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Volumn 53, Issue 1, 2007, Pages 1-6

Transcription protein STAT1: Biology and relation to cancer

Author keywords

Aberrations in cancer; Biology; IFNs; STAT1

Indexed keywords

ALPHA INTERFERON; CASPASE 11; CISPLATIN; DOXORUBICIN; GAMMA INTERFERON; INTERFERON; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 4; PROTEIN BAK; PROTEIN BAX; STAT1 PROTEIN; STAT2 PROTEIN;

EID: 33847418900     PISSN: 00155500     EISSN: 25337602     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (57)

References (71)
  • 1
    • 0032934156 scopus 로고    scopus 로고
    • Functional roles of STAT family proteins: Lessons from knockout mice
    • Akira, S. (1999) Functional roles of STAT family proteins: lessons from knockout mice. Stem Cells 17, 138-146.
    • (1999) Stem Cells , vol.17 , pp. 138-146
    • Akira, S.1
  • 2
    • 0036138705 scopus 로고    scopus 로고
    • A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: Dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus
    • Aoki, N., Matsuda, T. (2002) A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus. Mol. Endocrinol. 16, 58-69.
    • (2002) Mol. Endocrinol. , vol.16 , pp. 58-69
    • Aoki, N.1    Matsuda, T.2
  • 3
    • 0036625960 scopus 로고    scopus 로고
    • The role of STATs in apoptosis
    • Battle, T. E., Frank, D. A. (2002) The role of STATs in apoptosis. Curr. Mol. Med. 2, 381-392.
    • (2002) Curr. Mol. Med. , vol.2 , pp. 381-392
    • Battle, T.E.1    Frank, D.A.2
  • 4
    • 0042324670 scopus 로고    scopus 로고
    • Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients
    • Boudny, V., Kocak, I., Lauerova, L., Kovarik, J. (2003) Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients. Folia Biol. (Praha) 49, 142-146.
    • (2003) Folia Biol. (Praha) , vol.49 , pp. 142-146
    • Boudny, V.1    Kocak, I.2    Lauerova, L.3    Kovarik, J.4
  • 8
    • 0035142665 scopus 로고    scopus 로고
    • Activation of STAT proteins and growth control
    • Bromberg, J. F. (2001) Activation of STAT proteins and growth control. BioEssays 23, 161-169.
    • (2001) BioEssays , vol.23 , pp. 161-169
    • Bromberg, J.F.1
  • 9
    • 0034657336 scopus 로고    scopus 로고
    • The role of STATs in transcriptional control and their impact on cellular function
    • Bromberg, J., Darnell, J. E. Jr. (2000) The role of STATs in transcriptional control and their impact on cellular function. Oncogene 19, 2468-2473.
    • (2000) Oncogene , vol.19 , pp. 2468-2473
    • Bromberg, J.1    Darnell Jr., J.E.2
  • 10
    • 0029799912 scopus 로고    scopus 로고
    • Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon α and interferon γ
    • Bromberg, J. F., Horvath, C. M., Wen, Z., Schreiber, R. D., Darnell, J. E. Jr. (1996) Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon α and interferon γ. Proc. Natl. Acad. Sci. USA 93, 7673-7678.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 7673-7678
    • Bromberg, J.F.1    Horvath, C.M.2    Wen, Z.3    Schreiber, R.D.4    Darnell Jr., J.E.5
  • 12
    • 0036554816 scopus 로고    scopus 로고
    • Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention
    • Buettner, R., Mora, L. B., Jove, R. (2002) Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin. Cancer Res. 8, 945-954.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 945-954
    • Buettner, R.1    Mora, L.B.2    Jove, R.3
  • 13
    • 0034616170 scopus 로고    scopus 로고
    • Interleukin-4 mediates cell growth inhibition through activation of Stat1
    • Chang, T. L., Peng, X., Fu, X. Y. (2000) Interleukin-4 mediates cell growth inhibition through activation of Stat1. J. Biol. Chem. 275, 10212-10217.
    • (2000) J. Biol. Chem. , vol.275 , pp. 10212-10217
    • Chang, T.L.1    Peng, X.2    Fu, X.Y.3
  • 14
    • 0034254726 scopus 로고    scopus 로고
    • How Stat1 mediates constitutive gene expression: A complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene
    • Chattedee-Kishore, M., Wright, K. L., Ting, J. P., Stark, G. R. (2000). How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene. EMBO J. 19, 4111-4122.
