메뉴 건너뛰기




Volumn 474, Issue 7351, 2011, Pages 298-306

Intestinal homeostasis and its breakdown in inflammatory bowel disease

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INFLAMMASOME; INTERLEUKIN 10; INTERLEUKIN 23; INTERLEUKIN 6; PATTERN RECOGNITION RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 79959271087     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10208     Document Type: Review
Times cited : (1508)

References (100)
  • 2
    • 77952318832 scopus 로고    scopus 로고
    • Intestinal bacteria and the regulation of immune cell homeostasis
    • Hill, D. A. & Artis, D. Intestinal bacteria and the regulation of immune cell homeostasis. Annu. Rev. Immunol. 28, 623-667 (2010).
    • (2010) Annu. Rev. Immunol. , vol.28 , pp. 623-667
    • Hill, D.A.1    Artis, D.2
  • 3
    • 44349132270 scopus 로고    scopus 로고
    • Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
    • DOI 10.1038/nri2316, PII NRI2316
    • Artis, D. Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut. Nature Rev. Immunol. 8, 411-420 (2008). (Pubitemid 351733416)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.6 , pp. 411-420
    • Artis, D.1
  • 4
    • 77649086402 scopus 로고    scopus 로고
    • Immune adaptations that maintain homeostasis with the intestinal microbiota
    • Hooper, L. V. & Macpherson, A. J. Immune adaptations that maintain homeostasis with the intestinal microbiota. Nature Rev. Immunol. 10, 159-169 (2010).
    • (2010) Nature Rev. Immunol. , vol.10 , pp. 159-169
    • Hooper, L.V.1    MacPherson, A.J.2
  • 6
    • 58549111588 scopus 로고    scopus 로고
    • Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
    • Vaishnava, S., Behrendt, C. L., Ismail, A. S., Eckmann, L. & Hooper, L. V. Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc. Natl Acad. Sci. USA 105, 20858-20863 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 20858-20863
    • Vaishnava, S.1    Behrendt, C.L.2    Ismail, A.S.3    Eckmann, L.4    Hooper, L.V.5
  • 7
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell, K. et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456, 259-263 (2008).
    • (2008) Nature , vol.456 , pp. 259-263
    • Cadwell, K.1
  • 8
    • 67649607465 scopus 로고    scopus 로고
    • Autophagy immunity, and microbial adaptations
    • Deretic, V. & Levine, B. Autophagy, immunity, and microbial adaptations. Cell Host Microbe 5, 527-549 (2009).
    • (2009) Cell Host Microbe , vol.5 , pp. 527-549
    • Deretic, V.1    Levine, B.2
  • 9
    • 77954144700 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress: Implications for inflammatory bowel disease pathogenesis
    • Kaser, A., Martinez-Naves, E. & Blumberg, R. S. Endoplasmic reticulum stress: implications for inflammatory bowel disease pathogenesis. Curr. Opin. Gastroenterol. 26, 318-326 (2010).
    • (2010) Curr. Opin. Gastroenterol. , vol.26 , pp. 318-326
    • Kaser, A.1    Martinez-Naves, E.2    Blumberg, R.S.3
  • 10
    • 50249086073 scopus 로고    scopus 로고
    • XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
    • Kaser, A. et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134, 743-756 (2008).
    • (2008) Cell , vol.134 , pp. 743-756
    • Kaser, A.1
  • 11
    • 63449112387 scopus 로고    scopus 로고
    • TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis
    • Taylor, B. C. et al. TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J. Exp. Med. 206, 655-667 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 655-667
    • Taylor, B.C.1
  • 12
    • 75649093343 scopus 로고    scopus 로고
    • Toll-like receptor signalling in the intestinal epithelium: How bacterial recognition shapes intestinal function
    • Abreu, M. T. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nature Rev. Immunol. 10, 131-144 (2010).
