hPepT1 transports muramyl dipeptide, activating NF-κB and stimulating IL-8 secretion in human colonic Caco2/bbe cells

Gastroenterology

Volumn 127, Issue 5, 2004, Pages 1401-1409

  Vavricka, Stephan R ^a   Musch, Mark W ^a   Chang, Jonathan E ^a   Nakagawa, Yasushi ^a   Phanvijhitsiri, Kittiporn ^a   Waypa, Tonya S ^a   Merlin, Didier ^b   Schneewind, Olaf ^a   Chang, Eugene B ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; MURAMYL DIPEPTIDE; PEPTIDE TRANSPORTER 1; SARCOSINE; SMALL INTERFERING RNA;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CECUM; CELL LINE; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOSOL; DOWNSTREAM PROCESSING; DUODENUM; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FECES; HUMAN; HUMAN CELL; INTESTINE; MEASUREMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN TRANSPORT; STEREOCHEMISTRY; TIME;

EID: 7644234401     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2004.07.024     Document Type: Article

References (24)

1. J.P. Hugot, M. Chamillard, H. Zouali, S. Lesage, J.P. Cezard, J. Belaiche, S. Almer, C. Tysk, C.A. O'Morain, M. Gassull, V. Binder, Y. Finkel, A. Cortot, R. Modigliani, P. Laurent-Puig, C. Gower-Rousseau, J. Macry, J.F. Colombel, M. Sahatou, G. Thomas Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Nature 411 2001 599 603
2. Y. Ogura, D.K. Bonen, N. Inohara, D.L. Nicolae, F.F. Chen, R. Ramos, H. Britton, T. Moran, R. Karaliuskas, R.H. Duerr, J.P. Achkar, S.R. Brant, T.M. Bayless, B.S. Kirschner, S.B. Hanauer, G. Nunez, J.H. Cho A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease Nature 411 2001 603 606
3. S.E. Girardin, I.G. Boneca, J. Viala, M. Chamaillard, A. Labigne, G. Thomas, D.J. Philipott, P.J. Sansonetti Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection J Biol Chem 278 2003 8869 8872
4. D.K. Bonen, Y. Ogura, D.L. Nicolae, N. Inohara, L. Saab, T. Tanabe, F.F. Chen, S.J. Foster, R.H. Duerr, S.R. Brant, J.H. Cho, G. Nunez Crohn's disease-associated NOD2 variants share a signalling defect in response to lipopolysaccharide and peptidoglycan Gastroenterology 124 2003 140 146
5. Y.K. Fei, Y. Kanai, S. Nussberger, V. Ganapathy, F.H. Leibach, M.F. Romero, S.K. Singh, W.F. Boron, M.A. Hedinger Expression cloning of a mammalian proton-coupled oligopeptide transporter Nature 368 1994 563 566
6. R. Liang, Y.J. Fei, P.D. Prasad, S. Ramamoorthy, H. Han, T.L. Yang-Feng, M.A. Hediger, V. Ganapathy, F.H. Leibach Human intestinal H+/peptide cotransporter Cloning, functional expression, and chromosomal localization J Biol Chem 270 1995 6456 6463
7. A.E. Adibi The oligopeptide transport (PepT1) in human intestine biology and function Gastroenterology 113 1997 332 340
8. M.E. Ganapathy, M. Brandsch, P.D. Prasad, V. Ganapathy, F.H. Leibach Differential recognition of beta-lactam antibiotics by intestinal and renal peptide transporters, PEPT1 and PEPT2 J Biol Chem 270 1995 25672 25677
9. D. Merlin, A. Steel, A.T. Gewirtz, M. Si-Tahar, M.A. Hediger, J.L. Madara hPepT1-mediated epithelial transport of bacteria-derived chemotactic peptides enhances neutrophil-epithelial interactions J Clin Invest 102 1998 2011 2018
