Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice

Journal of Molecular Medicine

Volumn 89, Issue 7, 2011, Pages 713-727

  Shanmugam, Muthu K ^a   Rajendran, Peramaiyan ^a   Li, Feng ^a   Nema, Tarang ^b   Vali, Shireen ^c,d   Abbasi, Taher ^c,d   Kapoor, Shweta ^c,d   Sharma, Ashish ^c,d   Kumar, Alan Prem ^a,e   Ho, Paul C ^b   Hui, Kam M ^f   Sethi, Gautam ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c CELLWORKS GROUP INC   (United States)

^d Cellworks Research India Pvt Ltd   (India)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f DIVISION OF MEDICAL ONCOLOGY   (Singapore)

Author keywords

NF B; Prostate cancer; STAT3; Ursolic acid

Indexed keywords

I KAPPA B KINASE; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; STAT3 PROTEIN; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; URSOLIC ACID;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FUNCTIONAL PROTEOMICS; GENE ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MALE; MOUSE; NONHUMAN; PROSTATE CANCER; PROTEIN EXPRESSION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOWN-REGULATION; EIF-2 KINASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; I-KAPPA B KINASE; INTERLEUKIN-6; JANUS KINASE 2; MALE; MICE; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PROTEOMICS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79960009770     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-011-0746-2     Document Type: Article

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