Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3

Journal of Medicinal Chemistry

Volumn 54, Issue 10, 2011, Pages 3549-3563

  Mandal, Pijus K ^a   Gao, Fengqin ^a   Lu, Zhen ^a   Ren, Zhiyong ^a,b   Ramesh, Rajagopal ^a,c   Birtwistle, J Sanderson ^a   Kaluarachchi, Kumaralal K ^a   Chen, Xiaomin ^a,d   Bast, Robert C ^a   Liao, Warren S ^a   McMurray, John S ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 PHOSPHOCINNAMIDE; BETA METHYLCINNAMIDE; CINNAMIC ACID DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPEPTIDE; PRODRUG; PROTEIN P85; PROTEIN SH2; PROTEIN TYROSINE KINASE; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

EID: 79957742210     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2000882     Document Type: Article

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