Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)

Oncogene

Volumn 23, Issue 22, 2004, Pages 3999-4006

  Duensing, Anette ^a,e   Medeiros, Fabiola ^a   McConarty, Bryna ^a   Joseph, Nora E ^a   Panigrahy, Dipak ^b   Singer, Samuel ^c   Fletcher, Christopher D M ^a   Demetri, George D ^d   Fletcher, Jonathan A ^a,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

GIST; Imatinib; Kinase; KIT; Signal transduction

Indexed keywords

IMATINIB; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE B; PROTEIN P44; PROTEIN TYROSINE KINASE; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVATION; EXON; GASTROINTESTINAL STROMAL TUMOR; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; APOPTOSIS; CELL DIVISION; CYTOLOGY; FEMALE; GASTROINTESTINAL TUMOR; MALE; METABOLISM; PHYSIOLOGY; STROMA CELL;

APOPTOSIS; CELL DIVISION; FEMALE; GASTROINTESTINAL NEOPLASMS; HUMANS; MALE; ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-KIT; SIGNAL TRANSDUCTION; STROMAL CELLS;

EID: 2542520755     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207525     Document Type: Article

References (51)

1. Beghini A, Tibiletti MG, Roversi G, Chiaravalli AM, Serio G, Capella C and Larizza L. (2001). Cancer, 92, 657-662.
2. Blume-Jensen P, Janknecht R and Hunter T. (1998). Curr. Biol., 8, 779-782.
3. Brizzi MF, Dentelli P, Rosso A, Yarden Y and Pegoraro L. (1999). J. Biol. Chem., 274, 16965-16972.
4. Caruana G, Cambareri AC and Ashman LK. (1999). Oncogene, 18, 5573-5581.
5. Casteran N, De Sepulveda P, Beslu N, Aoubala M, Letard S, Lecocq E, Rottapel R and Dubreuil P. (2003). Oncogene, 22, 4710-4722.
6. Chen H, Isozaki K, Kinoshita K, Ohashi A, Shinomura Y, Matsuzawa Y, Kitamura Y and Hirota S. (2003). Int. J. Cancer, 105, 130-135.
7. Chian R, Young S, Danilkovitch-Miagkova A, Ronnstrand L, Leonard E, Ferrao P, Ashman L and Linnekin D. (2001). Blood, 98, 1365-1373.
8. Corless CL, McGreevey L, Haley A, Town A and Heinrich MC. (2002). Am. J. Pathol., 160, 1567-1572.
9. De Miguel MP, Cheng L, Holland EC, Federspiel MJ and Donovan PJ. (2002). Proc. Natl. Acad. Sci. USA, 99, 10458-10463.
10. Deberry C, Mou S and Linnekin D. (1997). Biochem. J., 327 (Part 1), 73-80.
11. Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD and Joensuu H. (2002). N. Engl. J. Med., 347, 472-480.
12. Dolci S, Pellegrini M, Di Agostino S, Geremia R and Rossi P. (2001). J. Biol. Chem., 276, 40225-40233.
13. Ernst SI, Hubbs AE, Przygodzki RM, Emory TS, Sobin LH and O'Leary TJ. (1998). Lab. Invest., 78, 1633-1636.
14. Feng LX, Ravindranath N and Dym M. (2000). J. Biol. Chem., 275, 25572-25576.
15. Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, Miettinen M, O'Leary TJ, Remotti H, Rubin BP, Shmookler B, Sobin LH and Weiss SW. (2002). Hum. Pathol., 33, 459-465.
16. Frost MJ, Ferrao PT, Hughes TP and Ashman LK. (2002). Mol. Cancer Ther., 1, 1115-1124.
17. Heinrich MC, Corless CL, Demetri GD, Blanke CD, von Mehren M, Joensuu H, McGreevey LS, Chen CJ, Van den Abbeele AD, Druker BJ, Kiese B, Eisenberg B, Roberts PJ, Singer S, Fletcher CD, Silberman S, Dimitrijevic S and Fletcher JA. (2003a). J. Clin. Oncol., 21, 4342-4349.
18. Heinrich MC, Corless CL, Duensing A, McGreevey L, Chen CJ, Joseph N, Singer S, Griffith DJ, Haley A, Town A, Demetri GD, Fletcher CD and Fletcher JA. (2003b). Science, 299, 708-710.
19. Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, Kawano K, Hanada M, Kurata A, Takeda M, Muhammad Tunio G, Matsuzawa Y, Kanakura Y, Shinomura Y and Kitamura Y. (1998). Science, 279, 577-580.
20. Hirota S, Okazaki T, Kitamura Y, O'Brien P, Kapusta L and Dardick I. (2000). Am. J. Surg. Pathol., 24, 326-327.
21. Hornick JL and Fletcher CD. (2002). Am. J. Clin. Pathol., 117, 188-193.
