:DC%2BD38XmslyrurY%3D
-
Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10:417-426
-
(2002)
Mol Cell
, vol.10
, pp. 417-426
-
-
Martinon, F.1
Burns, K.2
Tschopp, J.3
-
148
-
-
45549093755
-
A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide
-
18511561 1:CAS:528:DC%2BD1cXntF2ru7k%3D
-
Hsu LC, Ali SR, McGillivray S, Tseng PH, Mariathasan S, Humke EW, Eckmann L, Powell JJ et al (2008) A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci USA 105:7803-7808
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 7803-7808
-
-
Hsu, L.C.1
Ali, S.R.2
McGillivray, S.3
Tseng, P.H.4
Mariathasan, S.5
Humke, E.W.6
Eckmann, L.7
Powell, J.J.8
-
149
-
-
33847376042
-
Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation
-
17349957 1:CAS:528:DC%2BD2sXjs1Kisr0%3D
-
Faustin B, Lartigue L, Bruey JM, Luciano F, Sergienko E, Bailly-Maitre B, Volkmann N, Hanein D et al (2007) Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. Mol Cell 25:713-724
-
(2007)
Mol Cell
, vol.25
, pp. 713-724
-
-
Faustin, B.1
Lartigue, L.2
Bruey, J.M.3
Luciano, F.4
Sergienko, E.5
Bailly-Maitre, B.6
Volkmann, N.7
Hanein, D.8
-
150
-
-
7944232105
-
Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome
-
15530394 1:CAS:528:DC%2BD2cXpsVOrtr8%3D
-
Martinon F, Agostini L, Meylan E, Tschopp J (2004) Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol 14:1929-1934
-
(2004)
Curr Biol
, vol.14
, pp. 1929-1934
-
-
Martinon, F.1
Agostini, L.2
Meylan, E.3
Tschopp, J.4
-
151
-
-
70249110860
-
Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation
-
19542372 1:CAS:528:DC%2BD1MXotFWgt7w%3D
-
Franchi L, Eigenbrod T, Nunez G (2009) Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J Immunol 183:792-796
-
(2009)
J Immunol
, vol.183
, pp. 792-796
-
-
Franchi, L.1
Eigenbrod, T.2
Nunez, G.3
-
152
-
-
77749270973
-
Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor
-
19812205 1:CAS:528:DC%2BD1MXht1ymtbfK
-
Harder J, Franchi L, Munoz-Planillo R, Park JH, Reimer T, Nunez G (2009) Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor. J Immunol 183:5823-5829
-
(2009)
J Immunol
, vol.183
, pp. 5823-5829
-
-
Harder, J.1
Franchi, L.2
Munoz-Planillo, R.3
Park, J.H.4
Reimer, T.5
Nunez, G.6
-
153
-
-
58149159542
-
Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
-
19098911 1:CAS:528:DC%2BD1cXhsFajtbfM
-
Villani AC, Lemire M, Fortin G, Louis E, Silverberg MS, Collette C, Baba N, Libioulle C et al (2009) Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nat Genet 41:71-76
-
(2009)
Nat Genet
, vol.41
, pp. 71-76
-
-
Villani, A.C.1
Lemire, M.2
Fortin, G.3
Louis, E.4
Silverberg, M.S.5
Collette, C.6
Baba, N.7
Libioulle, C.8
-
154
-
-
84859877626
-
The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1beta and IL-18 production
-
22529966 1:CAS:528:DC%2BC38Xmtlyqsb0%3D
-
Verma D, Sarndahl E, Andersson H, Eriksson P, Fredrikson M, Jonsson JI, Lerm M, Soderkvist P (2012) The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1beta and IL-18 production. PLoS One 7:e34977
-
(2012)
PLoS One
, vol.7
, pp. 34977
-
-
Verma, D.1
Sarndahl, E.2
Andersson, H.3
Eriksson, P.4
Fredrikson, M.5
Jonsson, J.I.6
Lerm, M.7
Soderkvist, P.8
-
155
-
-
1642285783
-
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
-
15030775 1:CAS:528:DC%2BD2cXis1Kht78%3D
-
Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J (2004) NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20:319-325
-
(2004)
Immunity
, vol.20
, pp. 319-325
-
-
Agostini, L.1
Martinon, F.2
Burns, K.3
McDermott, M.F.4
Hawkins, P.N.5
Tschopp, J.6
-
156
-
-
33845890803
-
Inflammasome adaptors and sensors: Intracellular regulators of infection and inflammation
-
17186029 1:CAS:528:DC%2BD28XhtlChtL7M
-
Mariathasan S, Monack DM (2007) Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol 7:31-40
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 31-40
-
-
Mariathasan, S.1
Monack, D.M.2
-
157
-
-
77953105781
-
Extraintestinal manifestations of inflammatory bowel disease: Epidemiology, diagnosis, and management
-
20166813
-
Larsen S, Bendtzen K, Nielsen OH (2010) Extraintestinal manifestations of inflammatory bowel disease: epidemiology, diagnosis, and management. Ann Med 42:97-114
-
(2010)
Ann Med
, vol.42
, pp. 97-114
-
-
Larsen, S.1
Bendtzen, K.2
Nielsen, O.H.3
-
158
-
-
79956007512
-
Low bone mass in microscopic colitis
-
21595910
-
Lorinczy K, Lakatos G, Mullner K, Hritz I, Lakatos PL, Tulassay Z, Miheller P (2011) Low bone mass in microscopic colitis. BMC Gastroenterol 11:58
-
(2011)
BMC Gastroenterol
, vol.11
, pp. 58
-
-
Lorinczy, K.1
Lakatos, G.2
Mullner, K.3
Hritz, I.4
Lakatos, P.L.5
Tulassay, Z.6
Miheller, P.7
-
159
-
-
36749098487
-
Changes of OPG and RANKL concentrations in Crohn's disease after infliximab therapy
-
17663430
-
Miheller P, Muzes G, Racz K, Blazovits A, Lakatos P, Herszenyi L, Tulassay Z (2007) Changes of OPG and RANKL concentrations in Crohn's disease after infliximab therapy. Inflamm Bowel Dis 13:1379-1384
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 1379-1384
-
-
Miheller, P.1
Muzes, G.2
Racz, K.3
Blazovits, A.4
Lakatos, P.5
Herszenyi, L.6
Tulassay, Z.7
-
160
-
-
80053978532
-
Matrix-embedded cells control osteoclast formation
-
21909103 1:CAS:528:DC%2BC3MXhtFCntrnM
-
Xiong J, Onal M, Jilka RL, Weinstein RS, Manolagas SC, O'Brien CA (2011) Matrix-embedded cells control osteoclast formation. Nat Med 17:1235-1241
-
(2011)
Nat Med
, vol.17
, pp. 1235-1241
-
-
Xiong, J.1
Onal, M.2
Jilka, R.L.3
Weinstein, R.S.4
Manolagas, S.C.5
O'Brien, C.A.6
-
161
-
-
22544453861
-
Muramyl dipeptide enhances osteoclast formation induced by lipopolysaccharide, IL-1 alpha, and TNF-alpha through nucleotide-binding oligomerization domain 2-mediated signaling in osteoblasts
-
16034140 1:CAS:528:DC%2BD2MXmtlWisro%3D
-
Yang S, Takahashi N, Yamashita T, Sato N, Takahashi M, Mogi M, Uematsu T, Kobayashi Y et al (2005) Muramyl dipeptide enhances osteoclast formation induced by lipopolysaccharide, IL-1 alpha, and TNF-alpha through nucleotide-binding oligomerization domain 2-mediated signaling in osteoblasts. J Immunol 175:1956-1964
-
(2005)
J Immunol
, vol.175
, pp. 1956-1964
-
-
Yang, S.1
Takahashi, N.2
Yamashita, T.3
Sato, N.4
Takahashi, M.5
Mogi, M.6
Uematsu, T.7
Kobayashi, Y.8
-
162
-
-
77954842857
-
Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication
-
20500518 1:CAS:528:DC%2BC3cXhtVCktbvP
-
Motani K, Kawase K, Imamura R, Kinoshita T, Kushiyama H, Suda T (2010) Activation of ASC induces apoptosis or necrosis, depending on the cell type, and causes tumor eradication. Cancer Sci 101:1822-1827
-
(2010)
