Discovery of chromone-based inhibitors of the transcription factor STAT5

ChemBioChem

Volumn 9, Issue 5, 2008, Pages 723-727

  Müller, Judith ^a   Sperl, Bianca ^a   Reindll, Wolfgang ^a   Kiessling, Anke ^a   Berg, Thorsten ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

Inhibitors; Protein protein interactions; Screening; Signal transduction; Transcription factor

Indexed keywords

ACETYL HYDRAZONE; ACYL HYDRAZONE; BENZOPYRAN DERIVATIVE; CHROMONE DERIVATIVE; FORMYL CHROMONE; FORMYL HYDRAZONE; HYDRAZONE DERIVATIVE; NICOTINOYL HYDRAZONE DERIVATIVE; STAT3 PROTEIN; STAT5 PROTEIN; UNCLASSIFIED DRUG; ALDEHYDE; DNA; LIGAND;

ARTICLE; CARCINOGENESIS; CHEMICAL ANALYSIS; DNA BINDING; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; FLUORESCENCE POLARIZATION IMMUNOASSAY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; VALIDATION PROCESS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; HUMAN; MOLECULAR LIBRARY; SRC HOMOLOGY DOMAIN; TUMOR CELL LINE;

ALDEHYDES; CELL LINE, TUMOR; CHROMONES; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDRAZONES; LIGANDS; MOLECULAR STRUCTURE; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; SRC HOMOLOGY DOMAINS; STAT5 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 43149095374     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200700701     Document Type: Article

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