    • (2010) Nature Rev. Immunol. , vol.10 , pp. 131-144
    • Abreu, M.T.1
  • 13
    • 77952311371 scopus 로고    scopus 로고
    • Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis
    • Fagarasan, S., Kawamoto, S., Kanagawa, O. & Suzuki, K. Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis. Annu. Rev. Immunol. 28, 243-273 (2010).
    • (2010) Annu. Rev. Immunol. , vol.28 , pp. 243-273
    • Fagarasan, S.1    Kawamoto, S.2    Kanagawa, O.3    Suzuki, K.4
  • 14
    • 68149091349 scopus 로고    scopus 로고
    • Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism
    • Slack, E. et al. Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science 325, 617-620 (2009).
    • (2009) Science , vol.325 , pp. 617-620
    • Slack, E.1
  • 15
    • 77955346494 scopus 로고    scopus 로고
    • Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease
    • Asquith, M. J., Boulard, O., Powrie, F. & Maloy, K. J. Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease. Gastroenterology 139, 519-529 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 519-529
    • Asquith, M.J.1    Boulard, O.2    Powrie, F.3    Maloy, K.J.4
  • 17
    • 33244472793 scopus 로고    scopus 로고
    • Signalling pathways and molecular interactions of NOD1 and NOD2
    • DOI 10.1038/nri1747, PII N1747
    • Strober, W., Murray, P. J., Kitani, A. & Watanabe, T. Signalling pathways and molecular interactions of NOD1 and NOD2. Nature Rev. Immunol. 6, 9-20 (2006). (Pubitemid 43279749)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.1 , pp. 9-20
    • Strober, W.1    Murray, P.J.2    Kitani, A.3    Watanabe, T.4
  • 18
    • 57749094105 scopus 로고    scopus 로고
    • The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis
    • Chen, G. Y., Shaw, M. H., Redondo, G. & Nunez, G. The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis. Cancer Res. 68, 10060-10067 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 10060-10067
    • Chen, G.Y.1    Shaw, M.H.2    Redondo, G.3    Nunez, G.4
  • 19
    • 77949965210 scopus 로고    scopus 로고
    • Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases
    • Dupaul-Chicoine, J. et al. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity 32, 367-378 (2010).
    • (2010) Immunity , vol.32 , pp. 367-378
    • Dupaul-Chicoine, J.1
  • 20
    • 77950002937 scopus 로고    scopus 로고
    • The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
    • Zaki, M. H. et al. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 32, 379-391 (2010).
    • (2010) Immunity , vol.32 , pp. 379-391
    • Zaki, M.H.1
  • 21
    • 77952303410 scopus 로고    scopus 로고
    • The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
    • Allen, I. C. et al. The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J. Exp. Med. 207, 1045-1056 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1045-1056
    • Allen, I.C.1
  • 22
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder, K. & Tschopp, J. The inflammasomes. Cell 140, 821-832 (2010).
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 23
    • 77949982382 scopus 로고    scopus 로고
    • Interleukin-18 in intestinal inflammation: Friend and foe?
    • Siegmund, B Interleukin-18 in intestinal inflammation: friend and foe? Immunity 32, 300-302 (2010).
    • (2010) Immunity , vol.32 , pp. 300-302
    • Siegmund, B.1
  • 24
    • 77955350419 scopus 로고    scopus 로고
    • MyD88-mediated signaling prevents development of adenocarcinomas of the colon: Role of interleukin 18
    • Salcedo, R. et al. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J. Exp. Med. 207, 1625-1636 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1625-1636
    • Salcedo, R.1
  • 25
    • 77953486362 scopus 로고    scopus 로고
    • Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis
    • Feng, T., Wang, L., Schoeb, T. R., Elson, C. O. & Cong, Y. Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis. J. Exp. Med. 207, 1321-1332 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1321-1332
    • Feng, T.1    Wang, L.2    Schoeb, T.R.3    Elson, C.O.4    Cong, Y.5
  • 26
    • 77955383804 scopus 로고    scopus 로고
    • An innately dangerous balancing act: Intestinal homeostasis, inflammation, and colitis-associated cancer
    • Asquith, M. & Powrie, F. An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer. J. Exp. Med. 207, 1573-1577 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1573-1577
    • Asquith, M.1    Powrie, F.2
  • 27
    • 78650624793 scopus 로고    scopus 로고
    • Innate immune mechanisms of colitis and colitis-associated colorectal cancer
    • Saleh, M. & Trinchieri, G. Innate immune mechanisms of colitis and colitis-associated colorectal cancer. Nature Rev. Immunol. 11, 9-20 (2011).
