Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 17, 2005, Pages 5998-6003

  Nam, Sangkil ^a   Buettner, Ralf ^a   Turkson, James ^a   Kim, Donghwa ^b   Cheng, Jin Q ^a,b   Muehlbeyer, Stephan ^c   Hippe, Frankie ^c   Vatter, Sandra ^c   Merz, Karl Heinz ^c   Eisenbrand, Gerhard ^c   Jove, Richard ^a,b  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c Rheinland Pfälzische Technische Universität Kaiserslautern Landau   (Germany)

Author keywords

Signal transducer and activator of transcription 3; Src

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; E 564; E 728; E 804; INDIRUBIN; PROTEIN TYROSINE KINASE; STAT3 PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CARCINOGENESIS; CHINESE MEDICINE; DOWN REGULATION; ENZYME INHIBITION; GENETIC CODE; HERBAL MEDICINE; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; DNA-BINDING PROTEINS; FEMALE; GROWTH INHIBITORS; HUMANS; INDOLES; KINETICS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; PHOSPHORYLATION; PROSTATIC NEOPLASMS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 20944435625     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0409467102     Document Type: Article

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