    • (2000) EMBO J. , vol.19 , pp. 4111-4122
    • Chattedee-Kishore, M.1    Wright, K.L.2    Ting, J.P.3    Stark, G.R.4
  • 15
    • 0029923780 scopus 로고    scopus 로고
    • Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WNF1/CIP1 mediated by STAT1
    • Chin, Y. E., Kitagawa, M., Su, W. C., You, Z. H., Iwamoto, Y., Fu, X. Y. (1996) Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WNF1/CIP1 mediated by STAT1. Science 272, 719-722.
    • (1996) Science , vol.272 , pp. 719-722
    • Chin, Y.E.1    Kitagawa, M.2    Su, W.C.3    You, Z.H.4    Iwamoto, Y.5    Fu, X.Y.6
  • 16
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell, J. E. Jr., Kerr, I. M., Stark, Q. R. (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, Q.R.3
  • 17
    • 2642588293 scopus 로고    scopus 로고
    • Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: Exacerbation of joint inflammation in STAT-1 gene-knockout mice
    • de Hooge, A. S., van de Loo, F. A., Koenders, M. L., Bennink, M. B., Arntz, O. J., Kolbe, T., van den Berg, W. B. (2004) Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice. Arthritis Rheum. 50, 2014-2023.
    • (2004) Arthritis Rheum. , vol.50 , pp. 2014-2023
    • de Hooge, A.S.1    van de Loo, F.A.2    Koenders, M.L.3    Bennink, M.B.4    Arntz, O.J.5    Kolbe, T.6    van den Berg, W.B.7
  • 18
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
    • Durbin, J. E., Hackenmiller, R., Simon, M. C., Levy, D. E. (1996) Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84, 443-450.
    • (1996) Cell , vol.84 , pp. 443-450
    • Durbin, J.E.1    Hackenmiller, R.2    Simon, M.C.3    Levy, D.E.4
  • 20
    • 29144475515 scopus 로고    scopus 로고
    • Global changes in STAT target selection and transcription regulation upon interferon treatments
    • Hartman, S. E., Bertone, P., Nath, A. K., Royce, T. E., Gerstein, M., Weissman, S., Snyder, M. (2005) Global changes in STAT target selection and transcription regulation upon interferon treatments. Genes Dev. 19, 2953-2968.
    • (2005) Genes Dev. , vol.19 , pp. 2953-2968
    • Hartman, S.E.1    Bertone, P.2    Nath, A.K.3    Royce, T.E.4    Gerstein, M.5    Weissman, S.6    Snyder, M.7
  • 21
    • 0034057086 scopus 로고    scopus 로고
    • Thrombin inhibits tumor cell growth in association with up-regulation of p21 (waf/cipl) and caspases via a p53-independent, STAT1-dependent pathway
    • Huang, Y. Q., Li, J. J., Karpatkin, S. (2000) Thrombin inhibits tumor cell growth in association with up-regulation of p21 (waf/cipl) and caspases via a p53-independent, STAT1-dependent pathway J. Biol. Chem. 275, 6462-6468.
    • (2000) J. Biol. Chem. , vol.275 , pp. 6462-6468
    • Huang, Y.Q.1    Li, J.J.2    Karpatkin, S.3
  • 22
    • 0028921573 scopus 로고
    • Jaks, and Stats in signaling by the cytokine receptor superfamily
    • Ihle, J. N., Kerr, I. M. (1995) Jaks, and Stats in signaling by the cytokine receptor superfamily. Trends Genet. 11, 69-74.
    • (1995) Trends Genet. , vol.11 , pp. 69-74
    • Ihle, J.N.1    Kerr, I.M.2
  • 23
    • 0036005884 scopus 로고    scopus 로고
    • The roles of IFN γ in protection against tumor development and cancer immunoediting
    • Ikeda, H., Old, L. J., Schreiber, R. D. (2002) The roles of IFN γ in protection against tumor development and cancer immunoediting. Cytokine Growth Factor Rev. 13, 95-109.
