Identification and characterization of small molecule inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 7, 2013, Pages 2225-2229

  Zhang, Mingming ^a   Zhu, Weiliang ^b   Ding, Ning ^a   Zhang, Wei ^a   Li, Yingxia ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Antitumor activity; Cell viability; Small molecule inhibitors; STAT3 signaling; Virtual screening

Indexed keywords

CUCURBITACIN Q; DOUBLE STRANDED DNA; INTERLEUKIN 6; NICLOSAMIDE; PROTEIN TYROSINE KINASE; SCAFFOLD PROTEIN; SMALL MOLECULE TRANSPORT AGENT; STAT3 PROTEIN; STX 0119; TRICYCLIC AROMATIC COMPOUND; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; VIRTUAL SCREENING; X RAY CRYSTALLOGRAPHY;

CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; STAT3 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875209735     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.01.056     Document Type: Article

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