Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2

Journal of Immunology

Volumn 180, Issue 6, 2008, Pages 4050-4057

  Marina García, Noemí ^a   Franchi, Luigi ^a   Kim, Yun Gi ^a   Miller, Douglas ^b   McDonald, Christine ^a,c   Boons, Geert Jan ^b   Núñez, Gabriel ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CRYOPYRIN; FLUORESCENT DYE; GAP JUNCTION PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MITOGEN ACTIVATED PROTEIN KINASE; MURAMYL DIPEPTIDE; PANNEXIN 1; UNCLASSIFIED DRUG; ALEXA 488 HYDRAZIDE; CARD15 PROTEIN, MOUSE; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; HYDRAZINE DERIVATIVE; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINE; NERVE PROTEIN; PANX1 PROTEIN, MOUSE;

ACIDIFICATION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOSOL; ENDOSOME; ENZYME ACTIVATION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; ENZYMOLOGY; GENETICS; INTRACELLULAR FLUID; METABOLISM; MOUSE; MOUSE MUTANT; PH; PHYSIOLOGY; SECRETION;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ANIMALS; CARRIER PROTEINS; CASPASE 1; CELLS, CULTURED; CONNEXINS; CYTOSOL; ENDOSOMES; FLUORESCENT DYES; HYDRAZINES; HYDROGEN-ION CONCENTRATION; INTERLEUKIN-1BETA; INTRACELLULAR FLUID; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NOD2 SIGNALING ADAPTOR PROTEIN;

EID: 44849136632     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.6.4050     Document Type: Article

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