    • (2002) Cytokine Growth Factor Rev. , vol.13 , pp. 95-109
    • Ikeda, H.1    Old, L.J.2    Schreiber, R.D.3
  • 25
    • 0036790295 scopus 로고    scopus 로고
    • The C-terminal activation domain of the STAT-1 transcription factor is necessary and sufficient for stress-induced apoptosis
    • Janjua, S., Stephanou, A., Latchman, D. S. (2002) The C-terminal activation domain of the STAT-1 transcription factor is necessary and sufficient for stress-induced apoptosis. Cell Death Differ. 9, 1140-1146.
    • (2002) Cell Death Differ. , vol.9 , pp. 1140-1146
    • Janjua, S.1    Stephanou, A.2    Latchman, D.S.3
  • 27
    • 15444353992 scopus 로고    scopus 로고
    • Apoptosis of colorectal adenocarcinoma (COLO 201) by tumour necrosis factor-α (TNF-α) and/or interferon-γ (IFN-γ), resulting from down-modulation of Bcl-2 expression
    • Koshiji, M., Adachi, Y., Sogo, S., Taketani, S., Oyaizu, N., Than, S., Inaba, M., Phawa, S., Hioki, K., Ikehara, S. (1998) Apoptosis of colorectal adenocarcinoma (COLO 201) by tumour necrosis factor-α (TNF-α) and/or interferon-γ (IFN-γ), resulting from down-modulation of Bcl-2 expression. Clin. Exp. Immunol. 111, 211-218.
    • (1998) Clin. Exp. Immunol. , vol.111 , pp. 211-218
    • Koshiji, M.1    Adachi, Y.2    Sogo, S.3    Taketani, S.4    Oyaizu, N.5    Than, S.6    Inaba, M.7    Phawa, S.8    Hioki, K.9    Ikehara, S.10
  • 28
  • 29
  • 30
    • 0035862950 scopus 로고    scopus 로고
    • Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression
    • Kovarik, P., Mangold, M., Ramsauer, K., Heidari, H., Steinborn, R., Zotter, A., Levy, D. E., Muller, M., Decker, T. (2001) Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression. EMBO J. 20, 91-100.
    • (2001) EMBO J. , vol.20 , pp. 91-100
    • Kovarik, P.1    Mangold, M.2    Ramsauer, K.3    Heidari, H.4    Steinborn, R.5    Zotter, A.6    Levy, D.E.7    Muller, M.8    Decker, T.9
  • 31
    • 0030659512 scopus 로고    scopus 로고
    • Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases
    • Kumar, A., Commane, M., Flickinger, T. W., Horvath, C. M., Stark, G. R. (1997) Defective TNF-α-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science 278, 1630-1632.
    • (1997) Science , vol.278 , pp. 1630-1632
    • Kumar, A.1    Commane, M.2    Flickinger, T.W.3    Horvath, C.M.4    Stark, G.R.5
  • 32
    • 0034292328 scopus 로고    scopus 로고
    • Distinct requirements for IFNs and STAT1 in NK cell function
    • Lee, C. K., Rao, D. T., Gertner, R., Gimeno, R., Frey, A. B., Levy, D. E. (2000a) Distinct requirements for IFNs and STAT1 in NK cell function. J. Immunol. 165, 3571-3577.
    • (2000) J. Immunol. , vol.165 , pp. 3571-3577
    • Lee, C.K.1    Rao, D.T.2    Gertner, R.3    Gimeno, R.4    Frey, A.B.5    Levy, D.E.6
  • 33
    • 0034142230 scopus 로고    scopus 로고
    • STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-γ
    • Lee, C. K., Smith, E., Gimeno, R., Gertner, R., Levy, D. E. (2000b) STAT1 affects lymphocyte survival and proliferation partially independent of its role downstream of IFN-γ. J. Immunol. 164, 1286-1292.
    • (2000) J. Immunol. , vol.164 , pp. 1286-1292
    • Lee, C.K.1    Smith, E.2    Gimeno, R.3    Gertner, R.4    Levy, D.E.5
  • 34
    • 0000146587 scopus 로고    scopus 로고
    • Differential regulation and function of Fas expression on glial cells
    • Lee, S. J., Zhou, T., Choi, C., Wang, Z., Benveniste, E. N. (2000c) Differential regulation and function of Fas expression on glial cells. J. Immunol. 164, 1277-1285.