    • (2011) Nature Rev. Immunol. , vol.11 , pp. 9-20
    • Saleh, M.1    Trinchieri, G.2
  • 28
    • 77954738601 scopus 로고    scopus 로고
    • Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
    • Round, J. L. & Mazmanian, S. K. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc. Natl Acad. Sci. USA 107, 12204-12209 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 12204-12209
    • Round, J.L.1    Mazmanian, S.K.2
  • 29
    • 77956159711 scopus 로고    scopus 로고
    • Nucleotide-binding oligomerization domain-2 inhibits Toll-like receptor-4 signaling in the intestinal epithelium
    • Richardson, W. M. et al. Nucleotide-binding oligomerization domain-2 inhibits Toll-like receptor-4 signaling in the intestinal epithelium. Gastroenterology 139, 904-917 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 904-917
    • Richardson, W.M.1
  • 30
    • 73849121209 scopus 로고    scopus 로고
    • Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    • Travassos, L. H. et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nature Immunol. 11, 55-62 (2010).
    • (2010) Nature Immunol. , vol.11 , pp. 55-62
    • Travassos, L.H.1
  • 31
    • 73849151394 scopus 로고    scopus 로고
    • NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    • Cooney, R. et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nature Med. 16, 90-97 (2010).
    • (2010) Nature Med. , vol.16 , pp. 90-97
    • Cooney, R.1
  • 32
    • 56249090667 scopus 로고    scopus 로고
    • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
    • Saitoh, T. et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production. Nature 456, 264-268 (2008).
    • (2008) Nature , vol.456 , pp. 264-268
    • Saitoh, T.1
  • 33
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou, R., Yazdi, A. S., Menu, P. & Tschopp, J. A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221-225 (2011).
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 34
    • 77951290227 scopus 로고    scopus 로고
    • TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
    • Martinon, F., Chen, X., Lee, A. H. & Glimcher, L. H. TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nature Immunol. 11, 411-418 (2010).
    • (2010) Nature Immunol. , vol.11 , pp. 411-418
    • Martinon, F.1    Chen, X.2    Lee, A.H.3    Glimcher, L.H.4
  • 35
    • 76949094665 scopus 로고    scopus 로고
    • Future biologic targets for IBD: Potentials and pitfalls
    • Melmed, G. Y. & Targan, S. R. Future biologic targets for IBD: potentials and pitfalls. Nature Rev. Gastroenterol. Hepatol. 7, 110-117 (2010).
    • (2010) Nature Rev. Gastroenterol. Hepatol. , vol.7 , pp. 110-117
    • Melmed, G.Y.1    Targan, S.R.2
  • 36
    • 50149092873 scopus 로고    scopus 로고
    • IL-23 and Th17 cytokines in intestinal homeostasis
    • Maloy, K. J. & Kullberg, M. C. IL-23 and Th17 cytokines in intestinal homeostasis. Mucosal Immunol. 1, 339-349 (2008).
    • (2008) Mucosal Immunol. , vol.1 , pp. 339-349
    • Maloy, K.J.1    Kullberg, M.C.2
  • 38
    • 78049271424 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression
    • Goodall, J. C. et al. Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Proc. Natl Acad. Sci. USA 107, 17698-17703 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 17698-17703
    • Goodall, J.C.1
  • 39
    • 77955890952 scopus 로고    scopus 로고
    • Interleukin-23 drives intestinal inflammation through direct activity on T cells
    • Ahern, P. P. et al. Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity 33, 279-288 (2010).