Cancer Sci
, vol.101
, pp. 1822-1827
-
-
Motani, K.1
Kawase, K.2
Imamura, R.3
Kinoshita, T.4
Kushiyama, H.5
Suda, T.6
-
163
-
-
20444452880
-
Surface calreticulin mediates muramyl dipeptide-induced apoptosis in RK13 cells
-
15817475 1:CAS:528:DC%2BD2MXksl2htLs%3D
-
Chen D, Texada DE, Duggan C, Liang C, Reden TB, Kooragayala LM, Langford MP (2005) Surface calreticulin mediates muramyl dipeptide-induced apoptosis in RK13 cells. J Biol Chem 280:22425-22436
-
(2005)
J Biol Chem
, vol.280
, pp. 22425-22436
-
-
Chen, D.1
Texada, D.E.2
Duggan, C.3
Liang, C.4
Reden, T.B.5
Kooragayala, L.M.6
Langford, M.P.7
-
164
-
-
77952293789
-
Calreticulin: Non-endoplasmic reticulum functions in physiology and disease
-
19940256 1:CAS:528:DC%2BC3cXjtFagsLw%3D
-
Gold LI, Eggleton P, Sweetwyne MT, Van Duyn LB, Greives MR, Naylor SM, Michalak M, Murphy-Ullrich JE (2010) Calreticulin: non-endoplasmic reticulum functions in physiology and disease. FASEB J 24:665-683
-
(2010)
FASEB J
, vol.24
, pp. 665-683
-
-
Gold, L.I.1
Eggleton, P.2
Sweetwyne, M.T.3
Van Duyn, L.B.4
Greives, M.R.5
Naylor, S.M.6
Michalak, M.7
Murphy-Ullrich, J.E.8
-
165
-
-
18644384436
-
The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm
-
15761471 1:CAS:528:DC%2BD2MXkvVSrtL4%3D
-
Bender LM, Morgan MJ, Thomas LR, Liu ZG, Thorburn A (2005) The adaptor protein TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm. Cell Death Differ 12:473-481
-
(2005)
Cell Death Differ
, vol.12
, pp. 473-481
-
-
Bender, L.M.1
Morgan, M.J.2
Thomas, L.R.3
Liu, Z.G.4
Thorburn, A.5
-
166
-
-
78650654512
-
Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD
-
20943999 1:CAS:528:DC%2BC3cXhtlOhsbbM
-
Hindryckx P, De VM, Jacques P, Ferdinande L, Peeters H, Olievier K, Bogaert S, Brinkman B et al (2010) Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD. J Immunol 185:6306-6316
-
(2010)
J Immunol
, vol.185
, pp. 6306-6316
-
-
Hindryckx, P.1
De, V.M.2
Jacques, P.3
Ferdinande, L.4
Peeters, H.5
Olievier, K.6
Bogaert, S.7
Brinkman, B.8
-
167
-
-
1642633791
-
ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway
-
14730312 1:CAS:528:DC%2BD2cXosFSiug%3D%3D
-
Ohtsuka T, Ryu H, Minamishima YA, Macip S, Sagara J, Nakayama KI, Aaronson SA, Lee SW (2004) ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. Nat Cell Biol 6:121-128
-
(2004)
Nat Cell Biol
, vol.6
, pp. 121-128
-
-
Ohtsuka, T.1
Ryu, H.2
Minamishima, Y.A.3
Macip, S.4
Sagara, J.5
Nakayama, K.I.6
Aaronson, S.A.7
Lee, S.W.8
-
168
-
-
70649085135
-
Evidence for impaired CARD15 signalling in Crohn's disease without disease linked variants
-
19907652
-
Seidelin JB, Broom OJ, Olsen J, Nielsen OH (2009) Evidence for impaired CARD15 signalling in Crohn's disease without disease linked variants. PLoS One 4:e7794
-
(2009)
PLoS One
, vol.4
, pp. 7794
-
-
Seidelin, J.B.1
Broom, O.J.2
Olsen, J.3
Nielsen, O.H.4
-
169
-
-
37649013801
-
Chronic stimulation of Nod2 mediates tolerance to bacterial products
-
18032608 1:CAS:528:DC%2BD1cXisVOhsw%3D%3D
-
Hedl M, Li J, Cho JH, Abraham C (2007) Chronic stimulation of Nod2 mediates tolerance to bacterial products. Proc Natl Acad Sci USA 104:19440-19445
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19440-19445
-
-
Hedl, M.1
Li, J.2
Cho, J.H.3
Abraham, C.4
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