    • (2000) J. Immunol. , vol.164 , pp. 1277-1285
    • Lee, S.J.1    Zhou, T.2    Choi, C.3    Wang, Z.4    Benveniste, E.N.5
  • 35
    • 0034658690 scopus 로고    scopus 로고
    • Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice
    • Levy, D. E., Gilliland, D. G. (2000) Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice. Oncogene 19, 2505-2510.
    • (2000) Oncogene , vol.19 , pp. 2505-2510
    • Levy, D.E.1    Gilliland, D.G.2
  • 37
    • 0035902571 scopus 로고    scopus 로고
    • JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion
    • Mascareno, E., El-Shafei, M., Maulik, N., Sato, M., Guo, Y., Das, D. K., Siddiqui, M. A. (2001) JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion. Circulation 104, 325-329.
    • (2001) Circulation , vol.104 , pp. 325-329
    • Mascareno, E.1    El-Shafei, M.2    Maulik, N.3    Sato, M.4    Guo, Y.5    Das, D.K.6    Siddiqui, M.A.7
  • 39
    • 0027434082 scopus 로고
    • Complementation of a mutant cell line: Central role of the 91 kDa polypeptide of ISGF3 in the interferon-α and -γ signal transduction pathways
    • Muller, M., Laxton, C., Briscoe, J., Schindler, C., Improta, T., Darnell, J. E. Jr, Stark, G. R., Kerr, I. M. (1993) Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-α and -γ signal transduction pathways. EMBO J. 12, 4221-4228.
    • (1993) EMBO J. , vol.12 , pp. 4221-4228
    • Muller, M.1    Laxton, C.2    Briscoe, J.3    Schindler, C.4    Improta, T.5    Darnell Jr., J.E.6    Stark, G.R.7    Kerr, I.M.8
  • 40
    • 0033213901 scopus 로고    scopus 로고
    • Negative regulation of cytokine signaling: STAT-induced STAT inhibitor
    • Naka, T., Fujimoto, M., Kishimoto, T. (1999) Negative regulation of cytokine signaling: STAT-induced STAT inhibitor. Trends Biochem. Sci. 24, 394-398.
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 394-398
    • Naka, T.1    Fujimoto, M.2    Kishimoto, T.3
  • 41
    • 0346024088 scopus 로고    scopus 로고
    • Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: Increased susceptibility to autoimmune disease
    • Nishibori, T., Tanabe, Y., Su, L., David, M. (2004) Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease. J. Exp. Med. 199, 25-34.
    • (2004) J. Exp. Med. , vol.199 , pp. 25-34
    • Nishibori, T.1    Tanabe, Y.2    Su, L.3    David, M.4
  • 43
    • 0033973215 scopus 로고    scopus 로고
    • Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-α
    • Pansky, A., Hildebrand, P., Fasler-Kan, E., Baselgia, L., Ketterer, S., Beglinger, C., Heim, M. H. (2000) Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-α. Int. J. Cancer 85, 720-725.
    • (2000) Int. J. Cancer , vol.85 , pp. 720-725
    • Pansky, A.1    Hildebrand, P.2    Fasler-Kan, E.3    Baselgia, L.4    Ketterer, S.5    Beglinger, C.6    Heim, M.H.7
  • 45
    • 0034960254 scopus 로고    scopus 로고
    • STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2
    • Sahni, M., Raz, R., Coffin, J. D., Levy, D., Basilico, C. (2001) STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2. Development 128, 2119-2129.
    • (2001) Development , vol.128 , pp. 2119-2129
    • Sahni, M.1    Raz, R.2    Coffin, J.D.3    Levy, D.4    Basilico, C.5
  • 46
    • 0026725868 scopus 로고
    • Proteins of transcription factor ISGF-3: One gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon α
    • Schindler, C., Fu, X. Y., Improta, T., Aebersold, R., Darnell, J. E. Jr. (1992) Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon α. Proc. Natl. Acad. Sci. USA 89, 7836-7839.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7836-7839
    • Schindler, C.1    Fu, X.Y.2    Improta, T.3    Aebersold, R.4    Darnell Jr., J.E.5
  • 47
    • 0028937707 scopus 로고
    • Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity
    • Seidel, H. M., Milocco, L. H., Lamb, P., Darnell, J. E. Jr., Stein, R. B., Rosen, J. (1995) Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc. Natl. Acad. Sci. USA 92, 3041-3045.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3041-3045
    • Seidel, H.M.1    Milocco, L.H.2    Lamb, P.3    Darnell Jr., J.E.4    Stein, R.B.5    Rosen, J.6
  • 48
    • 0035953308 scopus 로고    scopus 로고
    • IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    • Shankaran, V., Ikeda, H., Bruce, A. T., White, J. M., Swanson, P. E., Old, L. J., Schreiber, R. D. (2001) IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 410, 1107-1111.