10. R.K. Bommakanti, G.M. Bokoch, J.O. Tolley, R.E. Schreiber, D.W. Siemsen, K.N. Klotz, A.J. Jesaitis Reconstitution of a physical complex between the N-formyl chemotactic peptide receptor and G protein Inhibition by pertussis toxin-catalysed ADP ribosylation J Biol Chem 267 1992 7576 7581
11. M. Buyse, A. Tsocas, F. Walker, D. Merlin, A. Bado PepT1-mediated fMLP transport induces intestinal inflammation in vivo Am J Physiol 283 2002 C1795 C1800
12. H. Ogihara, H. Saito, B.C. Shin, T. Terada, S. Takenoshita, Y. Nagamachi, K.I. Inui, K. Takata Immuno-localization of H+/peptide cotransporter in rat digestive tract Biochem Biophys Res Commun 220 1996 848 852
13. D. Merlin, M. Si-Tahar, S.V. Sitaraman, K. Eastburn, I. Williams, X. Liu, M.A. Hediger, J.L. Madara Colonic epithelial hPepT1 expression occurs in inflammatory bowel disease transport of bacterial peptides influences expression of MHC class 1 molecules Gastroenterology 120 2001 1666 1679
14. H.D. Hill, J.G. Straka Protein determination using bicinchoninic acid in the presence of sulfhydryl reagents Anal Biochem 170 1988 203 208
15. M.S. Inan, R.J. Rasoulpour, L. Yin, A.K. Hubbard, D.W. Rosenberg, C. Giardina The luminal short-chain fatty acid butyrate modulates NFkB activity in a human colonic epithelial cell line Gastroenterology 118 2001 724 734
16. D. Aminoff Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids Biochem J 81 1961 384 392
17. Y. Ogura, N. Inohara, A. Benito, F.F. Chen, S. Yamaoka, G. Nunez Nod2, a nod17apaf-1 family member that is restricted to monocytes and activates NF-κB J Biol Chem 276 2001 4812 4818
18. K.A. Reed, M.E. Hobert, C.E. Kolenda, K.A. Sands, M. Rathman, M. O'Connor, S. Lyons, A.T. Gewirtz, P.J. Sansonetti, J.L. Madara The salmonella typhimurium flagellar basal body protein FliE is required for flagellin production and to induce a proinflammatory response in epithelial cells J Biol Chem 277 2002 13346 13353
19. S.D. Savkovic, A. Koutsouris, G. Hecht Activation of NF-kappaB in intestinal epithelial cells by enteropathogenic Escherichia coli Am J Physiol 273 1997 C1160 C1167
20. O. Gutierrez, C. Pipaon, N. Inohara, A. Fontalba, Y. Ogura, F. Prosper, G. Nunez, J.L. Fernandez-Luna Induction of nod2 in myelomonocytic and intestinal epithelial cells via nuclear factor-kappa B activation J Biol Chem 277 2002 41701 41705
21. P. Rosenstiel, M. Fantini, K. Bräutigam, T. Kuhbacher, G. Waetzig, D. Seegert, S. Schreiber TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells Gastroenterology 124 2003 1001 1009
22. S. Lala, Y. Ogura, C. Osborne, S.Y. Hor, A. Bromfield, S. Davies, O. Oggunbiyi, G. Nunez, S. Keshav Crohn's disease and the nod2 gene a role for Paneth cells Gastroenterology 125 2003 47 57
23. M. Buyse, L. Charrier, S. Sitaraman, A. Gewirtz, D. Merlin Interferon-γ increases hPepT1-mediated uptake of di-tripeptides including the bacterial tripeptide fMLP in polarized intestinal epithelia Am J Pathol 163 2003 1969 1977
24. F.M. Ruemmele, C. Gurbindo, A.M. Mansour, R. Marchand, E. Levy, E.G. Seidman Effects of interferon gamma, apoptosis, and MHC class II expression of immature rat intestinal crypt (IEC-6) cells J Cell Physiol 176 1998 120 126