22. Huizinga JD, Thuneberg L, Kluppel M, Malysz J, Mikkelsen HB and Bernstein A. (1995). Nature, 373, 347-349.
23. Isozaki K, Terris B, Belghiti J, Schiffmann S, Hirota S and Vanderwinden JM. (2000). Am. J. Pathol., 157, 1581-1585.
24. Joensuu H, Roberts PJ, Sarlomo-Rikala M, Andersson LC, Tervahartiala P, Tuveson D, Silberman S, Capdeville R, Dimitrijevic S, Druker B and Demetri GD. (2001). N. Engl J. Med., 344, 1052-1056.
25. Kindblom LG, Remotti HE, Aldenborg F and Meis-Kindblom JM. (1998). Am. J. Pathol., 152, 1259-1269.
26. Klejman A, Schreiner SJ, Nieborowska-Skorska M, Slupianek A, Wilson M, Smithgall TE and Skorski T. (2002). EMBO J., 21, 5766-5774.
27. Lai CF, Ripperger J, Morella KK, Wang Y, Gearing DP, Horseman ND, Campos SP, Fey GH and Baumann H. (1995). J. Biol. Chem., 270, 23254-23257.
28. Lasota J, Jasinski M, Sarlomo-Rikala M and Miettinen M. (1999). Am. J. Pathol., 154, 53-60.
29. Lennartsson J, Blume-Jensen P, Hermanson M, Ponten E, Carlberg M and Ronnstrand L. (1999). Oncogene, 18, 5546-5553.
30. Lev S, Givol D and Yarden Y. (1992). Proc. Natl. Acad. Sci. USA, 89, 678-682.
31. Linnekin D. (1999). Int. J. Biochem. Cell Biol., 31, 1053-1074.
32. Linnekin D, Weiler SR, Mou S, DeBerry CS, Keller JR, Ruscetti FW, Ferris DK and Longo DL. (1996). Acta Haematol., 95, 224-228.
33. Lux ML, Rubin BP, Biase TL, Chen CJ, Maclure T, Demetri G, Xiao S, Singer S, Fletcher CD and Fletcher JA. (2000). Am. J. Pathol, 156, 791-795.
34. Maeyama H, Hidaka E, Ota H, Minami S, Kajiyama M, Kuraishi A, Mori H, Matsuda Y, Wada S, Sodeyama H, Nakata S, Kawamura N, Hata S, Watanabe M, Iijima Y and Katsuyama T. (2001). Gastroenterology, 120, 210-215.
35. Nieborowska-Skorska M, Hoser G, Kossev P, Wasik MA and Skorski T. (2002). Blood, 99, 4531-4539.
36. Ning ZQ, Li J and Arceci RJ. (2001a). Leuk. Lymphoma, 41, 513-522.
37. Ning ZQ, Li J and Arceci RJ. (2001b). Blood, 97, 3559-3567.
38. Nishida T, Hirota S, Taniguchi M, Hashimoto K, Isozaki K, Nakamura H, Kanakura Y, Tanaka T, Takabayashi A, Matsuda H and Kitamura Y. (1998). Nat. Genet., 19, 323-324.
39. Rubin BP, Singer S, Tsao C, Duensing A, Lux ML, Ruiz R, Hibbard MK, Chen CJ, Xiao S, Tuveson DA, Demetri GD, Fletcher CD and Fletcher JA. (2001). Cancer Res., 61, 8118-8121.
40. Sircar K, Hewlett BR, Huizinga JD, Chorneyko K, Berezin I and Riddell RH. (1999). Am. J. Surg. Pathol., 23, 377-389.
41. Sommer G, Agosti V, Ehlers I, Rossi F, Corbacioglu S, Farkas J, Moore M, Manova K, Antonescu CR and Besmer P. (2003). Proc. Natl. Acad. Sci. USA, 100, 6706-6711.
42. Taniguchi M, Nishida T, Hirota S, Isozaki K, Ito T, Nomura T, Matsuda H and Kitamura Y. (1999). Cancer Res., 59, 4297-4300.
43. Taylor ML and Metcalfe DD. (2000). Hematol. Oncol. Clin. North Am., 14, 517-535.
44. Thommes K, Lennartsson J, Carlberg M and Ronnstrand L. (1999). Biochem. J., 341 (Part 1), 211-216.
45. Tsai M, Chen RH, Tam SY, Blenis J and Galli SJ. (1993). Eur. J. Immunol., 23, 3286-3291.
46. Tuveson DA, Willis NA, Jacks T, Griffin JD, Singer S, Fletcher CD, Fletcher JA and Demetri GD. (2001). Oncogene, 20, 5054-5058.
47. van Oosterom AT, Judson I, Verweij J, Stroobants S, Donato dP, Dimitrijevic S, Martens M, Webb A, Sciot R, Van Glabbeke M, Silberman S and Nielsen OS. (2001). Lancet, 358, 1421-1423.
48. Voytyuk O, Lennartsson J, Mogi A, Caruana G, Courtneidge S, Ashman LK and Ronnstrand L. (2003). J. Biol. Chem., 278, 9159-9166.
49. Weiler SR, Mou S, DeBerry CS, Keller JR, Ruscetti FW, Ferris DK, Longo DL and Linnekin D. (1996). Blood, 87, 3688-3693.
50. Wu M, Hemesath TJ, Takemoto CM, Horstmann MA, Wells AG, Price ER, Fisher DZ and Fisher DE. (2000). Genes Dev., 14, 301-312.
51. Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U and Ullrich A. (1987). EMBO J., 6, 3341-3351.