    • (2001) Nature , vol.410 , pp. 1107-1111
    • Shankaran, V.1    Ikeda, H.2    Bruce, A.T.3    White, J.M.4    Swanson, P.E.5    Old, L.J.6    Schreiber, R.D.7
  • 49
    • 0035879751 scopus 로고    scopus 로고
    • IFN-γ induces cell death in human hepatoma cells through a TRAIL/death receptor-mediated apoptotic pathway
    • Shin, E. C., Ahn, J. M., Kim, C. H., Choi, Y., Alin, Y. S., Kim, H., Kim, S. J., Park, J. H. (2001) IFN-γ induces cell death in human hepatoma cells through a TRAIL/death receptor-mediated apoptotic pathway. Int. J. Cancer 93, 262-268.
    • (2001) Int. J. Cancer , vol.93 , pp. 262-268
    • Shin, E.C.1    Ahn, J.M.2    Kim, C.H.3    Choi, Y.4    Alin, Y.S.5    Kim, H.6    Kim, S.J.7    Park, J.H.8
  • 50
    • 0032921172 scopus 로고    scopus 로고
    • The STAT family of proteins in cytokine signaling
    • Shuai, K. (1999) The STAT family of proteins in cytokine signaling. Prog. Biophys. Mol. Biol. 71, 405-422.
    • (1999) Prog. Biophys. Mol. Biol. , vol.71 , pp. 405-422
    • Shuai, K.1
  • 51
    • 0034657917 scopus 로고    scopus 로고
    • Modulation of STAT signaling by STAT-interacting proteins
    • Shuai, K. (2000) Modulation of STAT signaling by STAT-interacting proteins. Oncogene 19, 2638-2644.
    • (2000) Oncogene , vol.19 , pp. 2638-2644
    • Shuai, K.1
  • 52
    • 0027772891 scopus 로고
    • Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins
    • Shuai, K., Ziemiecki, A., Wilks, A. F., Harpur, A. G., Sadowski, H. B., Gilman, M. Z., Darnell, J. E. (1993) Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature 366, 580-583.
    • (1993) Nature , vol.366 , pp. 580-583
    • Shuai, K.1    Ziemiecki, A.2    Wilks, A.F.3    Harpur, A.G.4    Sadowski, H.B.5    Gilman, M.Z.6    Darnell, J.E.7
  • 54
    • 0032966863 scopus 로고    scopus 로고
    • Negative regulation of the JAK/STAT pathway
    • Starr, R., Hilton, D. J. (1999) Negative regulation of the JAK/STAT pathway. BioEssays 21, 47-52.
    • (1999) BioEssays , vol.21 , pp. 47-52
    • Starr, R.1    Hilton, D.J.2
  • 56
    • 32144463144 scopus 로고    scopus 로고
    • Opposing actions of STAT-1 and STAT-3
    • Stephanou, A., Latchman, D. S. (2005) Opposing actions of STAT-1 and STAT-3. Growth Factors 23, 177-182.
    • (2005) Growth Factors , vol.23 , pp. 177-182
    • Stephanou, A.1    Latchman, D.S.2
  • 57
    • 0030896404 scopus 로고    scopus 로고
    • Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism
    • Su, W. C., Kitagawa, M., Xue, N., Xie, B., Garofalo, S., Cho, J., Deng, C., Horton, W. A., Fu, X. Y. (1997) Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism. Nature 386, 288-292.