    • (2010) Immunity , vol.33 , pp. 279-288
    • Ahern, P.P.1
  • 40
    • 59849114998 scopus 로고    scopus 로고
    • RORγ-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F
    • Leppkes, M. et al. RORγ-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology 136, 257-267 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 257-267
    • Leppkes, M.1
  • 41
    • 49249135394 scopus 로고    scopus 로고
    • Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor
    • Cosmi, L. et al. Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor. J. Exp. Med. 205, 1903-1916 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 1903-1916
    • Cosmi, L.1
  • 42
    • 63449133361 scopus 로고    scopus 로고
    • Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation
    • Kleinschek, M. A. et al. Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation. J. Exp. Med. 206, 525-534 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 525-534
    • Kleinschek, M.A.1
  • 44
    • 70049113279 scopus 로고    scopus 로고
    • CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner
    • Chaudhry, A. et al. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 326, 986-991 (2009).
    • (2009) Science , vol.326 , pp. 986-991
    • Chaudhry, A.1
  • 45
    • 77951878587 scopus 로고    scopus 로고
    • Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
    • Buonocore, S. et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464, 1371-1375 (2010).
    • (2010) Nature , vol.464 , pp. 1371-1375
    • Buonocore, S.1
  • 46
    • 69949120571 scopus 로고    scopus 로고
    • A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
    • Wu, S. et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nature Med. 15, 1016-1022 (2009).
    • (2009) Nature Med. , vol.15 , pp. 1016-1022
    • Wu, S.1
  • 47
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • Ivanov, I. I. et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139, 485-498 (2009).
    • (2009) Cell , vol.139 , pp. 485-498
    • Ivanov, I.I.1
  • 48
    • 70349742524 scopus 로고    scopus 로고
    • The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses
    • Gaboriau-Routhiau, V. et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 31, 677-689 (2009).
    • (2009) Immunity , vol.31 , pp. 677-689
    • Gaboriau-Routhiau, V.1
  • 50
    • 67650474246 scopus 로고    scopus 로고
    • STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    • Pickert, G. et al. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J. Exp. Med. 206, 1465-1472 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1465-1472
    • Pickert, G.1
  • 51
    • 77953495368 scopus 로고    scopus 로고
    • Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
    • Sonnenberg, G. F. et al. Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. J. Exp. Med. 207, 1293-1305 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1293-1305
    • Sonnenberg, G.F.1
  • 52
    • 64049089798 scopus 로고    scopus 로고
    • Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
    • Chung, Y. et al. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30, 576-587 (2009).
    • (2009) Immunity , vol.30 , pp. 576-587
    • Chung, Y.1
  • 53
    • 77955482224 scopus 로고    scopus 로고
    • Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome
    • Ng, J. et al. Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome. Gastroenterology 139, 542-552.e3 (2010).
    • (2010) Gastroenterology , vol.139
    • Ng, J.1
  • 54
    • 68349131301 scopus 로고    scopus 로고
    • The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation
    • Muller, A. J. et al. The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation. Cell Host Microbe 6, 125-136 (2009).
    • (2009) Cell Host Microbe , vol.6 , pp. 125-136
    • Muller, A.J.1
  • 55
    • 68249137286 scopus 로고    scopus 로고
    • Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity
    • Colonna, M. Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity. Immunity 31, 15-23 (2009).
    • (2009) Immunity , vol.31 , pp. 15-23
    • Colonna, M.1
  • 56
    • 77954143695 scopus 로고    scopus 로고
    • Innate IL-17-producing cells: The sentinels of the immune system
    • Cua, D. J. & Tato, C. M. Innate IL-17-producing cells: the sentinels of the immune system. Nature Rev. Immunol. 10, 479-489 (2010).
