Specific inhibition of interleukin-4-dependent Stat6 activation by an intracellularly delivered peptide

European Journal of Biochemistry

Volumn 268, Issue 17, 2001, Pages 4809-4814

  Stolzenberger, Sascha ^a   Haake, Markus ^a   Duschl, Albert ^a,b  

^a Physiological Chemistry II   (Germany)

^b Department of Chemistry and Biochemistry ^*  (Austria)

Author keywords

Antennapedia; IL 4; Inhibitor; Peptide; Stat6

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; PERVANADATE; STAT5 PROTEIN; STAT6 PROTEIN; STAT6B PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENE CONSTRUCT; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RECEPTOR GENE;

ANTENNAPEDIA HOMEODOMAIN PROTEIN; CELL MEMBRANE PERMEABILITY; DNA-BINDING PROTEINS; ENDOCYTOSIS; ENZYME INHIBITORS; HOMEODOMAIN PROTEINS; HUMANS; INTERLEUKIN-4; MILK PROTEINS; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; RECEPTORS, INTERLEUKIN-4; RECOMBINANT FUSION PROTEINS; STAT5 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; VANADATES;

EID: 0035725741     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.02417.x     Document Type: Article

References (42)

1. Molecular basis of allergic diseases
2. Interleukin-4 and interleukin-13: Their similarities and discrepancies
3. The IL-4 receptor: Signaling mechanisms and biologic functions
4. Differences between IL-4- and IL-4 receptor α-deficient mice in chronic Leishmaniasis reveal a protective role for IL-13 receptor signaling
5. IL-4 is required to generate and sustain in vivo IgE responses
6. In vivo biological effects of recombinant soluble interleukin-4 receptor
7. Inhibition of allergen-induced IgE and IgG1 production by soluble IL-4 receptor
8. Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo controlled trial
9. Conversion of human interleukin-4 into a high affinity antagonist by a single amino acid replacement
10. Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation
11. An antagonistic IL-4 mutant prevents type I allergy in the mouse. Inhibition of the IL-4/IL13 receptor system completely abrogates humoral immune response to allergen and development of allergic symptoms in vivo
12. The Jak-STAT pathway: Cytokine signalling from the receptor to the nucleus
13. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
14. Essential role of Stat6 in IL-4 signalling
15. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells
16. Molecular mechanisms of immunoglobulin E regulation
17. Interleukin-4 suppression of tumor necrosis factor α-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-kB
18. IL-4-induced STAT6 suppresses IFN-γ-stimulated STAT1-dependent transcription in mouse macrophages
19. Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor
20. An interleukin-4-induced transcription factor: IL-4 Stat
21. Components of a Stat recognition code: Evidence for two layers of molecular stability
22. Getting hydrophilic compounds into cells: Lessons from homeopeptides
23. Cell-penetrating peptides
24. Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor
25. The environmental pollutant pyrene induces the production of IL-4
26. Mutant proteins of human interleukin 2
27. Site-directed mutagenesis reveals the importance of disulfide bridges and aromatic residues for structure and proliferative activity of human interleukin-4
28. The interleukin-4 receptor: Structure, function, and signal transduction
29. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa
30. Different human interleukin-4 mutants preferentially activate human or murine common receptor γ chain
31. Solid phase synthesis of peptides containing the non-hydrolysable analog of (O) phosphotyrosine, p. (CH2PO3H2) Phe
32. IL4 and IL13 receptors share the γc chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells
33. Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells
34. In vivo protein transduction: Intracellular delivery of biologically active proteins, compounds and DNA
35. Trojan peptides: The penetratin system for intracellular delivery
36. A Sos-derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity
37. Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325
38. Inhibition of FGF-stimulated phosphatidylinositol hydrolysis and neurite outgrowth by a cell-membrane permeable phosphopeptide
39. Selective inhibition of growth factor-stimulated mitogenesis by a cell-permeable Grb2-binding peptide
40. p21WAF1-derived peptides linked to an internalization peptide inhibit human cancer cell growth
41. STAT6: An intracellular target for the inhibition of allergic disease
42. Signal transduction mechanisms as new targets for allergists