    • (1997) Nature , vol.386 , pp. 288-292
    • Su, W.C.1    Kitagawa, M.2    Xue, N.3    Xie, B.4    Garofalo, S.5    Cho, J.6    Deng, C.7    Horton, W.A.8    Fu, X.Y.9
  • 58
    • 0035313059 scopus 로고    scopus 로고
    • IFN-γ/TNF-α synergism as the final effector in autoimmune diabetes: A key role for STAT1/IFN regulatory factor-1 pathway in pancreatic β cell death
    • Suk, K., Kim, S., Kim, Y H., Kim, K. A., Chang, I., Yagita, H., Shong, M., Lee, M. S. (2001) IFN-γ/TNF-α synergism as the final effector in autoimmune diabetes: a key role for STAT1/IFN regulatory factor-1 pathway in pancreatic β cell death. J. Immunol. 166, 4481-4489.
    • (2001) J. Immunol. , vol.166 , pp. 4481-4489
    • Suk, K.1    Kim, S.2    Kim, Y.H.3    Kim, K.A.4    Chang, I.5    Yagita, H.6    Shong, M.7    Lee, M.S.8
  • 60
    • 0034046605 scopus 로고    scopus 로고
    • STAT family of transcription factors in cytokine-mediated biological responses
    • Takeda, K., Akira, S. (2000) STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev. 11, 199-207.
    • (2000) Cytokine Growth Factor Rev. , vol.11 , pp. 199-207
    • Takeda, K.1    Akira, S.2
  • 65
    • 0036793979 scopus 로고    scopus 로고
    • Prognostic significance of signal transducer and activator of transcription 1 activation in breast cancer
    • Widschwendter, A., Tonko-Geymayer, S., Welte, T., Daxenbichler, G., Marth, C., Doppler, W. (2002) Prognostic significance of signal transducer and activator of transcription 1 activation in breast cancer. Clin. Cancer Res. 8, 3065-3074.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 3065-3074
    • Widschwendter, A.1    Tonko-Geymayer, S.2    Welte, T.3    Daxenbichler, G.4    Marth, C.5    Doppler, W.6
  • 67
    • 33750577456 scopus 로고    scopus 로고
    • Proximal genomic localization of STAT1 binding and regulated transcriptional activity
    • Wormald, S., Hilton, D. J., Smyth, G. K., Speed, T. P. (2006a) Proximal genomic localization of STAT1 binding and regulated transcriptional activity. BMC Genomics 7, 254.
    • (2006) BMC Genomics , vol.7 , pp. 254
    • Wormald, S.1    Hilton, D.J.2    Smyth, G.K.3    Speed, T.P.4
  • 68
    • 33744963148 scopus 로고    scopus 로고
    • The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling
    • Wormald, S., Zhang, J. G., Krebs, D. L., Mielke, L. A., Silver, J., Alexander, W. S., Speed, T. P., Nicola, N. A., Hilton, D. J. (2006b) The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling. J. Biol. Chem. 281, 11135-11143.
    • (2006) J. Biol. Chem. , vol.281 , pp. 11135-11143
    • Wormald, S.1    Zhang, J.G.2    Krebs, D.L.3    Mielke, L.A.4    Silver, J.5    Alexander, W.S.6    Speed, T.P.7    Nicola, N.A.8    Hilton, D.J.9
  • 69
    • 0032528191 scopus 로고    scopus 로고
    • Expression of signal transducers and activators of transcription proteins in acute myeloid leukemia blasts
    • Xia, Z., Baer, M. R., Block, A. W., Baumann, H., Wetzler, M. (1998) Expression of signal transducers and activators of transcription proteins in acute myeloid leukemia blasts. Cancer Res. 58, 3173-3180.
    • (1998) Cancer Res. , vol.58 , pp. 3173-3180
    • Xia, Z.1    Baer, M.R.2    Block, A.W.3    Baumann, H.4    Wetzler, M.5
  • 70
    • 0032125574 scopus 로고    scopus 로고
    • IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: Requirement of STAT1 protein for up-regulation of Fas and FasL expression
    • Xu, X., Fu, X. Y, Plate, J., Chong, A. S. (1998) IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression. Cancer Res. 58, 2832-2837.
    • (1998) Cancer Res. , vol.58 , pp. 2832-2837
    • Xu, X.1    Fu, X.Y.2    Plate, J.3    Chong, A.S.4
  • 71
    • 0032980574 scopus 로고    scopus 로고
    • Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway
    • You, M., Yu, D. H., Feng, G. S. (1999) Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. Mol. Cell. Biol. 19, 2416-2424.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2416-2424
    • You, M.1    Yu, D.H.2    Feng, G.S.3


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