    • (2010) Nature Rev. Immunol. , vol.10 , pp. 479-489
    • Cua, D.J.1    Tato, C.M.2
  • 57
    • 78650209225 scopus 로고    scopus 로고
    • T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells
    • Park, S. G. et al. T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells. Immunity 33, 791-803 (2010).
    • (2010) Immunity , vol.33 , pp. 791-803
    • Park, S.G.1
  • 58
    • 68649126866 scopus 로고    scopus 로고
    • Interleukin-17-producing γδ T cells selectively expand in response to pathogen products and environmental signals
    • Martin, B., Hirota, K., Cua, D. J., Stockinger, B. & Veldhoen, M. Interleukin-17-producing γδ T cells selectively expand in response to pathogen products and environmental signals. Immunity 31, 321-330 (2009).
    • (2009) Immunity , vol.31 , pp. 321-330
    • Martin, B.1    Hirota, K.2    Cua, D.J.3    Stockinger, B.4    Veldhoen, M.5
  • 59
    • 68649088121 scopus 로고    scopus 로고
    • Interleukin-1 and IL-23 induce innate IL-17 production from γδ T cells, amplifying Th17 responses and autoimmunity
    • Sutton, C. E. et al. Interleukin-1 and IL-23 induce innate IL-17 production from γδ T cells, amplifying Th17 responses and autoimmunity. Immunity 31, 331-341 (2009).
    • (2009) Immunity , vol.31 , pp. 331-341
    • Sutton, C.E.1
  • 60
    • 78650310810 scopus 로고    scopus 로고
    • The expanding family of innate lymphoid cells: Regulators and effectors of immunity and tissue remodeling
    • Spits, H. & Di Santo, J. P. The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling. Nature Immunol. 12, 21-27 (2011).
    • (2011) Nature Immunol. , vol.12 , pp. 21-27
    • Spits, H.1    Di Santo, J.P.2
  • 61
    • 78049385155 scopus 로고    scopus 로고
    • Lineage relationship analysis of RORγ+ innate lymphoid cells
    • Sawa, S. et al. Lineage relationship analysis of RORγ+ innate lymphoid cells. Science 330, 665-669 (2010).
    • (2010) Science , vol.330 , pp. 665-669
    • Sawa, S.1
  • 62
    • 78751706261 scopus 로고    scopus 로고
    • CD4+ lymphoid tissue-inducer cells promote innate immunity in the gut
    • Sonnenberg, G. F., Monticelli, L. A., Elloso, M. M., Fouser, L. A. & Artis, D. CD4+ lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity 34, 122-134 (2011).
    • (2011) Immunity , vol.34 , pp. 122-134
    • Sonnenberg, G.F.1    Monticelli, L.A.2    Elloso, M.M.3    Fouser, L.A.4    Artis, D.5
  • 63
    • 75749122181 scopus 로고    scopus 로고
    • Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
    • Moro, K. et al. Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells. Nature 463, 540-544 (2010).
    • (2010) Nature , vol.463 , pp. 540-544
    • Moro, K.1
  • 64
    • 77951817294 scopus 로고    scopus 로고
    • IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses
    • Saenz, S. A. et al. IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses. Nature 464, 1362-1366 (2010).
    • (2010) Nature , vol.464 , pp. 1362-1366
    • Saenz, S.A.1
  • 65
    • 77951817855 scopus 로고    scopus 로고
    • Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
    • Neill, D. R. et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464, 1367-1370 (2010).
