Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-κB activation but proceeds independently of TLR signaling and P2X7 receptor

Journal of Immunology

Volumn 183, Issue 9, 2009, Pages 5823-5829

  Harder, Jürgen ^a   Franchi, Luigi ^a   Muñoz Planillo, Raúl ^a   Park, Jong Hwan ^a   Reimer, Thornik ^a   Núñez, Gabriel ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MYELOID DIFFERENTIATION FACTOR 88; PURINERGIC P2X7 RECEPTOR; STREPTOLYSIN O; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1;

ANIMAL EXPERIMENT; ARTICLE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL MODEL; EXPERIMENTAL MOUSE; GROUP A STREPTOCOCCAL INFECTION; IMMUNE RESPONSE; IMMUNOBLOTTING; IN VIVO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOCOCCUS PYOGENES; SURVIVAL;

ANIMALS; BACTERIAL PROTEINS; CARRIER PROTEINS; CASPASE 1; CELLS, CULTURED; DISEASE MODELS, ANIMAL; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; NF-KAPPA B; PERITONITIS; PROTEIN PRECURSORS; RECEPTORS, PURINERGIC P2; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES; STREPTOLYSINS; SURVIVAL ANALYSIS; TOLL-LIKE RECEPTORS;

EID: 77749270973     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900444     Document Type: Article

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