A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells

Molecular Cancer

Volumn 9, Issue , 2010, Pages

  Lin, Li ^a,b   Deangelis, Stephanie ^a   Foust, Elizabeth ^a   Fuchs, James ^c   Li, Chenglong ^c   Li, Pui Kai ^c   Schwartz, Eric B ^c   Lesinski, Gregory B ^c   Benson, Don ^c   Lü, Jiagao ^b   Hoyt, Dale ^c   Lin, Jiayuh ^a,d  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c OHIO STATE UNIVERSITY   (United States)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CURCUMIN; DNA; FLLL 32; GAMMA INTERFERON; INTERLEUKIN 6; LIPID KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE; PROTEIN SH2; PROTEIN SH3; PROTEIN TYROSINE KINASE; STAT3 PROTEIN; UNCLASSIFIED DRUG; DRUG DERIVATIVE; STAT3 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL VIABILITY; COLORECTAL CANCER; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; ENZYME DEGRADATION; ENZYME INHIBITION; FEMALE; GENE EXPRESSION REGULATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LIVER CANCER; MITOSIS INHIBITION; MOLECULAR DOCKING; MOUSE; MULTIPLE MYELOMA; NONHUMAN; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SOLID TUMOR; CELL DIVISION; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

CELL DIVISION; CELL LINE, TUMOR; CURCUMIN; DNA; HUMANS; PHOSPHORYLATION; STAT3 TRANSCRIPTION FACTOR;

EID: 77955520465     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-9-217     Document Type: Article

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