    • (2010) Nature , vol.464 , pp. 1367-1370
    • Neill, D.R.1
  • 66
    • 44349167059 scopus 로고    scopus 로고
    • Dendritic cells in intestinal immune regulation
    • DOI 10.1038/nri2335, PII NRI2235
    • Coombes, J. L. & Powrie, F. Dendritic cells in intestinal immune regulation. Nature Rev. Immunol. 8, 435-446 (2008). (Pubitemid 351733420)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.6 , pp. 435-446
    • Coombes, J.L.1    Powrie, F.2
  • 67
    • 77952794397 scopus 로고    scopus 로고
    • Securing the immune tightrope: Mononuclear phagocytes in the intestinal lamina propria
    • Varol, C., Zigmond, E. & Jung, S. Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria. Nature Rev. Immunol. 10, 415-426 (2010).
    • (2010) Nature Rev. Immunol. , vol.10 , pp. 415-426
    • Varol, C.1    Zigmond, E.2    Jung, S.3
  • 68
    • 70049099836 scopus 로고    scopus 로고
    • Intestinal lamina propria dendritic cell subsets have different origin and functions
    • Varol, C. et al. Intestinal lamina propria dendritic cell subsets have different origin and functions. Immunity 31, 502-512 (2009).
    • (2009) Immunity , vol.31 , pp. 502-512
    • Varol, C.1
  • 69
    • 70049098070 scopus 로고    scopus 로고
    • Origin of the lamina propria dendritic cell network
    • Bogunovic, M. et al. Origin of the lamina propria dendritic cell network. Immunity 31, 513-525 (2009).
    • (2009) Immunity , vol.31 , pp. 513-525
    • Bogunovic, M.1
  • 70
    • 73949107838 scopus 로고    scopus 로고
    • Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions
    • Schulz, O. et al. Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J. Exp. Med. 206, 3101-3114 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 3101-3114
    • Schulz, O.1
  • 71
    • 77949911050 scopus 로고    scopus 로고
    • Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions
    • Niess, J. H. & Adler, G. Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions. J. Immunol. 184, 2026-2037 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 2026-2037
    • Niess, J.H.1    Adler, G.2
  • 72
    • 77955634800 scopus 로고    scopus 로고
    • Activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine
    • Manicassamy, S. et al. Activation of β-catenin in dendritic cells regulates immunity versus tolerance in the intestine. Science 329, 849-853 (2010).
    • (2010) Science , vol.329 , pp. 849-853
    • Manicassamy, S.1
  • 73
    • 77954131234 scopus 로고    scopus 로고
    • Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells
    • Laffont, S., Siddiqui, K. R. & Powrie, F. Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells. Eur. J. Immunol. 40, 1877-1883 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , pp. 1877-1883
    • Laffont, S.1    Siddiqui, K.R.2    Powrie, F.3
  • 74
    • 78650807608 scopus 로고    scopus 로고
    • Intestinal macrophages and response to microbial encroachment
    • Smith, P. D. et al. Intestinal macrophages and response to microbial encroachment. Mucosal Immunol. 4, 31-42 (2011).
    • (2011) Mucosal Immunol. , vol.4 , pp. 31-42
    • Smith, P.D.1
  • 75
    • 70350464351 scopus 로고    scopus 로고
    • Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    • Murai, M. et al. Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nature Immunol. 10, 1178-1184 (2009).
    • (2009) Nature Immunol. , vol.10 , pp. 1178-1184
    • Murai, M.1
  • 76
    • 79951772860 scopus 로고    scopus 로고
    • Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria
    • Hadis, U. et al. Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity 34, 237-246 (2011).
    • (2011) Immunity , vol.34 , pp. 237-246
    • Hadis, U.1
  • 77
    • 77951934151 scopus 로고    scopus 로고
    • E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis
    • Siddiqui, K. R., Laffont, S. & Powrie, F. E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. Immunity 32, 557-567 (2010).
