The molecular basis of NOD2 susceptibility mutations in crohn’s disease

Mucosal Immunology

Volumn 1, Issue , 2008, Pages 5-9

  Strober, W ^a   Kitani, A ^a   Fuss, I ^a   Asano, N ^a   Watanabe, T ^a,b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; INTERFERON REGULATORY FACTOR 4; MURAMYL DIPEPTIDE; TOLL LIKE RECEPTOR;

ANTIGEN PRESENTING CELL; CELL STIMULATION; COLITIS; CROHN DISEASE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; INTESTINE FLORA; METABOLIC REGULATION; MUTATIONAL ANALYSIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CROHN DISEASE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MUTATION; NOD2 SIGNALING ADAPTOR PROTEIN; TOLL-LIKE RECEPTORS;

EID: 54349095688     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2008.42     Document Type: Review

References (8)

1. Hugot, J. P. et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature 411, 599-603 (2001).
2. Ogura, Y. et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease. Nature 411, 603-606 (2001).
3. Strober, W., Murray, P. J., Kitani, A. & Watanabe, T. Signalling pathways and molecular interactions of NOD1 and NOD2. Nat. Rev. Immunol. 6, 9-20 (2006).
4. Abbott, D. W., Wilkins, A., Asara, J. M. & Cantley, L. C. The Crohn’s disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr. Biol. 14, 2217-2227 (2004).
5. Watanabe, T., Kitani, A., Murray, P. J. & Strober, W. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat. Immunol. 5, 800-808 (2004).
6. Watanabe, T., Kitani, A., Murray, P. J., Wakatsuki, Y., Fuss, I. J. & Strober, W. Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 25, 473-485 (2006).
7. Yang, Z. et al. NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction. Gastroenterology 133, 1510-1521 (2007).
8. Watanabe, T. et al. Muramyl dipeptide activation of nucleotide binding oligomerization domain 2 protects mice from experimental colitis. J. Clin. Invest. 118, 545-559 (2008).