Antitumor activity of a novel small molecule STAT3 inhibitor against a human lymphoma cell line with high STAT3 activation

International Journal of Oncology

Volumn 38, Issue 5, 2011, Pages 1245-1252

  Ashizawa, Tadashi ^a   Miyata, Haruo ^a   Ishii, Hidee ^a   Oshita, Chie ^a   Matsuno, Kenji ^b   Masuda, Yoshiaki ^c   Furuya, Toshio ^c   Okawara, Tadashi ^d   Otsuka, Masami ^e   Ogo, Naohisa ^f   Asai, Akira ^b   Akiyama, Yasuto ^a  

^a SHIZUOKA CANCER CENTER   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

^c PharmaDesign Inc   (Japan)

^d KUMAMOTO HEALTH SCIENCE UNIVERSITY   (Japan)

^e KUMAMOTO UNIVERSITY   (Japan)

^f SHIZUOKA INSTITUTE OF ENVIRONMENT AND HYGIENE   (Japan)

Author keywords

Dimerization; Lymphoma; Phosphorylated STAT3; STAT3

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CYCLIN D1; CYTARABINE; INTERLEUKIN 6; KI 67 ANTIGEN; LEUKEMIA INHIBITORY FACTOR; MYC PROTEIN; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PROTEIN BCL XL; PROTEIN INHIBITOR; STAT3 PROTEIN; STX 0119; SURVIVIN; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL ASSAY; CONTROLLED STUDY; DIMERIZATION; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOMA; LYMPHOMA CELL LINE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TOXICITY TESTING; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; LYMPHOMA; MALE; MICE; MICE, INBRED BALB C; OXADIAZOLES; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; QUINOLINES; STAT3 TRANSCRIPTION FACTOR;

EID: 79955000497     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.957     Document Type: Article

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