    • (2010) Immunity , vol.32 , pp. 557-567
    • Siddiqui, K.R.1    Laffont, S.2    Powrie, F.3
  • 78
    • 77953644572 scopus 로고    scopus 로고
    • An independent subset of TLR expressing CCR2-dependent macrophages promotes colonic inflammation
    • Platt, A. M., Bain, C. C., Bordon, Y., Sester, D. P. & Mowat, A. M. An independent subset of TLR expressing CCR2-dependent macrophages promotes colonic inflammation. J. Immunol. 184, 6843-6854 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 6843-6854
    • Platt, A.M.1    Bain, C.C.2    Bordon, Y.3    Sester, D.P.4    Mowat, A.M.5
  • 79
    • 65749103989 scopus 로고    scopus 로고
    • Regulatory lymphocytes and intestinal inflammation
    • Izcue, A., Coombes, J. L. & Powrie, F. Regulatory lymphocytes and intestinal inflammation. Annu. Rev. Immunol. 27, 313-338 (2009).
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 313-338
    • Izcue, A.1    Coombes, J.L.2    Powrie, F.3
  • 80
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • Atarashi, K. et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 331, 337-341 (2011).
    • (2011) Science , vol.331 , pp. 337-341
    • Atarashi, K.1
  • 81
    • 77950349016 scopus 로고    scopus 로고
    • Th17 and regulatory T cells in mediating and restraining inflammation
    • Littman, D. R. & Rudensky, A. Y. Th17 and regulatory T cells in mediating and restraining inflammation. Cell 140, 845-858 (2010).
    • (2010) Cell , vol.140 , pp. 845-858
    • Littman, D.R.1    Rudensky, A.Y.2
  • 82
    • 53349164200 scopus 로고    scopus 로고
    • Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses
    • Hall, J. A. et al. Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity 29, 637-649 (2008).
    • (2008) Immunity , vol.29 , pp. 637-649
    • Hall, J.A.1
  • 83
    • 77951060733 scopus 로고    scopus 로고
    • OX40 is required for regulatory T cell-mediated control of colitis
    • Griseri, T., Asquith, M., Thompson, C. & Powrie, F. OX40 is required for regulatory T cell-mediated control of colitis. J. Exp. Med. 207, 699-709 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 699-709
    • Griseri, T.1    Asquith, M.2    Thompson, C.3    Powrie, F.4
  • 84
    • 70449532980 scopus 로고    scopus 로고
    • Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection
    • Oldenhove, G. et al. Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity 31, 772-786 (2009).
    • (2009) Immunity , vol.31 , pp. 772-786
    • Oldenhove, G.1
  • 85
    • 41549169557 scopus 로고    scopus 로고
    • Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor- and Interleukin-10
    • DOI 10.1016/j.immuni.2008.03.003, PII S1074761308001180
    • Li, M. O. & Flavell, R. A. Contextual regulation of inflammation: a duet by transforming growth factor-β and interleukin-10. Immunity 28, 468-476 (2008). (Pubitemid 351467045)
    • (2008) Immunity , vol.28 , Issue.4 , pp. 468-476
    • Li, M.O.1    Flavell, R.A.2
  • 86
    • 62949223226 scopus 로고    scopus 로고
    • Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression
    • Fantini, M. C. et al. Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression. Gastroenterology 136, 1308-1316.e3 (2009).
    • (2009) Gastroenterology , vol.136
    • Fantini, M.C.1
  • 87
    • 51649112340 scopus 로고    scopus 로고
    • T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance
    • Pesu, M. et al. T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance. Nature 455, 246-250 (2008).
    • (2008) Nature , vol.455 , pp. 246-250
    • Pesu, M.1
  • 88
    • 43249097073 scopus 로고    scopus 로고
    • CD3-specific antibody-induced immune tolerance involves transforming growth factor- from phagocytes digesting apoptotic T cells
    • DOI 10.1038/nm1749, PII NM1749
    • Perruche, S. et al. CD3-specific antibody-induced immune tolerance involves transforming growth factor-β from phagocytes digesting apoptotic T cells. Nature Med. 14, 528-535 (2008). (Pubitemid 351655213)
    • (2008) Nature Medicine , vol.14 , Issue.5 , pp. 528-535
    • Perruche, S.1    Zhang, P.2    Liu, Y.3    Saas, P.4    Bluestone, J.A.5    Chen, W.6
  • 89
    • 61949472508 scopus 로고    scopus 로고
    • Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation
    • Torchinsky, M. B., Garaude, J., Martin, A. P. & Blander, J. M. Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation. Nature 458, 78-82 (2009).
    • (2009) Nature , vol.458 , pp. 78-82
    • Torchinsky, M.B.1    Garaude, J.2    Martin, A.P.3    Blander, J.M.4
  • 90
    • 73349099737 scopus 로고    scopus 로고
    • A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota
    • Cong, Y., Feng, T., Fujihashi, K., Schoeb, T. R. & Elson, C. O. A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota. Proc. Natl Acad. Sci. USA 106, 19256-19261 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 19256-19261
    • Cong, Y.1    Feng, T.2    Fujihashi, K.3    Schoeb, T.R.4    Elson, C.O.5
  • 91
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • Saraiva, M. & O'Garra, A. The regulation of IL-10 production by immune cells. Nature Rev. Immunol. 10, 170-181 (2010).
    • (2010) Nature Rev. Immunol. , vol.10 , pp. 170-181
    • Saraiva, M.1    O'Garra, A.2
  • 92
    • 70949087383 scopus 로고    scopus 로고
    • Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
    • Glocker, E. O. et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N. Engl. J. Med. 361, 2033-2045 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 2033-2045
    • Glocker, E.O.1
  • 93
    • 69449105914 scopus 로고    scopus 로고
    • Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
    • Smith, A. M. et al. Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J. Exp. Med. 206, 1883-1897 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1883-1897
    • Smith, A.M.1
  • 94
    • 77957157893 scopus 로고    scopus 로고
    • Gut inflammation provides a respiratory electron acceptor for Salmonella
    • Winter, S. E. et al. Gut inflammation provides a respiratory electron acceptor for Salmonella. Nature 467, 426-429 (2010).
    • (2010) Nature , vol.467 , pp. 426-429
    • Winter, S.E.1
  • 95
    • 38649115342 scopus 로고    scopus 로고
    • Microbial Influences in Inflammatory Bowel Diseases
    • DOI 10.1053/j.gastro.2007.11.059, PII S0016508507021579
    • Sartor, R. B. Microbial influences in inflammatory bowel diseases. Gastroenterology 134, 577-594 (2008). (Pubitemid 351173057)
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 577-594
    • Sartor, R.B.1
  • 96
    • 78650099360 scopus 로고    scopus 로고
    • Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases
    • Frank, D. N. et al. Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases. Inflamm. Bowel Dis. 17, 179-184 (2011).
    • (2011) Inflamm. Bowel Dis. , vol.17 , pp. 179-184
    • Frank, D.N.1
  • 97
    • 78649686679 scopus 로고    scopus 로고
    • A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes
    • Willing, B. P. et al. A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology 139, 1844-1854.e1 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 1844-1854
    • Willing, B.P.1
  • 98
    • 78650408264 scopus 로고    scopus 로고
    • Diet gut microbiota and immune responses
    • Maslowski, K. M. & Mackay, C. R. Diet, gut microbiota and immune responses. Nature Immunol. 12, 5-9 (2011).
    • (2011) Nature Immunol. , vol.12 , pp. 5-9
    • Maslowski, K.M.1    MacKay, C.R.2
  • 99
    • 77953904042 scopus 로고    scopus 로고
    • Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
    • Cadwell, K. et al. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell 141, 1135-1145 (2010).
    • (2010) Cell , vol.141 , pp. 1135-1145
    • Cadwell, K.1
  • 100
    • 77956569409 scopus 로고    scopus 로고
    • Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis
    • Garrett, W. S. et al. Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe 8, 292-300 (2010).
    • (2010) Cell Host Microbe , vol.8 , pp. 292-300
    • Garrett, W.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.